Amino acid dipepetide frequency for Chthonomonas calidirosea (strain DSM 23976 / ICMP 18418 / T49)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.116AlaAla: 10.116 ± 0.131	1.252AlaCys: 1.252 ± 0.038	4.763AlaAsp: 4.763 ± 0.075	5.943AlaGlu: 5.943 ± 0.101	3.737AlaPhe: 3.737 ± 0.065	6.509AlaGly: 6.509 ± 0.09	2.493AlaHis: 2.493 ± 0.052	5.73AlaIle: 5.73 ± 0.085	3.355AlaLys: 3.355 ± 0.065	12.337AlaLeu: 12.337 ± 0.159	2.127AlaMet: 2.127 ± 0.051	2.87AlaAsn: 2.87 ± 0.065	4.734AlaPro: 4.734 ± 0.077	4.866AlaGln: 4.866 ± 0.113	6.389AlaArg: 6.389 ± 0.092	5.092AlaSer: 5.092 ± 0.072	5.022AlaThr: 5.022 ± 0.073	6.816AlaVal: 6.816 ± 0.087	1.313AlaTrp: 1.313 ± 0.036	2.947AlaTyr: 2.947 ± 0.055	0.002AlaXaa: 0.002 ± 0.002
Cys	1.071CysAla: 1.071 ± 0.039	0.216CysCys: 0.216 ± 0.015	0.575CysAsp: 0.575 ± 0.027	0.589CysGlu: 0.589 ± 0.029	0.429CysPhe: 0.429 ± 0.02	1.078CysGly: 1.078 ± 0.039	0.336CysHis: 0.336 ± 0.018	0.538CysIle: 0.538 ± 0.025	0.312CysLys: 0.312 ± 0.018	1.346CysLeu: 1.346 ± 0.042	0.211CysMet: 0.211 ± 0.015	0.373CysAsn: 0.373 ± 0.02	0.735CysPro: 0.735 ± 0.034	0.363CysGln: 0.363 ± 0.02	0.787CysArg: 0.787 ± 0.025	0.603CysSer: 0.603 ± 0.023	0.599CysThr: 0.599 ± 0.024	0.811CysVal: 0.811 ± 0.028	0.216CysTrp: 0.216 ± 0.014	0.447CysTyr: 0.447 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.584AspAla: 4.584 ± 0.074	0.438AspCys: 0.438 ± 0.022	2.003AspAsp: 2.003 ± 0.045	2.605AspGlu: 2.605 ± 0.054	1.893AspPhe: 1.893 ± 0.039	3.931AspGly: 3.931 ± 0.088	0.982AspHis: 0.982 ± 0.031	2.902AspIle: 2.902 ± 0.051	1.46AspLys: 1.46 ± 0.042	4.8AspLeu: 4.8 ± 0.083	0.936AspMet: 0.936 ± 0.032	1.405AspAsn: 1.405 ± 0.036	3.646AspPro: 3.646 ± 0.075	1.537AspGln: 1.537 ± 0.038	2.983AspArg: 2.983 ± 0.071	2.232AspSer: 2.232 ± 0.046	2.541AspThr: 2.541 ± 0.06	3.543AspVal: 3.543 ± 0.062	0.835AspTrp: 0.835 ± 0.027	1.745AspTyr: 1.745 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.179GluAla: 7.179 ± 0.113	0.527GluCys: 0.527 ± 0.024	2.41GluAsp: 2.41 ± 0.058	5.15GluGlu: 5.15 ± 0.104	1.663GluPhe: 1.663 ± 0.038	4.448GluGly: 4.448 ± 0.073	1.321GluHis: 1.321 ± 0.033	3.423GluIle: 3.423 ± 0.073	2.442GluLys: 2.442 ± 0.054	5.612GluLeu: 5.612 ± 0.1	1.48GluMet: 1.48 ± 0.036	1.914GluAsn: 1.914 ± 0.042	2.818GluPro: 2.818 ± 0.05	2.868GluGln: 2.868 ± 0.067	5.081GluArg: 5.081 ± 0.1	2.485GluSer: 2.485 ± 0.046	3.28GluThr: 3.28 ± 0.056	4.387GluVal: 4.387 ± 0.072	0.818GluTrp: 0.818 ± 0.027	1.321GluTyr: 1.321 ± 0.033	0.002GluXaa: 0.002 ± 0.002
