Amino acid dipepetide frequency for Bacteroides sp. CAG:144

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.019AlaAla: 6.019 ± 0.109	1.033AlaCys: 1.033 ± 0.041	4.395AlaAsp: 4.395 ± 0.084	4.73AlaGlu: 4.73 ± 0.082	3.333AlaPhe: 3.333 ± 0.075	5.322AlaGly: 5.322 ± 0.098	1.339AlaHis: 1.339 ± 0.049	5.031AlaIle: 5.031 ± 0.12	3.317AlaLys: 3.317 ± 0.088	7.184AlaLeu: 7.184 ± 0.131	1.76AlaMet: 1.76 ± 0.052	2.519AlaAsn: 2.519 ± 0.064	2.58AlaPro: 2.58 ± 0.067	2.733AlaGln: 2.733 ± 0.068	3.805AlaArg: 3.805 ± 0.077	4.24AlaSer: 4.24 ± 0.081	3.988AlaThr: 3.988 ± 0.086	5.44AlaVal: 5.44 ± 0.117	0.742AlaTrp: 0.742 ± 0.029	3.06AlaTyr: 3.06 ± 0.063	0.001AlaXaa: 0.001 ± 0.001
Cys	0.875CysAla: 0.875 ± 0.038	0.247CysCys: 0.247 ± 0.021	0.697CysAsp: 0.697 ± 0.033	0.794CysGlu: 0.794 ± 0.033	0.681CysPhe: 0.681 ± 0.032	1.155CysGly: 1.155 ± 0.046	0.338CysHis: 0.338 ± 0.022	0.988CysIle: 0.988 ± 0.036	0.597CysLys: 0.597 ± 0.028	1.148CysLeu: 1.148 ± 0.044	0.325CysMet: 0.325 ± 0.022	0.558CysAsn: 0.558 ± 0.03	0.552CysPro: 0.552 ± 0.03	0.314CysGln: 0.314 ± 0.024	1.015CysArg: 1.015 ± 0.042	0.837CysSer: 0.837 ± 0.033	0.735CysThr: 0.735 ± 0.034	0.787CysVal: 0.787 ± 0.034	0.149CysTrp: 0.149 ± 0.015	0.563CysTyr: 0.563 ± 0.03	0.0CysXaa: 0.0 ± 0.0
Asp	4.013AspAla: 4.013 ± 0.078	0.716AspCys: 0.716 ± 0.035	3.038AspAsp: 3.038 ± 0.07	4.001AspGlu: 4.001 ± 0.079	3.079AspPhe: 3.079 ± 0.079	4.249AspGly: 4.249 ± 0.099	0.837AspHis: 0.837 ± 0.035	4.428AspIle: 4.428 ± 0.083	3.576AspLys: 3.576 ± 0.072	4.648AspLeu: 4.648 ± 0.091	1.646AspMet: 1.646 ± 0.059	2.766AspAsn: 2.766 ± 0.066	1.983AspPro: 1.983 ± 0.055	1.048AspGln: 1.048 ± 0.045	2.964AspArg: 2.964 ± 0.07	3.209AspSer: 3.209 ± 0.081	3.254AspThr: 3.254 ± 0.076	3.563AspVal: 3.563 ± 0.079	0.697AspTrp: 0.697 ± 0.028	2.787AspTyr: 2.787 ± 0.065	0.001AspXaa: 0.001 ± 0.001
Glu	4.711GluAla: 4.711 ± 0.103	0.707GluCys: 0.707 ± 0.034	2.82GluAsp: 2.82 ± 0.064	4.697GluGlu: 4.697 ± 0.105	2.171GluPhe: 2.171 ± 0.063	3.997GluGly: 3.997 ± 0.078	1.086GluHis: 1.086 ± 0.038	5.242GluIle: 5.242 ± 0.107	5.345GluLys: 5.345 ± 0.09	5.392GluLeu: 5.392 ± 0.099	2.072GluMet: 2.072 ± 0.055	3.871GluAsn: 3.871 ± 0.096	1.724GluPro: 1.724 ± 0.05	2.328GluGln: 2.328 ± 0.063	3.267GluArg: 3.267 ± 0.086	3.527GluSer: 3.527 ± 0.069	3.541GluThr: 3.541 ± 0.07	3.897GluVal: 3.897 ± 0.083	0.826GluTrp: 0.826 ± 0.035	2.651GluTyr: 2.651 ± 0.062	0.001GluXaa: 0.001 ± 0.001
Phe	3.131PheAla: 3.131 ± 0.076	0.772PheCys: 0.772 ± 0.034	3.235PheAsp: 3.235 ± 0.072	2.571PheGlu: 2.571 ± 0.069	2.619PhePhe: 2.619 ± 0.081	3.404PheGly: 3.404 ± 0.082	0.872PheHis: 0.872 ± 0.034	3.284PheIle: 3.284 ± 0.08	2.0PheLys: 2.0 ± 0.054	4.396PheLeu: 4.396 ± 0.091	1.148PheMet: 1.148 ± 0.039	1.847PheAsn: 1.847 ± 0.058	1.805PhePro: 1.805 ± 0.054	1.033PheGln: 1.033 ± 0.043	2.146PheArg: 2.146 ± 0.055	3.686PheSer: 3.686 ± 0.083	2.895PheThr: 2.895 ± 0.07	3.209PheVal: 3.209 ± 0.078	0.538PheTrp: 0.538 ± 0.031	2.097PheTyr: 2.097 ± 0.065	0.0PheXaa: 0.0 ± 0.0
Gly	4.531GlyAla: 4.531 ± 0.105	1.024GlyCys: 1.024 ± 0.046	3.682GlyAsp: 3.682 ± 0.082	4.451GlyGlu: 4.451 ± 0.084	3.158GlyPhe: 3.158 ± 0.07	4.928GlyGly: 4.928 ± 0.114	1.404GlyHis: 1.404 ± 0.046	5.946GlyIle: 5.946 ± 0.091	4.902GlyLys: 4.902 ± 0.091	5.706GlyLeu: 5.706 ± 0.102	1.936GlyMet: 1.936 ± 0.047	3.698GlyAsn: 3.698 ± 0.077	1.345GlyPro: 1.345 ± 0.042	1.822GlyGln: 1.822 ± 0.057	3.732GlyArg: 3.732 ± 0.074	3.91GlySer: 3.91 ± 0.086	4.085GlyThr: 4.085 ± 0.088	4.934GlyVal: 4.934 ± 0.09	0.889GlyTrp: 0.889 ± 0.043	3.447GlyTyr: 3.447 ± 0.083	0.006GlyXaa: 0.006 ± 0.003
His	1.142HisAla: 1.142 ± 0.041	0.314HisCys: 0.314 ± 0.022	1.113HisAsp: 1.113 ± 0.042	0.94HisGlu: 0.94 ± 0.036	1.072HisPhe: 1.072 ± 0.041	1.222HisGly: 1.222 ± 0.035	0.573HisHis: 0.573 ± 0.034	1.845HisIle: 1.845 ± 0.06	1.012HisLys: 1.012 ± 0.041	1.909HisLeu: 1.909 ± 0.057	0.337HisMet: 0.337 ± 0.019	0.928HisAsn: 0.928 ± 0.036	0.843HisPro: 0.843 ± 0.033	0.538HisGln: 0.538 ± 0.028	1.141HisArg: 1.141 ± 0.041	1.087HisSer: 1.087 ± 0.037	1.251HisThr: 1.251 ± 0.041	1.061HisVal: 1.061 ± 0.037	0.22HisTrp: 0.22 ± 0.016	0.895HisTyr: 0.895 ± 0.032	0.001HisXaa: 0.001 ± 0.001
Ile	5.958IleAla: 5.958 ± 0.11	1.095IleCys: 1.095 ± 0.041	5.259IleAsp: 5.259 ± 0.091	4.996IleGlu: 4.996 ± 0.101	3.277IlePhe: 3.277 ± 0.076	5.236IleGly: 5.236 ± 0.098	1.258IleHis: 1.258 ± 0.045	4.927IleIle: 4.927 ± 0.104	3.644IleLys: 3.644 ± 0.079	6.234IleLeu: 6.234 ± 0.101	1.474IleMet: 1.474 ± 0.047	3.098IleAsn: 3.098 ± 0.077	3.484IlePro: 3.484 ± 0.076	2.032IleGln: 2.032 ± 0.049	3.372IleArg: 3.372 ± 0.069	4.888IleSer: 4.888 ± 0.102	4.328IleThr: 4.328 ± 0.081	5.11IleVal: 5.11 ± 0.11	0.675IleTrp: 0.675 ± 0.033	2.891IleTyr: 2.891 ± 0.069	0.004IleXaa: 0.004 ± 0.003
Lys	4.322LysAla: 4.322 ± 0.094	0.537LysCys: 0.537 ± 0.031	2.972LysAsp: 2.972 ± 0.068	4.62LysGlu: 4.62 ± 0.098	1.87LysPhe: 1.87 ± 0.052	4.004LysGly: 4.004 ± 0.084	0.97LysHis: 0.97 ± 0.032	4.262LysIle: 4.262 ± 0.081	4.402LysLys: 4.402 ± 0.092	4.311LysLeu: 4.311 ± 0.096	1.799LysMet: 1.799 ± 0.047	3.406LysAsn: 3.406 ± 0.081	1.954LysPro: 1.954 ± 0.055	1.983LysGln: 1.983 ± 0.05	2.855LysArg: 2.855 ± 0.072	3.287LysSer: 3.287 ± 0.069	3.155LysThr: 3.155 ± 0.066	3.469LysVal: 3.469 ± 0.075	0.655LysTrp: 0.655 ± 0.031	2.542LysTyr: 2.542 ± 0.063	0.001LysXaa: 0.001 ± 0.001
Leu	6.473LeuAla: 6.473 ± 0.113	1.413LeuCys: 1.413 ± 0.039	4.688LeuAsp: 4.688 ± 0.103	4.405LeuGlu: 4.405 ± 0.085	4.928LeuPhe: 4.928 ± 0.107	5.68LeuGly: 5.68 ± 0.101	2.052LeuHis: 2.052 ± 0.061	5.855LeuIle: 5.855 ± 0.104	4.967LeuLys: 4.967 ± 0.09	9.116LeuLeu: 9.116 ± 0.177	2.267LeuMet: 2.267 ± 0.059	3.714LeuAsn: 3.714 ± 0.082	4.425LeuPro: 4.425 ± 0.096	3.426LeuGln: 3.426 ± 0.079	4.95LeuArg: 4.95 ± 0.09	7.473LeuSer: 7.473 ± 0.12	4.915LeuThr: 4.915 ± 0.085	5.314LeuVal: 5.314 ± 0.095	1.031LeuTrp: 1.031 ± 0.046	3.848LeuTyr: 3.848 ± 0.094	0.0LeuXaa: 0.0 ± 0.0
Met	2.106MetAla: 2.106 ± 0.059	0.253MetCys: 0.253 ± 0.019	1.09MetAsp: 1.09 ± 0.043	1.494MetGlu: 1.494 ± 0.045	0.902MetPhe: 0.902 ± 0.041	1.811MetGly: 1.811 ± 0.056	0.522MetHis: 0.522 ± 0.028	1.56MetIle: 1.56 ± 0.047	2.108MetLys: 2.108 ± 0.055	2.305MetLeu: 2.305 ± 0.065	0.697MetMet: 0.697 ± 0.033	1.173MetAsn: 1.173 ± 0.038	1.147MetPro: 1.147 ± 0.041	1.098MetGln: 1.098 ± 0.035	1.424MetArg: 1.424 ± 0.044	1.638MetSer: 1.638 ± 0.051	1.456MetThr: 1.456 ± 0.048	1.511MetVal: 1.511 ± 0.046	0.25MetTrp: 0.25 ± 0.023	0.821MetTyr: 0.821 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	3.273AsnAla: 3.273 ± 0.079	0.552AsnCys: 0.552 ± 0.034	2.649AsnAsp: 2.649 ± 0.063	2.697AsnGlu: 2.697 ± 0.063	1.997AsnPhe: 1.997 ± 0.057	3.554AsnGly: 3.554 ± 0.084	0.833AsnHis: 0.833 ± 0.035	3.596AsnIle: 3.596 ± 0.07	2.476AsnLys: 2.476 ± 0.057	3.893AsnLeu: 3.893 ± 0.081	1.111AsnMet: 1.111 ± 0.039	2.34AsnAsn: 2.34 ± 0.079	2.374AsnPro: 2.374 ± 0.062	1.205AsnGln: 1.205 ± 0.044	2.736AsnArg: 2.736 ± 0.062	2.484AsnSer: 2.484 ± 0.066	2.678AsnThr: 2.678 ± 0.076	2.778AsnVal: 2.778 ± 0.086	0.525AsnTrp: 0.525 ± 0.029	2.123AsnTyr: 2.123 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.988ProAla: 2.988 ± 0.071	0.445ProCys: 0.445 ± 0.025	2.889ProAsp: 2.889 ± 0.071	3.46ProGlu: 3.46 ± 0.071	1.887ProPhe: 1.887 ± 0.052	2.633ProGly: 2.633 ± 0.073	0.804ProHis: 0.804 ± 0.034	2.497ProIle: 2.497 ± 0.061	1.714ProLys: 1.714 ± 0.048	3.4ProLeu: 3.4 ± 0.073	0.915ProMet: 0.915 ± 0.043	1.424ProAsn: 1.424 ± 0.045	0.966ProPro: 0.966 ± 0.037	1.559ProGln: 1.559 ± 0.044	1.602ProArg: 1.602 ± 0.049	2.431ProSer: 2.431 ± 0.063	2.061ProThr: 2.061 ± 0.06	3.155ProVal: 3.155 ± 0.065	0.398ProTrp: 0.398 ± 0.024	1.863ProTyr: 1.863 ± 0.056	0.0ProXaa: 0.0 ± 0.0
Gln	2.195GlnAla: 2.195 ± 0.058	0.302GlnCys: 0.302 ± 0.022	1.249GlnAsp: 1.249 ± 0.04	2.226GlnGlu: 2.226 ± 0.064	1.309GlnPhe: 1.309 ± 0.042	1.818GlnGly: 1.818 ± 0.054	0.574GlnHis: 0.574 ± 0.025	2.401GlnIle: 2.401 ± 0.061	2.179GlnLys: 2.179 ± 0.059	3.009GlnLeu: 3.009 ± 0.077	0.963GlnMet: 0.963 ± 0.036	1.675GlnAsn: 1.675 ± 0.052	1.274GlnPro: 1.274 ± 0.044	1.426GlnGln: 1.426 ± 0.059	1.727GlnArg: 1.727 ± 0.052	1.932GlnSer: 1.932 ± 0.054	1.773GlnThr: 1.773 ± 0.048	1.897GlnVal: 1.897 ± 0.063	0.354GlnTrp: 0.354 ± 0.024	1.397GlnTyr: 1.397 ± 0.052	0.0GlnXaa: 0.0 ± 0.0
Arg	3.037ArgAla: 3.037 ± 0.065	0.688ArgCys: 0.688 ± 0.035	2.451ArgAsp: 2.451 ± 0.061	3.543ArgGlu: 3.543 ± 0.078	2.677ArgPhe: 2.677 ± 0.065	2.707ArgGly: 2.707 ± 0.059	1.268ArgHis: 1.268 ± 0.045	4.36ArgIle: 4.36 ± 0.085	3.286ArgLys: 3.286 ± 0.08	5.168ArgLeu: 5.168 ± 0.108	1.575ArgMet: 1.575 ± 0.053	2.729ArgAsn: 2.729 ± 0.059	2.039ArgPro: 2.039 ± 0.057	2.038ArgGln: 2.038 ± 0.058	3.343ArgArg: 3.343 ± 0.092	2.804ArgSer: 2.804 ± 0.065	2.737ArgThr: 2.737 ± 0.063	3.027ArgVal: 3.027 ± 0.069	0.664ArgTrp: 0.664 ± 0.032	2.779ArgTyr: 2.779 ± 0.065	0.001ArgXaa: 0.001 ± 0.001
Ser	4.486SerAla: 4.486 ± 0.085	0.895SerCys: 0.895 ± 0.035	3.588SerAsp: 3.588 ± 0.077	3.604SerGlu: 3.604 ± 0.073	3.202SerPhe: 3.202 ± 0.078	5.045SerGly: 5.045 ± 0.09	1.284SerHis: 1.284 ± 0.045	4.37SerIle: 4.37 ± 0.086	2.807SerLys: 2.807 ± 0.065	6.429SerLeu: 6.429 ± 0.119	1.469SerMet: 1.469 ± 0.045	2.398SerAsn: 2.398 ± 0.061	2.654SerPro: 2.654 ± 0.064	1.865SerGln: 1.865 ± 0.055	3.53SerArg: 3.53 ± 0.071	4.074SerSer: 4.074 ± 0.099	3.426SerThr: 3.426 ± 0.076	4.455SerVal: 4.455 ± 0.083	0.772SerTrp: 0.772 ± 0.032	2.807SerTyr: 2.807 ± 0.072	0.0SerXaa: 0.0 ± 0.0
Thr	4.315ThrAla: 4.315 ± 0.086	0.597ThrCys: 0.597 ± 0.03	3.358ThrAsp: 3.358 ± 0.076	3.218ThrGlu: 3.218 ± 0.074	2.772ThrPhe: 2.772 ± 0.057	4.398ThrGly: 4.398 ± 0.088	1.212ThrHis: 1.212 ± 0.036	4.212ThrIle: 4.212 ± 0.088	2.104ThrLys: 2.104 ± 0.057	5.617ThrLeu: 5.617 ± 0.102	1.121ThrMet: 1.121 ± 0.034	1.903ThrAsn: 1.903 ± 0.061	3.015ThrPro: 3.015 ± 0.071	1.819ThrGln: 1.819 ± 0.055	2.775ThrArg: 2.775 ± 0.067	3.33ThrSer: 3.33 ± 0.079	3.258ThrThr: 3.258 ± 0.086	4.314ThrVal: 4.314 ± 0.089	0.534ThrTrp: 0.534 ± 0.031	2.435ThrTyr: 2.435 ± 0.065	0.001ThrXaa: 0.001 ± 0.001
Val	5.16ValAla: 5.16 ± 0.11	1.015ValCys: 1.015 ± 0.043	4.011ValAsp: 4.011 ± 0.083	4.26ValGlu: 4.26 ± 0.086	3.024ValPhe: 3.024 ± 0.061	4.428ValGly: 4.428 ± 0.089	1.111ValHis: 1.111 ± 0.04	4.564ValIle: 4.564 ± 0.084	3.813ValLys: 3.813 ± 0.089	5.907ValLeu: 5.907 ± 0.114	1.456ValMet: 1.456 ± 0.041	2.885ValAsn: 2.885 ± 0.065	2.574ValPro: 2.574 ± 0.063	1.787ValGln: 1.787 ± 0.054	3.142ValArg: 3.142 ± 0.07	5.016ValSer: 5.016 ± 0.1	3.433ValThr: 3.433 ± 0.063	5.027ValVal: 5.027 ± 0.106	0.824ValTrp: 0.824 ± 0.036	2.775ValTyr: 2.775 ± 0.061	0.0ValXaa: 0.0 ± 0.0
Trp	0.768TrpAla: 0.768 ± 0.034	0.197TrpCys: 0.197 ± 0.018	0.606TrpAsp: 0.606 ± 0.034	0.706TrpGlu: 0.706 ± 0.032	0.5TrpPhe: 0.5 ± 0.029	0.912TrpGly: 0.912 ± 0.041	0.249TrpHis: 0.249 ± 0.019	0.817TrpIle: 0.817 ± 0.038	0.729TrpLys: 0.729 ± 0.036	1.135TrpLeu: 1.135 ± 0.051	0.205TrpMet: 0.205 ± 0.018	0.654TrpAsn: 0.654 ± 0.036	0.327TrpPro: 0.327 ± 0.022	0.411TrpGln: 0.411 ± 0.023	0.625TrpArg: 0.625 ± 0.031	0.698TrpSer: 0.698 ± 0.036	0.513TrpThr: 0.513 ± 0.028	0.748TrpVal: 0.748 ± 0.038	0.178TrpTrp: 0.178 ± 0.019	0.493TrpTyr: 0.493 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.069TyrAla: 3.069 ± 0.068	0.554TyrCys: 0.554 ± 0.023	2.711TyrAsp: 2.711 ± 0.071	2.461TyrGlu: 2.461 ± 0.053	2.23TyrPhe: 2.23 ± 0.059	3.03TyrGly: 3.03 ± 0.066	0.855TyrHis: 0.855 ± 0.034	3.053TyrIle: 3.053 ± 0.054	2.398TyrLys: 2.398 ± 0.064	4.033TyrLeu: 4.033 ± 0.077	1.087TyrMet: 1.087 ± 0.038	2.291TyrAsn: 2.291 ± 0.068	2.027TyrPro: 2.027 ± 0.058	1.216TyrGln: 1.216 ± 0.044	2.765TyrArg: 2.765 ± 0.077	2.604TyrSer: 2.604 ± 0.077	2.824TyrThr: 2.824 ± 0.075	2.516TyrVal: 2.516 ± 0.063	0.55TyrTrp: 0.55 ± 0.032	2.064TyrTyr: 2.064 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.004XaaGly: 0.004 ± 0.002	0.004XaaHis: 0.004 ± 0.002	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.004XaaArg: 0.004 ± 0.002	0.001XaaSer: 0.001 ± 0.002	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.025XaaXaa: 0.025 ± 0.009

Statistics based on 2103 proteins (691520 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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