Amino acid dipepetide frequency for Pseudomonas phage vB_PaeP_PAO1_Ab05

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.178AlaAla: 13.178 ± 1.482
1.273AlaCys: 1.273 ± 0.397
5.615AlaAsp: 5.615 ± 0.625
8.011AlaGlu: 8.011 ± 0.737
3.819AlaPhe: 3.819 ± 0.426
11.156AlaGly: 11.156 ± 1.17
1.872AlaHis: 1.872 ± 0.351
3.893AlaIle: 3.893 ± 0.622
6.664AlaLys: 6.664 ± 0.794
11.081AlaLeu: 11.081 ± 0.879
3.594AlaMet: 3.594 ± 0.488
2.845AlaAsn: 2.845 ± 0.589
4.567AlaPro: 4.567 ± 0.744
5.99AlaGln: 5.99 ± 0.861
5.166AlaArg: 5.166 ± 0.723
3.893AlaSer: 3.893 ± 0.625
6.589AlaThr: 6.589 ± 0.655
8.461AlaVal: 8.461 ± 0.887
0.973AlaTrp: 0.973 ± 0.166
2.845AlaTyr: 2.845 ± 0.649
0.0AlaXaa: 0.0 ± 0.0
Cys
1.198CysAla: 1.198 ± 0.31
0.15CysCys: 0.15 ± 0.108
0.449CysAsp: 0.449 ± 0.184
0.524CysGlu: 0.524 ± 0.19
0.225CysPhe: 0.225 ± 0.131
0.599CysGly: 0.599 ± 0.269
0.299CysHis: 0.299 ± 0.196
0.674CysIle: 0.674 ± 0.35
0.524CysLys: 0.524 ± 0.283
1.048CysLeu: 1.048 ± 0.293
0.299CysMet: 0.299 ± 0.179
0.299CysAsn: 0.299 ± 0.149
0.599CysPro: 0.599 ± 0.205
0.599CysGln: 0.599 ± 0.247
0.599CysArg: 0.599 ± 0.219
0.15CysSer: 0.15 ± 0.106
0.599CysThr: 0.599 ± 0.211
0.524CysVal: 0.524 ± 0.195
0.15CysTrp: 0.15 ± 0.147
0.524CysTyr: 0.524 ± 0.23
0.0CysXaa: 0.0 ± 0.0
Asp
6.065AspAla: 6.065 ± 0.637
0.374AspCys: 0.374 ± 0.169
3.145AspAsp: 3.145 ± 0.454
4.417AspGlu: 4.417 ± 0.444
1.797AspPhe: 1.797 ± 0.454
4.642AspGly: 4.642 ± 0.712
1.423AspHis: 1.423 ± 0.341
3.369AspIle: 3.369 ± 0.36
2.621AspLys: 2.621 ± 0.583
5.016AspLeu: 5.016 ± 0.48
1.497AspMet: 1.497 ± 0.304
1.872AspAsn: 1.872 ± 0.442
3.744AspPro: 3.744 ± 0.447
2.246AspGln: 2.246 ± 0.41
3.594AspArg: 3.594 ± 0.617
3.369AspSer: 3.369 ± 0.402
3.968AspThr: 3.968 ± 0.718
3.519AspVal: 3.519 ± 0.487
0.973AspTrp: 0.973 ± 0.207
1.797AspTyr: 1.797 ± 0.497
0.0AspXaa: 0.0 ± 0.0
Glu
8.985GluAla: 8.985 ± 1.013
0.449GluCys: 0.449 ± 0.196
2.845GluAsp: 2.845 ± 0.461
3.669GluGlu: 3.669 ± 0.599
2.171GluPhe: 2.171 ± 0.388
4.792GluGly: 4.792 ± 0.628
1.572GluHis: 1.572 ± 0.264
2.471GluIle: 2.471 ± 0.429
1.872GluLys: 1.872 ± 0.419
6.214GluLeu: 6.214 ± 0.683
2.096GluMet: 2.096 ± 0.343
1.722GluAsn: 1.722 ± 0.326
1.198GluPro: 1.198 ± 0.388
3.444GluGln: 3.444 ± 0.512
4.118GluArg: 4.118 ± 0.521
1.947GluSer: 1.947 ± 0.459
2.022GluThr: 2.022 ± 0.469
5.391GluVal: 5.391 ± 0.706
0.973GluTrp: 0.973 ± 0.242
2.171GluTyr: 2.171 ± 0.41
0.0GluXaa: 0.0 ± 0.0
Phe
2.471PheAla: 2.471 ± 0.459
0.524PheCys: 0.524 ± 0.205
2.845PheAsp: 2.845 ± 0.397
1.947PheGlu: 1.947 ± 0.316
1.048PhePhe: 1.048 ± 0.247
1.797PheGly: 1.797 ± 0.404
0.674PheHis: 0.674 ± 0.177
1.647PheIle: 1.647 ± 0.291
1.797PheLys: 1.797 ± 0.296
2.471PheLeu: 2.471 ± 0.387
0.973PheMet: 0.973 ± 0.232
1.497PheAsn: 1.497 ± 0.264
1.797PhePro: 1.797 ± 0.395
1.572PheGln: 1.572 ± 0.24
2.471PheArg: 2.471 ± 0.426
2.246PheSer: 2.246 ± 0.524
1.198PheThr: 1.198 ± 0.259
2.171PheVal: 2.171 ± 0.393
0.374PheTrp: 0.374 ± 0.149
0.599PheTyr: 0.599 ± 0.214
0.0PheXaa: 0.0 ± 0.0
Gly
7.412GlyAla: 7.412 ± 0.915
1.348GlyCys: 1.348 ± 0.314
3.819GlyAsp: 3.819 ± 0.478
3.819GlyGlu: 3.819 ± 0.536
3.07GlyPhe: 3.07 ± 0.53
5.391GlyGly: 5.391 ± 0.752
1.048GlyHis: 1.048 ± 0.274
4.193GlyIle: 4.193 ± 0.399
4.268GlyLys: 4.268 ± 0.611
7.412GlyLeu: 7.412 ± 0.819
2.695GlyMet: 2.695 ± 0.559
2.022GlyAsn: 2.022 ± 0.497
2.396GlyPro: 2.396 ± 0.449
3.744GlyGln: 3.744 ± 0.623
6.214GlyArg: 6.214 ± 0.6
3.968GlySer: 3.968 ± 0.483
5.316GlyThr: 5.316 ± 0.552
6.888GlyVal: 6.888 ± 0.709
1.647GlyTrp: 1.647 ± 0.462
2.471GlyTyr: 2.471 ± 0.442
0.0GlyXaa: 0.0 ± 0.0
His
1.423HisAla: 1.423 ± 0.374
0.225HisCys: 0.225 ± 0.12
1.198HisAsp: 1.198 ± 0.258
1.348HisGlu: 1.348 ± 0.321
0.599HisPhe: 0.599 ± 0.247
1.348HisGly: 1.348 ± 0.329
0.449HisHis: 0.449 ± 0.215
0.749HisIle: 0.749 ± 0.245
1.048HisLys: 1.048 ± 0.334
2.022HisLeu: 2.022 ± 0.395
0.599HisMet: 0.599 ± 0.217
1.198HisAsn: 1.198 ± 0.284
0.749HisPro: 0.749 ± 0.243
0.973HisGln: 0.973 ± 0.242
1.872HisArg: 1.872 ± 0.406
0.973HisSer: 0.973 ± 0.286
1.048HisThr: 1.048 ± 0.276
2.246HisVal: 2.246 ± 0.489
0.449HisTrp: 0.449 ± 0.161
0.674HisTyr: 0.674 ± 0.18
0.0HisXaa: 0.0 ± 0.0
Ile
5.316IleAla: 5.316 ± 0.769
0.524IleCys: 0.524 ± 0.178
3.294IleAsp: 3.294 ± 0.521
2.695IleGlu: 2.695 ± 0.389
1.123IlePhe: 1.123 ± 0.307
2.77IleGly: 2.77 ± 0.452
1.198IleHis: 1.198 ± 0.28
1.722IleIle: 1.722 ± 0.448
2.546IleLys: 2.546 ± 0.464
2.471IleLeu: 2.471 ± 0.566
1.348IleMet: 1.348 ± 0.314
1.872IleAsn: 1.872 ± 0.347
2.171IlePro: 2.171 ± 0.346
2.022IleGln: 2.022 ± 0.371
2.92IleArg: 2.92 ± 0.418
1.273IleSer: 1.273 ± 0.386
2.396IleThr: 2.396 ± 0.407
3.07IleVal: 3.07 ± 0.536
0.599IleTrp: 0.599 ± 0.222
1.048IleTyr: 1.048 ± 0.317
0.0IleXaa: 0.0 ± 0.0
Lys
6.289LysAla: 6.289 ± 0.798
0.225LysCys: 0.225 ± 0.138
2.995LysAsp: 2.995 ± 0.624
2.396LysGlu: 2.396 ± 0.556
1.572LysPhe: 1.572 ± 0.3
4.343LysGly: 4.343 ± 0.538
0.973LysHis: 0.973 ± 0.329
1.348LysIle: 1.348 ± 0.283
1.497LysLys: 1.497 ± 0.392
4.043LysLeu: 4.043 ± 0.601
2.022LysMet: 2.022 ± 0.339
1.048LysAsn: 1.048 ± 0.31
2.396LysPro: 2.396 ± 0.407
2.396LysGln: 2.396 ± 0.395
3.145LysArg: 3.145 ± 0.467
1.797LysSer: 1.797 ± 0.368
2.546LysThr: 2.546 ± 0.422
3.968LysVal: 3.968 ± 0.553
0.674LysTrp: 0.674 ± 0.23
0.973LysTyr: 0.973 ± 0.3
0.0LysXaa: 0.0 ± 0.0
Leu
10.632LeuAla: 10.632 ± 0.876
0.898LeuCys: 0.898 ± 0.294
6.963LeuAsp: 6.963 ± 0.702
5.166LeuGlu: 5.166 ± 0.692
1.872LeuPhe: 1.872 ± 0.39
7.862LeuGly: 7.862 ± 0.881
2.621LeuHis: 2.621 ± 0.45
3.444LeuIle: 3.444 ± 0.397
3.294LeuLys: 3.294 ± 0.287
7.263LeuLeu: 7.263 ± 0.782
2.246LeuMet: 2.246 ± 0.377
3.893LeuAsn: 3.893 ± 0.65
4.417LeuPro: 4.417 ± 0.616
3.145LeuGln: 3.145 ± 0.402
6.813LeuArg: 6.813 ± 0.765
4.867LeuSer: 4.867 ± 0.604
5.091LeuThr: 5.091 ± 0.675
4.867LeuVal: 4.867 ± 0.499
1.273LeuTrp: 1.273 ± 0.237
3.07LeuTyr: 3.07 ± 0.429
0.0LeuXaa: 0.0 ± 0.0
Met
4.193MetAla: 4.193 ± 0.512
0.0MetCys: 0.0 ± 0.0
2.096MetAsp: 2.096 ± 0.27
1.497MetGlu: 1.497 ± 0.318
0.524MetPhe: 0.524 ± 0.245
2.022MetGly: 2.022 ± 0.296
0.824MetHis: 0.824 ± 0.224
0.749MetIle: 0.749 ± 0.193
0.973MetLys: 0.973 ± 0.265
2.546MetLeu: 2.546 ± 0.425
0.898MetMet: 0.898 ± 0.277
1.273MetAsn: 1.273 ± 0.327
1.423MetPro: 1.423 ± 0.313
1.647MetGln: 1.647 ± 0.478
1.797MetArg: 1.797 ± 0.323
2.096MetSer: 2.096 ± 0.315
2.995MetThr: 2.995 ± 0.445
1.048MetVal: 1.048 ± 0.24
0.374MetTrp: 0.374 ± 0.135
0.898MetTyr: 0.898 ± 0.237
0.0MetXaa: 0.0 ± 0.0
Asn
3.519AsnAla: 3.519 ± 0.544
0.075AsnCys: 0.075 ± 0.069
1.647AsnAsp: 1.647 ± 0.323
2.321AsnGlu: 2.321 ± 0.403
0.824AsnPhe: 0.824 ± 0.288
2.471AsnGly: 2.471 ± 0.398
0.524AsnHis: 0.524 ± 0.175
1.123AsnIle: 1.123 ± 0.35
2.096AsnLys: 2.096 ± 0.35
3.519AsnLeu: 3.519 ± 0.534
0.749AsnMet: 0.749 ± 0.258
1.273AsnAsn: 1.273 ± 0.363
2.621AsnPro: 2.621 ± 0.386
1.647AsnGln: 1.647 ± 0.36
1.947AsnArg: 1.947 ± 0.341
1.497AsnSer: 1.497 ± 0.439
2.396AsnThr: 2.396 ± 0.435
3.594AsnVal: 3.594 ± 0.633
1.198AsnTrp: 1.198 ± 0.35
1.348AsnTyr: 1.348 ± 0.243
0.0AsnXaa: 0.0 ± 0.0
Pro
5.016ProAla: 5.016 ± 0.8
0.374ProCys: 0.374 ± 0.197
2.246ProAsp: 2.246 ± 0.509
3.819ProGlu: 3.819 ± 0.614
1.348ProPhe: 1.348 ± 0.311
4.193ProGly: 4.193 ± 0.525
0.824ProHis: 0.824 ± 0.25
1.572ProIle: 1.572 ± 0.318
2.621ProLys: 2.621 ± 0.374
3.744ProLeu: 3.744 ± 0.431
0.674ProMet: 0.674 ± 0.212
2.171ProAsn: 2.171 ± 0.433
1.497ProPro: 1.497 ± 0.464
2.022ProGln: 2.022 ± 0.718
2.845ProArg: 2.845 ± 0.514
2.396ProSer: 2.396 ± 0.417
2.92ProThr: 2.92 ± 0.424
2.845ProVal: 2.845 ± 0.655
0.973ProTrp: 0.973 ± 0.253
1.423ProTyr: 1.423 ± 0.353
0.0ProXaa: 0.0 ± 0.0
Gln
6.888GlnAla: 6.888 ± 1.023
0.449GlnCys: 0.449 ± 0.192
2.022GlnAsp: 2.022 ± 0.302
2.92GlnGlu: 2.92 ± 0.459
1.722GlnPhe: 1.722 ± 0.363
3.744GlnGly: 3.744 ± 0.409
0.749GlnHis: 0.749 ± 0.211
1.947GlnIle: 1.947 ± 0.255
1.123GlnLys: 1.123 ± 0.252
4.268GlnLeu: 4.268 ± 0.484
0.898GlnMet: 0.898 ± 0.213
1.423GlnAsn: 1.423 ± 0.261
1.947GlnPro: 1.947 ± 0.684
2.695GlnGln: 2.695 ± 0.632
3.294GlnArg: 3.294 ± 0.525
2.096GlnSer: 2.096 ± 0.366
1.872GlnThr: 1.872 ± 0.322
3.669GlnVal: 3.669 ± 0.645
0.674GlnTrp: 0.674 ± 0.224
1.947GlnTyr: 1.947 ± 0.38
0.0GlnXaa: 0.0 ± 0.0
Arg
6.963ArgAla: 6.963 ± 0.921
0.674ArgCys: 0.674 ± 0.216
5.241ArgAsp: 5.241 ± 0.502
3.669ArgGlu: 3.669 ± 0.526
3.145ArgPhe: 3.145 ± 0.496
5.016ArgGly: 5.016 ± 0.509
1.198ArgHis: 1.198 ± 0.366
3.594ArgIle: 3.594 ± 0.467
3.519ArgLys: 3.519 ± 0.59
5.765ArgLeu: 5.765 ± 0.59
2.321ArgMet: 2.321 ± 0.41
3.145ArgAsn: 3.145 ± 0.472
2.845ArgPro: 2.845 ± 0.423
2.396ArgGln: 2.396 ± 0.372
6.589ArgArg: 6.589 ± 0.81
3.669ArgSer: 3.669 ± 0.62
2.995ArgThr: 2.995 ± 0.383
4.043ArgVal: 4.043 ± 0.61
1.647ArgTrp: 1.647 ± 0.406
2.096ArgTyr: 2.096 ± 0.453
0.0ArgXaa: 0.0 ± 0.0
Ser
4.792SerAla: 4.792 ± 0.594
0.524SerCys: 0.524 ± 0.256
2.621SerAsp: 2.621 ± 0.294
3.07SerGlu: 3.07 ± 0.414
1.123SerPhe: 1.123 ± 0.274
4.043SerGly: 4.043 ± 0.475
0.973SerHis: 0.973 ± 0.289
2.171SerIle: 2.171 ± 0.534
2.621SerLys: 2.621 ± 0.424
5.016SerLeu: 5.016 ± 0.632
1.497SerMet: 1.497 ± 0.322
1.423SerAsn: 1.423 ± 0.278
1.797SerPro: 1.797 ± 0.269
2.246SerGln: 2.246 ± 0.387
4.343SerArg: 4.343 ± 0.615
1.273SerSer: 1.273 ± 0.298
2.096SerThr: 2.096 ± 0.567
2.92SerVal: 2.92 ± 0.484
0.599SerTrp: 0.599 ± 0.192
1.572SerTyr: 1.572 ± 0.267
0.0SerXaa: 0.0 ± 0.0
Thr
7.113ThrAla: 7.113 ± 0.944
0.599ThrCys: 0.599 ± 0.231
3.369ThrAsp: 3.369 ± 0.573
2.246ThrGlu: 2.246 ± 0.377
1.872ThrPhe: 1.872 ± 0.385
4.492ThrGly: 4.492 ± 0.64
1.348ThrHis: 1.348 ± 0.238
2.77ThrIle: 2.77 ± 0.446
2.77ThrLys: 2.77 ± 0.46
4.792ThrLeu: 4.792 ± 0.6
1.348ThrMet: 1.348 ± 0.288
2.321ThrAsn: 2.321 ± 0.446
3.519ThrPro: 3.519 ± 0.507
2.396ThrGln: 2.396 ± 0.408
2.77ThrArg: 2.77 ± 0.383
3.07ThrSer: 3.07 ± 0.521
2.695ThrThr: 2.695 ± 0.642
2.845ThrVal: 2.845 ± 0.545
0.973ThrTrp: 0.973 ± 0.273
1.722ThrTyr: 1.722 ± 0.336
0.0ThrXaa: 0.0 ± 0.0
Val
6.664ValAla: 6.664 ± 0.745
0.824ValCys: 0.824 ± 0.285
4.867ValAsp: 4.867 ± 0.713
4.118ValGlu: 4.118 ± 0.484
2.695ValPhe: 2.695 ± 0.423
5.241ValGly: 5.241 ± 0.713
1.423ValHis: 1.423 ± 0.467
3.07ValIle: 3.07 ± 0.616
3.07ValLys: 3.07 ± 0.442
6.664ValLeu: 6.664 ± 0.656
2.695ValMet: 2.695 ± 0.511
2.546ValAsn: 2.546 ± 0.361
3.22ValPro: 3.22 ± 0.783
3.07ValGln: 3.07 ± 0.603
6.14ValArg: 6.14 ± 0.598
2.77ValSer: 2.77 ± 0.418
3.669ValThr: 3.669 ± 0.622
5.615ValVal: 5.615 ± 0.722
0.374ValTrp: 0.374 ± 0.173
2.246ValTyr: 2.246 ± 0.554
0.0ValXaa: 0.0 ± 0.0
Trp
1.348TrpAla: 1.348 ± 0.315
0.299TrpCys: 0.299 ± 0.154
1.123TrpAsp: 1.123 ± 0.3
0.599TrpGlu: 0.599 ± 0.211
0.674TrpPhe: 0.674 ± 0.245
0.973TrpGly: 0.973 ± 0.284
0.299TrpHis: 0.299 ± 0.165
0.749TrpIle: 0.749 ± 0.316
0.599TrpLys: 0.599 ± 0.149
1.423TrpLeu: 1.423 ± 0.343
0.524TrpMet: 0.524 ± 0.195
0.973TrpAsn: 0.973 ± 0.202
0.599TrpPro: 0.599 ± 0.225
0.599TrpGln: 0.599 ± 0.275
1.497TrpArg: 1.497 ± 0.376
1.198TrpSer: 1.198 ± 0.306
0.599TrpThr: 0.599 ± 0.258
0.898TrpVal: 0.898 ± 0.298
0.225TrpTrp: 0.225 ± 0.178
0.674TrpTyr: 0.674 ± 0.245
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.022TyrAla: 2.022 ± 0.396
0.225TyrCys: 0.225 ± 0.188
1.123TyrAsp: 1.123 ± 0.398
1.872TyrGlu: 1.872 ± 0.306
0.898TyrPhe: 0.898 ± 0.238
2.246TyrGly: 2.246 ± 0.347
0.898TyrHis: 0.898 ± 0.244
1.123TyrIle: 1.123 ± 0.32
1.123TyrLys: 1.123 ± 0.282
2.92TyrLeu: 2.92 ± 0.508
0.824TyrMet: 0.824 ± 0.243
1.572TyrAsn: 1.572 ± 0.315
2.022TyrPro: 2.022 ± 0.474
1.497TyrGln: 1.497 ± 0.364
2.396TyrArg: 2.396 ± 0.457
2.171TyrSer: 2.171 ± 0.493
2.022TyrThr: 2.022 ± 0.347
2.396TyrVal: 2.396 ± 0.388
0.749TyrTrp: 0.749 ± 0.217
0.374TyrTyr: 0.374 ± 0.317
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (13357 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski