Amino acid dipepetide frequency for Entomoplasma somnilux

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.961AlaAla: 3.961 ± 0.175
0.363AlaCys: 0.363 ± 0.035
2.561AlaAsp: 2.561 ± 0.114
3.056AlaGlu: 3.056 ± 0.132
2.943AlaPhe: 2.943 ± 0.135
3.643AlaGly: 3.643 ± 0.168
0.862AlaHis: 0.862 ± 0.062
6.242AlaIle: 6.242 ± 0.164
5.746AlaLys: 5.746 ± 0.173
5.292AlaLeu: 5.292 ± 0.16
1.475AlaMet: 1.475 ± 0.093
3.779AlaAsn: 3.779 ± 0.118
1.403AlaPro: 1.403 ± 0.08
1.835AlaGln: 1.835 ± 0.069
1.767AlaArg: 1.767 ± 0.095
3.14AlaSer: 3.14 ± 0.125
3.227AlaThr: 3.227 ± 0.144
3.333AlaVal: 3.333 ± 0.133
0.67AlaTrp: 0.67 ± 0.058
1.918AlaTyr: 1.918 ± 0.085
0.0AlaXaa: 0.0 ± 0.0
Cys
0.303CysAla: 0.303 ± 0.036
0.042CysCys: 0.042 ± 0.011
0.325CysAsp: 0.325 ± 0.035
0.363CysGlu: 0.363 ± 0.041
0.318CysPhe: 0.318 ± 0.036
0.446CysGly: 0.446 ± 0.048
0.098CysHis: 0.098 ± 0.021
0.382CysIle: 0.382 ± 0.043
0.382CysLys: 0.382 ± 0.038
0.496CysLeu: 0.496 ± 0.048
0.106CysMet: 0.106 ± 0.018
0.276CysAsn: 0.276 ± 0.033
0.136CysPro: 0.136 ± 0.023
0.151CysGln: 0.151 ± 0.025
0.098CysArg: 0.098 ± 0.019
0.382CysSer: 0.382 ± 0.045
0.223CysThr: 0.223 ± 0.023
0.337CysVal: 0.337 ± 0.036
0.079CysTrp: 0.079 ± 0.016
0.17CysTyr: 0.17 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
2.754AspAla: 2.754 ± 0.117
0.235AspCys: 0.235 ± 0.029
2.277AspAsp: 2.277 ± 0.101
3.749AspGlu: 3.749 ± 0.129
3.484AspPhe: 3.484 ± 0.129
2.569AspGly: 2.569 ± 0.11
0.726AspHis: 0.726 ± 0.046
4.85AspIle: 4.85 ± 0.14
5.073AspLys: 5.073 ± 0.158
6.045AspLeu: 6.045 ± 0.191
1.006AspMet: 1.006 ± 0.062
3.121AspAsn: 3.121 ± 0.113
1.502AspPro: 1.502 ± 0.087
1.755AspGln: 1.755 ± 0.076
1.158AspArg: 1.158 ± 0.071
3.34AspSer: 3.34 ± 0.133
2.315AspThr: 2.315 ± 0.109
3.261AspVal: 3.261 ± 0.111
0.76AspTrp: 0.76 ± 0.05
2.281AspTyr: 2.281 ± 0.105
0.0AspXaa: 0.0 ± 0.0
Glu
3.696GluAla: 3.696 ± 0.171
0.265GluCys: 0.265 ± 0.032
2.924GluAsp: 2.924 ± 0.115
4.766GluGlu: 4.766 ± 0.174
3.204GluPhe: 3.204 ± 0.125
2.792GluGly: 2.792 ± 0.135
0.927GluHis: 0.927 ± 0.063
8.246GluIle: 8.246 ± 0.205
6.779GluLys: 6.779 ± 0.168
6.798GluLeu: 6.798 ± 0.195
1.63GluMet: 1.63 ± 0.082
5.474GluAsn: 5.474 ± 0.179
1.256GluPro: 1.256 ± 0.066
2.795GluGln: 2.795 ± 0.085
1.793GluArg: 1.793 ± 0.093
3.189GluSer: 3.189 ± 0.124
3.34GluThr: 3.34 ± 0.128
3.768GluVal: 3.768 ± 0.155
0.832GluTrp: 0.832 ± 0.063
2.334GluTyr: 2.334 ± 0.099
0.0GluXaa: 0.0 ± 0.0
Phe
3.352PheAla: 3.352 ± 0.121
0.287PheCys: 0.287 ± 0.036
2.966PheAsp: 2.966 ± 0.112
3.552PheGlu: 3.552 ± 0.127
2.697PhePhe: 2.697 ± 0.14
3.159PheGly: 3.159 ± 0.107
0.541PheHis: 0.541 ± 0.046
4.952PheIle: 4.952 ± 0.187
5.016PheLys: 5.016 ± 0.162
4.747PheLeu: 4.747 ± 0.188
1.112PheMet: 1.112 ± 0.078
3.843PheAsn: 3.843 ± 0.121
1.093PhePro: 1.093 ± 0.066
1.286PheGln: 1.286 ± 0.068
1.226PheArg: 1.226 ± 0.075
3.722PheSer: 3.722 ± 0.152
2.678PheThr: 2.678 ± 0.09
3.537PheVal: 3.537 ± 0.127
0.605PheTrp: 0.605 ± 0.051
1.804PheTyr: 1.804 ± 0.095
0.0PheXaa: 0.0 ± 0.0
Gly
3.344GlyAla: 3.344 ± 0.136
0.306GlyCys: 0.306 ± 0.034
2.848GlyAsp: 2.848 ± 0.117
3.212GlyGlu: 3.212 ± 0.13
2.928GlyPhe: 2.928 ± 0.124
3.457GlyGly: 3.457 ± 0.165
0.908GlyHis: 0.908 ± 0.072
5.924GlyIle: 5.924 ± 0.181
4.452GlyLys: 4.452 ± 0.149
5.209GlyLeu: 5.209 ± 0.164
1.362GlyMet: 1.362 ± 0.078
3.166GlyAsn: 3.166 ± 0.152
1.335GlyPro: 1.335 ± 0.082
1.729GlyGln: 1.729 ± 0.096
1.627GlyArg: 1.627 ± 0.1
3.457GlySer: 3.457 ± 0.128
3.257GlyThr: 3.257 ± 0.13
3.855GlyVal: 3.855 ± 0.165
0.753GlyTrp: 0.753 ± 0.058
2.126GlyTyr: 2.126 ± 0.1
0.0GlyXaa: 0.0 ± 0.0
His
0.851HisAla: 0.851 ± 0.051
0.087HisCys: 0.087 ± 0.019
0.647HisAsp: 0.647 ± 0.06
0.927HisGlu: 0.927 ± 0.058
0.772HisPhe: 0.772 ± 0.057
0.874HisGly: 0.874 ± 0.065
0.269HisHis: 0.269 ± 0.03
1.226HisIle: 1.226 ± 0.076
1.263HisLys: 1.263 ± 0.077
1.214HisLeu: 1.214 ± 0.07
0.306HisMet: 0.306 ± 0.036
0.9HisAsn: 0.9 ± 0.074
0.484HisPro: 0.484 ± 0.045
0.499HisGln: 0.499 ± 0.045
0.393HisArg: 0.393 ± 0.038
0.794HisSer: 0.794 ± 0.058
0.658HisThr: 0.658 ± 0.054
0.783HisVal: 0.783 ± 0.057
0.189HisTrp: 0.189 ± 0.031
0.533HisTyr: 0.533 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
6.276IleAla: 6.276 ± 0.162
0.681IleCys: 0.681 ± 0.053
5.89IleAsp: 5.89 ± 0.172
6.892IleGlu: 6.892 ± 0.192
5.235IlePhe: 5.235 ± 0.176
5.64IleGly: 5.64 ± 0.162
1.154IleHis: 1.154 ± 0.064
9.313IleIle: 9.313 ± 0.255
9.869IleLys: 9.869 ± 0.183
8.965IleLeu: 8.965 ± 0.192
1.933IleMet: 1.933 ± 0.099
7.902IleAsn: 7.902 ± 0.181
2.659IlePro: 2.659 ± 0.104
2.731IleGln: 2.731 ± 0.102
2.417IleArg: 2.417 ± 0.134
7.339IleSer: 7.339 ± 0.185
5.277IleThr: 5.277 ± 0.154
6.151IleVal: 6.151 ± 0.147
0.927IleTrp: 0.927 ± 0.056
3.45IleTyr: 3.45 ± 0.125
0.0IleXaa: 0.0 ± 0.0
Lys
4.781LysAla: 4.781 ± 0.153
0.322LysCys: 0.322 ± 0.038
5.462LysAsp: 5.462 ± 0.143
7.566LysGlu: 7.566 ± 0.17
4.475LysPhe: 4.475 ± 0.136
4.293LysGly: 4.293 ± 0.153
1.434LysHis: 1.434 ± 0.074
10.301LysIle: 10.301 ± 0.203
9.673LysLys: 9.673 ± 0.251
7.592LysLeu: 7.592 ± 0.19
2.811LysMet: 2.811 ± 0.11
8.859LysAsn: 8.859 ± 0.223
2.576LysPro: 2.576 ± 0.103
3.378LysGln: 3.378 ± 0.119
2.614LysArg: 2.614 ± 0.113
5.303LysSer: 5.303 ± 0.167
5.935LysThr: 5.935 ± 0.153
5.027LysVal: 5.027 ± 0.15
1.146LysTrp: 1.146 ± 0.078
4.206LysTyr: 4.206 ± 0.151
0.0LysXaa: 0.0 ± 0.0
Leu
5.53LeuAla: 5.53 ± 0.181
0.465LeuCys: 0.465 ± 0.046
4.895LeuAsp: 4.895 ± 0.146
6.487LeuGlu: 6.487 ± 0.175
4.388LeuPhe: 4.388 ± 0.162
5.061LeuGly: 5.061 ± 0.167
1.116LeuHis: 1.116 ± 0.07
9.298LeuIle: 9.298 ± 0.24
9.116LeuLys: 9.116 ± 0.205
7.88LeuLeu: 7.88 ± 0.204
1.971LeuMet: 1.971 ± 0.102
7.115LeuAsn: 7.115 ± 0.205
2.387LeuPro: 2.387 ± 0.109
3.302LeuGln: 3.302 ± 0.132
2.519LeuArg: 2.519 ± 0.116
5.988LeuSer: 5.988 ± 0.156
5.527LeuThr: 5.527 ± 0.161
5.402LeuVal: 5.402 ± 0.15
0.851LeuTrp: 0.851 ± 0.054
2.304LeuTyr: 2.304 ± 0.089
0.0LeuXaa: 0.0 ± 0.0
Met
1.498MetAla: 1.498 ± 0.091
0.102MetCys: 0.102 ± 0.024
1.161MetAsp: 1.161 ± 0.064
1.12MetGlu: 1.12 ± 0.075
1.309MetPhe: 1.309 ± 0.097
1.407MetGly: 1.407 ± 0.088
0.356MetHis: 0.356 ± 0.038
2.304MetIle: 2.304 ± 0.102
2.069MetLys: 2.069 ± 0.081
1.994MetLeu: 1.994 ± 0.096
0.601MetMet: 0.601 ± 0.046
1.574MetAsn: 1.574 ± 0.08
0.764MetPro: 0.764 ± 0.06
0.764MetGln: 0.764 ± 0.056
0.567MetArg: 0.567 ± 0.049
1.566MetSer: 1.566 ± 0.078
1.173MetThr: 1.173 ± 0.067
1.233MetVal: 1.233 ± 0.081
0.235MetTrp: 0.235 ± 0.033
0.583MetTyr: 0.583 ± 0.05
0.0MetXaa: 0.0 ± 0.0
Asn
3.507AsnAla: 3.507 ± 0.127
0.371AsnCys: 0.371 ± 0.04
4.278AsnAsp: 4.278 ± 0.147
5.103AsnGlu: 5.103 ± 0.174
4.101AsnPhe: 4.101 ± 0.167
3.741AsnGly: 3.741 ± 0.132
1.127AsnHis: 1.127 ± 0.074
7.021AsnIle: 7.021 ± 0.183
7.997AsnLys: 7.997 ± 0.211
7.131AsnLeu: 7.131 ± 0.211
1.324AsnMet: 1.324 ± 0.07
6.211AsnAsn: 6.211 ± 0.208
2.285AsnPro: 2.285 ± 0.093
2.773AsnGln: 2.773 ± 0.104
1.785AsnArg: 1.785 ± 0.075
4.804AsnSer: 4.804 ± 0.185
2.932AsnThr: 2.932 ± 0.117
3.927AsnVal: 3.927 ± 0.126
1.142AsnTrp: 1.142 ± 0.095
2.992AsnTyr: 2.992 ± 0.12
0.0AsnXaa: 0.0 ± 0.0
Pro
1.26ProAla: 1.26 ± 0.075
0.113ProCys: 0.113 ± 0.021
1.154ProAsp: 1.154 ± 0.077
1.971ProGlu: 1.971 ± 0.087
1.509ProPhe: 1.509 ± 0.085
1.604ProGly: 1.604 ± 0.093
0.465ProHis: 0.465 ± 0.041
2.795ProIle: 2.795 ± 0.125
2.326ProLys: 2.326 ± 0.095
2.413ProLeu: 2.413 ± 0.118
0.499ProMet: 0.499 ± 0.053
1.895ProAsn: 1.895 ± 0.087
0.401ProPro: 0.401 ± 0.039
0.904ProGln: 0.904 ± 0.06
0.605ProArg: 0.605 ± 0.056
1.608ProSer: 1.608 ± 0.081
1.627ProThr: 1.627 ± 0.068
1.581ProVal: 1.581 ± 0.089
0.314ProTrp: 0.314 ± 0.032
0.957ProTyr: 0.957 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
1.785GlnAla: 1.785 ± 0.091
0.095GlnCys: 0.095 ± 0.019
1.608GlnAsp: 1.608 ± 0.081
2.406GlnGlu: 2.406 ± 0.092
1.4GlnPhe: 1.4 ± 0.075
1.475GlnGly: 1.475 ± 0.081
0.412GlnHis: 0.412 ± 0.045
3.753GlnIle: 3.753 ± 0.133
3.764GlnLys: 3.764 ± 0.125
2.814GlnLeu: 2.814 ± 0.109
0.707GlnMet: 0.707 ± 0.051
2.954GlnAsn: 2.954 ± 0.103
0.741GlnPro: 0.741 ± 0.06
1.282GlnGln: 1.282 ± 0.082
1.108GlnArg: 1.108 ± 0.073
1.755GlnSer: 1.755 ± 0.09
2.02GlnThr: 2.02 ± 0.082
1.642GlnVal: 1.642 ± 0.089
0.405GlnTrp: 0.405 ± 0.044
1.15GlnTyr: 1.15 ± 0.074
0.0GlnXaa: 0.0 ± 0.0
Arg
1.521ArgAla: 1.521 ± 0.097
0.174ArgCys: 0.174 ± 0.03
1.392ArgAsp: 1.392 ± 0.088
1.907ArgGlu: 1.907 ± 0.091
1.313ArgPhe: 1.313 ± 0.07
1.456ArgGly: 1.456 ± 0.087
0.371ArgHis: 0.371 ± 0.037
2.633ArgIle: 2.633 ± 0.118
2.811ArgLys: 2.811 ± 0.116
2.145ArgLeu: 2.145 ± 0.111
0.787ArgMet: 0.787 ± 0.055
1.793ArgAsn: 1.793 ± 0.091
0.775ArgPro: 0.775 ± 0.055
0.908ArgGln: 0.908 ± 0.067
1.059ArgArg: 1.059 ± 0.08
1.801ArgSer: 1.801 ± 0.104
1.494ArgThr: 1.494 ± 0.077
1.585ArgVal: 1.585 ± 0.083
0.272ArgTrp: 0.272 ± 0.029
1.002ArgTyr: 1.002 ± 0.077
0.0ArgXaa: 0.0 ± 0.0
Ser
3.457SerAla: 3.457 ± 0.14
0.322SerCys: 0.322 ± 0.032
3.053SerAsp: 3.053 ± 0.125
3.979SerGlu: 3.979 ± 0.134
3.673SerPhe: 3.673 ± 0.142
3.858SerGly: 3.858 ± 0.13
0.832SerHis: 0.832 ± 0.056
6.117SerIle: 6.117 ± 0.17
6.431SerLys: 6.431 ± 0.155
6.083SerLeu: 6.083 ± 0.165
1.305SerMet: 1.305 ± 0.076
4.146SerAsn: 4.146 ± 0.164
1.498SerPro: 1.498 ± 0.069
2.149SerGln: 2.149 ± 0.079
1.975SerArg: 1.975 ± 0.083
4.282SerSer: 4.282 ± 0.156
3.374SerThr: 3.374 ± 0.108
3.461SerVal: 3.461 ± 0.128
0.968SerTrp: 0.968 ± 0.088
2.281SerTyr: 2.281 ± 0.092
0.0SerXaa: 0.0 ± 0.0
Thr
2.894ThrAla: 2.894 ± 0.136
0.219ThrCys: 0.219 ± 0.033
2.444ThrAsp: 2.444 ± 0.103
2.875ThrGlu: 2.875 ± 0.114
2.894ThrPhe: 2.894 ± 0.114
3.575ThrGly: 3.575 ± 0.128
0.704ThrHis: 0.704 ± 0.055
5.712ThrIle: 5.712 ± 0.179
5.122ThrLys: 5.122 ± 0.144
4.971ThrLeu: 4.971 ± 0.129
1.021ThrMet: 1.021 ± 0.065
3.877ThrAsn: 3.877 ± 0.157
1.861ThrPro: 1.861 ± 0.104
1.767ThrGln: 1.767 ± 0.094
1.593ThrArg: 1.593 ± 0.092
3.688ThrSer: 3.688 ± 0.142
3.605ThrThr: 3.605 ± 0.145
3.204ThrVal: 3.204 ± 0.145
0.73ThrTrp: 0.73 ± 0.082
1.789ThrTyr: 1.789 ± 0.101
0.0ThrXaa: 0.0 ± 0.0
Val
4.029ValAla: 4.029 ± 0.168
0.382ValCys: 0.382 ± 0.041
3.692ValAsp: 3.692 ± 0.134
3.998ValGlu: 3.998 ± 0.14
2.746ValPhe: 2.746 ± 0.123
3.533ValGly: 3.533 ± 0.149
0.768ValHis: 0.768 ± 0.055
5.409ValIle: 5.409 ± 0.147
5.008ValLys: 5.008 ± 0.159
5.341ValLeu: 5.341 ± 0.157
1.294ValMet: 1.294 ± 0.079
3.836ValAsn: 3.836 ± 0.123
1.748ValPro: 1.748 ± 0.084
1.725ValGln: 1.725 ± 0.085
1.577ValArg: 1.577 ± 0.087
3.874ValSer: 3.874 ± 0.135
3.196ValThr: 3.196 ± 0.131
3.968ValVal: 3.968 ± 0.135
0.613ValTrp: 0.613 ± 0.046
1.925ValTyr: 1.925 ± 0.089
0.0ValXaa: 0.0 ± 0.0
Trp
0.503TrpAla: 0.503 ± 0.044
0.049TrpCys: 0.049 ± 0.015
0.734TrpAsp: 0.734 ± 0.061
0.681TrpGlu: 0.681 ± 0.051
0.681TrpPhe: 0.681 ± 0.054
0.594TrpGly: 0.594 ± 0.048
0.14TrpHis: 0.14 ± 0.021
1.218TrpIle: 1.218 ± 0.077
1.229TrpLys: 1.229 ± 0.093
0.946TrpLeu: 0.946 ± 0.061
0.337TrpMet: 0.337 ± 0.038
1.188TrpAsn: 1.188 ± 0.097
0.231TrpPro: 0.231 ± 0.029
0.269TrpGln: 0.269 ± 0.028
0.242TrpArg: 0.242 ± 0.027
0.908TrpSer: 0.908 ± 0.064
0.949TrpThr: 0.949 ± 0.108
0.636TrpVal: 0.636 ± 0.043
0.155TrpTrp: 0.155 ± 0.023
0.42TrpTyr: 0.42 ± 0.038
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.914TyrAla: 1.914 ± 0.09
0.235TyrCys: 0.235 ± 0.037
1.948TyrAsp: 1.948 ± 0.084
2.198TyrGlu: 2.198 ± 0.091
2.107TyrPhe: 2.107 ± 0.091
2.077TyrGly: 2.077 ± 0.087
0.461TyrHis: 0.461 ± 0.043
3.007TyrIle: 3.007 ± 0.119
3.628TyrLys: 3.628 ± 0.141
3.529TyrLeu: 3.529 ± 0.142
0.787TyrMet: 0.787 ± 0.06
2.644TyrAsn: 2.644 ± 0.12
0.866TyrPro: 0.866 ± 0.054
1.275TyrGln: 1.275 ± 0.067
1.074TyrArg: 1.074 ± 0.066
2.304TyrSer: 2.304 ± 0.095
1.736TyrThr: 1.736 ± 0.09
1.975TyrVal: 1.975 ± 0.093
0.461TyrTrp: 0.461 ± 0.046
1.248TyrTyr: 1.248 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 725 proteins (264357 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski