Amino acid dipepetide frequency for Aeromonas phage vB_AsaM-56

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.739AlaAla: 11.739 ± 1.168
1.656AlaCys: 1.656 ± 0.312
5.546AlaAsp: 5.546 ± 0.571
6.842AlaGlu: 6.842 ± 0.767
3.457AlaPhe: 3.457 ± 0.498
8.57AlaGly: 8.57 ± 0.923
2.017AlaHis: 2.017 ± 0.413
7.49AlaIle: 7.49 ± 0.872
5.257AlaLys: 5.257 ± 0.61
8.21AlaLeu: 8.21 ± 0.908
3.169AlaMet: 3.169 ± 0.552
3.817AlaAsn: 3.817 ± 0.587
3.601AlaPro: 3.601 ± 0.531
4.897AlaGln: 4.897 ± 0.594
6.122AlaArg: 6.122 ± 0.683
6.122AlaSer: 6.122 ± 0.617
6.122AlaThr: 6.122 ± 0.783
6.554AlaVal: 6.554 ± 0.698
2.017AlaTrp: 2.017 ± 0.438
3.025AlaTyr: 3.025 ± 0.492
0.0AlaXaa: 0.0 ± 0.0
Cys
1.512CysAla: 1.512 ± 0.361
0.216CysCys: 0.216 ± 0.114
0.72CysAsp: 0.72 ± 0.239
0.936CysGlu: 0.936 ± 0.299
0.36CysPhe: 0.36 ± 0.164
1.512CysGly: 1.512 ± 0.413
0.144CysHis: 0.144 ± 0.096
0.504CysIle: 0.504 ± 0.191
0.864CysLys: 0.864 ± 0.261
1.08CysLeu: 1.08 ± 0.365
0.144CysMet: 0.144 ± 0.096
0.36CysAsn: 0.36 ± 0.155
0.576CysPro: 0.576 ± 0.246
0.72CysGln: 0.72 ± 0.241
1.296CysArg: 1.296 ± 0.367
1.008CysSer: 1.008 ± 0.258
0.936CysThr: 0.936 ± 0.229
1.08CysVal: 1.08 ± 0.28
0.36CysTrp: 0.36 ± 0.157
0.72CysTyr: 0.72 ± 0.196
0.0CysXaa: 0.0 ± 0.0
Asp
5.906AspAla: 5.906 ± 0.701
1.224AspCys: 1.224 ± 0.238
2.665AspAsp: 2.665 ± 0.544
3.241AspGlu: 3.241 ± 0.564
1.873AspPhe: 1.873 ± 0.363
6.122AspGly: 6.122 ± 0.577
0.936AspHis: 0.936 ± 0.334
3.097AspIle: 3.097 ± 0.422
2.593AspLys: 2.593 ± 0.502
3.961AspLeu: 3.961 ± 0.44
1.584AspMet: 1.584 ± 0.327
2.305AspAsn: 2.305 ± 0.407
3.169AspPro: 3.169 ± 0.53
1.584AspGln: 1.584 ± 0.378
2.305AspArg: 2.305 ± 0.411
3.889AspSer: 3.889 ± 0.539
2.377AspThr: 2.377 ± 0.333
3.529AspVal: 3.529 ± 0.528
1.44AspTrp: 1.44 ± 0.353
1.584AspTyr: 1.584 ± 0.372
0.0AspXaa: 0.0 ± 0.0
Glu
6.05GluAla: 6.05 ± 0.677
0.576GluCys: 0.576 ± 0.235
2.665GluAsp: 2.665 ± 0.46
2.881GluGlu: 2.881 ± 0.591
2.449GluPhe: 2.449 ± 0.472
3.313GluGly: 3.313 ± 0.431
1.656GluHis: 1.656 ± 0.336
3.745GluIle: 3.745 ± 0.561
2.593GluLys: 2.593 ± 0.439
5.906GluLeu: 5.906 ± 0.764
3.529GluMet: 3.529 ± 0.63
1.945GluAsn: 1.945 ± 0.409
2.449GluPro: 2.449 ± 0.418
2.953GluGln: 2.953 ± 0.489
4.033GluArg: 4.033 ± 0.587
2.233GluSer: 2.233 ± 0.408
2.449GluThr: 2.449 ± 0.449
3.745GluVal: 3.745 ± 0.526
1.801GluTrp: 1.801 ± 0.407
1.296GluTyr: 1.296 ± 0.336
0.0GluXaa: 0.0 ± 0.0
Phe
3.097PheAla: 3.097 ± 0.486
0.648PheCys: 0.648 ± 0.234
2.521PheAsp: 2.521 ± 0.396
1.584PheGlu: 1.584 ± 0.306
0.792PhePhe: 0.792 ± 0.224
2.305PheGly: 2.305 ± 0.298
0.504PheHis: 0.504 ± 0.253
0.72PheIle: 0.72 ± 0.206
2.161PheLys: 2.161 ± 0.453
2.089PheLeu: 2.089 ± 0.418
1.512PheMet: 1.512 ± 0.36
1.801PheAsn: 1.801 ± 0.372
1.728PhePro: 1.728 ± 0.341
1.296PheGln: 1.296 ± 0.316
2.089PheArg: 2.089 ± 0.435
1.873PheSer: 1.873 ± 0.426
2.377PheThr: 2.377 ± 0.509
1.728PheVal: 1.728 ± 0.32
0.648PheTrp: 0.648 ± 0.235
1.152PheTyr: 1.152 ± 0.397
0.0PheXaa: 0.0 ± 0.0
Gly
7.346GlyAla: 7.346 ± 0.869
1.44GlyCys: 1.44 ± 0.573
3.817GlyAsp: 3.817 ± 0.638
4.249GlyGlu: 4.249 ± 0.482
4.465GlyPhe: 4.465 ± 0.607
7.346GlyGly: 7.346 ± 1.31
1.945GlyHis: 1.945 ± 0.565
4.321GlyIle: 4.321 ± 0.536
3.817GlyLys: 3.817 ± 0.578
6.698GlyLeu: 6.698 ± 1.202
2.161GlyMet: 2.161 ± 0.485
3.025GlyAsn: 3.025 ± 0.5
2.233GlyPro: 2.233 ± 0.386
3.961GlyGln: 3.961 ± 0.748
4.825GlyArg: 4.825 ± 0.548
6.05GlySer: 6.05 ± 0.651
3.889GlyThr: 3.889 ± 0.669
6.698GlyVal: 6.698 ± 0.793
1.873GlyTrp: 1.873 ± 0.332
2.449GlyTyr: 2.449 ± 0.459
0.0GlyXaa: 0.0 ± 0.0
His
2.449HisAla: 2.449 ± 0.5
0.648HisCys: 0.648 ± 0.213
1.008HisAsp: 1.008 ± 0.234
1.008HisGlu: 1.008 ± 0.266
0.72HisPhe: 0.72 ± 0.378
2.449HisGly: 2.449 ± 0.865
0.72HisHis: 0.72 ± 0.272
0.792HisIle: 0.792 ± 0.211
0.936HisLys: 0.936 ± 0.242
2.305HisLeu: 2.305 ± 0.474
0.432HisMet: 0.432 ± 0.177
0.504HisAsn: 0.504 ± 0.205
0.504HisPro: 0.504 ± 0.184
0.792HisGln: 0.792 ± 0.294
1.08HisArg: 1.08 ± 0.309
1.224HisSer: 1.224 ± 0.311
0.648HisThr: 0.648 ± 0.203
1.224HisVal: 1.224 ± 0.399
0.072HisTrp: 0.072 ± 0.076
0.36HisTyr: 0.36 ± 0.17
0.0HisXaa: 0.0 ± 0.0
Ile
5.257IleAla: 5.257 ± 0.679
0.72IleCys: 0.72 ± 0.242
3.241IleAsp: 3.241 ± 0.561
3.889IleGlu: 3.889 ± 0.564
1.152IlePhe: 1.152 ± 0.258
4.105IleGly: 4.105 ± 0.564
0.648IleHis: 0.648 ± 0.26
2.665IleIle: 2.665 ± 0.451
3.169IleLys: 3.169 ± 0.45
3.601IleLeu: 3.601 ± 0.494
0.936IleMet: 0.936 ± 0.275
2.665IleAsn: 2.665 ± 0.502
2.377IlePro: 2.377 ± 0.432
2.161IleGln: 2.161 ± 0.37
2.809IleArg: 2.809 ± 0.353
3.817IleSer: 3.817 ± 0.538
4.393IleThr: 4.393 ± 0.523
2.953IleVal: 2.953 ± 0.454
0.792IleTrp: 0.792 ± 0.257
1.656IleTyr: 1.656 ± 0.294
0.0IleXaa: 0.0 ± 0.0
Lys
5.329LysAla: 5.329 ± 0.657
0.648LysCys: 0.648 ± 0.244
2.449LysAsp: 2.449 ± 0.486
3.097LysGlu: 3.097 ± 0.492
1.873LysPhe: 1.873 ± 0.356
3.673LysGly: 3.673 ± 0.498
0.864LysHis: 0.864 ± 0.221
2.017LysIle: 2.017 ± 0.36
2.737LysLys: 2.737 ± 0.428
4.537LysLeu: 4.537 ± 0.71
1.801LysMet: 1.801 ± 0.374
1.512LysAsn: 1.512 ± 0.297
2.737LysPro: 2.737 ± 0.514
2.809LysGln: 2.809 ± 0.539
3.601LysArg: 3.601 ± 0.601
2.809LysSer: 2.809 ± 0.483
2.305LysThr: 2.305 ± 0.388
2.593LysVal: 2.593 ± 0.521
1.296LysTrp: 1.296 ± 0.308
1.512LysTyr: 1.512 ± 0.394
0.0LysXaa: 0.0 ± 0.0
Leu
10.659LeuAla: 10.659 ± 1.029
0.864LeuCys: 0.864 ± 0.252
5.185LeuAsp: 5.185 ± 0.633
4.969LeuGlu: 4.969 ± 0.535
2.161LeuPhe: 2.161 ± 0.405
6.626LeuGly: 6.626 ± 0.962
1.584LeuHis: 1.584 ± 0.355
4.249LeuIle: 4.249 ± 0.532
3.313LeuLys: 3.313 ± 0.497
6.338LeuLeu: 6.338 ± 0.958
1.945LeuMet: 1.945 ± 0.392
3.745LeuAsn: 3.745 ± 0.395
4.177LeuPro: 4.177 ± 0.604
3.313LeuGln: 3.313 ± 0.469
3.673LeuArg: 3.673 ± 0.577
5.329LeuSer: 5.329 ± 0.66
4.177LeuThr: 4.177 ± 0.567
5.546LeuVal: 5.546 ± 0.562
1.08LeuTrp: 1.08 ± 0.326
1.801LeuTyr: 1.801 ± 0.247
0.0LeuXaa: 0.0 ± 0.0
Met
4.753MetAla: 4.753 ± 0.624
0.432MetCys: 0.432 ± 0.183
1.152MetAsp: 1.152 ± 0.264
2.017MetGlu: 2.017 ± 0.374
0.288MetPhe: 0.288 ± 0.129
2.017MetGly: 2.017 ± 0.377
0.288MetHis: 0.288 ± 0.153
1.296MetIle: 1.296 ± 0.327
1.728MetLys: 1.728 ± 0.405
2.449MetLeu: 2.449 ± 0.541
0.792MetMet: 0.792 ± 0.329
1.44MetAsn: 1.44 ± 0.333
1.296MetPro: 1.296 ± 0.333
1.368MetGln: 1.368 ± 0.239
2.161MetArg: 2.161 ± 0.468
2.449MetSer: 2.449 ± 0.434
2.305MetThr: 2.305 ± 0.46
1.296MetVal: 1.296 ± 0.345
0.216MetTrp: 0.216 ± 0.154
0.576MetTyr: 0.576 ± 0.186
0.0MetXaa: 0.0 ± 0.0
Asn
3.961AsnAla: 3.961 ± 0.661
0.36AsnCys: 0.36 ± 0.139
1.44AsnAsp: 1.44 ± 0.342
2.089AsnGlu: 2.089 ± 0.443
1.008AsnPhe: 1.008 ± 0.236
4.033AsnGly: 4.033 ± 0.583
0.36AsnHis: 0.36 ± 0.173
2.161AsnIle: 2.161 ± 0.37
1.584AsnLys: 1.584 ± 0.318
2.449AsnLeu: 2.449 ± 0.444
1.08AsnMet: 1.08 ± 0.257
1.728AsnAsn: 1.728 ± 0.355
2.161AsnPro: 2.161 ± 0.415
1.512AsnGln: 1.512 ± 0.346
2.017AsnArg: 2.017 ± 0.337
2.737AsnSer: 2.737 ± 0.449
2.449AsnThr: 2.449 ± 0.38
3.097AsnVal: 3.097 ± 0.499
0.504AsnTrp: 0.504 ± 0.213
1.008AsnTyr: 1.008 ± 0.234
0.0AsnXaa: 0.0 ± 0.0
Pro
4.969ProAla: 4.969 ± 0.53
0.432ProCys: 0.432 ± 0.176
3.241ProAsp: 3.241 ± 0.504
2.449ProGlu: 2.449 ± 0.442
1.945ProPhe: 1.945 ± 0.368
3.889ProGly: 3.889 ± 0.611
0.936ProHis: 0.936 ± 0.295
1.945ProIle: 1.945 ± 0.363
2.017ProLys: 2.017 ± 0.39
2.737ProLeu: 2.737 ± 0.472
0.864ProMet: 0.864 ± 0.286
0.936ProAsn: 0.936 ± 0.289
2.233ProPro: 2.233 ± 0.477
2.089ProGln: 2.089 ± 0.501
1.44ProArg: 1.44 ± 0.366
3.169ProSer: 3.169 ± 0.479
2.809ProThr: 2.809 ± 0.55
3.673ProVal: 3.673 ± 0.499
0.72ProTrp: 0.72 ± 0.214
1.08ProTyr: 1.08 ± 0.293
0.0ProXaa: 0.0 ± 0.0
Gln
5.69GlnAla: 5.69 ± 0.642
1.008GlnCys: 1.008 ± 0.324
2.161GlnAsp: 2.161 ± 0.467
2.305GlnGlu: 2.305 ± 0.343
1.584GlnPhe: 1.584 ± 0.254
3.097GlnGly: 3.097 ± 0.577
0.72GlnHis: 0.72 ± 0.265
3.025GlnIle: 3.025 ± 0.537
1.873GlnLys: 1.873 ± 0.35
4.105GlnLeu: 4.105 ± 0.712
1.512GlnMet: 1.512 ± 0.302
1.44GlnAsn: 1.44 ± 0.272
1.224GlnPro: 1.224 ± 0.351
2.737GlnGln: 2.737 ± 1.164
2.737GlnArg: 2.737 ± 0.494
2.377GlnSer: 2.377 ± 0.464
1.656GlnThr: 1.656 ± 0.406
4.177GlnVal: 4.177 ± 0.672
0.576GlnTrp: 0.576 ± 0.237
1.728GlnTyr: 1.728 ± 0.399
0.0GlnXaa: 0.0 ± 0.0
Arg
4.825ArgAla: 4.825 ± 0.617
1.008ArgCys: 1.008 ± 0.276
2.665ArgAsp: 2.665 ± 0.522
2.881ArgGlu: 2.881 ± 0.457
1.945ArgPhe: 1.945 ± 0.307
3.817ArgGly: 3.817 ± 0.543
1.656ArgHis: 1.656 ± 0.47
2.881ArgIle: 2.881 ± 0.501
4.033ArgLys: 4.033 ± 0.618
4.753ArgLeu: 4.753 ± 0.556
1.945ArgMet: 1.945 ± 0.415
1.801ArgAsn: 1.801 ± 0.449
2.161ArgPro: 2.161 ± 0.383
3.097ArgGln: 3.097 ± 0.522
3.313ArgArg: 3.313 ± 0.608
3.889ArgSer: 3.889 ± 0.514
2.377ArgThr: 2.377 ± 0.509
3.601ArgVal: 3.601 ± 0.544
1.296ArgTrp: 1.296 ± 0.348
1.801ArgTyr: 1.801 ± 0.443
0.0ArgXaa: 0.0 ± 0.0
Ser
7.13SerAla: 7.13 ± 0.661
0.576SerCys: 0.576 ± 0.216
3.457SerAsp: 3.457 ± 0.469
3.097SerGlu: 3.097 ± 0.468
2.017SerPhe: 2.017 ± 0.49
6.266SerGly: 6.266 ± 0.683
1.728SerHis: 1.728 ± 0.335
3.673SerIle: 3.673 ± 0.586
3.457SerLys: 3.457 ± 0.542
4.537SerLeu: 4.537 ± 0.515
2.233SerMet: 2.233 ± 0.38
2.161SerAsn: 2.161 ± 0.37
2.593SerPro: 2.593 ± 0.493
2.953SerGln: 2.953 ± 0.514
2.881SerArg: 2.881 ± 0.338
4.393SerSer: 4.393 ± 0.553
2.449SerThr: 2.449 ± 0.453
4.609SerVal: 4.609 ± 0.668
1.44SerTrp: 1.44 ± 0.343
2.161SerTyr: 2.161 ± 0.416
0.0SerXaa: 0.0 ± 0.0
Thr
5.546ThrAla: 5.546 ± 0.654
0.36ThrCys: 0.36 ± 0.179
3.673ThrAsp: 3.673 ± 0.65
2.809ThrGlu: 2.809 ± 0.505
1.296ThrPhe: 1.296 ± 0.33
5.618ThrGly: 5.618 ± 0.659
1.008ThrHis: 1.008 ± 0.26
3.313ThrIle: 3.313 ± 0.533
2.017ThrLys: 2.017 ± 0.389
4.897ThrLeu: 4.897 ± 0.794
0.648ThrMet: 0.648 ± 0.217
1.728ThrAsn: 1.728 ± 0.379
3.241ThrPro: 3.241 ± 0.51
2.233ThrGln: 2.233 ± 0.401
1.945ThrArg: 1.945 ± 0.401
3.673ThrSer: 3.673 ± 0.512
2.737ThrThr: 2.737 ± 0.707
3.745ThrVal: 3.745 ± 0.58
1.008ThrTrp: 1.008 ± 0.255
1.656ThrTyr: 1.656 ± 0.298
0.0ThrXaa: 0.0 ± 0.0
Val
6.986ValAla: 6.986 ± 0.881
1.008ValCys: 1.008 ± 0.253
4.393ValAsp: 4.393 ± 0.629
5.041ValGlu: 5.041 ± 0.7
1.368ValPhe: 1.368 ± 0.439
4.249ValGly: 4.249 ± 0.828
1.224ValHis: 1.224 ± 0.555
3.601ValIle: 3.601 ± 0.47
4.321ValLys: 4.321 ± 0.725
5.185ValLeu: 5.185 ± 0.578
2.593ValMet: 2.593 ± 0.476
3.097ValAsn: 3.097 ± 0.532
2.665ValPro: 2.665 ± 0.414
2.305ValGln: 2.305 ± 0.49
3.889ValArg: 3.889 ± 0.508
4.537ValSer: 4.537 ± 0.516
4.609ValThr: 4.609 ± 0.61
4.825ValVal: 4.825 ± 0.614
1.08ValTrp: 1.08 ± 0.311
1.296ValTyr: 1.296 ± 0.275
0.0ValXaa: 0.0 ± 0.0
Trp
1.368TrpAla: 1.368 ± 0.282
0.576TrpCys: 0.576 ± 0.204
1.584TrpAsp: 1.584 ± 0.314
1.224TrpGlu: 1.224 ± 0.3
0.864TrpPhe: 0.864 ± 0.275
1.44TrpGly: 1.44 ± 0.344
0.576TrpHis: 0.576 ± 0.224
0.648TrpIle: 0.648 ± 0.195
0.72TrpLys: 0.72 ± 0.248
2.017TrpLeu: 2.017 ± 0.446
0.288TrpMet: 0.288 ± 0.144
0.432TrpAsn: 0.432 ± 0.164
1.44TrpPro: 1.44 ± 0.294
1.08TrpGln: 1.08 ± 0.224
1.512TrpArg: 1.512 ± 0.375
0.648TrpSer: 0.648 ± 0.215
0.432TrpThr: 0.432 ± 0.179
1.656TrpVal: 1.656 ± 0.37
0.648TrpTrp: 0.648 ± 0.218
0.504TrpTyr: 0.504 ± 0.217
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.656TyrAla: 1.656 ± 0.328
0.648TyrCys: 0.648 ± 0.195
1.801TyrAsp: 1.801 ± 0.411
1.656TyrGlu: 1.656 ± 0.417
1.008TyrPhe: 1.008 ± 0.255
2.161TyrGly: 2.161 ± 0.362
0.36TyrHis: 0.36 ± 0.174
0.864TyrIle: 0.864 ± 0.221
1.008TyrLys: 1.008 ± 0.247
2.881TyrLeu: 2.881 ± 0.478
1.08TyrMet: 1.08 ± 0.253
1.296TyrAsn: 1.296 ± 0.312
1.08TyrPro: 1.08 ± 0.273
1.873TyrGln: 1.873 ± 0.365
2.017TyrArg: 2.017 ± 0.424
1.584TyrSer: 1.584 ± 0.436
1.656TyrThr: 1.656 ± 0.312
1.945TyrVal: 1.945 ± 0.458
0.792TyrTrp: 0.792 ± 0.265
0.648TyrTyr: 0.648 ± 0.307
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (13886 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski