Amino acid dipepetide frequency for Methyloligella sp. GL2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.076AlaAla: 16.076 ± 0.205	1.036AlaCys: 1.036 ± 0.033	6.561AlaAsp: 6.561 ± 0.089	9.078AlaGlu: 9.078 ± 0.142	4.406AlaPhe: 4.406 ± 0.081	9.969AlaGly: 9.969 ± 0.115	2.049AlaHis: 2.049 ± 0.049	6.104AlaIle: 6.104 ± 0.078	5.355AlaLys: 5.355 ± 0.097	13.121AlaLeu: 13.121 ± 0.141	3.289AlaMet: 3.289 ± 0.061	2.673AlaAsn: 2.673 ± 0.051	5.941AlaPro: 5.941 ± 0.104	3.703AlaGln: 3.703 ± 0.062	7.009AlaArg: 7.009 ± 0.094	6.218AlaSer: 6.218 ± 0.088	5.2AlaThr: 5.2 ± 0.087	8.126AlaVal: 8.126 ± 0.111	1.397AlaTrp: 1.397 ± 0.042	2.733AlaTyr: 2.733 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.926CysAla: 0.926 ± 0.034	0.139CysCys: 0.139 ± 0.015	0.491CysAsp: 0.491 ± 0.025	0.538CysGlu: 0.538 ± 0.027	0.363CysPhe: 0.363 ± 0.021	0.94CysGly: 0.94 ± 0.033	0.237CysHis: 0.237 ± 0.018	0.406CysIle: 0.406 ± 0.019	0.231CysLys: 0.231 ± 0.014	0.821CysLeu: 0.821 ± 0.029	0.176CysMet: 0.176 ± 0.015	0.244CysAsn: 0.244 ± 0.018	0.452CysPro: 0.452 ± 0.023	0.236CysGln: 0.236 ± 0.016	0.587CysArg: 0.587 ± 0.026	0.481CysSer: 0.481 ± 0.023	0.414CysThr: 0.414 ± 0.022	0.597CysVal: 0.597 ± 0.024	0.108CysTrp: 0.108 ± 0.012	0.23CysTyr: 0.23 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.654AspAla: 6.654 ± 0.104	0.535AspCys: 0.535 ± 0.027	3.197AspAsp: 3.197 ± 0.07	4.088AspGlu: 4.088 ± 0.083	2.323AspPhe: 2.323 ± 0.047	5.191AspGly: 5.191 ± 0.089	1.207AspHis: 1.207 ± 0.039	3.16AspIle: 3.16 ± 0.057	2.164AspLys: 2.164 ± 0.051	5.763AspLeu: 5.763 ± 0.086	1.293AspMet: 1.293 ± 0.038	1.373AspAsn: 1.373 ± 0.04	3.36AspPro: 3.36 ± 0.064	1.738AspGln: 1.738 ± 0.045	3.84AspArg: 3.84 ± 0.06	2.489AspSer: 2.489 ± 0.054	2.698AspThr: 2.698 ± 0.053	4.006AspVal: 4.006 ± 0.067	1.079AspTrp: 1.079 ± 0.036	1.73AspTyr: 1.73 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	8.838GluAla: 8.838 ± 0.142	0.345GluCys: 0.345 ± 0.02	3.544GluAsp: 3.544 ± 0.062	4.639GluGlu: 4.639 ± 0.096	1.839GluPhe: 1.839 ± 0.048	5.022GluGly: 5.022 ± 0.083	1.277GluHis: 1.277 ± 0.039	3.996GluIle: 3.996 ± 0.076	2.857GluLys: 2.857 ± 0.057	5.984GluLeu: 5.984 ± 0.079	1.709GluMet: 1.709 ± 0.046	1.785GluAsn: 1.785 ± 0.043	3.236GluPro: 3.236 ± 0.066	2.319GluGln: 2.319 ± 0.051	4.79GluArg: 4.79 ± 0.085	2.864GluSer: 2.864 ± 0.062	4.424GluThr: 4.424 ± 0.075	4.269GluVal: 4.269 ± 0.061	0.693GluTrp: 0.693 ± 0.028	1.123GluTyr: 1.123 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.623PheAla: 4.623 ± 0.069	0.396PheCys: 0.396 ± 0.021	2.764PheAsp: 2.764 ± 0.058	2.315PheGlu: 2.315 ± 0.048	1.524PhePhe: 1.524 ± 0.046	3.876PheGly: 3.876 ± 0.069	0.74PheHis: 0.74 ± 0.028	1.711PheIle: 1.711 ± 0.049	1.129PheLys: 1.129 ± 0.037	3.695PheLeu: 3.695 ± 0.072	0.762PheMet: 0.762 ± 0.031	0.969PheAsn: 0.969 ± 0.034	1.62PhePro: 1.62 ± 0.046	1.097PheGln: 1.097 ± 0.033	2.118PheArg: 2.118 ± 0.049	2.334PheSer: 2.334 ± 0.045	2.05PheThr: 2.05 ± 0.047	2.739PheVal: 2.739 ± 0.055	0.583PheTrp: 0.583 ± 0.028	0.973PheTyr: 0.973 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.008GlyAla: 9.008 ± 0.116	0.821GlyCys: 0.821 ± 0.035	4.673GlyAsp: 4.673 ± 0.071	5.713GlyGlu: 5.713 ± 0.081	3.82GlyPhe: 3.82 ± 0.066	7.607GlyGly: 7.607 ± 0.211	1.838GlyHis: 1.838 ± 0.051	4.675GlyIle: 4.675 ± 0.074	3.957GlyLys: 3.957 ± 0.074	8.913GlyLeu: 8.913 ± 0.105	2.222GlyMet: 2.222 ± 0.047	2.232GlyAsn: 2.232 ± 0.063	3.723GlyPro: 3.723 ± 0.069	2.74GlyGln: 2.74 ± 0.065	5.327GlyArg: 5.327 ± 0.076	4.605GlySer: 4.605 ± 0.076	4.52GlyThr: 4.52 ± 0.077	5.871GlyVal: 5.871 ± 0.079	1.328GlyTrp: 1.328 ± 0.036	2.458GlyTyr: 2.458 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.103HisAla: 2.103 ± 0.048	0.24HisCys: 0.24 ± 0.017	1.122HisAsp: 1.122 ± 0.037	1.12HisGlu: 1.12 ± 0.036	0.901HisPhe: 0.901 ± 0.031	1.835HisGly: 1.835 ± 0.051	0.549HisHis: 0.549 ± 0.026	1.037HisIle: 1.037 ± 0.032	0.635HisLys: 0.635 ± 0.026	1.998HisLeu: 1.998 ± 0.048	0.468HisMet: 0.468 ± 0.022	0.472HisAsn: 0.472 ± 0.024	1.293HisPro: 1.293 ± 0.041	0.564HisGln: 0.564 ± 0.025	1.297HisArg: 1.297 ± 0.041	0.93HisSer: 0.93 ± 0.035	0.79HisThr: 0.79 ± 0.027	1.348HisVal: 1.348 ± 0.035	0.322HisTrp: 0.322 ± 0.016	0.601HisTyr: 0.601 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	7.473IleAla: 7.473 ± 0.094	0.549IleCys: 0.549 ± 0.026	3.59IleAsp: 3.59 ± 0.068	3.789IleGlu: 3.789 ± 0.072	1.795IlePhe: 1.795 ± 0.047	5.196IleGly: 5.196 ± 0.082	0.873IleHis: 0.873 ± 0.032	2.111IleIle: 2.111 ± 0.052	1.579IleLys: 1.579 ± 0.043	4.488IleLeu: 4.488 ± 0.071	0.873IleMet: 0.873 ± 0.035	1.286IleAsn: 1.286 ± 0.038	2.48IlePro: 2.48 ± 0.052	1.236IleGln: 1.236 ± 0.042	2.914IleArg: 2.914 ± 0.057	2.821IleSer: 2.821 ± 0.059	2.578IleThr: 2.578 ± 0.05	4.152IleVal: 4.152 ± 0.069	0.615IleTrp: 0.615 ± 0.023	1.279IleTyr: 1.279 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.651LysAla: 