Amino acid dipepetide frequency for Streptococcus satellite phage Javan738

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.284AlaAla: 0.284 ± 0.269
0.569AlaCys: 0.569 ± 0.456
2.558AlaAsp: 2.558 ± 1.009
3.127AlaGlu: 3.127 ± 0.899
3.127AlaPhe: 3.127 ± 0.792
1.421AlaGly: 1.421 ± 0.551
1.137AlaHis: 1.137 ± 0.645
3.695AlaIle: 3.695 ± 1.392
5.685AlaLys: 5.685 ± 1.721
3.98AlaLeu: 3.98 ± 1.236
1.706AlaMet: 1.706 ± 0.816
2.843AlaAsn: 2.843 ± 0.925
0.853AlaPro: 0.853 ± 0.494
2.558AlaGln: 2.558 ± 0.848
2.558AlaArg: 2.558 ± 0.746
1.99AlaSer: 1.99 ± 0.88
4.832AlaThr: 4.832 ± 1.07
1.99AlaVal: 1.99 ± 0.802
0.0AlaTrp: 0.0 ± 0.0
4.264AlaTyr: 4.264 ± 1.145
0.0AlaXaa: 0.0 ± 0.0
Cys
0.284CysAla: 0.284 ± 0.293
0.0CysCys: 0.0 ± 0.0
0.284CysAsp: 0.284 ± 0.284
0.284CysGlu: 0.284 ± 0.261
0.284CysPhe: 0.284 ± 0.269
0.853CysGly: 0.853 ± 0.465
0.284CysHis: 0.284 ± 0.261
0.284CysIle: 0.284 ± 0.279
0.569CysLys: 0.569 ± 0.412
0.853CysLeu: 0.853 ± 0.462
0.284CysMet: 0.284 ± 0.336
0.284CysAsn: 0.284 ± 0.239
0.853CysPro: 0.853 ± 0.435
0.0CysGln: 0.0 ± 0.0
0.284CysArg: 0.284 ± 0.269
0.569CysSer: 0.569 ± 0.456
0.569CysThr: 0.569 ± 0.387
0.284CysVal: 0.284 ± 0.239
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.706AspAla: 1.706 ± 0.674
0.853AspCys: 0.853 ± 0.434
4.548AspAsp: 4.548 ± 1.325
2.843AspGlu: 2.843 ± 1.052
5.117AspPhe: 5.117 ± 0.952
3.98AspGly: 3.98 ± 1.218
0.0AspHis: 0.0 ± 0.0
5.117AspIle: 5.117 ± 1.347
5.969AspLys: 5.969 ± 1.503
7.675AspLeu: 7.675 ± 1.583
0.569AspMet: 0.569 ± 0.4
4.548AspAsn: 4.548 ± 0.937
0.853AspPro: 0.853 ± 0.419
0.569AspGln: 0.569 ± 0.406
2.274AspArg: 2.274 ± 0.719
4.264AspSer: 4.264 ± 1.323
3.695AspThr: 3.695 ± 1.147
2.843AspVal: 2.843 ± 0.636
0.284AspTrp: 0.284 ± 0.239
2.843AspTyr: 2.843 ± 1.01
0.0AspXaa: 0.0 ± 0.0
Glu
2.558GluAla: 2.558 ± 0.867
1.421GluCys: 1.421 ± 0.547
4.548GluAsp: 4.548 ± 1.588
3.98GluGlu: 3.98 ± 1.184
2.843GluPhe: 2.843 ± 0.756
3.127GluGly: 3.127 ± 0.933
0.853GluHis: 0.853 ± 0.653
9.665GluIle: 9.665 ± 1.357
9.949GluLys: 9.949 ± 1.947
9.096GluLeu: 9.096 ± 2.093
1.421GluMet: 1.421 ± 0.872
5.401GluAsn: 5.401 ± 1.235
1.137GluPro: 1.137 ± 0.724
4.264GluGln: 4.264 ± 0.828
2.558GluArg: 2.558 ± 0.82
5.969GluSer: 5.969 ± 1.38
5.401GluThr: 5.401 ± 0.979
2.274GluVal: 2.274 ± 0.761
0.569GluTrp: 0.569 ± 0.439
3.695GluTyr: 3.695 ± 1.147
0.0GluXaa: 0.0 ± 0.0
Phe
0.569PheAla: 0.569 ± 0.416
0.569PheCys: 0.569 ± 0.478
2.843PheAsp: 2.843 ± 1.069
2.843PheGlu: 2.843 ± 0.88
2.274PhePhe: 2.274 ± 0.83
1.706PheGly: 1.706 ± 0.832
0.853PheHis: 0.853 ± 0.436
2.558PheIle: 2.558 ± 0.686
5.117PheLys: 5.117 ± 1.109
4.548PheLeu: 4.548 ± 1.167
1.137PheMet: 1.137 ± 0.524
1.706PheAsn: 1.706 ± 0.701
0.853PhePro: 0.853 ± 0.531
1.137PheGln: 1.137 ± 0.694
1.421PheArg: 1.421 ± 0.446
4.832PheSer: 4.832 ± 1.239
1.99PheThr: 1.99 ± 0.805
2.274PheVal: 2.274 ± 0.997
0.569PheTrp: 0.569 ± 0.316
1.99PheTyr: 1.99 ± 0.898
0.0PheXaa: 0.0 ± 0.0
Gly
2.274GlyAla: 2.274 ± 0.784
0.0GlyCys: 0.0 ± 0.0
1.99GlyAsp: 1.99 ± 0.898
2.274GlyGlu: 2.274 ± 0.709
1.706GlyPhe: 1.706 ± 0.651
2.274GlyGly: 2.274 ± 1.085
1.137GlyHis: 1.137 ± 0.654
3.127GlyIle: 3.127 ± 0.823
5.117GlyLys: 5.117 ± 1.041
4.548GlyLeu: 4.548 ± 0.952
1.137GlyMet: 1.137 ± 0.555
1.99GlyAsn: 1.99 ± 0.716
0.0GlyPro: 0.0 ± 0.0
2.274GlyGln: 2.274 ± 0.702
2.558GlyArg: 2.558 ± 0.767
2.843GlySer: 2.843 ± 1.049
2.274GlyThr: 2.274 ± 0.659
2.558GlyVal: 2.558 ± 0.804
0.569GlyTrp: 0.569 ± 0.365
4.264GlyTyr: 4.264 ± 1.069
0.0GlyXaa: 0.0 ± 0.0
His
1.99HisAla: 1.99 ± 0.688
0.0HisCys: 0.0 ± 0.0
0.569HisAsp: 0.569 ± 0.373
0.569HisGlu: 0.569 ± 0.376
0.853HisPhe: 0.853 ± 0.614
0.569HisGly: 0.569 ± 0.37
0.569HisHis: 0.569 ± 0.368
1.421HisIle: 1.421 ± 0.843
0.853HisLys: 0.853 ± 0.43
1.137HisLeu: 1.137 ± 0.651
0.0HisMet: 0.0 ± 0.0
1.137HisAsn: 1.137 ± 0.688
0.569HisPro: 0.569 ± 0.362
0.853HisGln: 0.853 ± 0.356
0.284HisArg: 0.284 ± 0.318
1.421HisSer: 1.421 ± 0.528
1.99HisThr: 1.99 ± 0.591
0.284HisVal: 0.284 ± 0.247
0.0HisTrp: 0.0 ± 0.0
0.853HisTyr: 0.853 ± 0.609
0.0HisXaa: 0.0 ± 0.0
Ile
2.843IleAla: 2.843 ± 1.073
0.0IleCys: 0.0 ± 0.0
3.98IleAsp: 3.98 ± 1.046
6.538IleGlu: 6.538 ± 1.412
2.558IlePhe: 2.558 ± 0.92
2.558IleGly: 2.558 ± 0.86
1.137IleHis: 1.137 ± 0.463
6.254IleIle: 6.254 ± 1.308
7.675IleLys: 7.675 ± 1.795
9.096IleLeu: 9.096 ± 1.4
0.569IleMet: 0.569 ± 0.351
5.969IleAsn: 5.969 ± 1.438
3.127IlePro: 3.127 ± 0.836
4.264IleGln: 4.264 ± 0.637
2.558IleArg: 2.558 ± 0.598
5.685IleSer: 5.685 ± 1.169
4.548IleThr: 4.548 ± 1.142
3.411IleVal: 3.411 ± 0.934
0.569IleTrp: 0.569 ± 0.376
1.99IleTyr: 1.99 ± 0.758
0.0IleXaa: 0.0 ± 0.0
Lys
6.538LysAla: 6.538 ± 1.462
0.853LysCys: 0.853 ± 0.452
6.254LysAsp: 6.254 ± 1.208
10.233LysGlu: 10.233 ± 1.577
3.127LysPhe: 3.127 ± 0.961
6.254LysGly: 6.254 ± 1.274
2.274LysHis: 2.274 ± 0.768
6.538LysIle: 6.538 ± 1.602
9.665LysLys: 9.665 ± 1.969
8.812LysLeu: 8.812 ± 1.42
2.843LysMet: 2.843 ± 0.932
5.969LysAsn: 5.969 ± 1.26
2.558LysPro: 2.558 ± 0.944
5.117LysGln: 5.117 ± 0.942
5.969LysArg: 5.969 ± 1.13
6.538LysSer: 6.538 ± 1.071
5.117LysThr: 5.117 ± 1.429
3.411LysVal: 3.411 ± 0.856
0.569LysTrp: 0.569 ± 0.371
3.695LysTyr: 3.695 ± 1.121
0.0LysXaa: 0.0 ± 0.0
Leu
8.243LeuAla: 8.243 ± 1.895
0.284LeuCys: 0.284 ± 0.336
8.812LeuAsp: 8.812 ± 1.052
10.233LeuGlu: 10.233 ± 1.615
3.127LeuPhe: 3.127 ± 0.928
4.832LeuGly: 4.832 ± 0.92
0.853LeuHis: 0.853 ± 0.422
7.106LeuIle: 7.106 ± 1.613
9.665LeuLys: 9.665 ± 1.664
8.528LeuLeu: 8.528 ± 1.644
3.127LeuMet: 3.127 ± 0.728
7.391LeuAsn: 7.391 ± 1.514
2.843LeuPro: 2.843 ± 0.952
3.98LeuGln: 3.98 ± 0.913
4.832LeuArg: 4.832 ± 1.059
5.401LeuSer: 5.401 ± 0.795
6.822LeuThr: 6.822 ± 1.234
5.685LeuVal: 5.685 ± 1.195
0.0LeuTrp: 0.0 ± 0.0
1.99LeuTyr: 1.99 ± 0.753
0.0LeuXaa: 0.0 ± 0.0
Met
1.421MetAla: 1.421 ± 0.963
0.284MetCys: 0.284 ± 0.281
1.99MetAsp: 1.99 ± 0.733
2.558MetGlu: 2.558 ± 0.767
0.569MetPhe: 0.569 ± 0.376
0.569MetGly: 0.569 ± 0.393
0.0MetHis: 0.0 ± 0.0
1.99MetIle: 1.99 ± 0.708
2.843MetLys: 2.843 ± 0.533
1.137MetLeu: 1.137 ± 0.503
0.284MetMet: 0.284 ± 0.273
1.706MetAsn: 1.706 ± 0.642
0.569MetPro: 0.569 ± 0.381
0.284MetGln: 0.284 ± 0.293
1.421MetArg: 1.421 ± 0.784
0.569MetSer: 0.569 ± 0.394
1.99MetThr: 1.99 ± 0.908
0.569MetVal: 0.569 ± 0.366
0.0MetTrp: 0.0 ± 0.0
1.137MetTyr: 1.137 ± 0.577
0.0MetXaa: 0.0 ± 0.0
Asn
3.127AsnAla: 3.127 ± 0.752
0.569AsnCys: 0.569 ± 0.424
2.274AsnAsp: 2.274 ± 1.003
3.127AsnGlu: 3.127 ± 1.009
2.843AsnPhe: 2.843 ± 0.893
2.558AsnGly: 2.558 ± 0.711
2.558AsnHis: 2.558 ± 0.863
3.127AsnIle: 3.127 ± 1.653
5.401AsnLys: 5.401 ± 1.568
5.685AsnLeu: 5.685 ± 1.124
1.706AsnMet: 1.706 ± 0.906
4.832AsnAsn: 4.832 ± 1.906
1.706AsnPro: 1.706 ± 0.576
3.411AsnGln: 3.411 ± 0.764
2.558AsnArg: 2.558 ± 0.742
4.548AsnSer: 4.548 ± 1.255
5.969AsnThr: 5.969 ± 1.087
1.706AsnVal: 1.706 ± 0.788
1.137AsnTrp: 1.137 ± 0.549
4.264AsnTyr: 4.264 ± 0.752
0.0AsnXaa: 0.0 ± 0.0
Pro
1.137ProAla: 1.137 ± 0.647
0.0ProCys: 0.0 ± 0.0
2.274ProAsp: 2.274 ± 0.752
1.99ProGlu: 1.99 ± 0.9
2.274ProPhe: 2.274 ± 0.841
0.284ProGly: 0.284 ± 0.279
0.284ProHis: 0.284 ± 0.261
1.421ProIle: 1.421 ± 0.523
3.98ProLys: 3.98 ± 1.574
0.569ProLeu: 0.569 ± 0.372
0.284ProMet: 0.284 ± 0.293
1.421ProAsn: 1.421 ± 0.451
0.853ProPro: 0.853 ± 0.607
0.569ProGln: 0.569 ± 0.344
2.274ProArg: 2.274 ± 0.729
0.853ProSer: 0.853 ± 0.529
0.853ProThr: 0.853 ± 0.406
1.137ProVal: 1.137 ± 0.447
0.0ProTrp: 0.0 ± 0.0
1.421ProTyr: 1.421 ± 0.455
0.0ProXaa: 0.0 ± 0.0
Gln
3.98GlnAla: 3.98 ± 0.896
0.569GlnCys: 0.569 ± 0.412
2.274GlnAsp: 2.274 ± 0.885
4.264GlnGlu: 4.264 ± 0.801
1.706GlnPhe: 1.706 ± 0.682
0.853GlnGly: 0.853 ± 0.534
0.569GlnHis: 0.569 ± 0.379
3.411GlnIle: 3.411 ± 1.145
3.127GlnLys: 3.127 ± 0.703
3.411GlnLeu: 3.411 ± 0.857
0.569GlnMet: 0.569 ± 0.355
2.558GlnAsn: 2.558 ± 0.857
0.853GlnPro: 0.853 ± 0.392
1.421GlnGln: 1.421 ± 0.616
1.706GlnArg: 1.706 ± 0.713
1.421GlnSer: 1.421 ± 0.621
2.843GlnThr: 2.843 ± 0.701
2.558GlnVal: 2.558 ± 0.659
0.853GlnTrp: 0.853 ± 0.401
1.137GlnTyr: 1.137 ± 0.451
0.0GlnXaa: 0.0 ± 0.0
Arg
1.137ArgAla: 1.137 ± 0.467
0.0ArgCys: 0.0 ± 0.0
2.843ArgAsp: 2.843 ± 0.738
5.685ArgGlu: 5.685 ± 1.026
1.706ArgPhe: 1.706 ± 0.66
2.274ArgGly: 2.274 ± 0.684
0.284ArgHis: 0.284 ± 0.261
3.695ArgIle: 3.695 ± 0.809
5.969ArgLys: 5.969 ± 1.356
5.685ArgLeu: 5.685 ± 1.456
1.706ArgMet: 1.706 ± 0.408
3.411ArgAsn: 3.411 ± 0.896
0.853ArgPro: 0.853 ± 0.41
1.99ArgGln: 1.99 ± 0.692
1.99ArgArg: 1.99 ± 0.776
1.421ArgSer: 1.421 ± 0.691
3.127ArgThr: 3.127 ± 0.778
0.569ArgVal: 0.569 ± 0.423
0.0ArgTrp: 0.0 ± 0.0
2.843ArgTyr: 2.843 ± 1.508
0.0ArgXaa: 0.0 ± 0.0
Ser
3.411SerAla: 3.411 ± 1.565
0.284SerCys: 0.284 ± 0.279
4.264SerAsp: 4.264 ± 0.752
6.822SerGlu: 6.822 ± 1.167
1.421SerPhe: 1.421 ± 0.743
3.98SerGly: 3.98 ± 0.713
0.853SerHis: 0.853 ± 0.442
4.264SerIle: 4.264 ± 1.202
5.685SerLys: 5.685 ± 1.305
7.391SerLeu: 7.391 ± 1.5
0.569SerMet: 0.569 ± 0.39
3.127SerAsn: 3.127 ± 0.858
1.421SerPro: 1.421 ± 0.505
2.558SerGln: 2.558 ± 0.641
3.127SerArg: 3.127 ± 1.005
3.411SerSer: 3.411 ± 1.165
3.127SerThr: 3.127 ± 0.706
3.411SerVal: 3.411 ± 0.658
0.853SerTrp: 0.853 ± 0.571
1.421SerTyr: 1.421 ± 0.578
0.0SerXaa: 0.0 ± 0.0
Thr
2.558ThrAla: 2.558 ± 0.868
0.0ThrCys: 0.0 ± 0.0
2.274ThrAsp: 2.274 ± 0.686
4.264ThrGlu: 4.264 ± 0.901
1.99ThrPhe: 1.99 ± 0.734
4.548ThrGly: 4.548 ± 0.815
1.99ThrHis: 1.99 ± 0.71
4.832ThrIle: 4.832 ± 0.892
5.685ThrLys: 5.685 ± 1.135
7.959ThrLeu: 7.959 ± 1.09
1.421ThrMet: 1.421 ± 0.537
3.127ThrAsn: 3.127 ± 0.854
1.99ThrPro: 1.99 ± 0.636
1.421ThrGln: 1.421 ± 0.829
3.411ThrArg: 3.411 ± 1.302
3.127ThrSer: 3.127 ± 0.963
4.264ThrThr: 4.264 ± 1.23
6.822ThrVal: 6.822 ± 1.407
0.569ThrTrp: 0.569 ± 0.427
1.99ThrTyr: 1.99 ± 1.259
0.0ThrXaa: 0.0 ± 0.0
Val
1.99ValAla: 1.99 ± 0.723
0.284ValCys: 0.284 ± 0.284
3.411ValAsp: 3.411 ± 1.34
3.98ValGlu: 3.98 ± 1.011
1.706ValPhe: 1.706 ± 0.636
1.421ValGly: 1.421 ± 0.676
0.0ValHis: 0.0 ± 0.0
4.264ValIle: 4.264 ± 0.862
3.98ValLys: 3.98 ± 1.2
3.98ValLeu: 3.98 ± 1.022
0.284ValMet: 0.284 ± 0.407
2.274ValAsn: 2.274 ± 0.691
1.137ValPro: 1.137 ± 0.482
2.274ValGln: 2.274 ± 0.859
1.99ValArg: 1.99 ± 0.562
4.264ValSer: 4.264 ± 1.111
3.411ValThr: 3.411 ± 0.874
2.274ValVal: 2.274 ± 0.84
0.0ValTrp: 0.0 ± 0.0
2.558ValTyr: 2.558 ± 0.913
0.0ValXaa: 0.0 ± 0.0
Trp
1.137TrpAla: 1.137 ± 0.474
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.421TrpGlu: 1.421 ± 0.699
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.284TrpIle: 0.284 ± 0.336
0.569TrpLys: 0.569 ± 0.367
1.137TrpLeu: 1.137 ± 0.657
0.284TrpMet: 0.284 ± 0.262
0.284TrpAsn: 0.284 ± 0.247
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.569TrpSer: 0.569 ± 0.377
0.0TrpThr: 0.0 ± 0.0
0.853TrpVal: 0.853 ± 0.469
0.0TrpTrp: 0.0 ± 0.0
0.284TrpTyr: 0.284 ± 0.269
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.99TyrAla: 1.99 ± 0.834
0.569TyrCys: 0.569 ± 0.344
2.558TyrAsp: 2.558 ± 0.844
3.695TyrGlu: 3.695 ± 0.798
2.558TyrPhe: 2.558 ± 0.938
0.853TyrGly: 0.853 ± 0.48
0.284TyrHis: 0.284 ± 0.245
2.274TyrIle: 2.274 ± 0.685
4.832TyrLys: 4.832 ± 1.397
8.528TyrLeu: 8.528 ± 1.495
1.706TyrMet: 1.706 ± 0.564
3.127TyrAsn: 3.127 ± 1.072
0.853TyrPro: 0.853 ± 0.43
1.137TyrGln: 1.137 ± 0.511
3.411TyrArg: 3.411 ± 0.932
1.706TyrSer: 1.706 ± 0.735
1.421TyrThr: 1.421 ± 0.667
0.853TyrVal: 0.853 ± 0.507
0.284TyrTrp: 0.284 ± 0.239
1.706TyrTyr: 1.706 ± 0.792
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 23 proteins (3519 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski