Amino acid dipepetide frequency for Clostridium sp. CAG:349

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.729AlaAla: 6.729 ± 0.155
1.105AlaCys: 1.105 ± 0.053
4.948AlaAsp: 4.948 ± 0.126
5.5AlaGlu: 5.5 ± 0.129
3.815AlaPhe: 3.815 ± 0.128
5.422AlaGly: 5.422 ± 0.111
1.11AlaHis: 1.11 ± 0.055
5.775AlaIle: 5.775 ± 0.136
6.316AlaLys: 6.316 ± 0.134
7.599AlaLeu: 7.599 ± 0.148
1.949AlaMet: 1.949 ± 0.075
2.954AlaAsn: 2.954 ± 0.088
2.255AlaPro: 2.255 ± 0.092
1.641AlaGln: 1.641 ± 0.067
3.578AlaArg: 3.578 ± 0.087
3.618AlaSer: 3.618 ± 0.093
4.187AlaThr: 4.187 ± 0.095
6.992AlaVal: 6.992 ± 0.152
0.398AlaTrp: 0.398 ± 0.033
2.828AlaTyr: 2.828 ± 0.1
0.0AlaXaa: 0.0 ± 0.0
Cys
1.278CysAla: 1.278 ± 0.065
0.239CysCys: 0.239 ± 0.033
0.982CysAsp: 0.982 ± 0.048
0.808CysGlu: 0.808 ± 0.044
0.709CysPhe: 0.709 ± 0.045
1.446CysGly: 1.446 ± 0.074
0.242CysHis: 0.242 ± 0.024
0.863CysIle: 0.863 ± 0.046
0.915CysLys: 0.915 ± 0.046
1.069CysLeu: 1.069 ± 0.042
0.28CysMet: 0.28 ± 0.023
0.614CysAsn: 0.614 ± 0.036
0.749CysPro: 0.749 ± 0.042
0.242CysGln: 0.242 ± 0.023
0.59CysArg: 0.59 ± 0.047
0.645CysSer: 0.645 ± 0.042
0.68CysThr: 0.68 ± 0.041
1.24CysVal: 1.24 ± 0.079
0.076CysTrp: 0.076 ± 0.015
0.486CysTyr: 0.486 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
4.976AspAla: 4.976 ± 0.117
0.896AspCys: 0.896 ± 0.049
4.014AspAsp: 4.014 ± 0.095
5.529AspGlu: 5.529 ± 0.134
3.77AspPhe: 3.77 ± 0.111
5.168AspGly: 5.168 ± 0.127
0.602AspHis: 0.602 ± 0.034
4.419AspIle: 4.419 ± 0.11
5.676AspLys: 5.676 ± 0.107
4.469AspLeu: 4.469 ± 0.092
1.634AspMet: 1.634 ± 0.062
3.037AspAsn: 3.037 ± 0.087
1.221AspPro: 1.221 ± 0.062
0.628AspGln: 0.628 ± 0.037
2.018AspArg: 2.018 ± 0.081
2.558AspSer: 2.558 ± 0.081
2.926AspThr: 2.926 ± 0.095
6.202AspVal: 6.202 ± 0.139
0.448AspTrp: 0.448 ± 0.038
2.615AspTyr: 2.615 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
4.033GluAla: 4.033 ± 0.121
0.918GluCys: 0.918 ± 0.046
3.224GluAsp: 3.224 ± 0.091
4.645GluGlu: 4.645 ± 0.127
2.743GluPhe: 2.743 ± 0.081
3.699GluGly: 3.699 ± 0.117
0.87GluHis: 0.87 ± 0.039
6.053GluIle: 6.053 ± 0.13
7.509GluLys: 7.509 ± 0.153
5.088GluLeu: 5.088 ± 0.124
1.842GluMet: 1.842 ± 0.073
5.353GluAsn: 5.353 ± 0.132
1.508GluPro: 1.508 ± 0.07
1.719GluGln: 1.719 ± 0.062
3.141GluArg: 3.141 ± 0.092
3.307GluSer: 3.307 ± 0.088
3.497GluThr: 3.497 ± 0.087
4.46GluVal: 4.46 ± 0.112
0.51GluTrp: 0.51 ± 0.041
2.802GluTyr: 2.802 ± 0.094
0.0GluXaa: 0.0 ± 0.0
Phe
3.616PheAla: 3.616 ± 0.108
0.711PheCys: 0.711 ± 0.041
3.772PheAsp: 3.772 ± 0.112
2.85PheGlu: 2.85 ± 0.076
2.359PhePhe: 2.359 ± 0.111
3.457PheGly: 3.457 ± 0.1
0.621PheHis: 0.621 ± 0.046
3.101PheIle: 3.101 ± 0.089
3.205PheLys: 3.205 ± 0.092
3.668PheLeu: 3.668 ± 0.118
1.166PheMet: 1.166 ± 0.056
2.361PheAsn: 2.361 ± 0.079
1.306PhePro: 1.306 ± 0.054
0.918PheGln: 0.918 ± 0.056
1.814PheArg: 1.814 ± 0.09
3.9PheSer: 3.9 ± 0.146
2.644PheThr: 2.644 ± 0.087
3.755PheVal: 3.755 ± 0.119
0.303PheTrp: 0.303 ± 0.027
1.645PheTyr: 1.645 ± 0.075
0.0PheXaa: 0.0 ± 0.0
Gly
5.764GlyAla: 5.764 ± 0.131
1.017GlyCys: 1.017 ± 0.06
3.947GlyAsp: 3.947 ± 0.093
4.434GlyGlu: 4.434 ± 0.113
3.336GlyPhe: 3.336 ± 0.096
5.166GlyGly: 5.166 ± 0.129
1.081GlyHis: 1.081 ± 0.041
5.47GlyIle: 5.47 ± 0.112
6.321GlyLys: 6.321 ± 0.112
5.614GlyLeu: 5.614 ± 0.118
1.847GlyMet: 1.847 ± 0.072
3.08GlyAsn: 3.08 ± 0.09
1.015GlyPro: 1.015 ± 0.069
1.541GlyGln: 1.541 ± 0.059
2.98GlyArg: 2.98 ± 0.08
3.298GlySer: 3.298 ± 0.088
3.801GlyThr: 3.801 ± 0.113
6.231GlyVal: 6.231 ± 0.127
0.529GlyTrp: 0.529 ± 0.04
3.013GlyTyr: 3.013 ± 0.09
0.0GlyXaa: 0.0 ± 0.0
His
1.14HisAla: 1.14 ± 0.057
0.232HisCys: 0.232 ± 0.025
0.925HisAsp: 0.925 ± 0.047
0.901HisGlu: 0.901 ± 0.044
0.688HisPhe: 0.688 ± 0.039
1.228HisGly: 1.228 ± 0.055
0.263HisHis: 0.263 ± 0.026
1.121HisIle: 1.121 ± 0.055
0.899HisLys: 0.899 ± 0.048
1.11HisLeu: 1.11 ± 0.049
0.242HisMet: 0.242 ± 0.024
0.633HisAsn: 0.633 ± 0.044
0.718HisPro: 0.718 ± 0.05
0.27HisGln: 0.27 ± 0.024
0.635HisArg: 0.635 ± 0.044
0.711HisSer: 0.711 ± 0.044
0.825HisThr: 0.825 ± 0.045
1.015HisVal: 1.015 ± 0.056
0.092HisTrp: 0.092 ± 0.016
0.443HisTyr: 0.443 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.423IleAla: 6.423 ± 0.133
1.012IleCys: 1.012 ± 0.049
4.915IleAsp: 4.915 ± 0.106
4.687IleGlu: 4.687 ± 0.108
3.009IlePhe: 3.009 ± 0.098
4.825IleGly: 4.825 ± 0.118
0.825IleHis: 0.825 ± 0.043
5.289IleIle: 5.289 ± 0.138
5.337IleLys: 5.337 ± 0.121
6.216IleLeu: 6.216 ± 0.158
1.705IleMet: 1.705 ± 0.076
3.544IleAsn: 3.544 ± 0.101
2.693IlePro: 2.693 ± 0.087
1.261IleGln: 1.261 ± 0.055
3.002IleArg: 3.002 ± 0.086
4.765IleSer: 4.765 ± 0.113
4.038IleThr: 4.038 ± 0.105
6.084IleVal: 6.084 ± 0.145
0.375IleTrp: 0.375 ± 0.032
2.499IleTyr: 2.499 ± 0.08
0.0IleXaa: 0.0 ± 0.0
Lys
5.415LysAla: 5.415 ± 0.118
1.093LysCys: 1.093 ± 0.056
5.076LysAsp: 5.076 ± 0.105
5.915LysGlu: 5.915 ± 0.123
2.964LysPhe: 2.964 ± 0.093
4.782LysGly: 4.782 ± 0.098
1.19LysHis: 1.19 ± 0.055
6.503LysIle: 6.503 ± 0.11
7.684LysLys: 7.684 ± 0.151
6.072LysLeu: 6.072 ± 0.134
2.342LysMet: 2.342 ± 0.071
5.474LysAsn: 5.474 ± 0.131
2.492LysPro: 2.492 ± 0.086
2.129LysGln: 2.129 ± 0.074
3.722LysArg: 3.722 ± 0.098
4.481LysSer: 4.481 ± 0.098
5.453LysThr: 5.453 ± 0.122
5.522LysVal: 5.522 ± 0.122
0.593LysTrp: 0.593 ± 0.042
3.627LysTyr: 3.627 ± 0.095
0.0LysXaa: 0.0 ± 0.0
Leu
6.05LeuAla: 6.05 ± 0.127
1.278LeuCys: 1.278 ± 0.058
4.953LeuAsp: 4.953 ± 0.124
4.72LeuGlu: 4.72 ± 0.118
3.997LeuPhe: 3.997 ± 0.127
5.261LeuGly: 5.261 ± 0.115
1.157LeuHis: 1.157 ± 0.051
6.015LeuIle: 6.015 ± 0.129
7.174LeuLys: 7.174 ± 0.13
7.068LeuLeu: 7.068 ± 0.168
2.245LeuMet: 2.245 ± 0.068
4.102LeuAsn: 4.102 ± 0.093
3.376LeuPro: 3.376 ± 0.093
2.015LeuGln: 2.015 ± 0.062
3.362LeuArg: 3.362 ± 0.093
7.188LeuSer: 7.188 ± 0.158
4.974LeuThr: 4.974 ± 0.1
5.462LeuVal: 5.462 ± 0.143
0.543LeuTrp: 0.543 ± 0.04
3.03LeuTyr: 3.03 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
1.868MetAla: 1.868 ± 0.074
0.365MetCys: 0.365 ± 0.027
1.287MetAsp: 1.287 ± 0.062
1.242MetGlu: 1.242 ± 0.056
0.991MetPhe: 0.991 ± 0.05
1.634MetGly: 1.634 ± 0.066
0.422MetHis: 0.422 ± 0.032
1.629MetIle: 1.629 ± 0.067
2.34MetLys: 2.34 ± 0.08
2.395MetLeu: 2.395 ± 0.086
0.616MetMet: 0.616 ± 0.041
1.273MetAsn: 1.273 ± 0.052
1.174MetPro: 1.174 ± 0.058
0.813MetGln: 0.813 ± 0.042
1.283MetArg: 1.283 ± 0.06
1.574MetSer: 1.574 ± 0.057
1.546MetThr: 1.546 ± 0.064
1.472MetVal: 1.472 ± 0.064
0.18MetTrp: 0.18 ± 0.023
0.799MetTyr: 0.799 ± 0.043
0.0MetXaa: 0.0 ± 0.0
Asn
4.263AsnAla: 4.263 ± 0.1
0.707AsnCys: 0.707 ± 0.047
3.118AsnAsp: 3.118 ± 0.096
3.122AsnGlu: 3.122 ± 0.092
2.212AsnPhe: 2.212 ± 0.08
3.86AsnGly: 3.86 ± 0.111
0.69AsnHis: 0.69 ± 0.035
3.369AsnIle: 3.369 ± 0.088
3.601AsnLys: 3.601 ± 0.101
4.208AsnLeu: 4.208 ± 0.111
1.299AsnMet: 1.299 ± 0.057
2.295AsnAsn: 2.295 ± 0.087
2.238AsnPro: 2.238 ± 0.075
0.868AsnGln: 0.868 ± 0.05
2.013AsnArg: 2.013 ± 0.076
2.411AsnSer: 2.411 ± 0.091
2.437AsnThr: 2.437 ± 0.074
4.479AsnVal: 4.479 ± 0.11
0.332AsnTrp: 0.332 ± 0.029
1.932AsnTyr: 1.932 ± 0.08
0.0AsnXaa: 0.0 ± 0.0
Pro
2.463ProAla: 2.463 ± 0.1
0.467ProCys: 0.467 ± 0.035
2.549ProAsp: 2.549 ± 0.081
3.013ProGlu: 3.013 ± 0.083
1.705ProPhe: 1.705 ± 0.069
1.508ProGly: 1.508 ± 0.064
0.557ProHis: 0.557 ± 0.036
1.84ProIle: 1.84 ± 0.066
2.193ProLys: 2.193 ± 0.075
2.729ProLeu: 2.729 ± 0.084
0.747ProMet: 0.747 ± 0.041
0.986ProAsn: 0.986 ± 0.048
0.832ProPro: 0.832 ± 0.047
0.808ProGln: 0.808 ± 0.05
1.067ProArg: 1.067 ± 0.05
1.83ProSer: 1.83 ± 0.063
1.634ProThr: 1.634 ± 0.068
2.997ProVal: 2.997 ± 0.091
0.213ProTrp: 0.213 ± 0.023
1.524ProTyr: 1.524 ± 0.063
0.0ProXaa: 0.0 ± 0.0
Gln
1.593GlnAla: 1.593 ± 0.062
0.254GlnCys: 0.254 ± 0.025
1.05GlnAsp: 1.05 ± 0.05
1.276GlnGlu: 1.276 ± 0.057
0.778GlnPhe: 0.778 ± 0.042
1.517GlnGly: 1.517 ± 0.06
0.356GlnHis: 0.356 ± 0.028
1.69GlnIle: 1.69 ± 0.061
2.198GlnLys: 2.198 ± 0.08
1.788GlnLeu: 1.788 ± 0.075
0.624GlnMet: 0.624 ± 0.04
1.475GlnAsn: 1.475 ± 0.064
0.673GlnPro: 0.673 ± 0.039
0.699GlnGln: 0.699 ± 0.045
1.079GlnArg: 1.079 ± 0.054
1.221GlnSer: 1.221 ± 0.057
1.176GlnThr: 1.176 ± 0.058
1.257GlnVal: 1.257 ± 0.054
0.138GlnTrp: 0.138 ± 0.016
0.972GlnTyr: 0.972 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
3.336ArgAla: 3.336 ± 0.092
0.545ArgCys: 0.545 ± 0.045
2.489ArgAsp: 2.489 ± 0.087
3.028ArgGlu: 3.028 ± 0.097
2.06ArgPhe: 2.06 ± 0.073
2.53ArgGly: 2.53 ± 0.086
0.697ArgHis: 0.697 ± 0.042
3.376ArgIle: 3.376 ± 0.094
3.329ArgLys: 3.329 ± 0.082
3.945ArgLeu: 3.945 ± 0.097
1.083ArgMet: 1.083 ± 0.055
2.06ArgAsn: 2.06 ± 0.078
1.178ArgPro: 1.178 ± 0.054
1.202ArgGln: 1.202 ± 0.053
2.229ArgArg: 2.229 ± 0.09
1.811ArgSer: 1.811 ± 0.071
2.129ArgThr: 2.129 ± 0.086
2.966ArgVal: 2.966 ± 0.087
0.239ArgTrp: 0.239 ± 0.025
1.757ArgTyr: 1.757 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
5.038SerAla: 5.038 ± 0.109
0.707SerCys: 0.707 ± 0.051
4.161SerAsp: 4.161 ± 0.114
3.872SerGlu: 3.872 ± 0.081
2.821SerPhe: 2.821 ± 0.084
5.292SerGly: 5.292 ± 0.125
0.837SerHis: 0.837 ± 0.043
3.701SerIle: 3.701 ± 0.095
3.838SerLys: 3.838 ± 0.096
4.82SerLeu: 4.82 ± 0.112
1.332SerMet: 1.332 ± 0.07
2.077SerAsn: 2.077 ± 0.076
1.894SerPro: 1.894 ± 0.067
1.183SerGln: 1.183 ± 0.058
2.288SerArg: 2.288 ± 0.071
3.13SerSer: 3.13 ± 0.092
2.833SerThr: 2.833 ± 0.09
4.841SerVal: 4.841 ± 0.111
0.396SerTrp: 0.396 ± 0.036
2.134SerTyr: 2.134 ± 0.069
0.0SerXaa: 0.0 ± 0.0
Thr
5.0ThrAla: 5.0 ± 0.115
0.645ThrCys: 0.645 ± 0.04
3.167ThrAsp: 3.167 ± 0.089
3.291ThrGlu: 3.291 ± 0.088
2.681ThrPhe: 2.681 ± 0.091
4.303ThrGly: 4.303 ± 0.106
0.948ThrHis: 0.948 ± 0.042
3.789ThrIle: 3.789 ± 0.103
3.661ThrLys: 3.661 ± 0.088
5.216ThrLeu: 5.216 ± 0.114
1.131ThrMet: 1.131 ± 0.049
2.07ThrAsn: 2.07 ± 0.075
2.295ThrPro: 2.295 ± 0.074
1.034ThrGln: 1.034 ± 0.049
2.039ThrArg: 2.039 ± 0.076
3.141ThrSer: 3.141 ± 0.091
3.032ThrThr: 3.032 ± 0.096
4.934ThrVal: 4.934 ± 0.116
0.256ThrTrp: 0.256 ± 0.029
1.98ThrTyr: 1.98 ± 0.073
0.0ThrXaa: 0.0 ± 0.0
Val
6.397ValAla: 6.397 ± 0.142
1.223ValCys: 1.223 ± 0.059
4.758ValAsp: 4.758 ± 0.113
5.168ValGlu: 5.168 ± 0.125
4.099ValPhe: 4.099 ± 0.125
5.112ValGly: 5.112 ± 0.116
0.97ValHis: 0.97 ± 0.056
5.799ValIle: 5.799 ± 0.135
6.788ValLys: 6.788 ± 0.127
7.046ValLeu: 7.046 ± 0.133
1.864ValMet: 1.864 ± 0.076
3.808ValAsn: 3.808 ± 0.097
2.575ValPro: 2.575 ± 0.072
1.747ValGln: 1.747 ± 0.06
3.286ValArg: 3.286 ± 0.096
5.192ValSer: 5.192 ± 0.125
4.415ValThr: 4.415 ± 0.105
6.944ValVal: 6.944 ± 0.162
0.474ValTrp: 0.474 ± 0.039
2.845ValTyr: 2.845 ± 0.082
0.0ValXaa: 0.0 ± 0.0
Trp
0.45TrpAla: 0.45 ± 0.036
0.154TrpCys: 0.154 ± 0.02
0.351TrpAsp: 0.351 ± 0.032
0.353TrpGlu: 0.353 ± 0.031
0.377TrpPhe: 0.377 ± 0.031
0.496TrpGly: 0.496 ± 0.042
0.128TrpHis: 0.128 ± 0.018
0.417TrpIle: 0.417 ± 0.035
0.436TrpLys: 0.436 ± 0.03
0.628TrpLeu: 0.628 ± 0.044
0.152TrpMet: 0.152 ± 0.023
0.353TrpAsn: 0.353 ± 0.028
0.147TrpPro: 0.147 ± 0.02
0.254TrpGln: 0.254 ± 0.028
0.296TrpArg: 0.296 ± 0.027
0.28TrpSer: 0.28 ± 0.027
0.396TrpThr: 0.396 ± 0.033
0.377TrpVal: 0.377 ± 0.033
0.119TrpTrp: 0.119 ± 0.019
0.325TrpTyr: 0.325 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.885TyrAla: 2.885 ± 0.085
0.586TyrCys: 0.586 ± 0.038
3.12TyrAsp: 3.12 ± 0.101
2.565TyrGlu: 2.565 ± 0.092
2.06TyrPhe: 2.06 ± 0.079
2.779TyrGly: 2.779 ± 0.078
0.526TyrHis: 0.526 ± 0.039
2.283TyrIle: 2.283 ± 0.075
3.111TyrLys: 3.111 ± 0.096
3.224TyrLeu: 3.224 ± 0.088
0.801TyrMet: 0.801 ± 0.045
1.904TyrAsn: 1.904 ± 0.072
1.323TyrPro: 1.323 ± 0.052
0.842TyrGln: 0.842 ± 0.044
1.57TyrArg: 1.57 ± 0.073
2.131TyrSer: 2.131 ± 0.081
1.992TyrThr: 1.992 ± 0.08
3.281TyrVal: 3.281 ± 0.101
0.275TyrTrp: 0.275 ± 0.03
1.759TyrTyr: 1.759 ± 0.08
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1346 proteins (421787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski