Amino acid dipepetide frequency for Roseburia sp. CAG:18

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.219AlaAla: 7.219 ± 0.134
1.216AlaCys: 1.216 ± 0.043
4.892AlaAsp: 4.892 ± 0.093
5.092AlaGlu: 5.092 ± 0.08
3.047AlaPhe: 3.047 ± 0.068
6.185AlaGly: 6.185 ± 0.09
1.221AlaHis: 1.221 ± 0.046
5.166AlaIle: 5.166 ± 0.1
5.402AlaLys: 5.402 ± 0.096
6.794AlaLeu: 6.794 ± 0.107
2.575AlaMet: 2.575 ± 0.054
2.654AlaAsn: 2.654 ± 0.055
1.906AlaPro: 1.906 ± 0.055
2.844AlaGln: 2.844 ± 0.061
2.967AlaArg: 2.967 ± 0.067
4.126AlaSer: 4.126 ± 0.086
3.423AlaThr: 3.423 ± 0.076
6.156AlaVal: 6.156 ± 0.1
0.67AlaTrp: 0.67 ± 0.029
2.991AlaTyr: 2.991 ± 0.076
0.0AlaXaa: 0.0 ± 0.0
Cys
1.065CysAla: 1.065 ± 0.038
0.252CysCys: 0.252 ± 0.021
0.852CysAsp: 0.852 ± 0.039
0.958CysGlu: 0.958 ± 0.039
0.586CysPhe: 0.586 ± 0.029
1.548CysGly: 1.548 ± 0.051
0.318CysHis: 0.318 ± 0.021
1.068CysIle: 1.068 ± 0.042
0.837CysLys: 0.837 ± 0.034
1.103CysLeu: 1.103 ± 0.039
0.541CysMet: 0.541 ± 0.028
0.623CysAsn: 0.623 ± 0.027
0.625CysPro: 0.625 ± 0.036
0.401CysGln: 0.401 ± 0.025
0.713CysArg: 0.713 ± 0.031
0.84CysSer: 0.84 ± 0.031
0.74CysThr: 0.74 ± 0.029
1.117CysVal: 1.117 ± 0.037
0.127CysTrp: 0.127 ± 0.011
0.592CysTyr: 0.592 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
4.963AspAla: 4.963 ± 0.097
0.775AspCys: 0.775 ± 0.032
3.115AspAsp: 3.115 ± 0.081
4.575AspGlu: 4.575 ± 0.085
2.685AspPhe: 2.685 ± 0.066
4.519AspGly: 4.519 ± 0.091
1.182AspHis: 1.182 ± 0.044
4.286AspIle: 4.286 ± 0.081
3.366AspLys: 3.366 ± 0.075
4.759AspLeu: 4.759 ± 0.079
1.881AspMet: 1.881 ± 0.051
2.172AspAsn: 2.172 ± 0.053
1.839AspPro: 1.839 ± 0.051
1.671AspGln: 1.671 ± 0.046
2.388AspArg: 2.388 ± 0.054
3.043AspSer: 3.043 ± 0.07
3.438AspThr: 3.438 ± 0.072
4.161AspVal: 4.161 ± 0.07
0.564AspTrp: 0.564 ± 0.033
2.836AspTyr: 2.836 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
5.288GluAla: 5.288 ± 0.079
0.824GluCys: 0.824 ± 0.031
4.284GluAsp: 4.284 ± 0.081
6.7GluGlu: 6.7 ± 0.121
2.362GluPhe: 2.362 ± 0.05
3.996GluGly: 3.996 ± 0.08
1.67GluHis: 1.67 ± 0.051
5.406GluIle: 5.406 ± 0.085
6.713GluLys: 6.713 ± 0.104
6.285GluLeu: 6.285 ± 0.089
2.351GluMet: 2.351 ± 0.064
4.175GluAsn: 4.175 ± 0.073
1.827GluPro: 1.827 ± 0.049
3.345GluGln: 3.345 ± 0.083
2.989GluArg: 2.989 ± 0.063
3.185GluSer: 3.185 ± 0.077
3.902GluThr: 3.902 ± 0.078
4.35GluVal: 4.35 ± 0.083
0.62GluTrp: 0.62 ± 0.033
2.849GluTyr: 2.849 ± 0.063
0.001GluXaa: 0.001 ± 0.001
Phe
3.207PheAla: 3.207 ± 0.073
0.764PheCys: 0.764 ± 0.035
2.544PheAsp: 2.544 ± 0.059
2.419PheGlu: 2.419 ± 0.056
1.73PhePhe: 1.73 ± 0.059
2.97PheGly: 2.97 ± 0.062
0.944PheHis: 0.944 ± 0.035
2.617PheIle: 2.617 ± 0.067
1.722PheLys: 1.722 ± 0.048
3.852PheLeu: 3.852 ± 0.093
1.138PheMet: 1.138 ± 0.041
1.296PheAsn: 1.296 ± 0.042
1.421PhePro: 1.421 ± 0.046
1.282PheGln: 1.282 ± 0.034
1.667PheArg: 1.667 ± 0.045
2.871PheSer: 2.871 ± 0.07
2.322PheThr: 2.322 ± 0.067
2.896PheVal: 2.896 ± 0.063
0.429PheTrp: 0.429 ± 0.025
1.751PheTyr: 1.751 ± 0.058
0.0PheXaa: 0.0 ± 0.0
Gly
4.816GlyAla: 4.816 ± 0.106
1.287GlyCys: 1.287 ± 0.044
3.46GlyAsp: 3.46 ± 0.076
4.629GlyGlu: 4.629 ± 0.075
2.972GlyPhe: 2.972 ± 0.065
4.604GlyGly: 4.604 ± 0.096
1.341GlyHis: 1.341 ± 0.042
6.118GlyIle: 6.118 ± 0.093
5.702GlyLys: 5.702 ± 0.087
5.504GlyLeu: 5.504 ± 0.091
2.706GlyMet: 2.706 ± 0.071
3.263GlyAsn: 3.263 ± 0.078
1.295GlyPro: 1.295 ± 0.044
2.249GlyGln: 2.249 ± 0.053
2.832GlyArg: 2.832 ± 0.063
3.911GlySer: 3.911 ± 0.073
4.413GlyThr: 4.413 ± 0.091
4.917GlyVal: 4.917 ± 0.09
0.68GlyTrp: 0.68 ± 0.036
3.252GlyTyr: 3.252 ± 0.068
0.001GlyXaa: 0.001 ± 0.001
His
1.468HisAla: 1.468 ± 0.04
0.297HisCys: 0.297 ± 0.024
0.915HisAsp: 0.915 ± 0.038
1.16HisGlu: 1.16 ± 0.046
0.927HisPhe: 0.927 ± 0.034
1.411HisGly: 1.411 ± 0.048
0.486HisHis: 0.486 ± 0.036
1.477HisIle: 1.477 ± 0.048
1.094HisLys: 1.094 ± 0.039
1.609HisLeu: 1.609 ± 0.049
0.727HisMet: 0.727 ± 0.029
0.735HisAsn: 0.735 ± 0.033
0.951HisPro: 0.951 ± 0.036
0.596HisGln: 0.596 ± 0.027
0.91HisArg: 0.91 ± 0.039
0.963HisSer: 0.963 ± 0.038
1.134HisThr: 1.134 ± 0.037
1.345HisVal: 1.345 ± 0.04
0.185HisTrp: 0.185 ± 0.017
0.866HisTyr: 0.866 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.922IleAla: 5.922 ± 0.094
1.321IleCys: 1.321 ± 0.043
3.997IleAsp: 3.997 ± 0.074
4.317IleGlu: 4.317 ± 0.075
2.743IlePhe: 2.743 ± 0.072
5.069IleGly: 5.069 ± 0.09
1.425IleHis: 1.425 ± 0.047
4.566IleIle: 4.566 ± 0.11
3.81IleLys: 3.81 ± 0.063
6.624IleLeu: 6.624 ± 0.111
1.976IleMet: 1.976 ± 0.06
2.705IleAsn: 2.705 ± 0.06
3.076IlePro: 3.076 ± 0.057
2.286IleGln: 2.286 ± 0.062
3.912IleArg: 3.912 ± 0.071
4.757IleSer: 4.757 ± 0.076
4.234IleThr: 4.234 ± 0.078
5.13IleVal: 5.13 ± 0.084
0.591IleTrp: 0.591 ± 0.028
2.726IleTyr: 2.726 ± 0.071
0.001IleXaa: 0.001 ± 0.001
Lys
4.926LysAla: 4.926 ± 0.088
0.695LysCys: 0.695 ± 0.032
4.257LysAsp: 4.257 ± 0.074
6.814LysGlu: 6.814 ± 0.106
1.987LysPhe: 1.987 ± 0.06
3.972LysGly: 3.972 ± 0.065
1.153LysHis: 1.153 ± 0.04
4.759LysIle: 4.759 ± 0.09
6.975LysLys: 6.975 ± 0.118
5.517LysLeu: 5.517 ± 0.086
2.255LysMet: 2.255 ± 0.061
4.031LysAsn: 4.031 ± 0.074
1.912LysPro: 1.912 ± 0.051
2.598LysGln: 2.598 ± 0.06
2.871LysArg: 2.871 ± 0.07
3.158LysSer: 3.158 ± 0.065
4.021LysThr: 4.021 ± 0.085
4.286LysVal: 4.286 ± 0.082
0.566LysTrp: 0.566 ± 0.03
2.784LysTyr: 2.784 ± 0.059
0.0LysXaa: 0.0 ± 0.0
Leu
6.945LeuAla: 6.945 ± 0.104
1.489LeuCys: 1.489 ± 0.046
4.941LeuAsp: 4.941 ± 0.075
5.723LeuGlu: 5.723 ± 0.087
3.662LeuPhe: 3.662 ± 0.087
5.752LeuGly: 5.752 ± 0.091
1.721LeuHis: 1.721 ± 0.05
5.638LeuIle: 5.638 ± 0.114
5.642LeuLys: 5.642 ± 0.078
8.166LeuLeu: 8.166 ± 0.146
2.622LeuMet: 2.622 ± 0.061
3.43LeuAsn: 3.43 ± 0.077
3.303LeuPro: 3.303 ± 0.074
3.257LeuGln: 3.257 ± 0.083
3.717LeuArg: 3.717 ± 0.081
5.987LeuSer: 5.987 ± 0.111
5.047LeuThr: 5.047 ± 0.089
5.786LeuVal: 5.786 ± 0.098
0.767LeuTrp: 0.767 ± 0.036
3.341LeuTyr: 3.341 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.474MetAla: 2.474 ± 0.062
0.374MetCys: 0.374 ± 0.022
2.195MetAsp: 2.195 ± 0.048
2.628MetGlu: 2.628 ± 0.069
1.026MetPhe: 1.026 ± 0.037
2.122MetGly: 2.122 ± 0.061
0.552MetHis: 0.552 ± 0.027
2.316MetIle: 2.316 ± 0.057
2.739MetLys: 2.739 ± 0.06
2.755MetLeu: 2.755 ± 0.068
0.98MetMet: 0.98 ± 0.041
1.533MetAsn: 1.533 ± 0.042
1.17MetPro: 1.17 ± 0.037
1.409MetGln: 1.409 ± 0.045
1.354MetArg: 1.354 ± 0.044
1.6MetSer: 1.6 ± 0.045
1.856MetThr: 1.856 ± 0.046
2.097MetVal: 2.097 ± 0.052
0.223MetTrp: 0.223 ± 0.018
0.982MetTyr: 0.982 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
3.216AsnAla: 3.216 ± 0.065
0.633AsnCys: 0.633 ± 0.034
2.286AsnAsp: 2.286 ± 0.055
2.801AsnGlu: 2.801 ± 0.067
1.561AsnPhe: 1.561 ± 0.041
3.358AsnGly: 3.358 ± 0.078
0.959AsnHis: 0.959 ± 0.034
3.232AsnIle: 3.232 ± 0.08
2.512AsnLys: 2.512 ± 0.067
3.687AsnLeu: 3.687 ± 0.07
1.347AsnMet: 1.347 ± 0.044
1.895AsnAsn: 1.895 ± 0.065
1.937AsnPro: 1.937 ± 0.055
1.546AsnGln: 1.546 ± 0.053
2.079AsnArg: 2.079 ± 0.06
2.228AsnSer: 2.228 ± 0.059
2.422AsnThr: 2.422 ± 0.062
3.012AsnVal: 3.012 ± 0.062
0.446AsnTrp: 0.446 ± 0.023
1.94AsnTyr: 1.94 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.343ProAla: 2.343 ± 0.053
0.453ProCys: 0.453 ± 0.023
2.464ProAsp: 2.464 ± 0.059
3.152ProGlu: 3.152 ± 0.076
1.484ProPhe: 1.484 ± 0.047
2.262ProGly: 2.262 ± 0.064
0.552ProHis: 0.552 ± 0.031
1.841ProIle: 1.841 ± 0.048
2.059ProLys: 2.059 ± 0.058
2.557ProLeu: 2.557 ± 0.061
0.921ProMet: 0.921 ± 0.033
1.147ProAsn: 1.147 ± 0.039
0.63ProPro: 0.63 ± 0.031
1.292ProGln: 1.292 ± 0.04
0.904ProArg: 0.904 ± 0.034
1.621ProSer: 1.621 ± 0.046
1.447ProThr: 1.447 ± 0.046
3.123ProVal: 3.123 ± 0.062
0.333ProTrp: 0.333 ± 0.022
1.422ProTyr: 1.422 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.567GlnAla: 2.567 ± 0.06
0.338GlnCys: 0.338 ± 0.022
1.62GlnAsp: 1.62 ± 0.052
3.044GlnGlu: 3.044 ± 0.076
1.329GlnPhe: 1.329 ± 0.042
2.141GlnGly: 2.141 ± 0.05
0.519GlnHis: 0.519 ± 0.026
2.992GlnIle: 2.992 ± 0.067
3.371GlnLys: 3.371 ± 0.066
3.072GlnLeu: 3.072 ± 0.07
1.612GlnMet: 1.612 ± 0.042
1.778GlnAsn: 1.778 ± 0.048
1.06GlnPro: 1.06 ± 0.043
1.619GlnGln: 1.619 ± 0.056
1.326GlnArg: 1.326 ± 0.041
1.679GlnSer: 1.679 ± 0.048
2.102GlnThr: 2.102 ± 0.059
2.312GlnVal: 2.312 ± 0.06
0.309GlnTrp: 0.309 ± 0.02
1.413GlnTyr: 1.413 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.727ArgAla: 2.727 ± 0.063
0.588ArgCys: 0.588 ± 0.033
2.186ArgAsp: 2.186 ± 0.068
3.628ArgGlu: 3.628 ± 0.084
1.833ArgPhe: 1.833 ± 0.054
2.427ArgGly: 2.427 ± 0.065
0.856ArgHis: 0.856 ± 0.036
3.313ArgIle: 3.313 ± 0.058
3.473ArgLys: 3.473 ± 0.072
3.694ArgLeu: 3.694 ± 0.07
1.641ArgMet: 1.641 ± 0.053
1.941ArgAsn: 1.941 ± 0.046
1.325ArgPro: 1.325 ± 0.043
1.912ArgGln: 1.912 ± 0.049
2.145ArgArg: 2.145 ± 0.067
2.059ArgSer: 2.059 ± 0.06
2.232ArgThr: 2.232 ± 0.062
2.849ArgVal: 2.849 ± 0.056
0.317ArgTrp: 0.317 ± 0.02
1.716ArgTyr: 1.716 ± 0.044
0.001ArgXaa: 0.001 ± 0.001
Ser
4.324SerAla: 4.324 ± 0.08
0.814SerCys: 0.814 ± 0.035
3.486SerAsp: 3.486 ± 0.068
3.46SerGlu: 3.46 ± 0.075
2.511SerPhe: 2.511 ± 0.056
4.921SerGly: 4.921 ± 0.106
1.059SerHis: 1.059 ± 0.039
3.742SerIle: 3.742 ± 0.079
3.242SerLys: 3.242 ± 0.073
4.687SerLeu: 4.687 ± 0.085
1.963SerMet: 1.963 ± 0.052
2.181SerAsn: 2.181 ± 0.062
1.533SerPro: 1.533 ± 0.048
1.89SerGln: 1.89 ± 0.058
2.463SerArg: 2.463 ± 0.061
3.629SerSer: 3.629 ± 0.093
2.841SerThr: 2.841 ± 0.068
4.444SerVal: 4.444 ± 0.076
0.478SerTrp: 0.478 ± 0.031
2.601SerTyr: 2.601 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
4.284ThrAla: 4.284 ± 0.083
0.738ThrCys: 0.738 ± 0.029
3.47ThrAsp: 3.47 ± 0.068
3.774ThrGlu: 3.774 ± 0.091
2.191ThrPhe: 2.191 ± 0.052
4.865ThrGly: 4.865 ± 0.084
0.942ThrHis: 0.942 ± 0.036
4.128ThrIle: 4.128 ± 0.074
3.414ThrLys: 3.414 ± 0.075
4.898ThrLeu: 4.898 ± 0.087
1.548ThrMet: 1.548 ± 0.044
2.185ThrAsn: 2.185 ± 0.051
2.058ThrPro: 2.058 ± 0.059
1.881ThrGln: 1.881 ± 0.057
2.072ThrArg: 2.072 ± 0.051
3.065ThrSer: 3.065 ± 0.072
3.139ThrThr: 3.139 ± 0.077
4.608ThrVal: 4.608 ± 0.109
0.476ThrTrp: 0.476 ± 0.024
2.359ThrTyr: 2.359 ± 0.068
0.001ThrXaa: 0.001 ± 0.001
Val
5.187ValAla: 5.187 ± 0.087
1.305ValCys: 1.305 ± 0.042
4.002ValAsp: 4.002 ± 0.075
4.523ValGlu: 4.523 ± 0.082
3.01ValPhe: 3.01 ± 0.065
4.289ValGly: 4.289 ± 0.085
1.207ValHis: 1.207 ± 0.042
5.25ValIle: 5.25 ± 0.088
4.434ValLys: 4.434 ± 0.083
6.852ValLeu: 6.852 ± 0.117
2.117ValMet: 2.117 ± 0.052
3.013ValAsn: 3.013 ± 0.062
2.48ValPro: 2.48 ± 0.062
2.152ValGln: 2.152 ± 0.055
3.051ValArg: 3.051 ± 0.072
4.837ValSer: 4.837 ± 0.089
4.562ValThr: 4.562 ± 0.098
5.072ValVal: 5.072 ± 0.098
0.68ValTrp: 0.68 ± 0.032
2.9ValTyr: 2.9 ± 0.061
0.0ValXaa: 0.0 ± 0.0
Trp
0.52TrpAla: 0.52 ± 0.028
0.134TrpCys: 0.134 ± 0.013
0.564TrpAsp: 0.564 ± 0.03
0.637TrpGlu: 0.637 ± 0.031
0.41TrpPhe: 0.41 ± 0.023
0.632TrpGly: 0.632 ± 0.03
0.181TrpHis: 0.181 ± 0.014
0.65TrpIle: 0.65 ± 0.029
0.803TrpLys: 0.803 ± 0.031
0.775TrpLeu: 0.775 ± 0.034
0.324TrpMet: 0.324 ± 0.021
0.533TrpAsn: 0.533 ± 0.03
0.202TrpPro: 0.202 ± 0.018
0.363TrpGln: 0.363 ± 0.023
0.332TrpArg: 0.332 ± 0.022
0.451TrpSer: 0.451 ± 0.025
0.389TrpThr: 0.389 ± 0.022
0.501TrpVal: 0.501 ± 0.029
0.123TrpTrp: 0.123 ± 0.012
0.404TrpTyr: 0.404 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.081TyrAla: 3.081 ± 0.071
0.611TyrCys: 0.611 ± 0.028
2.685TyrAsp: 2.685 ± 0.064
3.088TyrGlu: 3.088 ± 0.064
1.785TyrPhe: 1.785 ± 0.051
2.909TyrGly: 2.909 ± 0.066
0.97TyrHis: 0.97 ± 0.032
2.624TyrIle: 2.624 ± 0.063
2.225TyrLys: 2.225 ± 0.06
3.744TyrLeu: 3.744 ± 0.077
1.156TyrMet: 1.156 ± 0.037
1.805TyrAsn: 1.805 ± 0.057
1.457TyrPro: 1.457 ± 0.045
1.613TyrGln: 1.613 ± 0.049
2.172TyrArg: 2.172 ± 0.06
2.258TyrSer: 2.258 ± 0.058
2.432TyrThr: 2.432 ± 0.056
2.764TyrVal: 2.764 ± 0.068
0.343TyrTrp: 0.343 ± 0.025
1.989TyrTyr: 1.989 ± 0.062
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.001
0.0XaaPhe: 0.0 ± 0.0
0.001XaaGly: 0.001 ± 0.001
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.001XaaLys: 0.001 ± 0.001
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.001XaaPro: 0.001 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.008XaaXaa: 0.008 ± 0.003
Statistics based on 2378 proteins (763030 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski