Amino acid dipepetide frequency for Sus scrofa (Pig)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.12AlaAla: 7.12 ± 0.032	1.41AlaCys: 1.41 ± 0.009	2.956AlaAsp: 2.956 ± 0.012	4.913AlaGlu: 4.913 ± 0.022	2.672AlaPhe: 2.672 ± 0.011	4.962AlaGly: 4.962 ± 0.023	1.57AlaHis: 1.57 ± 0.008	2.834AlaIle: 2.834 ± 0.011	3.466AlaLys: 3.466 ± 0.015	7.29AlaLeu: 7.29 ± 0.02	1.478AlaMet: 1.478 ± 0.008	2.018AlaAsn: 2.018 ± 0.009	4.394AlaPro: 4.394 ± 0.023	3.249AlaGln: 3.249 ± 0.014	3.845AlaArg: 3.845 ± 0.016	5.816AlaSer: 5.816 ± 0.019	3.513AlaThr: 3.513 ± 0.014	4.8AlaVal: 4.8 ± 0.016	0.81AlaTrp: 0.81 ± 0.006	1.52AlaTyr: 1.52 ± 0.007	0.0AlaXaa: 0.0 ± 0.0
Cys	1.272CysAla: 1.272 ± 0.008	0.622CysCys: 0.622 ± 0.007	1.009CysAsp: 1.009 ± 0.009	1.223CysGlu: 1.223 ± 0.011	0.838CysPhe: 0.838 ± 0.006	1.688CysGly: 1.688 ± 0.015	0.643CysHis: 0.643 ± 0.005	0.967CysIle: 0.967 ± 0.006	1.1CysLys: 1.1 ± 0.009	2.176CysLeu: 2.176 ± 0.013	0.414CysMet: 0.414 ± 0.004	0.766CysAsn: 0.766 ± 0.006	1.381CysPro: 1.381 ± 0.011	1.032CysGln: 1.032 ± 0.008	1.319CysArg: 1.319 ± 0.009	1.997CysSer: 1.997 ± 0.011	1.091CysThr: 1.091 ± 0.007	1.301CysVal: 1.301 ± 0.009	0.313CysTrp: 0.313 ± 0.004	0.556CysTyr: 0.556 ± 0.004	0.0CysXaa: 0.0 ± 0.0
Asp	2.978AspAla: 2.978 ± 0.011	1.021AspCys: 1.021 ± 0.008	2.588AspAsp: 2.588 ± 0.011	3.377AspGlu: 3.377 ± 0.015	2.127AspPhe: 2.127 ± 0.009	3.273AspGly: 3.273 ± 0.014	1.133AspHis: 1.133 ± 0.007	2.57AspIle: 2.57 ± 0.012	2.565AspLys: 2.565 ± 0.012	5.088AspLeu: 5.088 ± 0.015	1.087AspMet: 1.087 ± 0.007	1.63AspAsn: 1.63 ± 0.009	2.921AspPro: 2.921 ± 0.011	1.833AspGln: 1.833 ± 0.009	2.465AspArg: 2.465 ± 0.012	4.06AspSer: 4.06 ± 0.015	2.435AspThr: 2.435 ± 0.01	3.067AspVal: 3.067 ± 0.015	0.615AspTrp: 0.615 ± 0.006	1.422AspTyr: 1.422 ± 0.009	0.0AspXaa: 0.0 ± 0.0
Glu	5.338GluAla: 5.338 ± 0.024	1.378GluCys: 1.378 ± 0.015	4.374GluAsp: 4.374 ± 0.016	7.883GluGlu: 7.883 ± 0.039	2.025GluPhe: 2.025 ± 0.009	4.243GluGly: 4.243 ± 0.016	1.514GluHis: 1.514 ± 0.008	3.218GluIle: 3.218 ± 0.013	5.478GluLys: 5.478 ± 0.027	6.451GluLeu: 6.451 ± 0.024	1.665GluMet: 1.665 ± 0.008	3.132GluAsn: 3.132 ± 0.013	3.272GluPro: 3.272 ± 0.015	3.14GluGln: 3.14 ± 0.015	4.058GluArg: 4.058 ± 0.02	4.319GluSer: 4.319 ± 0.017	3.376GluThr: 3.376 ± 0.011	4.144GluVal: 4.144 ± 0.015	0.696GluTrp: 0.696 ± 0.005	1.558GluTyr: 1.558 ± 0.008	0.0GluXaa: 0.0 ± 0.0
Phe	1.998PheAla: 1.998 ± 0.01	0.958PheCys: 0.958 ± 0.007	1.658PheAsp: 1.658 ± 0.008	1.994PheGlu: 1.994 ± 0.01	1.689PhePhe: 1.689 ± 0.01	2.188PheGly: 2.188 ± 0.012	1.026PheHis: 1.026 ± 0.007	1.872PheIle: 1.872 ± 0.012	1.792PheLys: 1.792 ± 0.009	4.191PheLeu: 4.191 ± 0.016	0.768PheMet: 0.768 ± 0.006	1.315PheAsn: 1.315 ± 0.007	2.016PhePro: 2.016 ± 0.011	1.754PheGln: 1.754 ± 0.008	1.985PheArg: 1.985 ± 0.009	3.537PheSer: 3.537 ± 0.014	2.009PheThr: 2.009 ± 0.011	2.135PheVal: 2.135 ± 0.011	0.5PheTrp: 0.5 ± 0.004	1.211PheTyr: 1.211 ± 0.007	0.0PheXaa: 0.0 ± 0.0
Gly	4.713GlyAla: 4.713 ± 0.022	1.311GlyCys: 1.311 ± 0.009	3.164GlyAsp: 3.164 ± 0.013	4.136GlyGlu: 4.136 ± 0.019	2.436GlyPhe: 2.436 ± 0.013	5.185GlyGly: 5.185 ± 0.028	1.692GlyHis: 1.692 ± 0.009	2.749GlyIle: 2.749 ± 0.012	3.757GlyLys: 3.757 ± 0.016	5.949GlyLeu: 5.949 ± 0.021	1.25GlyMet: 1.25 ± 0.009	2.299GlyAsn: 2.299 ± 0.011	4.488GlyPro: 4.488 ± 0.037	2.792GlyGln: 2.792 ± 0.012	3.946GlyArg: 3.946 ± 0.018	5.848GlySer: 5.848 ± 0.019	3.585GlyThr: 3.585 ± 0.013	3.594GlyVal: 3.594 ± 0.016	0.82GlyTrp: 0.82 ± 0.007	1.688GlyTyr: 1.688 ± 0.009	0.0GlyXaa: 0.0 ± 0.0
His	1.327HisAla: 1.327 ± 0.007	0.713HisCys: 0.713 ± 0.006	0.878HisAsp: 0.878 ± 0.005	1.281HisGlu: 1.281 ± 0.008	1.101HisPhe: 1.101 ± 0.007	1.563HisGly: 1.563 ± 0.009	0.879HisHis: 0.879 ± 0.007	1.244HisIle: 1.244 ± 0.007	1.242HisLys: 1.242 ± 0.008	2.947HisLeu: 2.947 ± 0.011	0.581HisMet: 0.581 ± 0.005	0.811HisAsn: 0.811 ± 0.006	1.726HisPro: 1.726 ± 0.017	1.314HisGln: 1.314 ± 0.01	1.594HisArg: 1.594 ± 0.009	2.253HisSer: 2.253 ± 0.011	1.465HisThr: 1.465 ± 0.011	1.5HisVal: 1.5 ± 0.008	0.338HisTrp: 0.338 ± 0.004	0.786HisTyr: 0.786 ± 0.006	0.0HisXaa: 0.0 ± 0.0
Ile	2.593IleAla: 2.593 ± 0.012	1.112IleCys: 1.112 ± 0.008	2.023IleAsp: 2.023 ± 0.009	2.579IleGlu: 2.579 ± 0.01	1.939IlePhe: 1.939 ± 0.012	2.18IleGly: 2.18 ± 0.011	1.366IleHis: 1.366 ± 0.013	2.437IleIle: 2.437 ± 0.014	2.769IleLys: 2.769 ± 0.014	4.637IleLeu: 4.637 ± 0.018	1.001IleMet: 1.001 ± 0.007	1.873IleAsn: 1.873 ± 0.012	2.584IlePro: 2.584 ± 0.011	2.317IleGln: 2.317 ± 0.012	2.413IleArg: 2.413 ± 0.009	3.712IleSer: 3.712 ± 0.013	2.512IleThr: 2.512 ± 0.011	2.47IleVal: 2.47 ± 0.011	0.512IleTrp: 0.512 ± 0.005	1.426IleTyr: 1.426 ± 0.009	0.0IleXaa: 0.0 ± 0.0
Lys	4.107LysAla: 4.107 ± 0.014	1.114LysCys: 1.114 ± 0.009	3.199LysAsp: 3.199 ± 0.013	5.191LysGlu: 5.191 ± 0.026	1.728LysPhe: 1.728 ± 0.009	3.3LysGly: 3.3 ± 0.018	1.385LysHis: 1.385 ± 0.009	2.863LysIle: 2.863 ± 0.013	4.721LysLys: 4.721 ± 0.025	5.219LysLeu: 5.219 ± 0.018	1.439LysMet: 1.439 ± 0.007	2.387LysAsn: 2.387 ± 0.011	3.1LysPro: 3.1 ± 0.015	2.587LysGln: 2.587 ± 0.013	3.275LysArg: 3.275 ± 0.013	3.889LysSer: 3.889 ± 0.018	3.12LysThr: 3.12 ± 0.012	3.454LysVal: 3.454 ± 0.013	0.616LysTrp: 0.616 ± 0.005	1.536LysTyr: 1.536 ± 0.01	0.001LysXaa: 0.001 ± 0.0
Leu	6.889LeuAla: 6.889 ± 0.021	2.171LeuCys: 2.171 ± 0.011	4.688LeuAsp: 4.688 ± 0.014	7.274LeuGlu: 7.274 ± 0.028	3.462LeuPhe: 3.462 ± 0.015	5.999LeuGly: 5.999 ± 0.019	2.734LeuHis: 2.734 ± 0.011	3.972LeuIle: 3.972 ± 0.015	5.894LeuLys: 5.894 ± 0.019	10.901LeuLeu: 10.901 ± 0.029	2.027LeuMet: 2.027 ± 0.009	3.551LeuAsn: 3.551 ± 0.013	6.084LeuPro: 6.084 ± 0.023	5.755LeuGln: 5.755 ± 0.023	6.037LeuArg: 6.037 ± 0.022	8.038LeuSer: 8.038 ± 0.022	5.049LeuThr: 5.049 ± 0.016	5.498LeuVal: 5.498 ± 0.019	1.159LeuTrp: 1.159 ± 0.008	2.555LeuTyr: 2.555 ± 0.012	0.0LeuXaa: 0.0 ± 0.0
Met	1.944MetAla: 1.944 ± 0.009	0.402MetCys: 0.402 ± 0.004	1.225MetAsp: 1.225 ± 0.008	1.838MetGlu: 1.838 ± 0.009	0.719MetPhe: 0.719 ± 0.006	1.262MetGly: 1.262 ± 0.009	0.442MetHis: 0.442 ± 0.004	0.869MetIle: 0.869 ± 0.006	1.443MetLys: 1.443 ± 0.007	1.941MetLeu: 1.941 ± 0.008	0.564MetMet: 0.564 ± 0.005	0.885MetAsn: 0.885 ± 0.007	1.07MetPro: 1.07 ± 0.008	0.923MetGln: 0.923 ± 0.007	1.025MetArg: 1.025 ± 0.006	1.517MetSer: 1.517 ± 0.008	1.093MetThr: 1.093 ± 0.007	1.361MetVal: 1.361 ± 0.007	0.239MetTrp: 0.239 ± 0.003	0.593MetTyr: 0.593 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.04AsnAla: 2.04 ± 0.01	0.791AsnCys: 0.791 ± 0.006	1.465AsnAsp: 1.465 ± 0.009	2.214AsnGlu: 2.214 ± 0.011	1.454AsnPhe: 1.454 ± 0.009	2.364AsnGly: 2.364 ± 0.012	0.948AsnHis: 0.948 ± 0.006	2.17AsnIle: 2.17 ± 0.013	2.261AsnLys: 2.261 ± 0.01	3.679AsnLeu: 3.679 ± 0.013	0.876AsnMet: 0.876 ± 0.005	1.439AsnAsn: 1.439 ± 0.009	2.172AsnPro: 2.172 ± 0.009	1.653AsnGln: 1.653 ± 0.009	1.817AsnArg: 1.817 ± 0.009	3.007AsnSer: 3.007 ± 0.014	1.893AsnThr: 1.893 ± 0.01	2.12AsnVal: 2.12 ± 0.011	0.442AsnTrp: 0.442 ± 0.005	1.083AsnTyr: 1.083 ± 0.007	0.0AsnXaa: 0.0 ± 0.0
Pro	5.105ProAla: 5.105 ± 0.024	1.143ProCys: 1.143 ± 0.009	2.804ProAsp: 2.804 ± 0.01	4.489ProGlu: 4.489 ± 0.018	1.968ProPhe: 1.968 ± 0.01	5.54ProGly: 5.54 ± 0.049	1.429ProHis: 1.429 ± 0.007	1.846ProIle: 1.846 ± 0.009	2.837ProLys: 2.837 ± 0.015	5.372ProLeu: 5.372 ± 0.02	1.058ProMet: 1.058 ± 0.006	1.774ProAsn: 1.774 ± 0.009	6.258ProPro: 6.258 ± 0.042	2.835ProGln: 2.835 ± 0.015	3.562ProArg: 3.562 ± 0.017	5.769ProSer: 5.769 ± 0.023	3.053ProThr: 3.053 ± 0.015	3.787ProVal: 3.787 ± 0.014	0.722ProTrp: 0.722 ± 0.006	1.434ProTyr: 1.434 ± 0.01	0.0ProXaa: 0.0 ± 0.0
Gln	3.513GlnAla: 3.513 ± 0.014	0.926GlnCys: 0.926 ± 0.008	2.316GlnAsp: 2.316 ± 0.01	3.895GlnGlu: 3.895 ± 0.016	1.346GlnPhe: 1.346 ± 0.007	2.861GlnGly: 2.861 ± 0.013	1.275GlnHis: 1.275 ± 0.008	1.988GlnIle: 1.988 ± 0.01	2.969GlnLys: 2.969 ± 0.013	4.744GlnLeu: 4.744 ± 0.019	1.105GlnMet: 1.105 ± 0.006	1.802GlnAsn: 1.802 ± 0.009	2.79GlnPro: 2.79 ± 0.016	3.04GlnGln: 3.04 ± 0.024	2.979GlnArg: 2.979 ± 0.014	3.065GlnSer: 3.065 ± 0.013	2.316GlnThr: 2.316 ± 0.011	2.826GlnVal: 2.826 ± 0.011	0.541GlnTrp: 0.541 ± 0.005	1.113GlnTyr: 1.113 ± 0.006	0.0GlnXaa: 0.0 ± 0.0
Arg	4.015ArgAla: 4.015 ± 0.017	1.222ArgCys: 1.222 ± 0.01	2.78ArgAsp: 2.78 ± 0.014	4.068ArgGlu: 4.068 ± 0.018	1.842ArgPhe: 1.842 ± 0.009	3.786ArgGly: 3.786 ± 0.019	1.537ArgHis: 1.537 ± 0.008	2.446ArgIle: 2.446 ± 0.011	3.675ArgLys: 3.675 ± 0.015	5.506ArgLeu: 5.506 ± 0.02	1.193ArgMet: 1.193 ± 0.007	2.143ArgAsn: 2.143 ± 0.009	3.415ArgPro: 3.415 ± 0.015	2.668ArgGln: 2.668 ± 0.012	4.434ArgArg: 4.434 ± 0.021	4.335ArgSer: 4.335 ± 0.021	2.813ArgThr: 2.813 ± 0.012	3.179ArgVal: 3.179 ± 0.013	0.719ArgTrp: 0.719 ± 0.006	1.473ArgTyr: 1.473 ± 0.008	0.001ArgXaa: 0.001 ± 0.0
Ser	5.439SerAla: 5.439 ± 0.017	1.793SerCys: 1.793 ± 0.011	3.845SerAsp: 3.845 ± 0.016	5.11SerGlu: 5.11 ± 0.018	3.065SerPhe: 3.065 ± 0.013	5.722SerGly: 5.722 ± 0.021	2.107SerHis: 2.107 ± 0.012	3.231SerIle: 3.231 ± 0.013	3.978SerLys: 3.978 ± 0.017	8.265SerLeu: 8.265 ± 0.025	1.551SerMet: 1.551 ± 0.008	2.606SerAsn: 2.606 ± 0.013	6.052SerPro: 6.052 ± 0.024	3.838SerGln: 3.838 ± 0.017	4.596SerArg: 4.596 ± 0.021	9.164SerSer: 9.164 ± 0.039	4.331SerThr: 4.331 ± 0.017	4.82SerVal: 4.82 ± 0.015	1.083SerTrp: 1.083 ± 0.008	2.051SerTyr: 2.051 ± 0.01	0.001SerXaa: 0.001 ± 0.0
Thr	3.726ThrAla: 3.726 ± 0.013	1.278ThrCys: 1.278 ± 0.01	2.431ThrAsp: 2.431 ± 0.011	3.488ThrGlu: 3.488 ± 0.013	2.107ThrPhe: 2.107 ± 0.009	3.476ThrGly: 3.476 ± 0.016	1.28ThrHis: 1.28 ± 0.009	2.371ThrIle: 2.371 ± 0.012	2.607ThrLys: 2.607 ± 0.013	5.298ThrLeu: 5.298 ± 0.015	1.09ThrMet: 1.09 ± 0.006	1.679ThrAsn: 1.679 ± 0.009	3.571ThrPro: 3.571 ± 0.016	2.216ThrGln: 2.216 ± 0.011	2.477ThrArg: 2.477 ± 0.009	4.508ThrSer: 4.508 ± 0.015	2.848ThrThr: 2.848 ± 0.017	3.803ThrVal: 3.803 ± 0.015	0.714ThrTrp: 0.714 ± 0.006	1.403ThrTyr: 1.403 ± 0.008	0.0ThrXaa: 0.0 ± 0.0
Val	4.313ValAla: 4.313 ± 0.014	1.438ValCys: 1.438 ± 0.009	2.908ValAsp: 2.908 ± 0.014	3.826ValGlu: 3.826 ± 0.015	2.397ValPhe: 2.397 ± 0.011	3.4ValGly: 3.4 ± 0.014	1.544ValHis: 1.544 ± 0.008	2.881ValIle: 2.881 ± 0.012	3.374ValLys: 3.374 ± 0.014	6.221ValLeu: 6.221 ± 0.016	1.306ValMet: 1.306 ± 0.007	2.209ValAsn: 2.209 ± 0.011	3.661ValPro: 3.661 ± 0.015	2.717ValGln: 2.717 ± 0.011	3.064ValArg: 3.064 ± 0.012	4.804ValSer: 4.804 ± 0.015	3.723ValThr: 3.723 ± 0.016	3.956ValVal: 3.956 ± 0.016	0.721ValTrp: 0.721 ± 0.006	1.592ValTyr: 1.592 ± 0.01	0.0ValXaa: 0.0 ± 0.0
Trp	0.816TrpAla: 0.816 ± 0.006	0.244TrpCys: 0.244 ± 0.003	0.67TrpAsp: 0.67 ± 0.005	0.822TrpGlu: 0.822 ± 0.007	0.453TrpPhe: 0.453 ± 0.005	0.757TrpGly: 0.757 ± 0.007	0.297TrpHis: 0.297 ± 0.003	0.565TrpIle: 0.565 ± 0.005	0.802TrpLys: 0.802 ± 0.007	1.212TrpLeu: 1.212 ± 0.009	0.322TrpMet: 0.322 ± 0.004	0.531TrpAsn: 0.531 ± 0.004	0.549TrpPro: 0.549 ± 0.005	0.521TrpGln: 0.521 ± 0.005	0.775TrpArg: 0.775 ± 0.006	0.853TrpSer: 0.853 ± 0.007	0.671TrpThr: 0.671 ± 0.007	0.691TrpVal: 0.691 ± 0.005	0.204TrpTrp: 0.204 ± 0.003	0.363TrpTyr: 0.363 ± 0.004	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.392TyrAla: 1.392 ± 0.008	0.661TyrCys: 0.661 ± 0.005	1.272TyrAsp: 1.272 ± 0.009	1.661TyrGlu: 1.661 ± 0.01	1.226TyrPhe: 1.226 ± 0.007	1.655TyrGly: 1.655 ± 0.01	0.741TyrHis: 0.741 ± 0.005	1.363TyrIle: 1.363 ± 0.008	1.502TyrLys: 1.502 ± 0.013	2.653TyrLeu: 2.653 ± 0.011	0.577TyrMet: 0.577 ± 0.005	1.04TyrAsn: 1.04 ± 0.006	1.28TyrPro: 1.28 ± 0.007	1.226TyrGln: 1.226 ± 0.007	1.583TyrArg: 1.583 ± 0.008	2.154TyrSer: 2.154 ± 0.011	1.475TyrThr: 1.475 ± 0.008	1.55TyrVal: 1.55 ± 0.008	0.354TyrTrp: 0.354 ± 0.005	0.923TyrTyr: 0.923 ± 0.006	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.001

Statistics based on 49865 proteins (29285362 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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