4.651 ± 0.077	0.207LysCys: 0.207 ± 0.014	2.158LysAsp: 2.158 ± 0.057	2.302LysGlu: 2.302 ± 0.056	0.965LysPhe: 0.965 ± 0.031	3.048LysGly: 3.048 ± 0.053	0.649LysHis: 0.649 ± 0.027	1.973LysIle: 1.973 ± 0.047	1.698LysLys: 1.698 ± 0.057	4.047LysLeu: 4.047 ± 0.073	0.824LysMet: 0.824 ± 0.028	0.945LysAsn: 0.945 ± 0.036	2.669LysPro: 2.669 ± 0.064	1.371LysGln: 1.371 ± 0.039	2.876LysArg: 2.876 ± 0.058	2.201LysSer: 2.201 ± 0.056	2.513LysThr: 2.513 ± 0.05	2.726LysVal: 2.726 ± 0.055	0.369LysTrp: 0.369 ± 0.021	0.749LysTyr: 0.749 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.333LeuAla: 13.333 ± 0.156	0.918LeuCys: 0.918 ± 0.03	6.023LeuAsp: 6.023 ± 0.082	5.844LeuGlu: 5.844 ± 0.08	3.722LeuPhe: 3.722 ± 0.067	8.399LeuGly: 8.399 ± 0.099	1.836LeuHis: 1.836 ± 0.043	5.401LeuIle: 5.401 ± 0.09	4.193LeuLys: 4.193 ± 0.067	9.874LeuLeu: 9.874 ± 0.134	2.241LeuMet: 2.241 ± 0.055	2.605LeuAsn: 2.605 ± 0.05	5.477LeuPro: 5.477 ± 0.078	3.011LeuGln: 3.011 ± 0.063	6.443LeuArg: 6.443 ± 0.083	6.349LeuSer: 6.349 ± 0.076	5.655LeuThr: 5.655 ± 0.08	6.887LeuVal: 6.887 ± 0.089	1.159LeuTrp: 1.159 ± 0.04	2.343LeuTyr: 2.343 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.936MetAla: 2.936 ± 0.057	0.14MetCys: 0.14 ± 0.013	1.073MetAsp: 1.073 ± 0.032	1.25MetGlu: 1.25 ± 0.041	0.723MetPhe: 0.723 ± 0.029	1.761MetGly: 1.761 ± 0.042	0.406MetHis: 0.406 ± 0.023	1.214MetIle: 1.214 ± 0.038	0.911MetLys: 0.911 ± 0.033	2.496MetLeu: 2.496 ± 0.05	0.606MetMet: 0.606 ± 0.026	0.64MetAsn: 0.64 ± 0.03	1.538MetPro: 1.538 ± 0.046	0.924MetGln: 0.924 ± 0.03	1.84MetArg: 1.84 ± 0.046	1.593MetSer: 1.593 ± 0.042	1.618MetThr: 1.618 ± 0.048	1.601MetVal: 1.601 ± 0.041	0.222MetTrp: 0.222 ± 0.014	0.29MetTyr: 0.29 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.099AsnAla: 3.099 ± 0.056	0.236AsnCys: 0.236 ± 0.018	1.407AsnAsp: 1.407 ± 0.04	1.328AsnGlu: 1.328 ± 0.042	0.978AsnPhe: 0.978 ± 0.033	2.308AsnGly: 2.308 ± 0.058	0.485AsnHis: 0.485 ± 0.024	1.339AsnIle: 1.339 ± 0.037	0.805AsnLys: 0.805 ± 0.031	2.493AsnLeu: 2.493 ± 0.051	0.605AsnMet: 0.605 ± 0.028	0.699AsnAsn: 0.699 ± 0.029	1.783AsnPro: 1.783 ± 0.044	0.765AsnGln: 0.765 ± 0.03	1.68AsnArg: 1.68 ± 0.041	1.307AsnSer: 1.307 ± 0.038	1.253AsnThr: 1.253 ± 0.038	1.863AsnVal: 1.863 ± 0.054	0.408AsnTrp: 0.408 ± 0.021	0.72AsnTyr: 0.72 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	6.068ProAla: 6.068 ± 0.091	0.358ProCys: 0.358 ± 0.02	3.813ProAsp: 3.813 ± 0.069	4.636ProGlu: 4.636 ± 0.073	2.06ProPhe: 2.06 ± 0.048	4.659ProGly: 4.659 ± 0.082	1.049ProHis: 1.049 ± 0.032	2.418ProIle: 2.418 ± 0.048	2.271ProLys: 2.271 ± 0.054	4.801ProLeu: 4.801 ± 0.072	1.24ProMet: 1.24 ± 0.034	1.445ProAsn: 1.445 ± 0.039	2.728ProPro: 2.728 ± 0.091	1.794ProGln: 1.794 ± 0.05	2.742ProArg: 2.742 ± 0.049	2.946ProSer: 2.946 ± 0.065	2.258ProThr: 2.258 ± 0.045	3.965ProVal: 3.965 ± 0.059	0.682ProTrp: 0.682 ± 0.028	1.39ProTyr: 1.39 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.931GlnAla: 3.931 ± 0.076	0.22GlnCys: 0.22 ± 0.017	1.648GlnAsp: 1.648 ± 0.043	1.838GlnGlu: 1.838 ± 0.045	1.055GlnPhe: 1.055 ± 0.035	2.656GlnGly: 2.656 ± 0.059	0.617GlnHis: 0.617 ± 0.027	1.704GlnIle: 1.704 ± 0.048	1.214GlnLys: 1.214 ± 0.036	3.061GlnLeu: 3.061 ± 0.059	0.796GlnMet: 0.796 ± 0.026	0.874GlnAsn: 0.874 ± 0.032	1.734GlnPro: 1.734 ± 0.045	1.198GlnGln: 1.198 ± 0.046	2.103GlnArg: 2.103 ± 0.051	1.908GlnSer: 1.908 ± 0.046	1.682GlnThr: 1.682 ± 0.049	2.148GlnVal: 2.148 ± 0.044	0.376GlnTrp: 0.376 ± 0.021	0.673GlnTyr: 0.673 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.731ArgAla: 6.731 ± 0.085	0.511ArgCys: 0.511 ± 0.025	3.619ArgAsp: 3.619 ± 0.066	4.046ArgGlu: 4.046 ± 0.066	2.842ArgPhe: 2.842 ± 0.06	4.542ArgGly: 4.542 ± 0.072	1.519ArgHis: 1.519 ± 0.039	3.613ArgIle: 3.613 ± 0.062	2.552ArgLys: 2.552 ± 0.057	7.178ArgLeu: 7.178 ± 0.092	1.602ArgMet: 1.602 ± 0.044	1.677ArgAsn: 1.677 ± 0.045	3.191ArgPro: 3.191 ± 0.062	2.385ArgGln: 2.385 ± 0.054	4.743ArgArg: 4.743 ± 0.101	3.394ArgSer: 3.394 ± 0.064	2.719ArgThr: 2.719 ± 0.056	3.96ArgVal: 3.96 ± 0.065	0.862ArgTrp: 0.862 ± 0.03	1.903ArgTyr: 1.903 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.904SerAla: 5.904 ± 0.092	0.481SerCys: 0.481 ± 0.022	3.134SerAsp: 3.134 ± 0.063	3.396SerGlu: 3.396 ± 0.068	2.508SerPhe: 2.508 ± 0.051	5.385SerGly: 5.385 ± 0.092	1.185SerHis: 1.185 ± 0.038	2.605SerIle: 2.605 ± 0.05	1.949SerLys: 1.949 ± 0.051	5.737SerLeu: 5.737 ± 0.081	1.364SerMet: 1.364 ± 0.041	1.429SerAsn: 1.429 ± 0.038	2.929SerPro: 2.929 ± 0.057	1.732SerGln: 1.732 ± 0.049	3.397SerArg: 3.397 ± 0.067	3.089SerSer: 3.089 ± 0.067	2.393SerThr: 2.393 ± 0.054	3.657SerVal: 3.657 ± 0.067	0.81SerTrp: 0.81 ± 0.03	1.539SerTyr: 1.539 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	5.836ThrAla: 5.836 ± 0.089	0.419ThrCys: 0.419 ± 0.018	2.892ThrAsp: 2.892 ± 0.056	3.076ThrGlu: 3.076 ± 0.063	1.816ThrPhe: 1.816 ± 0.047	5.238ThrGly: 5.238 ± 0.083	1.0ThrHis: 1.0 ± 0.035	2.549ThrIle: 2.549 ± 0.059	1.676ThrLys: 1.676 ± 0.042	5.517ThrLeu: 5.517 ± 0.088	1.103ThrMet: 1.103 ± 0.033	1.184ThrAsn: 1.184 ± 0.036	3.451ThrPro: 3.451 ± 0.055	1.31ThrGln: 1.31 ± 0.044	2.937ThrArg: 2.937 ± 0.045	2.564ThrSer: 2.564 ± 0.062	2.455ThrThr: 2.455 ± 0.07	4.343ThrVal: 4.343 ± 0.081	0.629ThrTrp: 0.629 ± 0.027	1.34ThrTyr: 1.34 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.096ValAla: 8.096 ± 0.11	0.63ValCys: 0.63 ± 0.027	3.823ValAsp: 3.823 ± 0.07	4.473ValGlu: 4.473 ± 0.071	2.773ValPhe: 2.773 ± 0.053	5.075ValGly: 5.075 ± 0.077	1.278ValHis: 1.278 ± 0.04	3.954ValIle: 3.954 ± 0.075	2.541ValLys: 2.541 ± 0.056	7.555ValLeu: 7.555 ± 0.103	1.766ValMet: 1.766 ± 0.045	1.905ValAsn: 1.905 ± 0.047	3.824ValPro: 3.824 ± 0.074	1.907ValGln: 1.907 ± 0.046	3.99ValArg: 3.99 ± 0.062	4.38ValSer: 4.38 ± 0.068	4.323ValThr: 4.323 ± 0.067	5.496ValVal: 5.496 ± 0.086	0.867ValTrp: 0.867 ± 0.031	1.625ValTyr: 1.625 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.171TrpAla: 1.171 ± 0.04	0.153TrpCys: 0.153 ± 0.012	0.633TrpAsp: 0.633 ± 0.028	0.632TrpGlu: 0.632 ± 0.027	0.546TrpPhe: 0.546 ± 0.024	0.931TrpGly: 0.931 ± 0.035	0.316TrpHis: 0.316 ± 0.017	0.667TrpIle: 0.667 ± 0.027	0.482TrpLys: 0.482 ± 0.023	1.624TrpLeu: 1.624 ± 0.04	0.366TrpMet: 0.366 ± 0.022	0.451TrpAsn: 0.451 ± 0.021	0.696TrpPro: 0.696 ± 0.027	0.595TrpGln: 0.595 ± 0.025	1.068TrpArg: 1.068 ± 0.032	0.81TrpSer: 0.81 ± 0.034	0.673TrpThr: 0.673 ± 0.026	0.821TrpVal: 0.821 ± 0.032	0.222TrpTrp: 0.222 ± 0.015	0.337TrpTyr: 0.337 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.591TyrAla: 2.591 ± 0.058	0.283TyrCys: 0.283 ± 0.02	1.721TyrAsp: 1.721 ± 0.041	1.455TyrGlu: 1.455 ± 0.041	1.057TyrPhe: 1.057 ± 0.039	2.41TyrGly: 2.41 ± 0.053	0.517TyrHis: 0.517 ± 0.022	1.042TyrIle: 1.042 ± 0.035	0.743TyrLys: 0.743 ± 0.033	2.549TyrLeu: 2.549 ± 0.054	0.472TyrMet: 0.472 ± 0.024	0.671TyrAsn: 0.671 ± 0.03	1.194TyrPro: 1.194 ± 0.042	0.812TyrGln: 0.812 ± 0.032	1.888TyrArg: 1.888 ± 0.048	1.344TyrSer: 1.344 ± 0.047	1.119TyrThr: 1.119 ± 0.039	1.703TyrVal: 1.703 ± 0.046	0.463TyrTrp: 0.463 ± 0.025	0.715TyrTyr: 0.715 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2937 proteins (941881 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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