Phe	3.486PheAla: 3.486 ± 0.058	0.623PheCys: 0.623 ± 0.028	2.105PheAsp: 2.105 ± 0.049	1.944PheGlu: 1.944 ± 0.047	1.507PhePhe: 1.507 ± 0.042	3.151PheGly: 3.151 ± 0.058	1.057PheHis: 1.057 ± 0.036	1.663PheIle: 1.663 ± 0.052	0.84PheLys: 0.84 ± 0.029	4.029PheLeu: 4.029 ± 0.079	0.653PheMet: 0.653 ± 0.027	1.131PheAsn: 1.131 ± 0.037	1.927PhePro: 1.927 ± 0.057	1.449PheGln: 1.449 ± 0.038	2.221PheArg: 2.221 ± 0.055	2.202PheSer: 2.202 ± 0.059	2.169PheThr: 2.169 ± 0.046	2.691PheVal: 2.691 ± 0.052	0.684PheTrp: 0.684 ± 0.027	1.376PheTyr: 1.376 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	6.512GlyAla: 6.512 ± 0.086	1.022GlyCys: 1.022 ± 0.035	3.584GlyAsp: 3.584 ± 0.064	3.958GlyGlu: 3.958 ± 0.065	3.103GlyPhe: 3.103 ± 0.061	6.178GlyGly: 6.178 ± 0.12	1.953GlyHis: 1.953 ± 0.05	4.406GlyIle: 4.406 ± 0.072	3.297GlyLys: 3.297 ± 0.058	7.823GlyLeu: 7.823 ± 0.102	1.765GlyMet: 1.765 ± 0.046	2.465GlyAsn: 2.465 ± 0.06	3.18GlyPro: 3.18 ± 0.075	2.998GlyGln: 2.998 ± 0.064	4.702GlyArg: 4.702 ± 0.079	4.154GlySer: 4.154 ± 0.085	4.442GlyThr: 4.442 ± 0.084	5.607GlyVal: 5.607 ± 0.078	1.347GlyTrp: 1.347 ± 0.04	2.756GlyTyr: 2.756 ± 0.059	0.001GlyXaa: 0.001 ± 0.001
His	2.201HisAla: 2.201 ± 0.044	0.322HisCys: 0.322 ± 0.019	1.084HisAsp: 1.084 ± 0.033	1.234HisGlu: 1.234 ± 0.038	1.082HisPhe: 1.082 ± 0.032	1.81HisGly: 1.81 ± 0.048	0.812HisHis: 0.812 ± 0.032	1.34HisIle: 1.34 ± 0.038	0.703HisLys: 0.703 ± 0.028	2.912HisLeu: 2.912 ± 0.05	0.465HisMet: 0.465 ± 0.023	0.803HisAsn: 0.803 ± 0.029	1.882HisPro: 1.882 ± 0.046	1.019HisGln: 1.019 ± 0.031	1.753HisArg: 1.753 ± 0.047	1.187HisSer: 1.187 ± 0.033	1.362HisThr: 1.362 ± 0.035	1.712HisVal: 1.712 ± 0.04	0.453HisTrp: 0.453 ± 0.022	0.866HisTyr: 0.866 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.321IleAla: 6.321 ± 0.075	0.653IleCys: 0.653 ± 0.027	2.572IleAsp: 2.572 ± 0.055	3.669IleGlu: 3.669 ± 0.064	1.731IlePhe: 1.731 ± 0.053	4.845IleGly: 4.845 ± 0.077	1.198IleHis: 1.198 ± 0.035	2.242IleIle: 2.242 ± 0.051	1.402IleLys: 1.402 ± 0.04	5.194IleLeu: 5.194 ± 0.08	0.838IleMet: 0.838 ± 0.026	1.564IleAsn: 1.564 ± 0.046	2.988IlePro: 2.988 ± 0.055	1.829IleGln: 1.829 ± 0.046	3.287IleArg: 3.287 ± 0.063	2.734IleSer: 2.734 ± 0.047	3.099IleThr: 3.099 ± 0.056	4.339IleVal: 4.339 ± 0.08	0.641IleTrp: 0.641 ± 0.028	1.707IleTyr: 1.707 ± 0.047	0.001IleXaa: 0.001 ± 0.001
Lys	3.615LysAla: 3.615 ± 0.073	0.23LysCys: 0.23 ± 0.015	1.401LysAsp: 1.401 ± 0.045	2.511LysGlu: 2.511 ± 0.057	0.733LysPhe: 0.733 ± 0.026	2.412LysGly: 2.412 ± 0.059	0.68LysHis: 0.68 ± 0.027	1.613LysIle: 1.613 ± 0.039	1.232LysLys: 1.232 ± 0.04	3.265LysLeu: 3.265 ± 0.056	0.887LysMet: 0.887 ± 0.033	1.077LysAsn: 1.077 ± 0.035	2.214LysPro: 2.214 ± 0.052	1.627LysGln: 1.627 ± 0.042	2.567LysArg: 2.567 ± 0.059	1.516LysSer: 1.516 ± 0.043	2.088LysThr: 2.088 ± 0.047	2.481LysVal: 2.481 ± 0.063	0.404LysTrp: 0.404 ± 0.02	0.75LysTyr: 0.75 ± 0.032	0.001LysXaa: 0.001 ± 0.001
Leu	11.048LeuAla: 11.048 ± 0.123	1.548LeuCys: 1.548 ± 0.04	4.933LeuAsp: 4.933 ± 0.074	6.476LeuGlu: 6.476 ± 0.096	4.392LeuPhe: 4.392 ± 0.08	7.527LeuGly: 7.527 ± 0.119	2.887LeuHis: 2.887 ± 0.059	5.189LeuIle: 5.189 ± 0.089	3.708LeuLys: 3.708 ± 0.066	13.471LeuLeu: 13.471 ± 0.201	2.008LeuMet: 2.008 ± 0.047	3.011LeuAsn: 3.011 ± 0.056	6.808LeuPro: 6.808 ± 0.095	5.455LeuGln: 5.455 ± 0.095	7.488LeuArg: 7.488 ± 0.103	6.546LeuSer: 6.546 ± 0.095	5.872LeuThr: 5.872 ± 0.084	7.164LeuVal: 7.164 ± 0.085	1.537LeuTrp: 1.537 ± 0.05	3.376LeuTyr: 3.376 ± 0.068	0.0LeuXaa: 0.0 ± 0.0
Met	2.231MetAla: 2.231 ± 0.045	0.169MetCys: 0.169 ± 0.012	0.852MetAsp: 0.852 ± 0.032	1.379MetGlu: 1.379 ± 0.036	0.489MetPhe: 0.489 ± 0.023	1.659MetGly: 1.659 ± 0.041	0.5MetHis: 0.5 ± 0.023	0.858MetIle: 0.858 ± 0.029	0.838MetLys: 0.838 ± 0.029	2.152MetLeu: 2.152 ± 0.047	0.431MetMet: 0.431 ± 0.023	0.735MetAsn: 0.735 ± 0.029	1.449MetPro: 1.449 ± 0.038	1.014MetGln: 1.014 ± 0.037	1.658MetArg: 1.658 ± 0.038	1.085MetSer: 1.085 ± 0.033	1.005MetThr: 1.005 ± 0.031	1.434MetVal: 1.434 ± 0.042	0.215MetTrp: 0.215 ± 0.014	0.377MetTyr: 0.377 ± 0.02	0.001MetXaa: 0.001 ± 0.001
Asn	3.173AsnAla: 3.173 ± 0.063	0.311AsnCys: 0.311 ± 0.021	1.501AsnAsp: 1.501 ± 0.044	1.507AsnGlu: 1.507 ± 0.036	1.111AsnPhe: 1.111 ± 0.035	2.93AsnGly: 2.93 ± 0.075	0.723AsnHis: 0.723 ± 0.024	1.679AsnIle: 1.679 ± 0.043	0.808AsnLys: 0.808 ± 0.028	3.42AsnLeu: 3.42 ± 0.069	0.592AsnMet: 0.592 ± 0.024	1.206AsnAsn: 1.206 ± 0.047	2.572AsnPro: 2.572 ± 0.061	1.181AsnGln: 1.181 ± 0.039	2.159AsnArg: 2.159 ± 0.044	1.589AsnSer: 1.589 ± 0.051	1.844AsnThr: 1.844 ± 0.047	2.233AsnVal: 2.233 ± 0.053	0.476AsnTrp: 0.476 ± 0.02	1.125AsnTyr: 1.125 ± 0.037	0.001AsnXaa: 0.001 ± 0.001
Pro	4.705ProAla: 4.705 ± 0.069	0.515ProCys: 0.515 ± 0.029	3.588ProAsp: 3.588 ± 0.064	3.898ProGlu: 3.898 ± 0.078	2.212ProPhe: 2.212 ± 0.051	3.959ProGly: 3.959 ± 0.075	1.594ProHis: 1.594 ± 0.04	3.297ProIle: 3.297 ± 0.06	2.067ProLys: 2.067 ± 0.049	6.182ProLeu: 6.182 ± 0.082	1.187ProMet: 1.187 ± 0.035	2.615ProAsn: 2.615 ± 0.06	3.989ProPro: 3.989 ± 0.084	2.683ProGln: 2.683 ± 0.052	2.733ProArg: 2.733 ± 0.056	3.962ProSer: 3.962 ± 0.076	3.699ProThr: 3.699 ± 0.06	3.862ProVal: 3.862 ± 0.061	0.761ProTrp: 0.761 ± 0.029	2.023ProTyr: 2.023 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	4.687GlnAla: 4.687 ± 0.1	0.33GlnCys: 0.33 ± 0.019	1.599GlnAsp: 1.599 ± 0.042	2.991GlnGlu: 2.991 ± 0.069	1.329GlnPhe: 1.329 ± 0.037	2.859GlnGly: 2.859 ± 0.061	1.029GlnHis: 1.029 ± 0.032	2.666GlnIle: 2.666 ± 0.052	1.938GlnLys: 1.938 ± 0.052	4.322GlnLeu: 4.322 ± 0.085	1.095GlnMet: 1.095 ± 0.033	1.662GlnAsn: 1.662 ± 0.046	2.554GlnPro: 2.554 ± 0.053	2.853GlnGln: 2.853 ± 0.103	3.142GlnArg: 3.142 ± 0.061	1.976GlnSer: 1.976 ± 0.043	2.627GlnThr: 2.627 ± 0.058	2.903GlnVal: 2.903 ± 0.056	0.625GlnTrp: 0.625 ± 0.027	0.899GlnTyr: 0.899 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	6.248ArgAla: 6.248 ± 0.091	0.811ArgCys: 0.811 ± 0.03	2.905ArgAsp: 2.905 ± 0.054	4.141ArgGlu: 4.141 ± 0.082	2.992ArgPhe: 2.992 ± 0.056	3.967ArgGly: 3.967 ± 0.068	1.62ArgHis: 1.62 ± 0.036	3.961ArgIle: 3.961 ± 0.063	2.31ArgLys: 2.31 ± 0.05	7.917ArgLeu: 7.917 ± 0.12	1.497ArgMet: 1.497 ± 0.043	1.885ArgAsn: 1.885 ± 0.045	3.428ArgPro: 3.428 ± 0.062	2.887ArgGln: 2.887 ± 0.068	4.939ArgArg: 4.939 ± 0.097	3.285ArgSer: 3.285 ± 0.061	3.099ArgThr: 3.099 ± 0.059	4.581ArgVal: 4.581 ± 0.078	1.098ArgTrp: 1.098 ± 0.037	2.571ArgTyr: 2.571 ± 0.051	0.001ArgXaa: 0.001 ± 0.001
Ser	5.003SerAla: 5.003 ± 0.079	0.538SerCys: 0.538 ± 0.025	2.674SerAsp: 2.674 ± 0.06	2.767SerGlu: 2.767 ± 0.054	2.151SerPhe: 2.151 ± 0.049	4.365SerGly: 4.365 ± 0.087	1.301SerHis: 1.301 ± 0.038	2.589SerIle: 2.589 ± 0.058	1.555SerLys: 1.555 ± 0.038	6.174SerLeu: 6.174 ± 0.096	1.105SerMet: 1.105 ± 0.029	1.83SerAsn: 1.83 ± 0.054	3.643SerPro: 3.643 ± 0.068	2.183SerGln: 2.183 ± 0.051	2.949SerArg: 2.949 ± 0.051	3.513SerSer: 3.513 ± 0.085	2.953SerThr: 2.953 ± 0.056	3.65SerVal: 3.65 ± 0.065	0.814SerTrp: 0.814 ± 0.03	1.694SerTyr: 1.694 ± 0.054	0.0SerXaa: 0.0 ± 0.0
Thr	5.073ThrAla: 5.073 ± 0.08	0.588ThrCys: 0.588 ± 0.024	2.801ThrAsp: 2.801 ± 0.057	2.758ThrGlu: 2.758 ± 0.058	2.065ThrPhe: 2.065 ± 0.041	4.483ThrGly: 4.483 ± 0.086	1.317ThrHis: 1.317 ± 0.042	2.972ThrIle: 2.972 ± 0.052	1.55ThrLys: 1.55 ± 0.045	6.834ThrLeu: 6.834 ± 0.082	1.057ThrMet: 1.057 ± 0.035	1.754ThrAsn: 1.754 ± 0.05	4.143ThrPro: 4.143 ± 0.075	2.14ThrGln: 2.14 ± 0.049	2.841ThrArg: 2.841 ± 0.058	3.075ThrSer: 3.075 ± 0.056	3.328ThrThr: 3.328 ± 0.071	4.156ThrVal: 4.156 ± 0.07	0.726ThrTrp: 0.726 ± 0.032	1.669ThrTyr: 1.669 ± 0.04	0.001ThrXaa: 0.001 ± 0.001
Val	7.094ValAla: 7.094 ± 0.088	0.964ValCys: 0.964 ± 0.033	3.291ValAsp: 3.291 ± 0.068	4.614ValGlu: 4.614 ± 0.081	2.526ValPhe: 2.526 ± 0.056	5.553ValGly: 5.553 ± 0.087	1.784ValHis: 1.784 ± 0.039	3.608ValIle: 3.608 ± 0.054	2.21ValLys: 2.21 ± 0.048	7.54ValLeu: 7.54 ± 0.108	1.365ValMet: 1.365 ± 0.041	2.128ValAsn: 2.128 ± 0.05	4.21ValPro: 4.21 ± 0.077	2.905ValGln: 2.905 ± 0.055	4.899ValArg: 4.899 ± 0.076	3.875ValSer: 3.875 ± 0.066	3.888ValThr: 3.888 ± 0.071	5.896ValVal: 5.896 ± 0.085	0.955ValTrp: 0.955 ± 0.031	2.071ValTyr: 2.071 ± 0.05	0.001ValXaa: 0.001 ± 0.001
Trp	1.086TrpAla: 1.086 ± 0.034	0.221TrpCys: 0.221 ± 0.016	0.662TrpAsp: 0.662 ± 0.026	0.804TrpGlu: 0.804 ± 0.029	0.562TrpPhe: 0.562 ± 0.027	1.013TrpGly: 1.013 ± 0.032	0.494TrpHis: 0.494 ± 0.021	0.779TrpIle: 0.779 ± 0.026	0.504TrpLys: 0.504 ± 0.021	1.69TrpLeu: 1.69 ± 0.048	0.377TrpMet: 0.377 ± 0.017	0.646TrpAsn: 0.646 ± 0.025	0.739TrpPro: 0.739 ± 0.027	0.897TrpGln: 0.897 ± 0.032	1.095TrpArg: 1.095 ± 0.037	0.789TrpSer: 0.789 ± 0.03	0.658TrpThr: 0.658 ± 0.029	0.966TrpVal: 0.966 ± 0.033	0.331TrpTrp: 0.331 ± 0.019	0.432TrpTyr: 0.432 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.982TyrAla: 2.982 ± 0.059	0.359TyrCys: 0.359 ± 0.021	1.695TyrAsp: 1.695 ± 0.046	1.692TyrGlu: 1.692 ± 0.042	1.201TyrPhe: 1.201 ± 0.044	2.575TyrGly: 2.575 ± 0.061	0.92TyrHis: 0.92 ± 0.03	1.397TyrIle: 1.397 ± 0.034	0.773TyrLys: 0.773 ± 0.032	3.422TyrLeu: 3.422 ± 0.059	0.454TyrMet: 0.454 ± 0.02	1.067TyrAsn: 1.067 ± 0.033	1.868TyrPro: 1.868 ± 0.05	1.332TyrGln: 1.332 ± 0.04	2.464TyrArg: 2.464 ± 0.052	1.55TyrSer: 1.55 ± 0.039	1.755TyrThr: 1.755 ± 0.042	2.147TyrVal: 2.147 ± 0.047	0.495TyrTrp: 0.495 ± 0.022	1.056TyrTyr: 1.056 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.004XaaArg: 0.004 ± 0.003	0.001XaaSer: 0.001 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.009XaaXaa: 0.009 ± 0.008

Statistics based on 2809 proteins (1019034 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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