Amino acid dipepetide frequency for Bdellovibrio bacteriovorus W

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.536AlaAla: 6.536 ± 0.107	0.802AlaCys: 0.802 ± 0.03	3.861AlaAsp: 3.861 ± 0.074	5.186AlaGlu: 5.186 ± 0.081	3.395AlaPhe: 3.395 ± 0.076	5.587AlaGly: 5.587 ± 0.102	1.609AlaHis: 1.609 ± 0.039	4.623AlaIle: 4.623 ± 0.069	5.38AlaLys: 5.38 ± 0.099	8.653AlaLeu: 8.653 ± 0.107	2.073AlaMet: 2.073 ± 0.054	3.211AlaAsn: 3.211 ± 0.066	3.127AlaPro: 3.127 ± 0.062	3.777AlaGln: 3.777 ± 0.074	3.66AlaArg: 3.66 ± 0.066	5.385AlaSer: 5.385 ± 0.081	3.948AlaThr: 3.948 ± 0.078	4.981AlaVal: 4.981 ± 0.088	0.819AlaTrp: 0.819 ± 0.03	2.227AlaTyr: 2.227 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.701CysAla: 0.701 ± 0.03	0.053CysCys: 0.053 ± 0.008	0.522CysAsp: 0.522 ± 0.026	0.574CysGlu: 0.574 ± 0.028	0.424CysPhe: 0.424 ± 0.023	0.69CysGly: 0.69 ± 0.035	0.248CysHis: 0.248 ± 0.017	0.455CysIle: 0.455 ± 0.024	0.403CysLys: 0.403 ± 0.024	0.863CysLeu: 0.863 ± 0.032	0.181CysMet: 0.181 ± 0.014	0.299CysAsn: 0.299 ± 0.022	0.478CysPro: 0.478 ± 0.024	0.377CysGln: 0.377 ± 0.02	0.439CysArg: 0.439 ± 0.024	0.753CysSer: 0.753 ± 0.037	0.502CysThr: 0.502 ± 0.024	0.622CysVal: 0.622 ± 0.027	0.119CysTrp: 0.119 ± 0.025	0.248CysTyr: 0.248 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.391AspAla: 3.391 ± 0.054	0.461AspCys: 0.461 ± 0.023	2.307AspAsp: 2.307 ± 0.059	3.365AspGlu: 3.365 ± 0.073	3.054AspPhe: 3.054 ± 0.061	3.436AspGly: 3.436 ± 0.072	1.014AspHis: 1.014 ± 0.033	3.614AspIle: 3.614 ± 0.067	2.938AspLys: 2.938 ± 0.059	5.916AspLeu: 5.916 ± 0.089	1.121AspMet: 1.121 ± 0.035	1.714AspAsn: 1.714 ± 0.051	2.319AspPro: 2.319 ± 0.048	1.889AspGln: 1.889 ± 0.047	2.596AspArg: 2.596 ± 0.052	3.513AspSer: 3.513 ± 0.067	2.159AspThr: 2.159 ± 0.049	3.406AspVal: 3.406 ± 0.064	0.648AspTrp: 0.648 ± 0.029	1.703AspTyr: 1.703 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	5.458GluAla: 5.458 ± 0.097	0.425GluCys: 0.425 ± 0.021	3.221GluAsp: 3.221 ± 0.059	4.805GluGlu: 4.805 ± 0.092	2.976GluPhe: 2.976 ± 0.058	4.009GluGly: 4.009 ± 0.076	1.143GluHis: 1.143 ± 0.037	4.986GluIle: 4.986 ± 0.08	5.542GluLys: 5.542 ± 0.084	6.426GluLeu: 6.426 ± 0.093	1.912GluMet: 1.912 ± 0.045	3.342GluAsn: 3.342 ± 0.064	1.862GluPro: 1.862 ± 0.045	2.369GluGln: 2.369 ± 0.062	3.195GluArg: 3.195 ± 0.065	4.459GluSer: 4.459 ± 0.074	3.206GluThr: 3.206 ± 0.06	4.95GluVal: 4.95 ± 0.076	0.719GluTrp: 0.719 ± 0.032	1.845GluTyr: 1.845 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.703PheAla: 3.703 ± 0.072	0.5PheCys: 0.5 ± 0.024	2.628PheAsp: 2.628 ± 0.052	3.132PheGlu: 3.132 ± 0.058	2.496PhePhe: 2.496 ± 0.061	3.089PheGly: 3.089 ± 0.059	0.932PheHis: 0.932 ± 0.033	3.017PheIle: 3.017 ± 0.059	3.147PheLys: 3.147 ± 0.064	4.824PheLeu: 4.824 ± 0.09	1.157PheMet: 1.157 ± 0.039	2.021PheAsn: 2.021 ± 0.047	1.7PhePro: 1.7 ± 0.056	1.681PheGln: 1.681 ± 0.042	1.856PheArg: 1.856 ± 0.048	3.712PheSer: 3.712 ± 0.063	2.375PheThr: 2.375 ± 0.052	3.239PheVal: 3.239 ± 0.063	0.561PheTrp: 0.561 ± 0.029	1.584PheTyr: 1.584 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	5.3GlyAla: 5.3 ± 0.079	0.697GlyCys: 0.697 ± 0.031	3.457GlyAsp: 3.457 ± 0.06	4.023GlyGlu: 4.023 ± 0.07	3.453GlyPhe: 3.453 ± 0.067	5.227GlyGly: 5.227 ± 0.137	1.402GlyHis: 1.402 ± 0.043	4.387GlyIle: 4.387 ± 0.077	4.628GlyLys: 4.628 ± 0.073	6.528GlyLeu: 6.528 ± 0.09	1.839GlyMet: 1.839 ± 0.053	2.77GlyAsn: 2.77 ± 0.081	2.092GlyPro: 2.092 ± 0.049	2.483GlyGln: 2.483 ± 0.054	3.029GlyArg: 3.029 ± 0.056	4.857GlySer: 4.857 ± 0.1	3.954GlyThr: 3.954 ± 0.093	5.128GlyVal: 5.128 ± 0.104	0.772GlyTrp: 0.772 ± 0.03	2.226GlyTyr: 2.226 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.271HisAla: 1.271 ± 0.038	0.227HisCys: 0.227 ± 0.017	0.925HisAsp: 0.925 ± 0.031	1.101HisGlu: 1.101 ± 0.039	1.147HisPhe: 1.147 ± 0.037	1.301HisGly: 1.301 ± 0.044	0.511HisHis: 0.511 ± 0.031	1.183HisIle: 1.183 ± 0.038	1.074HisLys: 1.074 ± 0.037	2.18HisLeu: 2.18 ± 0.055	0.44HisMet: 0.44 ± 0.018	0.622HisAsn: 0.622 ± 0.028	1.09HisPro: 1.09 ± 0.038	0.817HisGln: 0.817 ± 0.036	1.047HisArg: 1.047 ± 0.035	1.415HisSer: 1.415 ± 0.038	0.875HisThr: 0.875 ± 0.032	1.118HisVal: 1.118 ± 0.036	0.316HisTrp: 0.316 ± 0.019	0.689HisTyr: 0.689 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.165IleAla: 5.165 ± 0.08	0.626IleCys: 0.626 ± 0.026	3.371IleAsp: 3.371 ± 0.069	4.457IleGlu: 4.457 ± 0.07	2.861IlePhe: 2.861 ± 0.063	4.12IleGly: 4.12 ± 0.072	1.301IleHis: 1.301 ± 0.036	3.417IleIle: 3.417 ± 0.066	3.583IleLys: 3.583 ± 0.066	6.258IleLeu: 6.258 ± 0.097	1.171IleMet: 1.171 ± 0.039	2.523IleAsn: 2.523 ± 0.052	2.868IlePro: 2.868 ± 0.062	2.713IleGln: 2.713 ± 0.06	3.126IleArg: 3.126 ± 0.06	4.885IleSer: 4.885 ± 0.079	3.192IleThr: 3.192 ± 0.07	4.041IleVal: 4.041 ± 0.068	0.563IleTrp: 0.563 ± 0.025	1.961IleTyr: 1.961 ± 0.051	0.0IleXaa: 0.0 ± 0.0
Lys	5.645LysAla: 5.645 ± 0.109	0.384LysCys: 0.384 ± 0.024	4.089LysAsp: 4.089 ± 0.059	4.803LysGlu: 4.803 ± 0.087	2.503LysPhe: 2.503 ± 0.052	4.041LysGly: 4.041 ± 0.073	1.079LysHis: 1.079 ± 0.034	4.711LysIle: 4.711 ± 0.072	5.895LysLys: 5.895 ± 0.113	5.426LysLeu: 5.426 ± 0.081	1.982LysMet: 1.982 ± 0.049	3.943LysAsn: 3.943 ± 0.068	2.346LysPro: 2.346 ± 0.053	1.931LysGln: 1.931 ± 0.047	2.775LysArg: 2.775 ± 0.057	4.69LysSer: 4.69 ± 0.081	4.032LysThr: 4.032 ± 0.062	4.96LysVal: 4.96 ± 0.083	0.667LysTrp: 0.667 ± 0.029	1.989LysTyr: 1.989 ± 0.053	0.0LysXaa: 0.0 ± 0.0
Leu	8.034LeuAla: 8.034 ± 0.084	0.872LeuCys: 0.872 ± 0.03	4.774LeuAsp: 4.774 ± 0.076	6.831LeuGlu: 6.831 ± 0.094	4.296LeuPhe: 4.296 ± 0.092	6.919LeuGly: 6.919 ± 0.099	1.787LeuHis: 1.787 ± 0.045	5.815LeuIle: 5.815 ± 0.094	7.855LeuLys: 7.855 ± 0.096	9.051LeuLeu: 9.051 ± 0.129	2.565LeuMet: 2.565 ± 0.053	4.64LeuAsn: 4.64 ± 0.08	4.21LeuPro: 4.21 ± 0.064	3.812LeuGln: 3.812 ± 0.073	5.039LeuArg: 5.039 ± 0.077	8.084LeuSer: 8.084 ± 0.094	5.124LeuThr: 5.124 ± 0.082	6.179LeuVal: 6.179 ± 0.084	1.064LeuTrp: 1.064 ± 0.044	2.51LeuTyr: 2.51 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.313MetAla: 2.313 ± 0.06	0.17MetCys: 0.17 ± 0.013	1.368MetAsp: 1.368 ± 0.039	1.444MetGlu: 1.444 ± 0.047	0.827MetPhe: 0.827 ± 0.032	2.012MetGly: 2.012 ± 0.056	0.361MetHis: 0.361 ± 0.019	1.541MetIle: 1.541 ± 0.042	2.239MetLys: 2.239 ± 0.051	1.911MetLeu: 1.911 ± 0.05	0.727MetMet: 0.727 ± 0.037	1.368MetAsn: 1.368 ± 0.042	0.956MetPro: 0.956 ± 0.043	0.955MetGln: 0.955 ± 0.031	1.275MetArg: 1.275 ± 0.032	1.916MetSer: 1.916 ± 0.044	1.602MetThr: 1.602 ± 0.045	1.447MetVal: 1.447 ± 0.038	0.196MetTrp: 0.196 ± 0.015	0.494MetTyr: 0.494 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.034AsnAla: 3.034 ± 0.06	0.424AsnCys: 0.424 ± 0.025	1.993AsnAsp: 1.993 ± 0.048	2.577AsnGlu: 2.577 ± 0.054	2.26AsnPhe: 2.26 ± 0.05	2.826AsnGly: 2.826 ± 0.078	0.794AsnHis: 0.794 ± 0.031	2.87AsnIle: 2.87 ± 0.065	2.609AsnLys: 2.609 ± 0.058	4.485AsnLeu: 4.485 ± 0.063	1.024AsnMet: 1.024 ± 0.034	1.813AsnAsn: 1.813 ± 0.066	2.382AsnPro: 2.382 ± 0.052	1.721AsnGln: 1.721 ± 0.048	1.979AsnArg: 1.979 ± 0.05	3.419AsnSer: 3.419 ± 0.077	2.207AsnThr: 2.207 ± 0.06	2.535AsnVal: 2.535 ± 0.064	0.589AsnTrp: 0.589 ± 0.027	1.482AsnTyr: 1.482 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	3.092ProAla: 3.092 ± 0.064	0.283ProCys: 0.283 ± 0.018	1.91ProAsp: 1.91 ± 0.046	3.43ProGlu: 3.43 ± 0.061	1.906ProPhe: 1.906 ± 0.042	2.419ProGly: 2.419 ± 0.06	0.869ProHis: 0.869 ± 0.034	2.113ProIle: 2.113 ± 0.055	2.328ProLys: 2.328 ± 0.064	4.009ProLeu: 4.009 ± 0.064	1.049ProMet: 1.049 ± 0.036	1.61ProAsn: 1.61 ± 0.04	1.567ProPro: 1.567 ± 0.064	1.969ProGln: 1.969 ± 0.052	1.69ProArg: 1.69 ± 0.05	2.918ProSer: 2.918 ± 0.065	2.275ProThr: 2.275 ± 0.059	2.996ProVal: 2.996 ± 0.062	0.504ProTrp: 0.504 ± 0.022	1.265ProTyr: 1.265 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.311GlnAla: 3.311 ± 0.069	0.31GlnCys: 0.31 ± 0.019	1.813GlnAsp: 1.813 ± 0.046	2.875GlnGlu: 2.875 ± 0.071	1.621GlnPhe: 1.621 ± 0.039	2.718GlnGly: 2.718 ± 0.053	0.646GlnHis: 0.646 ± 0.025	2.531GlnIle: 2.531 ± 0.056	3.227GlnLys: 3.227 ± 0.068	3.371GlnLeu: 3.371 ± 0.066	1.167GlnMet: 1.167 ± 0.043	1.921GlnAsn: 1.921 ± 0.043	1.204GlnPro: 1.204 ± 0.041	1.519GlnGln: 1.519 ± 0.048	2.01GlnArg: 2.01 ± 0.047	2.884GlnSer: 2.884 ± 0.065	2.011GlnThr: 2.011 ± 0.051	2.82GlnVal: 2.82 ± 0.053	0.582GlnTrp: 0.582 ± 0.026	1.122GlnTyr: 1.122 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.53ArgAla: 3.53 ± 0.061	0.374ArgCys: 0.374 ± 0.023	2.472ArgAsp: 2.472 ± 0.055	3.124ArgGlu: 3.124 ± 0.058	2.312ArgPhe: 2.312 ± 0.05	2.946ArgGly: 2.946 ± 0.061	0.914ArgHis: 0.914 ± 0.029	3.216ArgIle: 3.216 ± 0.064	3.062ArgLys: 3.062 ± 0.07	4.721ArgLeu: 4.721 ± 0.072	1.323ArgMet: 1.323 ± 0.035	1.992ArgAsn: 1.992 ± 0.053	1.871ArgPro: 1.871 ± 0.045	1.878ArgGln: 1.878 ± 0.051	2.428ArgArg: 2.428 ± 0.05	3.226ArgSer: 3.226 ± 0.055	2.246ArgThr: 2.246 ± 0.049	3.247ArgVal: 3.247 ± 0.053	0.618ArgTrp: 0.618 ± 0.027	1.566ArgTyr: 1.566 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	5.736SerAla: 5.736 ± 0.092	0.759SerCys: 0.759 ± 0.037	3.496SerAsp: 3.496 ± 0.064	4.895SerGlu: 4.895 ± 0.089	4.068SerPhe: 4.068 ± 0.066	5.284SerGly: 5.284 ± 0.098	1.529SerHis: 1.529 ± 0.037	4.241SerIle: 4.241 ± 0.069	4.332SerLys: 4.332 ± 0.078	8.265SerLeu: 8.265 ± 0.097	1.682SerMet: 1.682 ± 0.05	2.719SerAsn: 2.719 ± 0.064	3.054SerPro: 3.054 ± 0.063	3.273SerGln: 3.273 ± 0.058	3.253SerArg: 3.253 ± 0.061	5.872SerSer: 5.872 ± 0.116	3.583SerThr: 3.583 ± 0.085	4.825SerVal: 4.825 ± 0.087	0.978SerTrp: 0.978 ± 0.028	2.402SerTyr: 2.402 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.119ThrAla: 4.119 ± 0.079	0.528ThrCys: 0.528 ± 0.031	2.45ThrAsp: 2.45 ± 0.058	3.212ThrGlu: 3.212 ± 0.068	2.306ThrPhe: 2.306 ± 0.051	3.886ThrGly: 3.886 ± 0.083	1.145ThrHis: 1.145 ± 0.04	2.833ThrIle: 2.833 ± 0.055	2.916ThrLys: 2.916 ± 0.062	5.581ThrLeu: 5.581 ± 0.084	1.113ThrMet: 1.113 ± 0.038	2.041ThrAsn: 2.041 ± 0.063	2.795ThrPro: 2.795 ± 0.061	2.186ThrGln: 2.186 ± 0.048	2.224ThrArg: 2.224 ± 0.052	3.95ThrSer: 3.95 ± 0.085	2.806ThrThr: 2.806 ± 0.062	3.554ThrVal: 3.554 ± 0.07	0.575ThrTrp: 0.575 ± 0.026	1.629ThrTyr: 1.629 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	5.539ValAla: 5.539 ± 0.087	0.639ValCys: 0.639 ± 0.029	3.667ValAsp: 3.667 ± 0.06	4.493ValGlu: 4.493 ± 0.076	3.247ValPhe: 3.247 ± 0.061	4.704ValGly: 4.704 ± 0.078	1.267ValHis: 1.267 ± 0.039	4.228ValIle: 4.228 ± 0.07	4.184ValLys: 4.184 ± 0.088	6.75ValLeu: 6.75 ± 0.098	1.56ValMet: 1.56 ± 0.046	2.695ValAsn: 2.695 ± 0.061	2.596ValPro: 2.596 ± 0.051	2.529ValGln: 2.529 ± 0.054	3.302ValArg: 3.302 ± 0.06	5.072ValSer: 5.072 ± 0.078	3.687ValThr: 3.687 ± 0.075	4.797ValVal: 4.797 ± 0.103	0.649ValTrp: 0.649 ± 0.025	1.852ValTyr: 1.852 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.881TrpAla: 0.881 ± 0.031	0.099TrpCys: 0.099 ± 0.011	0.595TrpAsp: 0.595 ± 0.031	0.585TrpGlu: 0.585 ± 0.022	0.461TrpPhe: 0.461 ± 0.025	0.972TrpGly: 0.972 ± 0.049	0.208TrpHis: 0.208 ± 0.015	0.748TrpIle: 0.748 ± 0.033	0.819TrpLys: 0.819 ± 0.028	1.076TrpLeu: 1.076 ± 0.036	0.365TrpMet: 0.365 ± 0.018	0.561TrpAsn: 0.561 ± 0.024	0.392TrpPro: 0.392 ± 0.02	0.449TrpGln: 0.449 ± 0.019	0.483TrpArg: 0.483 ± 0.025	0.861TrpSer: 0.861 ± 0.034	0.63TrpThr: 0.63 ± 0.029	0.873TrpVal: 0.873 ± 0.036	0.134TrpTrp: 0.134 ± 0.012	0.295TrpTyr: 0.295 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.082TyrAla: 2.082 ± 0.05	0.317TyrCys: 0.317 ± 0.023	1.645TyrAsp: 1.645 ± 0.039	1.939TyrGlu: 1.939 ± 0.043	1.739TyrPhe: 1.739 ± 0.041	2.067TyrGly: 2.067 ± 0.052	0.589TyrHis: 0.589 ± 0.025	1.673TyrIle: 1.673 ± 0.046	1.73TyrLys: 1.73 ± 0.046	3.165TyrLeu: 3.165 ± 0.058	0.671TyrMet: 0.671 ± 0.027	1.221TyrAsn: 1.221 ± 0.04	1.291TyrPro: 1.291 ± 0.039	1.335TyrGln: 1.335 ± 0.044	1.664TyrArg: 1.664 ± 0.045	2.374TyrSer: 2.374 ± 0.056	1.433TyrThr: 1.433 ± 0.043	1.741TyrVal: 1.741 ± 0.048	0.412TyrTrp: 0.412 ± 0.022	1.082TyrTyr: 1.082 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2854 proteins (902569 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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