Amino acid dipepetide frequency for Mycobacterium phage DmpstrDiver

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.733AlaAla: 10.733 ± 0.775
1.082AlaCys: 1.082 ± 0.184
6.463AlaAsp: 6.463 ± 0.457
7.374AlaGlu: 7.374 ± 0.545
3.53AlaPhe: 3.53 ± 0.289
7.402AlaGly: 7.402 ± 0.751
2.335AlaHis: 2.335 ± 0.315
4.897AlaIle: 4.897 ± 0.413
4.014AlaLys: 4.014 ± 0.352
8.541AlaLeu: 8.541 ± 0.565
3.388AlaMet: 3.388 ± 0.358
3.274AlaAsn: 3.274 ± 0.366
4.185AlaPro: 4.185 ± 0.369
2.847AlaGln: 2.847 ± 0.322
6.918AlaArg: 6.918 ± 0.508
4.868AlaSer: 4.868 ± 0.364
4.925AlaThr: 4.925 ± 0.319
6.491AlaVal: 6.491 ± 0.376
1.964AlaTrp: 1.964 ± 0.226
2.847AlaTyr: 2.847 ± 0.268
0.0AlaXaa: 0.0 ± 0.0
Cys
1.11CysAla: 1.11 ± 0.219
0.114CysCys: 0.114 ± 0.058
1.196CysAsp: 1.196 ± 0.211
1.253CysGlu: 1.253 ± 0.229
0.399CysPhe: 0.399 ± 0.108
1.936CysGly: 1.936 ± 0.292
0.37CysHis: 0.37 ± 0.125
0.655CysIle: 0.655 ± 0.163
0.769CysLys: 0.769 ± 0.153
0.968CysLeu: 0.968 ± 0.186
0.37CysMet: 0.37 ± 0.114
0.712CysAsn: 0.712 ± 0.162
0.797CysPro: 0.797 ± 0.166
0.399CysGln: 0.399 ± 0.103
0.996CysArg: 0.996 ± 0.231
0.712CysSer: 0.712 ± 0.145
0.826CysThr: 0.826 ± 0.161
0.74CysVal: 0.74 ± 0.158
0.256CysTrp: 0.256 ± 0.077
0.456CysTyr: 0.456 ± 0.129
0.0CysXaa: 0.0 ± 0.0
Asp
5.865AspAla: 5.865 ± 0.398
0.94AspCys: 0.94 ± 0.189
4.299AspAsp: 4.299 ± 0.413
5.239AspGlu: 5.239 ± 0.498
2.249AspPhe: 2.249 ± 0.218
6.975AspGly: 6.975 ± 0.501
1.993AspHis: 1.993 ± 0.268
3.331AspIle: 3.331 ± 0.301
2.278AspLys: 2.278 ± 0.257
5.409AspLeu: 5.409 ± 0.393
0.968AspMet: 0.968 ± 0.152
2.164AspAsn: 2.164 ± 0.274
3.103AspPro: 3.103 ± 0.306
2.078AspGln: 2.078 ± 0.201
4.328AspArg: 4.328 ± 0.334
3.018AspSer: 3.018 ± 0.321
3.16AspThr: 3.16 ± 0.283
4.128AspVal: 4.128 ± 0.322
1.993AspTrp: 1.993 ± 0.257
2.363AspTyr: 2.363 ± 0.263
0.0AspXaa: 0.0 ± 0.0
Glu
7.004GluAla: 7.004 ± 0.567
1.196GluCys: 1.196 ± 0.207
4.271GluAsp: 4.271 ± 0.353
5.153GluGlu: 5.153 ± 0.478
2.904GluPhe: 2.904 ± 0.29
4.014GluGly: 4.014 ± 0.312
1.48GluHis: 1.48 ± 0.228
3.815GluIle: 3.815 ± 0.343
2.477GluLys: 2.477 ± 0.381
6.548GluLeu: 6.548 ± 0.482
2.534GluMet: 2.534 ± 0.305
1.765GluAsn: 1.765 ± 0.247
3.36GluPro: 3.36 ± 0.314
2.562GluGln: 2.562 ± 0.251
5.068GluArg: 5.068 ± 0.428
3.416GluSer: 3.416 ± 0.355
3.701GluThr: 3.701 ± 0.313
4.498GluVal: 4.498 ± 0.356
1.424GluTrp: 1.424 ± 0.204
2.676GluTyr: 2.676 ± 0.341
0.0GluXaa: 0.0 ± 0.0
Phe
2.562PheAla: 2.562 ± 0.261
0.512PheCys: 0.512 ± 0.11
2.534PheAsp: 2.534 ± 0.327
2.192PheGlu: 2.192 ± 0.265
1.053PhePhe: 1.053 ± 0.162
3.189PheGly: 3.189 ± 0.366
0.655PheHis: 0.655 ± 0.172
1.395PheIle: 1.395 ± 0.181
1.11PheLys: 1.11 ± 0.168
2.107PheLeu: 2.107 ± 0.257
0.74PheMet: 0.74 ± 0.123
1.395PheAsn: 1.395 ± 0.18
1.822PhePro: 1.822 ± 0.266
0.826PheGln: 0.826 ± 0.184
1.851PheArg: 1.851 ± 0.218
1.964PheSer: 1.964 ± 0.244
1.993PheThr: 1.993 ± 0.226
2.249PheVal: 2.249 ± 0.232
0.598PheTrp: 0.598 ± 0.132
0.826PheTyr: 0.826 ± 0.158
0.0PheXaa: 0.0 ± 0.0
Gly
7.232GlyAla: 7.232 ± 0.69
1.424GlyCys: 1.424 ± 0.237
5.466GlyAsp: 5.466 ± 0.399
5.523GlyGlu: 5.523 ± 0.372
3.16GlyPhe: 3.16 ± 0.358
9.054GlyGly: 9.054 ± 1.774
2.078GlyHis: 2.078 ± 0.234
3.559GlyIle: 3.559 ± 0.377
3.9GlyLys: 3.9 ± 0.406
7.345GlyLeu: 7.345 ± 0.546
2.05GlyMet: 2.05 ± 0.258
3.246GlyAsn: 3.246 ± 0.324
3.416GlyPro: 3.416 ± 0.316
2.534GlyGln: 2.534 ± 0.344
5.409GlyArg: 5.409 ± 0.371
5.068GlySer: 5.068 ± 0.495
5.267GlyThr: 5.267 ± 0.419
5.523GlyVal: 5.523 ± 0.399
2.164GlyTrp: 2.164 ± 0.288
2.932GlyTyr: 2.932 ± 0.284
0.0GlyXaa: 0.0 ± 0.0
His
1.68HisAla: 1.68 ± 0.215
0.512HisCys: 0.512 ± 0.147
1.708HisAsp: 1.708 ± 0.244
1.708HisGlu: 1.708 ± 0.223
0.569HisPhe: 0.569 ± 0.15
2.164HisGly: 2.164 ± 0.239
0.854HisHis: 0.854 ± 0.159
1.025HisIle: 1.025 ± 0.213
0.797HisLys: 0.797 ± 0.161
2.448HisLeu: 2.448 ± 0.253
0.484HisMet: 0.484 ± 0.109
0.626HisAsn: 0.626 ± 0.143
1.737HisPro: 1.737 ± 0.209
0.94HisGln: 0.94 ± 0.16
1.993HisArg: 1.993 ± 0.231
0.826HisSer: 0.826 ± 0.151
0.655HisThr: 0.655 ± 0.147
1.31HisVal: 1.31 ± 0.189
0.74HisTrp: 0.74 ± 0.15
0.854HisTyr: 0.854 ± 0.149
0.0HisXaa: 0.0 ± 0.0
Ile
5.466IleAla: 5.466 ± 0.397
0.683IleCys: 0.683 ± 0.136
3.986IleAsp: 3.986 ± 0.3
3.758IleGlu: 3.758 ± 0.288
0.996IlePhe: 0.996 ± 0.158
3.957IleGly: 3.957 ± 0.402
1.253IleHis: 1.253 ± 0.194
2.078IleIle: 2.078 ± 0.244
1.651IleLys: 1.651 ± 0.2
3.616IleLeu: 3.616 ± 0.319
0.826IleMet: 0.826 ± 0.15
1.879IleAsn: 1.879 ± 0.238
2.989IlePro: 2.989 ± 0.305
1.367IleGln: 1.367 ± 0.192
2.676IleArg: 2.676 ± 0.272
2.335IleSer: 2.335 ± 0.244
3.018IleThr: 3.018 ± 0.332
3.388IleVal: 3.388 ± 0.303
0.797IleTrp: 0.797 ± 0.151
1.424IleTyr: 1.424 ± 0.198
0.0IleXaa: 0.0 ± 0.0
Lys
4.185LysAla: 4.185 ± 0.457
0.797LysCys: 0.797 ± 0.161
1.822LysAsp: 1.822 ± 0.225
2.078LysGlu: 2.078 ± 0.26
1.025LysPhe: 1.025 ± 0.166
3.189LysGly: 3.189 ± 0.221
1.082LysHis: 1.082 ± 0.187
1.936LysIle: 1.936 ± 0.278
2.021LysLys: 2.021 ± 0.32
3.587LysLeu: 3.587 ± 0.327
1.537LysMet: 1.537 ± 0.198
0.797LysAsn: 0.797 ± 0.173
2.762LysPro: 2.762 ± 0.289
0.968LysGln: 0.968 ± 0.197
2.961LysArg: 2.961 ± 0.314
2.164LysSer: 2.164 ± 0.363
1.708LysThr: 1.708 ± 0.222
3.075LysVal: 3.075 ± 0.331
0.996LysTrp: 0.996 ± 0.17
1.053LysTyr: 1.053 ± 0.147
0.0LysXaa: 0.0 ± 0.0
Leu
8.854LeuAla: 8.854 ± 0.55
1.025LeuCys: 1.025 ± 0.202
5.609LeuAsp: 5.609 ± 0.363
5.352LeuGlu: 5.352 ± 0.46
2.392LeuPhe: 2.392 ± 0.276
6.833LeuGly: 6.833 ± 0.438
1.879LeuHis: 1.879 ± 0.233
3.075LeuIle: 3.075 ± 0.33
3.132LeuLys: 3.132 ± 0.256
6.235LeuLeu: 6.235 ± 0.519
1.936LeuMet: 1.936 ± 0.221
3.075LeuAsn: 3.075 ± 0.263
4.242LeuPro: 4.242 ± 0.357
2.534LeuGln: 2.534 ± 0.305
5.409LeuArg: 5.409 ± 0.41
5.324LeuSer: 5.324 ± 0.36
5.21LeuThr: 5.21 ± 0.326
5.125LeuVal: 5.125 ± 0.4
1.623LeuTrp: 1.623 ± 0.203
2.078LeuTyr: 2.078 ± 0.291
0.0LeuXaa: 0.0 ± 0.0
Met
2.534MetAla: 2.534 ± 0.261
0.171MetCys: 0.171 ± 0.084
1.424MetAsp: 1.424 ± 0.196
1.452MetGlu: 1.452 ± 0.221
0.655MetPhe: 0.655 ± 0.124
1.851MetGly: 1.851 ± 0.283
0.512MetHis: 0.512 ± 0.106
1.537MetIle: 1.537 ± 0.202
1.224MetLys: 1.224 ± 0.186
1.395MetLeu: 1.395 ± 0.211
0.541MetMet: 0.541 ± 0.121
1.025MetAsn: 1.025 ± 0.157
1.253MetPro: 1.253 ± 0.203
0.598MetGln: 0.598 ± 0.127
1.31MetArg: 1.31 ± 0.167
2.676MetSer: 2.676 ± 0.284
2.164MetThr: 2.164 ± 0.3
1.11MetVal: 1.11 ± 0.199
0.399MetTrp: 0.399 ± 0.1
0.484MetTyr: 0.484 ± 0.12
0.0MetXaa: 0.0 ± 0.0
Asn
3.103AsnAla: 3.103 ± 0.34
0.342AsnCys: 0.342 ± 0.097
1.908AsnAsp: 1.908 ± 0.225
1.794AsnGlu: 1.794 ± 0.215
1.025AsnPhe: 1.025 ± 0.192
3.815AsnGly: 3.815 ± 0.306
0.854AsnHis: 0.854 ± 0.15
1.31AsnIle: 1.31 ± 0.18
1.281AsnLys: 1.281 ± 0.214
2.876AsnLeu: 2.876 ± 0.328
0.484AsnMet: 0.484 ± 0.125
0.683AsnAsn: 0.683 ± 0.13
2.648AsnPro: 2.648 ± 0.246
0.883AsnGln: 0.883 ± 0.164
2.42AsnArg: 2.42 ± 0.268
1.623AsnSer: 1.623 ± 0.235
1.623AsnThr: 1.623 ± 0.223
2.164AsnVal: 2.164 ± 0.283
0.968AsnTrp: 0.968 ± 0.18
0.94AsnTyr: 0.94 ± 0.173
0.0AsnXaa: 0.0 ± 0.0
Pro
5.125ProAla: 5.125 ± 0.407
0.911ProCys: 0.911 ± 0.182
3.815ProAsp: 3.815 ± 0.378
4.812ProGlu: 4.812 ± 0.455
1.708ProPhe: 1.708 ± 0.243
5.352ProGly: 5.352 ± 0.533
0.911ProHis: 0.911 ± 0.144
2.363ProIle: 2.363 ± 0.253
2.135ProLys: 2.135 ± 0.272
4.1ProLeu: 4.1 ± 0.326
0.996ProMet: 0.996 ± 0.157
1.851ProAsn: 1.851 ± 0.233
2.989ProPro: 2.989 ± 0.31
1.224ProGln: 1.224 ± 0.184
3.416ProArg: 3.416 ± 0.361
2.534ProSer: 2.534 ± 0.268
2.961ProThr: 2.961 ± 0.367
3.9ProVal: 3.9 ± 0.324
1.395ProTrp: 1.395 ± 0.235
1.424ProTyr: 1.424 ± 0.202
0.0ProXaa: 0.0 ± 0.0
Gln
3.274GlnAla: 3.274 ± 0.29
0.626GlnCys: 0.626 ± 0.156
1.053GlnAsp: 1.053 ± 0.169
1.851GlnGlu: 1.851 ± 0.251
1.338GlnPhe: 1.338 ± 0.183
2.05GlnGly: 2.05 ± 0.281
0.74GlnHis: 0.74 ± 0.135
1.651GlnIle: 1.651 ± 0.218
1.851GlnLys: 1.851 ± 0.338
2.562GlnLeu: 2.562 ± 0.27
0.94GlnMet: 0.94 ± 0.154
0.911GlnAsn: 0.911 ± 0.155
1.936GlnPro: 1.936 ± 0.269
1.082GlnGln: 1.082 ± 0.204
2.164GlnArg: 2.164 ± 0.259
1.566GlnSer: 1.566 ± 0.186
1.537GlnThr: 1.537 ± 0.227
2.107GlnVal: 2.107 ± 0.256
0.569GlnTrp: 0.569 ± 0.142
0.541GlnTyr: 0.541 ± 0.117
0.0GlnXaa: 0.0 ± 0.0
Arg
6.577ArgAla: 6.577 ± 0.537
1.11ArgCys: 1.11 ± 0.211
4.441ArgAsp: 4.441 ± 0.295
4.498ArgGlu: 4.498 ± 0.442
2.05ArgPhe: 2.05 ± 0.225
4.84ArgGly: 4.84 ± 0.345
1.566ArgHis: 1.566 ± 0.227
3.815ArgIle: 3.815 ± 0.353
3.018ArgLys: 3.018 ± 0.302
5.239ArgLeu: 5.239 ± 0.387
2.05ArgMet: 2.05 ± 0.25
1.964ArgAsn: 1.964 ± 0.198
3.644ArgPro: 3.644 ± 0.356
2.534ArgGln: 2.534 ± 0.304
5.666ArgArg: 5.666 ± 0.493
3.274ArgSer: 3.274 ± 0.278
3.388ArgThr: 3.388 ± 0.423
4.498ArgVal: 4.498 ± 0.388
2.135ArgTrp: 2.135 ± 0.267
2.05ArgTyr: 2.05 ± 0.269
0.0ArgXaa: 0.0 ± 0.0
Ser
6.007SerAla: 6.007 ± 0.463
0.74SerCys: 0.74 ± 0.159
3.616SerAsp: 3.616 ± 0.336
4.071SerGlu: 4.071 ± 0.385
1.338SerPhe: 1.338 ± 0.192
5.096SerGly: 5.096 ± 0.636
1.11SerHis: 1.11 ± 0.17
2.904SerIle: 2.904 ± 0.236
1.851SerLys: 1.851 ± 0.261
4.555SerLeu: 4.555 ± 0.359
1.509SerMet: 1.509 ± 0.202
1.822SerAsn: 1.822 ± 0.226
2.961SerPro: 2.961 ± 0.287
1.367SerGln: 1.367 ± 0.193
3.502SerArg: 3.502 ± 0.307
3.303SerSer: 3.303 ± 0.332
2.932SerThr: 2.932 ± 0.327
3.416SerVal: 3.416 ± 0.345
1.68SerTrp: 1.68 ± 0.222
1.31SerTyr: 1.31 ± 0.195
0.0SerXaa: 0.0 ± 0.0
Thr
4.698ThrAla: 4.698 ± 0.392
1.053ThrCys: 1.053 ± 0.187
3.217ThrAsp: 3.217 ± 0.275
3.189ThrGlu: 3.189 ± 0.302
2.021ThrPhe: 2.021 ± 0.244
5.239ThrGly: 5.239 ± 0.453
1.167ThrHis: 1.167 ± 0.183
3.189ThrIle: 3.189 ± 0.388
1.908ThrLys: 1.908 ± 0.27
4.612ThrLeu: 4.612 ± 0.325
0.911ThrMet: 0.911 ± 0.202
1.68ThrAsn: 1.68 ± 0.275
4.413ThrPro: 4.413 ± 0.4
1.395ThrGln: 1.395 ± 0.213
3.046ThrArg: 3.046 ± 0.247
2.932ThrSer: 2.932 ± 0.294
2.876ThrThr: 2.876 ± 0.317
4.498ThrVal: 4.498 ± 0.422
1.367ThrTrp: 1.367 ± 0.221
1.822ThrTyr: 1.822 ± 0.246
0.0ThrXaa: 0.0 ± 0.0
Val
7.146ValAla: 7.146 ± 0.538
0.74ValCys: 0.74 ± 0.177
5.239ValAsp: 5.239 ± 0.42
5.239ValGlu: 5.239 ± 0.38
1.708ValPhe: 1.708 ± 0.221
5.096ValGly: 5.096 ± 0.504
1.537ValHis: 1.537 ± 0.195
3.587ValIle: 3.587 ± 0.304
2.733ValLys: 2.733 ± 0.277
4.441ValLeu: 4.441 ± 0.396
1.082ValMet: 1.082 ± 0.192
2.135ValAsn: 2.135 ± 0.227
3.388ValPro: 3.388 ± 0.307
2.363ValGln: 2.363 ± 0.264
4.584ValArg: 4.584 ± 0.389
4.413ValSer: 4.413 ± 0.342
4.299ValThr: 4.299 ± 0.354
5.296ValVal: 5.296 ± 0.489
0.968ValTrp: 0.968 ± 0.168
1.879ValTyr: 1.879 ± 0.24
0.0ValXaa: 0.0 ± 0.0
Trp
1.737TrpAla: 1.737 ± 0.179
0.512TrpCys: 0.512 ± 0.14
1.509TrpAsp: 1.509 ± 0.211
1.196TrpGlu: 1.196 ± 0.187
0.769TrpPhe: 0.769 ± 0.154
1.452TrpGly: 1.452 ± 0.193
0.712TrpHis: 0.712 ± 0.153
1.082TrpIle: 1.082 ± 0.162
0.74TrpLys: 0.74 ± 0.135
1.936TrpLeu: 1.936 ± 0.259
0.626TrpMet: 0.626 ± 0.121
0.712TrpAsn: 0.712 ± 0.123
1.11TrpPro: 1.11 ± 0.168
0.769TrpGln: 0.769 ± 0.152
2.021TrpArg: 2.021 ± 0.272
1.851TrpSer: 1.851 ± 0.238
1.424TrpThr: 1.424 ± 0.233
2.078TrpVal: 2.078 ± 0.244
0.683TrpTrp: 0.683 ± 0.137
0.626TrpTyr: 0.626 ± 0.153
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.189TyrAla: 3.189 ± 0.309
0.541TyrCys: 0.541 ± 0.133
2.306TyrAsp: 2.306 ± 0.273
2.135TyrGlu: 2.135 ± 0.24
0.683TyrPhe: 0.683 ± 0.142
2.847TyrGly: 2.847 ± 0.269
0.541TyrHis: 0.541 ± 0.118
0.94TyrIle: 0.94 ± 0.181
0.854TyrLys: 0.854 ± 0.148
2.42TyrLeu: 2.42 ± 0.281
0.313TyrMet: 0.313 ± 0.09
1.025TyrAsn: 1.025 ± 0.163
1.167TyrPro: 1.167 ± 0.188
1.082TyrGln: 1.082 ± 0.169
2.648TyrArg: 2.648 ± 0.28
1.224TyrSer: 1.224 ± 0.172
1.566TyrThr: 1.566 ± 0.21
2.278TyrVal: 2.278 ± 0.255
0.826TyrTrp: 0.826 ± 0.153
0.74TyrTyr: 0.74 ± 0.14
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 241 proteins (35125 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski