Amino acid dipepetide frequency for Bacteroidetes bacterium UKL13-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.125AlaAla: 5.125 ± 0.13
0.714AlaCys: 0.714 ± 0.031
3.692AlaAsp: 3.692 ± 0.07
3.816AlaGlu: 3.816 ± 0.091
3.416AlaPhe: 3.416 ± 0.064
4.855AlaGly: 4.855 ± 0.133
1.174AlaHis: 1.174 ± 0.037
5.529AlaIle: 5.529 ± 0.099
4.691AlaLys: 4.691 ± 0.103
6.135AlaLeu: 6.135 ± 0.098
1.716AlaMet: 1.716 ± 0.046
4.027AlaAsn: 4.027 ± 0.098
2.153AlaPro: 2.153 ± 0.077
2.873AlaGln: 2.873 ± 0.062
2.263AlaArg: 2.263 ± 0.059
4.398AlaSer: 4.398 ± 0.131
4.337AlaThr: 4.337 ± 0.217
4.106AlaVal: 4.106 ± 0.095
0.614AlaTrp: 0.614 ± 0.023
2.637AlaTyr: 2.637 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.626CysAla: 0.626 ± 0.027
0.165CysCys: 0.165 ± 0.015
0.56CysAsp: 0.56 ± 0.029
0.51CysGlu: 0.51 ± 0.026
0.482CysPhe: 0.482 ± 0.022
0.732CysGly: 0.732 ± 0.033
0.218CysHis: 0.218 ± 0.02
0.768CysIle: 0.768 ± 0.033
0.682CysLys: 0.682 ± 0.033
0.847CysLeu: 0.847 ± 0.037
0.208CysMet: 0.208 ± 0.015
0.548CysAsn: 0.548 ± 0.027
0.353CysPro: 0.353 ± 0.021
0.247CysGln: 0.247 ± 0.019
0.328CysArg: 0.328 ± 0.02
0.677CysSer: 0.677 ± 0.03
0.552CysThr: 0.552 ± 0.055
0.59CysVal: 0.59 ± 0.022
0.117CysTrp: 0.117 ± 0.011
0.373CysTyr: 0.373 ± 0.02
0.0CysXaa: 0.0 ± 0.0
Asp
3.73AspAla: 3.73 ± 0.074
0.465AspCys: 0.465 ± 0.024
2.35AspAsp: 2.35 ± 0.062
3.423AspGlu: 3.423 ± 0.09
2.972AspPhe: 2.972 ± 0.061
3.239AspGly: 3.239 ± 0.065
0.776AspHis: 0.776 ± 0.031
4.02AspIle: 4.02 ± 0.074
3.741AspLys: 3.741 ± 0.107
4.399AspLeu: 4.399 ± 0.085
1.231AspMet: 1.231 ± 0.047
2.425AspAsn: 2.425 ± 0.053
1.542AspPro: 1.542 ± 0.047
1.317AspGln: 1.317 ± 0.038
1.798AspArg: 1.798 ± 0.061
3.515AspSer: 3.515 ± 0.083
3.09AspThr: 3.09 ± 0.089
3.49AspVal: 3.49 ± 0.063
0.583AspTrp: 0.583 ± 0.024
2.374AspTyr: 2.374 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
3.911GluAla: 3.911 ± 0.097
0.488GluCys: 0.488 ± 0.024
2.578GluAsp: 2.578 ± 0.066
3.803GluGlu: 3.803 ± 0.116
2.645GluPhe: 2.645 ± 0.055
3.248GluGly: 3.248 ± 0.09
1.27GluHis: 1.27 ± 0.049
4.536GluIle: 4.536 ± 0.101
4.878GluLys: 4.878 ± 0.119
6.1GluLeu: 6.1 ± 0.128
1.64GluMet: 1.64 ± 0.054
3.303GluAsn: 3.303 ± 0.067
1.555GluPro: 1.555 ± 0.052
2.645GluGln: 2.645 ± 0.068
2.366GluArg: 2.366 ± 0.059
2.958GluSer: 2.958 ± 0.078
3.268GluThr: 3.268 ± 0.07
3.771GluVal: 3.771 ± 0.078
0.655GluTrp: 0.655 ± 0.031
2.323GluTyr: 2.323 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
3.506PheAla: 3.506 ± 0.067
0.532PheCys: 0.532 ± 0.027
2.973PheAsp: 2.973 ± 0.071
3.184PheGlu: 3.184 ± 0.081
2.439PhePhe: 2.439 ± 0.067
3.596PheGly: 3.596 ± 0.074
0.915PheHis: 0.915 ± 0.038
3.859PheIle: 3.859 ± 0.081
3.188PheLys: 3.188 ± 0.074
4.015PheLeu: 4.015 ± 0.1
1.169PheMet: 1.169 ± 0.039
3.185PheAsn: 3.185 ± 0.071
1.714PhePro: 1.714 ± 0.041
1.47PheGln: 1.47 ± 0.039
1.764PheArg: 1.764 ± 0.046
3.657PheSer: 3.657 ± 0.071
3.322PheThr: 3.322 ± 0.072
3.323PheVal: 3.323 ± 0.069
0.574PheTrp: 0.574 ± 0.031
2.02PheTyr: 2.02 ± 0.055
0.0PheXaa: 0.0 ± 0.0
Gly
4.36GlyAla: 4.36 ± 0.124
0.748GlyCys: 0.748 ± 0.038
3.061GlyAsp: 3.061 ± 0.072
3.341GlyGlu: 3.341 ± 0.076
3.629GlyPhe: 3.629 ± 0.074
4.699GlyGly: 4.699 ± 0.169
1.03GlyHis: 1.03 ± 0.041
5.414GlyIle: 5.414 ± 0.104
5.18GlyLys: 5.18 ± 0.089
5.793GlyLeu: 5.793 ± 0.098
1.709GlyMet: 1.709 ± 0.048
3.874GlyAsn: 3.874 ± 0.122
1.355GlyPro: 1.355 ± 0.044
1.888GlyGln: 1.888 ± 0.053
2.25GlyArg: 2.25 ± 0.069
4.282GlySer: 4.282 ± 0.194
4.399GlyThr: 4.399 ± 0.267
4.487GlyVal: 4.487 ± 0.101
0.773GlyTrp: 0.773 ± 0.039
2.84GlyTyr: 2.84 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
1.222HisAla: 1.222 ± 0.044
0.242HisCys: 0.242 ± 0.019
0.788HisAsp: 0.788 ± 0.028
0.998HisGlu: 0.998 ± 0.04
1.236HisPhe: 1.236 ± 0.041
1.047HisGly: 1.047 ± 0.043
0.576HisHis: 0.576 ± 0.034
1.597HisIle: 1.597 ± 0.048
1.288HisLys: 1.288 ± 0.039
1.794HisLeu: 1.794 ± 0.055
0.326HisMet: 0.326 ± 0.022
1.035HisAsn: 1.035 ± 0.033
0.972HisPro: 0.972 ± 0.038
0.816HisGln: 0.816 ± 0.037
0.742HisArg: 0.742 ± 0.028
1.165HisSer: 1.165 ± 0.041
1.159HisThr: 1.159 ± 0.039
1.005HisVal: 1.005 ± 0.038
0.205HisTrp: 0.205 ± 0.017
0.888HisTyr: 0.888 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.884IleAla: 5.884 ± 0.091
0.823IleCys: 0.823 ± 0.043
4.775IleAsp: 4.775 ± 0.082
5.112IleGlu: 5.112 ± 0.101
3.153IlePhe: 3.153 ± 0.072
5.271IleGly: 5.271 ± 0.113
1.512IleHis: 1.512 ± 0.048
5.728IleIle: 5.728 ± 0.107
5.342IleLys: 5.342 ± 0.111
6.511IleLeu: 6.511 ± 0.11
1.433IleMet: 1.433 ± 0.047
4.638IleAsn: 4.638 ± 0.078
3.138IlePro: 3.138 ± 0.068
2.844IleGln: 2.844 ± 0.057
2.88IleArg: 2.88 ± 0.062
5.29IleSer: 5.29 ± 0.083
5.22IleThr: 5.22 ± 0.118
4.737IleVal: 4.737 ± 0.089
0.634IleTrp: 0.634 ± 0.028
2.688IleTyr: 2.688 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
4.885LysAla: 4.885 ± 0.107
0.455LysCys: 0.455 ± 0.026
3.77LysAsp: 3.77 ± 0.089
4.981LysGlu: 4.981 ± 0.122
2.601LysPhe: 2.601 ± 0.06
4.553LysGly: 4.553 ± 0.086
1.676LysHis: 1.676 ± 0.052
5.117LysIle: 5.117 ± 0.112
5.473LysLys: 5.473 ± 0.12
6.61LysLeu: 6.61 ± 0.135
1.999LysMet: 1.999 ± 0.058
4.16LysAsn: 4.16 ± 0.077
2.793LysPro: 2.793 ± 0.07
3.362LysGln: 3.362 ± 0.08
3.084LysArg: 3.084 ± 0.08
4.203LysSer: 4.203 ± 0.091
4.163LysThr: 4.163 ± 0.091
4.663LysVal: 4.663 ± 0.091
0.788LysTrp: 0.788 ± 0.032
2.857LysTyr: 2.857 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
6.005LeuAla: 6.005 ± 0.092
0.873LeuCys: 0.873 ± 0.032
4.393LeuAsp: 4.393 ± 0.085
4.774LeuGlu: 4.774 ± 0.103
4.928LeuPhe: 4.928 ± 0.111
5.545LeuGly: 5.545 ± 0.107
1.872LeuHis: 1.872 ± 0.055
6.676LeuIle: 6.676 ± 0.137
6.938LeuLys: 6.938 ± 0.146
9.169LeuLeu: 9.169 ± 0.204
2.228LeuMet: 2.228 ± 0.062
5.806LeuAsn: 5.806 ± 0.09
3.761LeuPro: 3.761 ± 0.078
3.556LeuGln: 3.556 ± 0.073
3.513LeuArg: 3.513 ± 0.075
6.748LeuSer: 6.748 ± 0.105
5.689LeuThr: 5.689 ± 0.128
5.582LeuVal: 5.582 ± 0.099
0.796LeuTrp: 0.796 ± 0.032
3.28LeuTyr: 3.28 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
1.643MetAla: 1.643 ± 0.045
0.223MetCys: 0.223 ± 0.015
1.197MetAsp: 1.197 ± 0.039
1.465MetGlu: 1.465 ± 0.046
0.931MetPhe: 0.931 ± 0.037
1.654MetGly: 1.654 ± 0.046
0.538MetHis: 0.538 ± 0.027
1.639MetIle: 1.639 ± 0.053
2.038MetLys: 2.038 ± 0.055
2.388MetLeu: 2.388 ± 0.064
0.741MetMet: 0.741 ± 0.034
1.516MetAsn: 1.516 ± 0.044
0.998MetPro: 0.998 ± 0.04
1.054MetGln: 1.054 ± 0.036
1.041MetArg: 1.041 ± 0.032
1.485MetSer: 1.485 ± 0.041
1.087MetThr: 1.087 ± 0.035
1.522MetVal: 1.522 ± 0.046
0.2MetTrp: 0.2 ± 0.015
0.726MetTyr: 0.726 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.03AsnAla: 4.03 ± 0.105
0.566AsnCys: 0.566 ± 0.029
2.962AsnAsp: 2.962 ± 0.064
3.443AsnGlu: 3.443 ± 0.081
2.599AsnPhe: 2.599 ± 0.06
4.214AsnGly: 4.214 ± 0.117
1.088AsnHis: 1.088 ± 0.043
5.111AsnIle: 5.111 ± 0.096
4.146AsnLys: 4.146 ± 0.092
4.926AsnLeu: 4.926 ± 0.1
1.459AsnMet: 1.459 ± 0.046
4.035AsnAsn: 4.035 ± 0.149
2.941AsnPro: 2.941 ± 0.075
2.265AsnGln: 2.265 ± 0.055
2.379AsnArg: 2.379 ± 0.056
3.58AsnSer: 3.58 ± 0.103
3.903AsnThr: 3.903 ± 0.16
3.536AsnVal: 3.536 ± 0.077
0.774AsnTrp: 0.774 ± 0.034
2.613AsnTyr: 2.613 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
2.396ProAla: 2.396 ± 0.075
0.313ProCys: 0.313 ± 0.021
2.01ProAsp: 2.01 ± 0.051
2.307ProGlu: 2.307 ± 0.052
2.094ProPhe: 2.094 ± 0.057
2.035ProGly: 2.035 ± 0.067
0.679ProHis: 0.679 ± 0.027
2.833ProIle: 2.833 ± 0.06
2.351ProLys: 2.351 ± 0.069
2.95ProLeu: 2.95 ± 0.063
0.871ProMet: 0.871 ± 0.036
2.347ProAsn: 2.347 ± 0.061
0.973ProPro: 0.973 ± 0.038
1.431ProGln: 1.431 ± 0.042
1.134ProArg: 1.134 ± 0.04
2.33ProSer: 2.33 ± 0.06
2.334ProThr: 2.334 ± 0.088
2.393ProVal: 2.393 ± 0.053
0.318ProTrp: 0.318 ± 0.021
1.469ProTyr: 1.469 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.242GlnAla: 2.242 ± 0.061
0.269GlnCys: 0.269 ± 0.017
1.403GlnAsp: 1.403 ± 0.036
1.884GlnGlu: 1.884 ± 0.055
1.838GlnPhe: 1.838 ± 0.053
1.823GlnGly: 1.823 ± 0.045
0.88GlnHis: 0.88 ± 0.039
2.645GlnIle: 2.645 ± 0.06
2.878GlnLys: 2.878 ± 0.071
4.241GlnLeu: 4.241 ± 0.1
0.899GlnMet: 0.899 ± 0.037
2.306GlnAsn: 2.306 ± 0.047
1.333GlnPro: 1.333 ± 0.047
2.303GlnGln: 2.303 ± 0.072
1.436GlnArg: 1.436 ± 0.041
2.389GlnSer: 2.389 ± 0.055
2.491GlnThr: 2.491 ± 0.059
2.135GlnVal: 2.135 ± 0.056
0.385GlnTrp: 0.385 ± 0.022
1.696GlnTyr: 1.696 ± 0.048
0.0GlnXaa: 0.0 ± 0.0
Arg
2.149ArgAla: 2.149 ± 0.049
0.273ArgCys: 0.273 ± 0.018
1.695ArgAsp: 1.695 ± 0.051
2.124ArgGlu: 2.124 ± 0.065
2.066ArgPhe: 2.066 ± 0.05
2.054ArgGly: 2.054 ± 0.063
0.588ArgHis: 0.588 ± 0.03
3.15ArgIle: 3.15 ± 0.068
3.019ArgLys: 3.019 ± 0.081
3.555ArgLeu: 3.555 ± 0.068
1.14ArgMet: 1.14 ± 0.043
2.541ArgAsn: 2.541 ± 0.058
1.211ArgPro: 1.211 ± 0.045
1.095ArgGln: 1.095 ± 0.041
1.376ArgArg: 1.376 ± 0.052
2.059ArgSer: 2.059 ± 0.049
2.116ArgThr: 2.116 ± 0.049
2.415ArgVal: 2.415 ± 0.062
0.477ArgTrp: 0.477 ± 0.023
1.744ArgTyr: 1.744 ± 0.049
0.0ArgXaa: 0.0 ± 0.0
Ser
4.311SerAla: 4.311 ± 0.15
0.701SerCys: 0.701 ± 0.031
3.086SerAsp: 3.086 ± 0.062
3.29SerGlu: 3.29 ± 0.076
3.733SerPhe: 3.733 ± 0.065
4.769SerGly: 4.769 ± 0.19
1.037SerHis: 1.037 ± 0.036
5.57SerIle: 5.57 ± 0.097
4.358SerLys: 4.358 ± 0.1
6.085SerLeu: 6.085 ± 0.095
1.509SerMet: 1.509 ± 0.042
4.039SerAsn: 4.039 ± 0.116
2.154SerPro: 2.154 ± 0.055
2.0SerGln: 2.0 ± 0.047
2.178SerArg: 2.178 ± 0.046
4.537SerSer: 4.537 ± 0.145
4.15SerThr: 4.15 ± 0.191
4.396SerVal: 4.396 ± 0.08
0.655SerTrp: 0.655 ± 0.034
2.694SerTyr: 2.694 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.561ThrAla: 4.561 ± 0.232
0.46ThrCys: 0.46 ± 0.023
3.125ThrAsp: 3.125 ± 0.071
3.232ThrGlu: 3.232 ± 0.069
3.243ThrPhe: 3.243 ± 0.081
4.61ThrGly: 4.61 ± 0.289
1.137ThrHis: 1.137 ± 0.036
5.305ThrIle: 5.305 ± 0.167
3.546ThrLys: 3.546 ± 0.061
5.98ThrLeu: 5.98 ± 0.106
1.105ThrMet: 1.105 ± 0.035
3.578ThrAsn: 3.578 ± 0.127
2.665ThrPro: 2.665 ± 0.073
2.284ThrGln: 2.284 ± 0.056
1.962ThrArg: 1.962 ± 0.051
4.142ThrSer: 4.142 ± 0.206
4.112ThrThr: 4.112 ± 0.263
4.102ThrVal: 4.102 ± 0.121
0.664ThrTrp: 0.664 ± 0.047
2.648ThrTyr: 2.648 ± 0.1
0.0ThrXaa: 0.0 ± 0.0
Val
4.418ValAla: 4.418 ± 0.082
0.717ValCys: 0.717 ± 0.032
3.419ValAsp: 3.419 ± 0.078
3.599ValGlu: 3.599 ± 0.07
3.495ValPhe: 3.495 ± 0.068
3.971ValGly: 3.971 ± 0.087
1.104ValHis: 1.104 ± 0.035
4.624ValIle: 4.624 ± 0.076
4.68ValLys: 4.68 ± 0.086
5.931ValLeu: 5.931 ± 0.092
1.559ValMet: 1.559 ± 0.046
3.918ValAsn: 3.918 ± 0.105
2.151ValPro: 2.151 ± 0.055
1.956ValGln: 1.956 ± 0.046
2.26ValArg: 2.26 ± 0.061
4.465ValSer: 4.465 ± 0.085
3.791ValThr: 3.791 ± 0.113
4.324ValVal: 4.324 ± 0.078
0.636ValTrp: 0.636 ± 0.027
2.546ValTyr: 2.546 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.567TrpAla: 0.567 ± 0.024
0.11TrpCys: 0.11 ± 0.009
0.561TrpAsp: 0.561 ± 0.029
0.535TrpGlu: 0.535 ± 0.024
0.543TrpPhe: 0.543 ± 0.028
0.716TrpGly: 0.716 ± 0.033
0.207TrpHis: 0.207 ± 0.018
0.777TrpIle: 0.777 ± 0.03
0.818TrpLys: 0.818 ± 0.036
1.024TrpLeu: 1.024 ± 0.042
0.325TrpMet: 0.325 ± 0.022
0.741TrpAsn: 0.741 ± 0.031
0.28TrpPro: 0.28 ± 0.02
0.474TrpGln: 0.474 ± 0.025
0.405TrpArg: 0.405 ± 0.022
0.57TrpSer: 0.57 ± 0.029
0.544TrpThr: 0.544 ± 0.037
0.678TrpVal: 0.678 ± 0.028
0.149TrpTrp: 0.149 ± 0.015
0.465TrpTyr: 0.465 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.702TyrAla: 2.702 ± 0.06
0.447TyrCys: 0.447 ± 0.024
2.082TyrAsp: 2.082 ± 0.06
2.122TyrGlu: 2.122 ± 0.068
2.361TyrPhe: 2.361 ± 0.064
2.481TyrGly: 2.481 ± 0.056
0.821TyrHis: 0.821 ± 0.033
2.713TyrIle: 2.713 ± 0.059
2.954TyrLys: 2.954 ± 0.076
3.68TyrLeu: 3.68 ± 0.084
0.817TyrMet: 0.817 ± 0.03
2.551TyrAsn: 2.551 ± 0.058
1.528TyrPro: 1.528 ± 0.046
1.595TyrGln: 1.595 ± 0.046
1.69TyrArg: 1.69 ± 0.048
2.802TyrSer: 2.802 ± 0.069
2.733TyrThr: 2.733 ± 0.069
2.308TyrVal: 2.308 ± 0.054
0.495TyrTrp: 0.495 ± 0.024
1.98TyrTyr: 1.98 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2576 proteins (874788 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski