Amino acid dipepetide frequency for Apis mellifera associated microvirus 42

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.112AlaAla: 9.112 ± 4.063
0.0AlaCys: 0.0 ± 0.0
4.556AlaAsp: 4.556 ± 1.985
4.556AlaGlu: 4.556 ± 1.556
3.037AlaPhe: 3.037 ± 2.393
7.593AlaGly: 7.593 ± 1.519
0.759AlaHis: 0.759 ± 0.537
4.556AlaIle: 4.556 ± 2.017
6.074AlaLys: 6.074 ± 3.085
9.871AlaLeu: 9.871 ± 2.885
3.037AlaMet: 3.037 ± 1.404
3.037AlaAsn: 3.037 ± 1.529
8.352AlaPro: 8.352 ± 2.413
2.278AlaGln: 2.278 ± 0.554
6.834AlaArg: 6.834 ± 1.985
6.074AlaSer: 6.074 ± 0.786
2.278AlaThr: 2.278 ± 0.965
6.834AlaVal: 6.834 ± 1.269
0.0AlaTrp: 0.0 ± 0.0
2.278AlaTyr: 2.278 ± 0.554
0.0AlaXaa: 0.0 ± 0.0
Cys
0.759CysAla: 0.759 ± 0.762
0.759CysCys: 0.759 ± 0.762
1.519CysAsp: 1.519 ± 0.574
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.519CysGly: 1.519 ± 1.523
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.759CysLys: 0.759 ± 0.899
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.759CysGln: 0.759 ± 0.762
1.519CysArg: 1.519 ± 1.523
0.759CysSer: 0.759 ± 0.762
0.0CysThr: 0.0 ± 0.0
1.519CysVal: 1.519 ± 0.881
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.037AspAla: 3.037 ± 0.744
0.0AspCys: 0.0 ± 0.0
1.519AspAsp: 1.519 ± 1.197
3.037AspGlu: 3.037 ± 1.973
4.556AspPhe: 4.556 ± 1.781
3.037AspGly: 3.037 ± 1.101
0.0AspHis: 0.0 ± 0.0
2.278AspIle: 2.278 ± 1.345
0.0AspLys: 0.0 ± 0.0
3.037AspLeu: 3.037 ± 1.599
0.759AspMet: 0.759 ± 0.537
0.0AspAsn: 0.0 ± 0.0
3.037AspPro: 3.037 ± 2.5
2.278AspGln: 2.278 ± 0.554
2.278AspArg: 2.278 ± 1.698
3.037AspSer: 3.037 ± 1.356
3.797AspThr: 3.797 ± 2.516
2.278AspVal: 2.278 ± 0.81
0.759AspTrp: 0.759 ± 0.537
2.278AspTyr: 2.278 ± 1.61
0.0AspXaa: 0.0 ± 0.0
Glu
3.797GluAla: 3.797 ± 0.625
0.0GluCys: 0.0 ± 0.0
5.315GluAsp: 5.315 ± 1.424
5.315GluGlu: 5.315 ± 2.669
3.797GluPhe: 3.797 ± 1.325
3.037GluGly: 3.037 ± 1.493
1.519GluHis: 1.519 ± 1.073
2.278GluIle: 2.278 ± 1.083
3.797GluLys: 3.797 ± 1.619
3.037GluLeu: 3.037 ± 1.597
1.519GluMet: 1.519 ± 1.073
3.037GluAsn: 3.037 ± 1.949
1.519GluPro: 1.519 ± 0.851
3.037GluGln: 3.037 ± 0.994
3.037GluArg: 3.037 ± 0.703
2.278GluSer: 2.278 ± 0.554
0.759GluThr: 0.759 ± 0.681
6.074GluVal: 6.074 ± 1.833
0.759GluTrp: 0.759 ± 0.762
4.556GluTyr: 4.556 ± 1.723
0.0GluXaa: 0.0 ± 0.0
Phe
3.797PheAla: 3.797 ± 1.156
0.0PheCys: 0.0 ± 0.0
2.278PheAsp: 2.278 ± 1.628
2.278PheGlu: 2.278 ± 1.174
2.278PhePhe: 2.278 ± 0.554
4.556PheGly: 4.556 ± 1.002
0.0PheHis: 0.0 ± 0.0
2.278PheIle: 2.278 ± 1.174
1.519PheLys: 1.519 ± 1.135
2.278PheLeu: 2.278 ± 2.285
1.519PheMet: 1.519 ± 0.851
0.0PheAsn: 0.0 ± 0.0
0.759PhePro: 0.759 ± 0.537
0.759PheGln: 0.759 ± 0.537
1.519PheArg: 1.519 ± 1.073
2.278PheSer: 2.278 ± 1.61
2.278PheThr: 2.278 ± 1.345
2.278PheVal: 2.278 ± 0.81
0.759PheTrp: 0.759 ± 0.537
0.759PheTyr: 0.759 ± 0.537
0.0PheXaa: 0.0 ± 0.0
Gly
5.315GlyAla: 5.315 ± 2.602
2.278GlyCys: 2.278 ± 2.285
4.556GlyAsp: 4.556 ± 0.994
5.315GlyGlu: 5.315 ± 0.88
0.759GlyPhe: 0.759 ± 0.537
9.871GlyGly: 9.871 ± 2.295
1.519GlyHis: 1.519 ± 0.574
2.278GlyIle: 2.278 ± 1.345
2.278GlyLys: 2.278 ± 1.238
6.074GlyLeu: 6.074 ± 2.024
0.759GlyMet: 0.759 ± 0.762
3.797GlyAsn: 3.797 ± 1.156
3.797GlyPro: 3.797 ± 1.718
3.797GlyGln: 3.797 ± 1.745
9.112GlyArg: 9.112 ± 3.035
5.315GlySer: 5.315 ± 1.382
6.074GlyThr: 6.074 ± 1.381
6.074GlyVal: 6.074 ± 1.379
0.759GlyTrp: 0.759 ± 0.537
6.074GlyTyr: 6.074 ± 2.231
0.0GlyXaa: 0.0 ± 0.0
His
3.797HisAla: 3.797 ± 1.142
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.759HisGlu: 0.759 ± 0.866
0.0HisPhe: 0.0 ± 0.0
1.519HisGly: 1.519 ± 1.073
1.519HisHis: 1.519 ± 0.881
0.759HisIle: 0.759 ± 0.537
0.0HisLys: 0.0 ± 0.0
0.759HisLeu: 0.759 ± 0.762
0.759HisMet: 0.759 ± 0.537
0.0HisAsn: 0.0 ± 0.0
2.278HisPro: 2.278 ± 0.554
0.0HisGln: 0.0 ± 0.0
2.278HisArg: 2.278 ± 0.847
1.519HisSer: 1.519 ± 1.073
0.759HisThr: 0.759 ± 0.899
2.278HisVal: 2.278 ± 1.238
0.759HisTrp: 0.759 ± 0.537
1.519HisTyr: 1.519 ± 1.523
0.0HisXaa: 0.0 ± 0.0
Ile
3.797IleAla: 3.797 ± 0.996
0.0IleCys: 0.0 ± 0.0
3.797IleAsp: 3.797 ± 0.996
0.759IleGlu: 0.759 ± 0.537
0.759IlePhe: 0.759 ± 0.537
4.556IleGly: 4.556 ± 1.923
0.759IleHis: 0.759 ± 0.537
3.037IleIle: 3.037 ± 1.09
0.0IleLys: 0.0 ± 0.0
3.037IleLeu: 3.037 ± 1.101
0.759IleMet: 0.759 ± 0.681
2.278IleAsn: 2.278 ± 0.554
1.519IlePro: 1.519 ± 0.764
5.315IleGln: 5.315 ± 1.013
6.074IleArg: 6.074 ± 2.043
2.278IleSer: 2.278 ± 0.817
3.797IleThr: 3.797 ± 2.097
0.0IleVal: 0.0 ± 0.0
1.519IleTrp: 1.519 ± 1.073
1.519IleTyr: 1.519 ± 1.073
0.0IleXaa: 0.0 ± 0.0
Lys
6.834LysAla: 6.834 ± 2.891
0.759LysCys: 0.759 ± 0.537
2.278LysAsp: 2.278 ± 1.238
4.556LysGlu: 4.556 ± 0.897
0.759LysPhe: 0.759 ± 0.681
6.074LysGly: 6.074 ± 2.642
2.278LysHis: 2.278 ± 1.17
0.0LysIle: 0.0 ± 0.0
4.556LysLys: 4.556 ± 2.66
4.556LysLeu: 4.556 ± 1.87
0.0LysMet: 0.0 ± 0.0
0.759LysAsn: 0.759 ± 0.762
2.278LysPro: 2.278 ± 1.083
1.519LysGln: 1.519 ± 0.764
4.556LysArg: 4.556 ± 2.233
2.278LysSer: 2.278 ± 1.137
1.519LysThr: 1.519 ± 0.574
1.519LysVal: 1.519 ± 1.064
0.0LysTrp: 0.0 ± 0.0
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
7.593LeuAla: 7.593 ± 1.359
0.759LeuCys: 0.759 ± 0.899
2.278LeuAsp: 2.278 ± 1.662
4.556LeuGlu: 4.556 ± 2.536
1.519LeuPhe: 1.519 ± 1.523
10.63LeuGly: 10.63 ± 3.96
1.519LeuHis: 1.519 ± 1.135
2.278LeuIle: 2.278 ± 0.554
2.278LeuLys: 2.278 ± 2.285
3.037LeuLeu: 3.037 ± 1.248
0.759LeuMet: 0.759 ± 0.785
3.037LeuAsn: 3.037 ± 1.248
5.315LeuPro: 5.315 ± 0.715
7.593LeuGln: 7.593 ± 3.08
6.834LeuArg: 6.834 ± 3.713
4.556LeuSer: 4.556 ± 1.634
5.315LeuThr: 5.315 ± 1.404
4.556LeuVal: 4.556 ± 1.634
0.0LeuTrp: 0.0 ± 0.0
1.519LeuTyr: 1.519 ± 0.764
0.0LeuXaa: 0.0 ± 0.0
Met
3.037MetAla: 3.037 ± 1.285
0.0MetCys: 0.0 ± 0.0
0.759MetAsp: 0.759 ± 0.762
2.278MetGlu: 2.278 ± 0.817
1.519MetPhe: 1.519 ± 0.851
1.519MetGly: 1.519 ± 0.574
1.519MetHis: 1.519 ± 0.574
0.0MetIle: 0.0 ± 0.0
0.759MetLys: 0.759 ± 0.537
0.759MetLeu: 0.759 ± 0.681
0.759MetMet: 0.759 ± 0.762
0.0MetAsn: 0.0 ± 0.0
0.759MetPro: 0.759 ± 0.899
1.519MetGln: 1.519 ± 0.851
1.519MetArg: 1.519 ± 1.073
1.519MetSer: 1.519 ± 0.574
0.0MetThr: 0.0 ± 0.0
1.519MetVal: 1.519 ± 0.899
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.556AsnAla: 4.556 ± 0.994
0.0AsnCys: 0.0 ± 0.0
0.0AsnAsp: 0.0 ± 0.0
1.519AsnGlu: 1.519 ± 1.073
0.0AsnPhe: 0.0 ± 0.0
3.797AsnGly: 3.797 ± 1.855
0.759AsnHis: 0.759 ± 0.537
2.278AsnIle: 2.278 ± 1.131
3.797AsnLys: 3.797 ± 1.332
1.519AsnLeu: 1.519 ± 1.523
0.759AsnMet: 0.759 ± 0.866
3.037AsnAsn: 3.037 ± 1.562
4.556AsnPro: 4.556 ± 2.441
1.519AsnGln: 1.519 ± 1.064
3.037AsnArg: 3.037 ± 0.85
0.759AsnSer: 0.759 ± 0.681
3.037AsnThr: 3.037 ± 1.143
3.037AsnVal: 3.037 ± 1.65
0.0AsnTrp: 0.0 ± 0.0
1.519AsnTyr: 1.519 ± 0.764
0.0AsnXaa: 0.0 ± 0.0
Pro
6.074ProAla: 6.074 ± 2.156
0.759ProCys: 0.759 ± 0.762
3.037ProAsp: 3.037 ± 1.057
5.315ProGlu: 5.315 ± 1.428
2.278ProPhe: 2.278 ± 0.554
6.074ProGly: 6.074 ± 2.693
1.519ProHis: 1.519 ± 0.574
3.037ProIle: 3.037 ± 1.86
0.759ProLys: 0.759 ± 0.537
6.834ProLeu: 6.834 ± 1.352
0.759ProMet: 0.759 ± 0.762
1.519ProAsn: 1.519 ± 0.881
6.834ProPro: 6.834 ± 3.887
3.797ProGln: 3.797 ± 1.539
3.037ProArg: 3.037 ± 0.703
4.556ProSer: 4.556 ± 3.148
5.315ProThr: 5.315 ± 0.757
6.074ProVal: 6.074 ± 2.451
0.759ProTrp: 0.759 ± 0.537
0.759ProTyr: 0.759 ± 0.866
0.0ProXaa: 0.0 ± 0.0
Gln
2.278GlnAla: 2.278 ± 1.345
1.519GlnCys: 1.519 ± 1.523
3.797GlnAsp: 3.797 ± 1.855
1.519GlnGlu: 1.519 ± 0.881
2.278GlnPhe: 2.278 ± 1.345
0.759GlnGly: 0.759 ± 0.537
2.278GlnHis: 2.278 ± 0.81
1.519GlnIle: 1.519 ± 0.899
4.556GlnLys: 4.556 ± 0.649
3.037GlnLeu: 3.037 ± 1.702
0.0GlnMet: 0.0 ± 0.0
1.519GlnAsn: 1.519 ± 1.362
3.037GlnPro: 3.037 ± 1.766
3.037GlnGln: 3.037 ± 1.219
3.797GlnArg: 3.797 ± 0.626
2.278GlnSer: 2.278 ± 1.34
6.834GlnThr: 6.834 ± 1.519
1.519GlnVal: 1.519 ± 1.073
2.278GlnTrp: 2.278 ± 1.544
0.759GlnTyr: 0.759 ± 0.762
0.0GlnXaa: 0.0 ± 0.0
Arg
3.797ArgAla: 3.797 ± 1.855
0.0ArgCys: 0.0 ± 0.0
0.759ArgAsp: 0.759 ± 0.537
3.797ArgGlu: 3.797 ± 2.167
3.797ArgPhe: 3.797 ± 1.142
2.278ArgGly: 2.278 ± 0.847
0.759ArgHis: 0.759 ± 0.762
5.315ArgIle: 5.315 ± 1.404
4.556ArgLys: 4.556 ± 3.422
8.352ArgLeu: 8.352 ± 2.082
3.037ArgMet: 3.037 ± 1.697
4.556ArgAsn: 4.556 ± 2.922
6.074ArgPro: 6.074 ± 2.024
2.278ArgGln: 2.278 ± 2.047
7.593ArgArg: 7.593 ± 4.043
6.074ArgSer: 6.074 ± 2.529
6.074ArgThr: 6.074 ± 2.723
3.037ArgVal: 3.037 ± 1.702
0.759ArgTrp: 0.759 ± 0.681
5.315ArgTyr: 5.315 ± 2.034
0.0ArgXaa: 0.0 ± 0.0
Ser
8.352SerAla: 8.352 ± 1.988
1.519SerCys: 1.519 ± 0.881
1.519SerAsp: 1.519 ± 0.574
2.278SerGlu: 2.278 ± 0.817
1.519SerPhe: 1.519 ± 1.073
3.797SerGly: 3.797 ± 0.626
0.759SerHis: 0.759 ± 0.899
1.519SerIle: 1.519 ± 0.764
3.797SerLys: 3.797 ± 1.217
3.037SerLeu: 3.037 ± 1.05
0.0SerMet: 0.0 ± 0.0
3.037SerAsn: 3.037 ± 0.744
6.834SerPro: 6.834 ± 3.148
3.037SerGln: 3.037 ± 0.994
2.278SerArg: 2.278 ± 1.149
6.834SerSer: 6.834 ± 2.044
5.315SerThr: 5.315 ± 1.12
3.797SerVal: 3.797 ± 0.899
1.519SerTrp: 1.519 ± 0.851
0.0SerTyr: 0.0 ± 0.0
0.0SerXaa: 0.0 ± 0.0
Thr
7.593ThrAla: 7.593 ± 1.903
0.759ThrCys: 0.759 ± 0.762
1.519ThrAsp: 1.519 ± 1.073
3.797ThrGlu: 3.797 ± 1.855
3.037ThrPhe: 3.037 ± 1.599
5.315ThrGly: 5.315 ± 1.786
0.759ThrHis: 0.759 ± 0.762
9.112ThrIle: 9.112 ± 4.002
2.278ThrLys: 2.278 ± 1.711
4.556ThrLeu: 4.556 ± 1.81
0.0ThrMet: 0.0 ± 0.0
2.278ThrAsn: 2.278 ± 0.81
2.278ThrPro: 2.278 ± 1.662
2.278ThrGln: 2.278 ± 1.544
3.037ThrArg: 3.037 ± 1.865
2.278ThrSer: 2.278 ± 1.61
7.593ThrThr: 7.593 ± 2.479
3.037ThrVal: 3.037 ± 1.143
1.519ThrTrp: 1.519 ± 0.881
3.037ThrTyr: 3.037 ± 1.189
0.0ThrXaa: 0.0 ± 0.0
Val
3.797ValAla: 3.797 ± 2.999
0.759ValCys: 0.759 ± 0.762
0.759ValAsp: 0.759 ± 0.866
1.519ValGlu: 1.519 ± 0.764
0.759ValPhe: 0.759 ± 0.537
5.315ValGly: 5.315 ± 1.111
1.519ValHis: 1.519 ± 0.764
2.278ValIle: 2.278 ± 0.554
1.519ValLys: 1.519 ± 1.073
6.074ValLeu: 6.074 ± 1.701
2.278ValMet: 2.278 ± 1.61
4.556ValAsn: 4.556 ± 1.946
7.593ValPro: 7.593 ± 2.099
3.037ValGln: 3.037 ± 1.702
7.593ValArg: 7.593 ± 1.814
2.278ValSer: 2.278 ± 1.149
4.556ValThr: 4.556 ± 0.797
0.759ValVal: 0.759 ± 0.537
1.519ValTrp: 1.519 ± 0.851
1.519ValTyr: 1.519 ± 0.574
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
3.797TrpGlu: 3.797 ± 1.742
0.759TrpPhe: 0.759 ± 0.537
0.759TrpGly: 0.759 ± 0.681
0.759TrpHis: 0.759 ± 0.537
0.0TrpIle: 0.0 ± 0.0
2.278TrpLys: 2.278 ± 2.044
0.759TrpLeu: 0.759 ± 0.681
0.759TrpMet: 0.759 ± 0.762
1.519TrpAsn: 1.519 ± 1.073
0.0TrpPro: 0.0 ± 0.0
0.759TrpGln: 0.759 ± 0.537
0.0TrpArg: 0.0 ± 0.0
2.278TrpSer: 2.278 ± 1.901
0.0TrpThr: 0.0 ± 0.0
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.797TyrAla: 3.797 ± 1.855
0.0TyrCys: 0.0 ± 0.0
0.759TyrAsp: 0.759 ± 0.537
1.519TyrGlu: 1.519 ± 1.197
0.759TyrPhe: 0.759 ± 0.537
3.797TyrGly: 3.797 ± 2.167
0.759TyrHis: 0.759 ± 0.762
0.759TyrIle: 0.759 ± 0.537
1.519TyrLys: 1.519 ± 0.881
6.074TyrLeu: 6.074 ± 1.84
0.759TyrMet: 0.759 ± 0.505
1.519TyrAsn: 1.519 ± 1.362
2.278TyrPro: 2.278 ± 1.711
0.0TyrGln: 0.0 ± 0.0
2.278TyrArg: 2.278 ± 1.61
1.519TyrSer: 1.519 ± 0.851
0.759TyrThr: 0.759 ± 0.762
3.797TyrVal: 3.797 ± 1.297
0.759TyrTrp: 0.759 ± 0.537
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1318 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski