Amino acid dipepetide frequency for Companilactobacillus farciminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.884AlaAla: 4.884 ± 0.102	0.326AlaCys: 0.326 ± 0.023	4.143AlaAsp: 4.143 ± 0.088	3.382AlaGlu: 3.382 ± 0.08	2.914AlaPhe: 2.914 ± 0.069	4.629AlaGly: 4.629 ± 0.101	1.14AlaHis: 1.14 ± 0.043	5.534AlaIle: 5.534 ± 0.114	5.362AlaLys: 5.362 ± 0.116	6.368AlaLeu: 6.368 ± 0.098	1.859AlaMet: 1.859 ± 0.057	3.458AlaAsn: 3.458 ± 0.074	1.896AlaPro: 1.896 ± 0.059	2.782AlaGln: 2.782 ± 0.066	2.113AlaArg: 2.113 ± 0.056	3.962AlaSer: 3.962 ± 0.074	4.163AlaThr: 4.163 ± 0.083	4.7AlaVal: 4.7 ± 0.097	0.596AlaTrp: 0.596 ± 0.028	2.22AlaTyr: 2.22 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.345CysAla: 0.345 ± 0.024	0.038CysCys: 0.038 ± 0.008	0.312CysAsp: 0.312 ± 0.022	0.204CysGlu: 0.204 ± 0.018	0.223CysPhe: 0.223 ± 0.018	0.414CysGly: 0.414 ± 0.023	0.132CysHis: 0.132 ± 0.013	0.296CysIle: 0.296 ± 0.021	0.209CysLys: 0.209 ± 0.017	0.477CysLeu: 0.477 ± 0.024	0.123CysMet: 0.123 ± 0.013	0.162CysAsn: 0.162 ± 0.016	0.203CysPro: 0.203 ± 0.018	0.184CysGln: 0.184 ± 0.015	0.155CysArg: 0.155 ± 0.015	0.303CysSer: 0.303 ± 0.02	0.228CysThr: 0.228 ± 0.02	0.304CysVal: 0.304 ± 0.019	0.051CysTrp: 0.051 ± 0.01	0.145CysTyr: 0.145 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	3.759AspAla: 3.759 ± 0.088	0.262AspCys: 0.262 ± 0.024	4.362AspAsp: 4.362 ± 0.104	4.347AspGlu: 4.347 ± 0.098	3.287AspPhe: 3.287 ± 0.071	3.89AspGly: 3.89 ± 0.089	1.254AspHis: 1.254 ± 0.041	4.555AspIle: 4.555 ± 0.1	5.192AspLys: 5.192 ± 0.095	6.11AspLeu: 6.11 ± 0.099	1.616AspMet: 1.616 ± 0.054	3.645AspAsn: 3.645 ± 0.085	2.238AspPro: 2.238 ± 0.067	2.568AspGln: 2.568 ± 0.061	1.955AspArg: 1.955 ± 0.057	3.811AspSer: 3.811 ± 0.091	3.313AspThr: 3.313 ± 0.085	4.143AspVal: 4.143 ± 0.097	0.709AspTrp: 0.709 ± 0.031	2.794AspTyr: 2.794 ± 0.065	0.0AspXaa: 0.0 ± 0.0
Glu	3.374GluAla: 3.374 ± 0.083	0.177GluCys: 0.177 ± 0.017	3.423GluAsp: 3.423 ± 0.082	3.426GluGlu: 3.426 ± 0.076	2.419GluPhe: 2.419 ± 0.061	2.601GluGly: 2.601 ± 0.076	1.138GluHis: 1.138 ± 0.047	4.566GluIle: 4.566 ± 0.09	5.101GluLys: 5.101 ± 0.082	5.592GluLeu: 5.592 ± 0.102	1.698GluMet: 1.698 ± 0.049	3.6GluAsn: 3.6 ± 0.083	1.543GluPro: 1.543 ± 0.049	2.319GluGln: 2.319 ± 0.063	1.869GluArg: 1.869 ± 0.056	2.911GluSer: 2.911 ± 0.069	3.02GluThr: 3.02 ± 0.067	3.642GluVal: 3.642 ± 0.081	0.53GluTrp: 0.53 ± 0.031	2.071GluTyr: 2.071 ± 0.056	0.0GluXaa: 0.0 ± 0.0
Phe	2.846PheAla: 2.846 ± 0.068	0.236PheCys: 0.236 ± 0.017	3.179PheAsp: 3.179 ± 0.064	2.365PheGlu: 2.365 ± 0.063	2.204PhePhe: 2.204 ± 0.075	3.348PheGly: 3.348 ± 0.08	0.797PheHis: 0.797 ± 0.033	3.639PheIle: 3.639 ± 0.089	2.923PheLys: 2.923 ± 0.062	4.197PheLeu: 4.197 ± 0.099	1.106PheMet: 1.106 ± 0.036	2.655PheAsn: 2.655 ± 0.06	1.452PhePro: 1.452 ± 0.049	1.44PheGln: 1.44 ± 0.04	1.239PheArg: 1.239 ± 0.042	3.317PheSer: 3.317 ± 0.076	2.633PheThr: 2.633 ± 0.056	3.32PheVal: 3.32 ± 0.071	0.542PheTrp: 0.542 ± 0.033	1.8PheTyr: 1.8 ± 0.053	0.0PheXaa: 0.0 ± 0.0
Gly	4.226GlyAla: 4.226 ± 0.082	0.346GlyCys: 0.346 ± 0.019	3.524GlyAsp: 3.524 ± 0.081	2.981GlyGlu: 2.981 ± 0.067	3.126GlyPhe: 3.126 ± 0.078	4.059GlyGly: 4.059 ± 0.108	1.261GlyHis: 1.261 ± 0.046	6.0GlyIle: 6.0 ± 0.094	4.794GlyLys: 4.794 ± 0.081	6.214GlyLeu: 6.214 ± 0.105	1.826GlyMet: 1.826 ± 0.058	3.161GlyAsn: 3.161 ± 0.081	1.482GlyPro: 1.482 ± 0.048	2.484GlyGln: 2.484 ± 0.066	2.119GlyArg: 2.119 ± 0.059	4.253GlySer: 4.253 ± 0.077	4.211GlyThr: 4.211 ± 0.09	4.704GlyVal: 4.704 ± 0.089	0.597GlyTrp: 0.597 ± 0.032	2.749GlyTyr: 2.749 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.132HisAla: 1.132 ± 0.042	0.096HisCys: 0.096 ± 0.011	1.135HisAsp: 1.135 ± 0.039	0.977HisGlu: 0.977 ± 0.035	0.943HisPhe: 0.943 ± 0.042	1.298HisGly: 1.298 ± 0.044	0.564HisHis: 0.564 ± 0.028	1.362HisIle: 1.362 ± 0.048	1.1HisLys: 1.1 ± 0.044	1.836HisLeu: 1.836 ± 0.059	0.462HisMet: 0.462 ± 0.029	1.069HisAsn: 1.069 ± 0.043	0.871HisPro: 0.871 ± 0.038	0.839HisGln: 0.839 ± 0.032	0.738HisArg: 0.738 ± 0.032	1.11HisSer: 1.11 ± 0.043	0.935HisThr: 0.935 ± 0.036	1.223HisVal: 1.223 ± 0.048	0.212HisTrp: 0.212 ± 0.018	0.793HisTyr: 0.793 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	5.889IleAla: 5.889 ± 0.095	0.507IleCys: 0.507 ± 0.028	5.236IleAsp: 5.236 ± 0.088	4.143IleGlu: 4.143 ± 0.085	3.768IlePhe: 3.768 ± 0.093	5.494IleGly: 5.494 ± 0.102	1.335IleHis: 1.335 ± 0.048	6.16IleIle: 6.16 ± 0.112	5.771IleLys: 5.771 ± 0.095	7.349IleLeu: 7.349 ± 0.134	1.975IleMet: 1.975 ± 0.058	4.627IleAsn: 4.627 ± 0.09	3.046IlePro: 3.046 ± 0.078	2.714IleGln: 2.714 ± 0.073	2.309IleArg: 2.309 ± 0.064	5.542IleSer: 5.542 ± 0.094	4.756IleThr: 4.756 ± 0.083	5.795IleVal: 5.795 ± 0.103	0.643IleTrp: 0.643 ± 0.029	2.697IleTyr: 2.697 ± 0.07	0.0IleXaa: 0.0 ± 0.0
Lys	4.784LysAla: 4.784 ± 0.091	0.174LysCys: 0.174 ± 0.018	5.066LysAsp: 5.066 ± 0.088	4.889LysGlu: 4.889 ± 0.099	2.913LysPhe: 2.913 ± 0.064	3.55LysGly: 3.55 ± 0.081	1.371LysHis: 1.371 ± 0.051	6.23LysIle: 6.23 ± 0.092	7.094LysLys: 7.094 ± 0.121	6.742LysLeu: 6.742 ± 0.103	2.593LysMet: 2.593 ± 0.059	5.205LysAsn: 5.205 ± 0.095	2.306LysPro: 2.306 ± 0.061	3.062LysGln: 3.062 ± 0.071	2.843LysArg: 2.843 ± 0.062	4.31LysSer: 4.31 ± 0.097	4.674LysThr: 4.674 ± 0.085	5.062LysVal: 5.062 ± 0.094	0.643LysTrp: 0.643 ± 0.03	3.392LysTyr: 3.392 ± 0.074	0.0LysXaa: 0.0 ± 0.0
Leu	6.776LeuAla: 6.776 ± 0.11	0.499LeuCys: 0.499 ± 0.031	5.871LeuAsp: 5.871 ± 0.109	4.707LeuGlu: 4.707 ± 0.081	3.981LeuPhe: 3.981 ± 0.088	6.378LeuGly: 6.378 ± 0.117	1.6LeuHis: 1.6 ± 0.046	7.395LeuIle: 7.395 ± 0.153	7.217LeuLys: 7.217 ± 0.104	8.714LeuLeu: 8.714 ± 0.144	2.469LeuMet: 2.469 ± 0.058	5.671LeuAsn: 5.671 ± 0.109	3.836LeuPro: 3.836 ± 0.079	3.362LeuGln: 3.362 ± 0.083	3.091LeuArg: 3.091 ± 0.08	6.652LeuSer: 6.652 ± 0.108	5.881LeuThr: 5.881 ± 0.095	6.494LeuVal: 6.494 ± 0.117	0.755LeuTrp: 0.755 ± 0.034	2.813LeuTyr: 2.813 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.024MetAla: 2.024 ± 0.058	0.123MetCys: 0.123 ± 0.013	1.556MetAsp: 1.556 ± 0.05	1.316MetGlu: 1.316 ± 0.049	1.074MetPhe: 1.074 ± 0.042	1.791MetGly: 1.791 ± 0.046	0.464MetHis: 0.464 ± 0.025	2.203MetIle: 2.203 ± 0.056	2.122MetLys: 2.122 ± 0.052	2.275MetLeu: 2.275 ± 0.066	0.835MetMet: 0.835 ± 0.034	1.677MetAsn: 1.677 ± 0.054	1.098MetPro: 1.098 ± 0.04	1.046MetGln: 1.046 ± 0.035	0.932MetArg: 0.932 ± 0.038	1.898MetSer: 1.898 ± 0.055	1.819MetThr: 1.819 ± 0.047	1.68MetVal: 1.68 ± 0.05	0.199MetTrp: 0.199 ± 0.019	0.729MetTyr: 0.729 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.384AsnAla: 3.384 ± 0.07	0.299AsnCys: 0.299 ± 0.023	3.771AsnAsp: 3.771 ± 0.083	3.219AsnGlu: 3.219 ± 0.075	2.558AsnPhe: 2.558 ± 0.063	3.987AsnGly: 3.987 ± 0.1	1.309AsnHis: 1.309 ± 0.046	4.268AsnIle: 4.268 ± 0.087	4.376AsnLys: 4.376 ± 0.091	5.416AsnLeu: 5.416 ± 0.099	1.362AsnMet: 1.362 ± 0.042	3.877AsnAsn: 3.877 ± 0.119	2.39AsnPro: 2.39 ± 0.059	2.622AsnGln: 2.622 ± 0.069	2.035AsnArg: 2.035 ± 0.059	3.803AsnSer: 3.803 ± 0.105	2.874AsnThr: 2.874 ± 0.08	3.675AsnVal: 3.675 ± 0.069	0.654AsnTrp: 0.654 ± 0.034	2.513AsnTyr: 2.513 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	2.116ProAla: 2.116 ± 0.066	0.129ProCys: 0.129 ± 0.011	2.381ProAsp: 2.381 ± 0.066	2.58ProGlu: 2.58 ± 0.063	1.665ProPhe: 1.665 ± 0.059	1.948ProGly: 1.948 ± 0.061	0.581ProHis: 0.581 ± 0.027	2.735ProIle: 2.735 ± 0.071	2.551ProLys: 2.551 ± 0.063	2.923ProLeu: 2.923 ± 0.057	0.851ProMet: 0.851 ± 0.033	2.056ProAsn: 2.056 ± 0.064	0.497ProPro: 0.497 ± 0.028	1.326ProGln: 1.326 ± 0.041	0.977ProArg: 0.977 ± 0.045	2.023ProSer: 2.023 ± 0.06	2.226ProThr: 2.226 ± 0.07	2.59ProVal: 2.59 ± 0.067	0.348ProTrp: 0.348 ± 0.021	1.298ProTyr: 1.298 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	2.92GlnAla: 2.92 ± 0.079	0.1GlnCys: 0.1 ± 0.012	1.993GlnAsp: 1.993 ± 0.06	2.343GlnGlu: 2.343 ± 0.067	1.51GlnPhe: 1.51 ± 0.051	1.906GlnGly: 1.906 ± 0.05	0.677GlnHis: 0.677 ± 0.033	3.207GlnIle: 3.207 ± 0.069	3.498GlnLys: 3.498 ± 0.079	3.869GlnLeu: 3.869 ± 0.087	1.177GlnMet: 1.177 ± 0.052	2.41GlnAsn: 2.41 ± 0.064	1.236GlnPro: 1.236 ± 0.038	1.851GlnGln: 1.851 ± 0.056	1.625GlnArg: 1.625 ± 0.052	2.098GlnSer: 2.098 ± 0.059	2.49GlnThr: 2.49 ± 0.065	2.684GlnVal: 2.684 ± 0.07	0.351GlnTrp: 0.351 ± 0.024	1.371GlnTyr: 1.371 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	2.053ArgAla: 2.053 ± 0.061	0.141ArgCys: 0.141 ± 0.015	2.04ArgAsp: 2.04 ± 0.063	1.951ArgGlu: 1.951 ± 0.056	1.532ArgPhe: 1.532 ± 0.049	1.891ArgGly: 1.891 ± 0.053	0.713ArgHis: 0.713 ± 0.035	2.591ArgIle: 2.591 ± 0.061	2.601ArgLys: 2.601 ± 0.073	3.284ArgLeu: 3.284 ± 0.079	1.006ArgMet: 1.006 ± 0.038	1.974ArgAsn: 1.974 ± 0.055	1.083ArgPro: 1.083 ± 0.047	1.419ArgGln: 1.419 ± 0.048	1.588ArgArg: 1.588 ± 0.055	1.785ArgSer: 1.785 ± 0.051	1.697ArgThr: 1.697 ± 0.052	2.322ArgVal: 2.322 ± 0.06	0.271ArgTrp: 0.271 ± 0.018	1.42ArgTyr: 1.42 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.013SerAla: 4.013 ± 0.086	0.204SerCys: 0.204 ± 0.019	4.401SerAsp: 4.401 ± 0.098	3.501SerGlu: 3.501 ± 0.075	3.132SerPhe: 3.132 ± 0.071	4.665SerGly: 4.665 ± 0.083	1.13SerHis: 1.13 ± 0.04	4.971SerIle: 4.971 ± 0.092	4.679SerLys: 4.679 ± 0.078	5.987SerLeu: 5.987 ± 0.085	1.596SerMet: 1.596 ± 0.059	3.484SerAsn: 3.484 ± 0.096	1.884SerPro: 1.884 ± 0.06	2.487SerGln: 2.487 ± 0.065	2.132SerArg: 2.132 ± 0.056	4.329SerSer: 4.329 ± 0.12	3.79SerThr: 3.79 ± 0.087	4.221SerVal: 4.221 ± 0.079	0.701SerTrp: 0.701 ± 0.034	2.419SerTyr: 2.419 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	4.071ThrAla: 4.071 ± 0.097	0.216ThrCys: 0.216 ± 0.017	3.877ThrAsp: 3.877 ± 0.096	2.89ThrGlu: 2.89 ± 0.073	2.553ThrPhe: 2.553 ± 0.06	4.34ThrGly: 4.34 ± 0.091	0.987ThrHis: 0.987 ± 0.041	5.12ThrIle: 5.12 ± 0.091	4.491ThrLys: 4.491 ± 0.088	5.288ThrLeu: 5.288 ± 0.102	1.39ThrMet: 1.39 ± 0.045	3.487ThrAsn: 3.487 ± 0.093	2.523ThrPro: 2.523 ± 0.061	1.914ThrGln: 1.914 ± 0.061	1.698ThrArg: 1.698 ± 0.05	3.846ThrSer: 3.846 ± 0.083	3.943ThrThr: 3.943 ± 0.137	4.378ThrVal: 4.378 ± 0.104	0.584ThrTrp: 0.584 ± 0.027	2.155ThrTyr: 2.155 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	5.124ValAla: 5.124 ± 0.099	0.4ValCys: 0.4 ± 0.024	4.578ValAsp: 4.578 ± 0.09	3.635ValGlu: 3.635 ± 0.079	2.885ValPhe: 2.885 ± 0.073	4.878ValGly: 4.878 ± 0.099	1.123ValHis: 1.123 ± 0.041	5.645ValIle: 5.645 ± 0.113	4.932ValLys: 4.932 ± 0.089	6.389ValLeu: 6.389 ± 0.096	1.748ValMet: 1.748 ± 0.052	3.558ValAsn: 3.558 ± 0.075	2.59ValPro: 2.59 ± 0.069	2.294ValGln: 2.294 ± 0.067	2.02ValArg: 2.02 ± 0.063	4.698ValSer: 4.698 ± 0.083	4.497ValThr: 4.497 ± 0.099	4.94ValVal: 4.94 ± 0.1	0.588ValTrp: 0.588 ± 0.03	2.32ValTyr: 2.32 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.541TrpAla: 0.541 ± 0.029	0.049TrpCys: 0.049 ± 0.007	0.532TrpAsp: 0.532 ± 0.027	0.399TrpGlu: 0.399 ± 0.027	0.512TrpPhe: 0.512 ± 0.031	0.585TrpGly: 0.585 ± 0.03	0.239TrpHis: 0.239 ± 0.02	0.83TrpIle: 0.83 ± 0.037	0.591TrpLys: 0.591 ± 0.032	1.068TrpLeu: 1.068 ± 0.044	0.275TrpMet: 0.275 ± 0.019	0.59TrpAsn: 0.59 ± 0.028	0.246TrpPro: 0.246 ± 0.02	0.439TrpGln: 0.439 ± 0.023	0.339TrpArg: 0.339 ± 0.022	0.603TrpSer: 0.603 ± 0.028	0.562TrpThr: 0.562 ± 0.032	0.577TrpVal: 0.577 ± 0.031	0.146TrpTrp: 0.146 ± 0.017	0.413TrpTyr: 0.413 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.171TyrAla: 2.171 ± 0.05	0.185TyrCys: 0.185 ± 0.016	2.429TyrAsp: 2.429 ± 0.056	1.767TyrGlu: 1.767 ± 0.06	2.04TyrPhe: 2.04 ± 0.053	2.465TyrGly: 2.465 ± 0.059	0.881TyrHis: 0.881 ± 0.036	2.451TyrIle: 2.451 ± 0.063	2.301TyrLys: 2.301 ± 0.057	4.063TyrLeu: 4.063 ± 0.094	0.893TyrMet: 0.893 ± 0.034	2.023TyrAsn: 2.023 ± 0.054	1.38TyrPro: 1.38 ± 0.043	2.162TyrGln: 2.162 ± 0.066	1.585TyrArg: 1.585 ± 0.056	2.469TyrSer: 2.469 ± 0.066	2.04TyrThr: 2.04 ± 0.063	2.388TyrVal: 2.388 ± 0.066	0.417TyrTrp: 0.417 ± 0.025	1.678TyrTyr: 1.678 ± 0.068	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2217 proteins (690053 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---