Amino acid dipepetide frequency for Mycobacterium sp. 1245111.1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.702AlaAla: 19.702 ± 0.167	0.945AlaCys: 0.945 ± 0.028	8.409AlaAsp: 8.409 ± 0.068	7.511AlaGlu: 7.511 ± 0.085	3.513AlaPhe: 3.513 ± 0.05	11.504AlaGly: 11.504 ± 0.092	2.725AlaHis: 2.725 ± 0.042	5.538AlaIle: 5.538 ± 0.063	3.271AlaLys: 3.271 ± 0.048	12.583AlaLeu: 12.583 ± 0.103	2.914AlaMet: 2.914 ± 0.041	2.936AlaAsn: 2.936 ± 0.049	5.99AlaPro: 5.99 ± 0.075	4.077AlaGln: 4.077 ± 0.053	8.127AlaArg: 8.127 ± 0.074	6.247AlaSer: 6.247 ± 0.062	7.273AlaThr: 7.273 ± 0.07	11.152AlaVal: 11.152 ± 0.091	1.657AlaTrp: 1.657 ± 0.033	2.277AlaTyr: 2.277 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.043CysAla: 1.043 ± 0.026	0.079CysCys: 0.079 ± 0.007	0.579CysAsp: 0.579 ± 0.017	0.421CysGlu: 0.421 ± 0.016	0.246CysPhe: 0.246 ± 0.014	0.903CysGly: 0.903 ± 0.027	0.192CysHis: 0.192 ± 0.01	0.282CysIle: 0.282 ± 0.014	0.149CysLys: 0.149 ± 0.01	0.659CysLeu: 0.659 ± 0.02	0.124CysMet: 0.124 ± 0.008	0.18CysAsn: 0.18 ± 0.011	0.509CysPro: 0.509 ± 0.018	0.232CysGln: 0.232 ± 0.012	0.58CysArg: 0.58 ± 0.02	0.525CysSer: 0.525 ± 0.017	0.458CysThr: 0.458 ± 0.018	0.639CysVal: 0.639 ± 0.02	0.133CysTrp: 0.133 ± 0.009	0.201CysTyr: 0.201 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.88AspAla: 7.88 ± 0.086	0.476AspCys: 0.476 ± 0.017	4.656AspAsp: 4.656 ± 0.072	4.109AspGlu: 4.109 ± 0.061	1.995AspPhe: 1.995 ± 0.034	5.987AspGly: 5.987 ± 0.072	1.579AspHis: 1.579 ± 0.035	2.783AspIle: 2.783 ± 0.049	1.44AspLys: 1.44 ± 0.036	6.007AspLeu: 6.007 ± 0.067	1.086AspMet: 1.086 ± 0.025	1.395AspAsn: 1.395 ± 0.032	4.364AspPro: 4.364 ± 0.053	1.904AspGln: 1.904 ± 0.036	4.421AspArg: 4.421 ± 0.055	2.971AspSer: 2.971 ± 0.04	3.129AspThr: 3.129 ± 0.043	5.517AspVal: 5.517 ± 0.058	1.05AspTrp: 1.05 ± 0.029	1.515AspTyr: 1.515 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.072GluAla: 6.072 ± 0.08	0.357GluCys: 0.357 ± 0.015	2.422GluAsp: 2.422 ± 0.037	2.418GluGlu: 2.418 ± 0.047	1.891GluPhe: 1.891 ± 0.035	3.221GluGly: 3.221 ± 0.043	1.596GluHis: 1.596 ± 0.031	2.759GluIle: 2.759 ± 0.046	1.43GluLys: 1.43 ± 0.037	6.689GluLeu: 6.689 ± 0.077	1.1GluMet: 1.1 ± 0.025	1.146GluAsn: 1.146 ± 0.027	3.016GluPro: 3.016 ± 0.05	2.233GluGln: 2.233 ± 0.038	4.21GluArg: 4.21 ± 0.06	2.752GluSer: 2.752 ± 0.045	2.668GluThr: 2.668 ± 0.044	4.253GluVal: 4.253 ± 0.053	0.795GluTrp: 0.795 ± 0.024	1.128GluTyr: 1.128 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.11PheAla: 4.11 ± 0.058	0.331PheCys: 0.331 ± 0.013	2.637PheAsp: 2.637 ± 0.047	1.65PheGlu: 1.65 ± 0.033	1.024PhePhe: 1.024 ± 0.028	3.442PheGly: 3.442 ± 0.05	0.678PheHis: 0.678 ± 0.02	1.13PheIle: 1.13 ± 0.026	0.577PheLys: 0.577 ± 0.019	2.507PheLeu: 2.507 ± 0.045	0.551PheMet: 0.551 ± 0.018	0.8PheAsn: 0.8 ± 0.024	1.563PhePro: 1.563 ± 0.034	0.739PheGln: 0.739 ± 0.019	1.642PheArg: 1.642 ± 0.025	1.876PheSer: 1.876 ± 0.039	2.084PheThr: 2.084 ± 0.034	2.606PheVal: 2.606 ± 0.041	0.445PheTrp: 0.445 ± 0.016	0.771PheTyr: 0.771 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	9.73GlyAla: 9.73 ± 0.092	0.782GlyCys: 0.782 ± 0.021	5.146GlyAsp: 5.146 ± 0.058	4.31GlyGlu: 4.31 ± 0.058	3.038GlyPhe: 3.038 ± 0.042	7.782GlyGly: 7.782 ± 0.175	2.111GlyHis: 2.111 ± 0.042	4.118GlyIle: 4.118 ± 0.055	2.435GlyLys: 2.435 ± 0.038	8.458GlyLeu: 8.458 ± 0.074	2.152GlyMet: 2.152 ± 0.037	2.114GlyAsn: 2.114 ± 0.066	4.558GlyPro: 4.558 ± 0.057	2.914GlyGln: 2.914 ± 0.047	5.933GlyArg: 5.933 ± 0.059	5.364GlySer: 5.364 ± 0.057	5.039GlyThr: 5.039 ± 0.066	7.328GlyVal: 7.328 ± 0.067	1.613GlyTrp: 1.613 ± 0.032	2.433GlyTyr: 2.433 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.62HisAla: 2.62 ± 0.04	0.238HisCys: 0.238 ± 0.011	1.504HisAsp: 1.504 ± 0.032	1.133HisGlu: 1.133 ± 0.029	0.708HisPhe: 0.708 ± 0.021	2.238HisGly: 2.238 ± 0.038	0.732HisHis: 0.732 ± 0.023	0.955HisIle: 0.955 ± 0.028	0.414HisLys: 0.414 ± 0.014	2.189HisLeu: 2.189 ± 0.041	0.367HisMet: 0.367 ± 0.015	0.56HisAsn: 0.56 ± 0.021	1.718HisPro: 1.718 ± 0.035	0.752HisGln: 0.752 ± 0.022	1.919HisArg: 1.919 ± 0.033	1.195HisSer: 1.195 ± 0.024	1.266HisThr: 1.266 ± 0.025	1.81HisVal: 1.81 ± 0.033	0.426HisTrp: 0.426 ± 0.017	0.598HisTyr: 0.598 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.48IleAla: 6.48 ± 0.066	0.426IleCys: 0.426 ± 0.017	3.62IleAsp: 3.62 ± 0.047	2.802IleGlu: 2.802 ± 0.046	1.122IlePhe: 1.122 ± 0.028	4.532IleGly: 4.532 ± 0.053	0.918IleHis: 0.918 ± 0.022	1.479IleIle: 1.479 ± 0.034	0.98IleLys: 0.98 ± 0.027	2.981IleLeu: 2.981 ± 0.048	0.632IleMet: 0.632 ± 0.019	1.274IleAsn: 1.274 ± 0.028	2.495IlePro: 2.495 ± 0.035	1.039IleGln: 1.039 ± 0.028	2.671IleArg: 2.671 ± 0.04	2.486IleSer: 2.486 ± 0.038	2.832IleThr: 2.832 ± 0.039	3.747IleVal: 3.747 ± 0.053	0.507IleTrp: 0.507 ± 0.018	0.855IleTyr: 0.855 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.807LysAla: 2.807 ± 0.052	0.129LysCys: 0.129 ± 0.009	1.273LysAsp: 1.273 ± 0.033	1.015LysGlu: 1.015 ± 0.03	0.688LysPhe: 0.688 ± 0.023	1.66LysGly: 1.66 ± 0.037	0.577LysHis: 0.577 ± 0.02	1.111LysIle: 1.111 ± 0.027	0.707LysLys: 0.707 ± 0.026	2.414LysLeu: 2.414 ± 0.043	0.516LysMet: 0.516 ± 0.018	0.543LysAsn: 0.543 ± 0.018	1.566LysPro: 1.566 ± 0.034	0.789LysGln: 0.789 ± 0.025	1.682LysArg: 1.682 ± 0.035	1.352LysSer: 1.352 ± 0.031	1.457LysThr: 1.457 ± 0.034	2.07LysVal: 2.07 ± 0.041	0.333LysTrp: 0.333 ± 0.012	0.525LysTyr: 0.525 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	13.804LeuAla: 13.804 ± 0.118	0.83LeuCys: 0.83 ± 0.025	6.527LeuAsp: 6.527 ± 0.076	4.378LeuGlu: 4.378 ± 0.057	2.734LeuPhe: 2.734 ± 0.042	8.447LeuGly: 8.447 ± 0.077	2.187LeuHis: 2.187 ± 0.036	4.203LeuIle: 4.203 ± 0.055	1.965LeuLys: 1.965 ± 0.039	9.389LeuLeu: 9.389 ± 0.1	1.801LeuMet: 1.801 ± 0.029	2.298LeuAsn: 2.298 ± 0.042	5.788LeuPro: 5.788 ± 0.058	2.686LeuGln: 2.686 ± 0.046	7.324LeuArg: 7.324 ± 0.075	5.796LeuSer: 5.796 ± 0.057	6.277LeuThr: 6.277 ± 0.069	8.035LeuVal: 8.035 ± 0.082	1.243LeuTrp: 1.243 ± 0.03	1.696LeuTyr: 1.696 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.648MetAla: 2.648 ± 0.048	0.181MetCys: 0.181 ± 0.01	0.9MetAsp: 0.9 ± 0.023	0.727MetGlu: 0.727 ± 0.023	0.636MetPhe: 0.636 ± 0.022	1.488MetGly: 1.488 ± 0.032	0.44MetHis: 0.44 ± 0.017	0.921MetIle: 0.921 ± 0.028	0.493MetLys: 0.493 ± 0.019	2.108MetLeu: 2.108 ± 0.034	0.453MetMet: 0.453 ± 0.016	0.55MetAsn: 0.55 ± 0.022	1.291MetPro: 1.291 ± 0.031	0.591MetGln: 0.591 ± 0.019	1.587MetArg: 1.587 ± 0.029	1.623MetSer: 1.623 ± 0.035	1.817MetThr: 1.817 ± 0.034	1.578MetVal: 1.578 ± 0.03	0.284MetTrp: 0.284 ± 0.014	0.348MetTyr: 0.348 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.952AsnAla: 2.952 ± 0.041	0.193AsnCys: 0.193 ± 0.012	1.374AsnAsp: 1.374 ± 0.028	1.112AsnGlu: 1.112 ± 0.036	0.792AsnPhe: 0.792 ± 0.023	2.384AsnGly: 2.384 ± 0.066	0.508AsnHis: 0.508 ± 0.019	1.044AsnIle: 1.044 ± 0.021	0.506AsnLys: 0.506 ± 0.017	2.185AsnLeu: 2.185 ± 0.037	0.456AsnMet: 0.456 ± 0.017	0.65AsnAsn: 0.65 ± 0.022	1.855AsnPro: 1.855 ± 0.032	0.706AsnGln: 0.706 ± 0.023	1.669AsnArg: 1.669 ± 0.035	1.311AsnSer: 1.311 ± 0.027	1.371AsnThr: 1.371 ± 0.031	1.903AsnVal: 1.903 ± 0.036	0.41AsnTrp: 0.41 ± 0.017	0.613AsnTyr: 0.613 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	7.094ProAla: 7.094 ± 0.08	0.294ProCys: 0.294 ± 0.015	4.408ProAsp: 4.408 ± 0.048	3.545ProGlu: 3.545 ± 0.048	1.738ProPhe: 1.738 ± 0.035	5.517ProGly: 5.517 ± 0.068	1.296ProHis: 1.296 ± 0.028	2.348ProIle: 2.348 ± 0.04	1.416ProLys: 1.416 ± 0.027	4.928ProLeu: 4.928 ± 0.062	1.226ProMet: 1.226 ± 0.026	1.432ProAsn: 1.432 ± 0.03	3.832ProPro: 3.832 ± 0.081	1.913ProGln: 1.913 ± 0.034	3.318ProArg: 3.318 ± 0.043	3.258ProSer: 3.258 ± 0.05	3.448ProThr: 3.448 ± 0.048	4.8ProVal: 4.8 ± 0.064	0.86ProTrp: 0.86 ± 0.024	1.254ProTyr: 1.254 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.727GlnAla: 3.727 ± 0.052	0.236GlnCys: 0.236 ± 0.013	1.295GlnAsp: 1.295 ± 0.028	1.136GlnGlu: 1.136 ± 0.028	1.074GlnPhe: 1.074 ± 0.027	1.996GlnGly: 1.996 ± 0.037	0.893GlnHis: 0.893 ± 0.023	1.581GlnIle: 1.581 ± 0.034	0.69GlnLys: 0.69 ± 0.024	3.79GlnLeu: 3.79 ± 0.055	0.681GlnMet: 0.681 ± 0.021	0.674GlnAsn: 0.674 ± 0.021	2.031GlnPro: 2.031 ± 0.037	1.339GlnGln: 1.339 ± 0.031	2.919GlnArg: 2.919 ± 0.046	1.574GlnSer: 1.574 ± 0.029	1.664GlnThr: 1.664 ± 0.027	2.515GlnVal: 2.515 ± 0.04	0.614GlnTrp: 0.614 ± 0.021	0.702GlnTyr: 0.702 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.857ArgAla: 7.857 ± 0.073	0.608ArgCys: 0.608 ± 0.02	4.284ArgAsp: 4.284 ± 0.057	3.679ArgGlu: 3.679 ± 0.053	2.344ArgPhe: 2.344 ± 0.039	5.072ArgGly: 5.072 ± 0.063	1.758ArgHis: 1.758 ± 0.038	3.355ArgIle: 3.355 ± 0.042	1.634ArgLys: 1.634 ± 0.031	7.427ArgLeu: 7.427 ± 0.078	1.713ArgMet: 1.713 ± 0.029	1.631ArgAsn: 1.631 ± 0.032	3.817ArgPro: 3.817 ± 0.048	2.389ArgGln: 2.389 ± 0.043	6.395ArgArg: 6.395 ± 0.084	3.922ArgSer: 3.922 ± 0.052	3.781ArgThr: 3.781 ± 0.049	5.432ArgVal: 5.432 ± 0.052	1.354ArgTrp: 1.354 ± 0.032	1.922ArgTyr: 1.922 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	7.184SerAla: 7.184 ± 0.071	0.434SerCys: 0.434 ± 0.017	3.351SerAsp: 3.351 ± 0.047	2.686SerGlu: 2.686 ± 0.044	1.746SerPhe: 1.746 ± 0.034	5.691SerGly: 5.691 ± 0.063	1.142SerHis: 1.142 ± 0.028	2.381SerIle: 2.381 ± 0.038	1.266SerLys: 1.266 ± 0.028	4.98SerLeu: 4.98 ± 0.055	1.437SerMet: 1.437 ± 0.026	1.265SerAsn: 1.265 ± 0.029	3.176SerPro: 3.176 ± 0.053	1.656SerGln: 1.656 ± 0.033	3.744SerArg: 3.744 ± 0.048	3.362SerSer: 3.362 ± 0.049	3.512SerThr: 3.512 ± 0.049	4.598SerVal: 4.598 ± 0.058	0.917SerTrp: 0.917 ± 0.022	1.31SerTyr: 1.31 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.666ThrAla: 7.666 ± 0.082	0.403ThrCys: 0.403 ± 0.017	3.664ThrAsp: 3.664 ± 0.041	3.107ThrGlu: 3.107 ± 0.035	1.854ThrPhe: 1.854 ± 0.035	5.635ThrGly: 5.635 ± 0.075	1.208ThrHis: 1.208 ± 0.028	2.559ThrIle: 2.559 ± 0.04	1.34ThrLys: 1.34 ± 0.032	5.611ThrLeu: 5.611 ± 0.063	1.236ThrMet: 1.236 ± 0.026	1.339ThrAsn: 1.339 ± 0.032	3.732ThrPro: 3.732 ± 0.05	1.561ThrGln: 1.561 ± 0.032	3.531ThrArg: 3.531 ± 0.054	3.311ThrSer: 3.311 ± 0.043	3.799ThrThr: 3.799 ± 0.06	5.456ThrVal: 5.456 ± 0.061	0.91ThrTrp: 0.91 ± 0.022	1.316ThrTyr: 1.316 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	10.915ValAla: 10.915 ± 0.099	0.751ValCys: 0.751 ± 0.02	5.878ValAsp: 5.878 ± 0.068	4.572ValGlu: 4.572 ± 0.061	2.657ValPhe: 2.657 ± 0.037	6.824ValGly: 6.824 ± 0.067	1.898ValHis: 1.898 ± 0.035	3.956ValIle: 3.956 ± 0.047	1.776ValLys: 1.776 ± 0.037	8.358ValLeu: 8.358 ± 0.081	1.581ValMet: 1.581 ± 0.033	2.254ValAsn: 2.254 ± 0.042	4.465ValPro: 4.465 ± 0.056	2.147ValGln: 2.147 ± 0.033	5.597ValArg: 5.597 ± 0.06	4.712ValSer: 4.712 ± 0.055	5.295ValThr: 5.295 ± 0.062	8.133ValVal: 8.133 ± 0.087	1.042ValTrp: 1.042 ± 0.026	1.559ValTyr: 1.559 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.58TrpAla: 1.58 ± 0.033	0.178TrpCys: 0.178 ± 0.011	0.905TrpAsp: 0.905 ± 0.028	0.701TrpGlu: 0.701 ± 0.019	0.518TrpPhe: 0.518 ± 0.021	1.034TrpGly: 1.034 ± 0.029	0.385TrpHis: 0.385 ± 0.015	0.679TrpIle: 0.679 ± 0.019	0.332TrpLys: 0.332 ± 0.014	1.786TrpLeu: 1.786 ± 0.041	0.334TrpMet: 0.334 ± 0.015	0.429TrpAsn: 0.429 ± 0.016	0.832TrpPro: 0.832 ± 0.018	0.685TrpGln: 0.685 ± 0.019	1.266TrpArg: 1.266 ± 0.033	0.99TrpSer: 0.99 ± 0.028	0.897TrpThr: 0.897 ± 0.027	1.104TrpVal: 1.104 ± 0.026	0.339TrpTrp: 0.339 ± 0.016	0.345TrpTyr: 0.345 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.478TyrAla: 2.478 ± 0.037	0.262TyrCys: 0.262 ± 0.013	1.431TyrAsp: 1.431 ± 0.03	1.142TyrGlu: 1.142 ± 0.029	0.848TyrPhe: 0.848 ± 0.023	2.002TyrGly: 2.002 ± 0.043	0.519TyrHis: 0.519 ± 0.017	0.694TyrIle: 0.694 ± 0.024	0.394TyrLys: 0.394 ± 0.016	2.357TyrLeu: 2.357 ± 0.036	0.3TyrMet: 0.3 ± 0.014	0.527TyrAsn: 0.527 ± 0.02	1.327TyrPro: 1.327 ± 0.03	0.779TyrGln: 0.779 ± 0.021	1.84TyrArg: 1.84 ± 0.035	1.211TyrSer: 1.211 ± 0.025	1.172TyrThr: 1.172 ± 0.025	1.697TyrVal: 1.697 ± 0.035	0.386TyrTrp: 0.386 ± 0.016	0.519TyrTyr: 0.519 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5178 proteins (1648677 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---