Amino acid dipepetide frequency for Solimonas aquatica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.156AlaAla: 18.156 ± 0.172	1.4AlaCys: 1.4 ± 0.036	6.185AlaAsp: 6.185 ± 0.072	7.114AlaGlu: 7.114 ± 0.091	3.654AlaPhe: 3.654 ± 0.062	10.478AlaGly: 10.478 ± 0.107	2.485AlaHis: 2.485 ± 0.048	4.961AlaIle: 4.961 ± 0.067	3.491AlaLys: 3.491 ± 0.07	15.227AlaLeu: 15.227 ± 0.142	3.062AlaMet: 3.062 ± 0.045	2.666AlaAsn: 2.666 ± 0.052	6.444AlaPro: 6.444 ± 0.094	7.895AlaGln: 7.895 ± 0.111	9.748AlaArg: 9.748 ± 0.117	6.56AlaSer: 6.56 ± 0.077	5.176AlaThr: 5.176 ± 0.076	8.149AlaVal: 8.149 ± 0.091	1.744AlaTrp: 1.744 ± 0.046	3.061AlaTyr: 3.061 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.391CysAla: 1.391 ± 0.037	0.145CysCys: 0.145 ± 0.01	0.468CysAsp: 0.468 ± 0.019	0.629CysGlu: 0.629 ± 0.026	0.326CysPhe: 0.326 ± 0.016	1.108CysGly: 1.108 ± 0.033	0.257CysHis: 0.257 ± 0.014	0.395CysIle: 0.395 ± 0.018	0.238CysLys: 0.238 ± 0.012	0.967CysLeu: 0.967 ± 0.025	0.173CysMet: 0.173 ± 0.012	0.229CysAsn: 0.229 ± 0.015	0.499CysPro: 0.499 ± 0.025	0.322CysGln: 0.322 ± 0.017	0.694CysArg: 0.694 ± 0.024	0.616CysSer: 0.616 ± 0.024	0.486CysThr: 0.486 ± 0.018	0.699CysVal: 0.699 ± 0.022	0.15CysTrp: 0.15 ± 0.01	0.259CysTyr: 0.259 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.963AspAla: 6.963 ± 0.09	0.554AspCys: 0.554 ± 0.022	2.361AspAsp: 2.361 ± 0.058	3.248AspGlu: 3.248 ± 0.051	2.058AspPhe: 2.058 ± 0.04	4.471AspGly: 4.471 ± 0.081	1.073AspHis: 1.073 ± 0.029	2.166AspIle: 2.166 ± 0.042	1.634AspLys: 1.634 ± 0.04	5.385AspLeu: 5.385 ± 0.065	0.924AspMet: 0.924 ± 0.025	1.291AspAsn: 1.291 ± 0.037	2.951AspPro: 2.951 ± 0.052	1.71AspGln: 1.71 ± 0.037	3.13AspArg: 3.13 ± 0.053	2.641AspSer: 2.641 ± 0.056	2.348AspThr: 2.348 ± 0.068	3.311AspVal: 3.311 ± 0.056	0.992AspTrp: 0.992 ± 0.026	1.76AspTyr: 1.76 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.617GluAla: 7.617 ± 0.101	0.399GluCys: 0.399 ± 0.02	2.553GluAsp: 2.553 ± 0.041	2.639GluGlu: 2.639 ± 0.06	1.812GluPhe: 1.812 ± 0.044	3.653GluGly: 3.653 ± 0.055	1.474GluHis: 1.474 ± 0.038	2.742GluIle: 2.742 ± 0.046	1.838GluLys: 1.838 ± 0.043	6.936GluLeu: 6.936 ± 0.083	1.094GluMet: 1.094 ± 0.032	1.415GluAsn: 1.415 ± 0.033	2.537GluPro: 2.537 ± 0.044	3.209GluGln: 3.209 ± 0.058	4.722GluArg: 4.722 ± 0.078	2.546GluSer: 2.546 ± 0.047	2.527GluThr: 2.527 ± 0.049	3.799GluVal: 3.799 ± 0.067	0.628GluTrp: 0.628 ± 0.021	1.292GluTyr: 1.292 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.302PheAla: 4.302 ± 0.053	0.411PheCys: 0.411 ± 0.018	2.287PheAsp: 2.287 ± 0.039	1.979PheGlu: 1.979 ± 0.045	1.326PhePhe: 1.326 ± 0.04	3.16PheGly: 3.16 ± 0.055	0.719PheHis: 0.719 ± 0.024	1.44PheIle: 1.44 ± 0.034	1.074PheLys: 1.074 ± 0.029	3.038PheLeu: 3.038 ± 0.051	0.738PheMet: 0.738 ± 0.024	1.152PheAsn: 1.152 ± 0.029	1.422PhePro: 1.422 ± 0.034	1.008PheGln: 1.008 ± 0.028	1.961PheArg: 1.961 ± 0.039	2.098PheSer: 2.098 ± 0.044	1.805PheThr: 1.805 ± 0.045	2.457PheVal: 2.457 ± 0.042	0.516PheTrp: 0.516 ± 0.02	0.989PheTyr: 0.989 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	9.272GlyAla: 9.272 ± 0.099	0.909GlyCys: 0.909 ± 0.032	3.896GlyAsp: 3.896 ± 0.072	5.108GlyGlu: 5.108 ± 0.065	3.242GlyPhe: 3.242 ± 0.052	7.313GlyGly: 7.313 ± 0.12	1.851GlyHis: 1.851 ± 0.035	3.917GlyIle: 3.917 ± 0.059	3.057GlyLys: 3.057 ± 0.053	9.022GlyLeu: 9.022 ± 0.085	1.933GlyMet: 1.933 ± 0.042	2.255GlyAsn: 2.255 ± 0.06	2.896GlyPro: 2.896 ± 0.052	3.131GlyGln: 3.131 ± 0.055	5.429GlyArg: 5.429 ± 0.065	5.128GlySer: 5.128 ± 0.118	3.793GlyThr: 3.793 ± 0.072	6.017GlyVal: 6.017 ± 0.067	1.307GlyTrp: 1.307 ± 0.033	2.512GlyTyr: 2.512 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.488HisAla: 2.488 ± 0.045	0.329HisCys: 0.329 ± 0.018	1.127HisAsp: 1.127 ± 0.029	1.302HisGlu: 1.302 ± 0.033	0.895HisPhe: 0.895 ± 0.028	2.086HisGly: 2.086 ± 0.043	0.68HisHis: 0.68 ± 0.028	0.849HisIle: 0.849 ± 0.023	0.544HisLys: 0.544 ± 0.021	2.442HisLeu: 2.442 ± 0.048	0.432HisMet: 0.432 ± 0.017	0.531HisAsn: 0.531 ± 0.018	1.35HisPro: 1.35 ± 0.034	0.818HisGln: 0.818 ± 0.027	1.645HisArg: 1.645 ± 0.044	1.122HisSer: 1.122 ± 0.029	0.892HisThr: 0.892 ± 0.026	1.222HisVal: 1.222 ± 0.029	0.504HisTrp: 0.504 ± 0.02	0.791HisTyr: 0.791 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.194IleAla: 6.194 ± 0.07	0.454IleCys: 0.454 ± 0.02	2.883IleAsp: 2.883 ± 0.056	3.12IleGlu: 3.12 ± 0.055	1.245IlePhe: 1.245 ± 0.033	4.105IleGly: 4.105 ± 0.068	0.834IleHis: 0.834 ± 0.026	1.548IleIle: 1.548 ± 0.038	1.404IleLys: 1.404 ± 0.034	3.283IleLeu: 3.283 ± 0.056	0.653IleMet: 0.653 ± 0.025	1.338IleAsn: 1.338 ± 0.038	1.961IlePro: 1.961 ± 0.04	1.291IleGln: 1.291 ± 0.036	2.834IleArg: 2.834 ± 0.049	2.494IleSer: 2.494 ± 0.05	2.073IleThr: 2.073 ± 0.039	3.245IleVal: 3.245 ± 0.058	0.537IleTrp: 0.537 ± 0.022	1.022IleTyr: 1.022 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.734LysAla: 3.734 ± 0.063	0.174LysCys: 0.174 ± 0.011	1.482LysAsp: 1.482 ± 0.036	1.272LysGlu: 1.272 ± 0.038	0.814LysPhe: 0.814 ± 0.027	2.106LysGly: 2.106 ± 0.046	0.564LysHis: 0.564 ± 0.023	1.46LysIle: 1.46 ± 0.036	1.208LysLys: 1.208 ± 0.036	3.868LysLeu: 3.868 ± 0.054	0.637LysMet: 0.637 ± 0.022	0.913LysAsn: 0.913 ± 0.029	2.141LysPro: 2.141 ± 0.048	1.259LysGln: 1.259 ± 0.033	2.212LysArg: 2.212 ± 0.046	1.648LysSer: 1.648 ± 0.034	1.813LysThr: 1.813 ± 0.04	2.107LysVal: 2.107 ± 0.042	0.308LysTrp: 0.308 ± 0.014	0.673LysTyr: 0.673 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	15.051LeuAla: 15.051 ± 0.148	1.285LeuCys: 1.285 ± 0.038	6.425LeuAsp: 6.425 ± 0.071	5.409LeuGlu: 5.409 ± 0.078	3.584LeuPhe: 3.584 ± 0.054	8.952LeuGly: 8.952 ± 0.099	2.662LeuHis: 2.662 ± 0.05	4.934LeuIle: 4.934 ± 0.065	3.82LeuLys: 3.82 ± 0.059	14.246LeuLeu: 14.246 ± 0.19	2.379LeuMet: 2.379 ± 0.046	2.936LeuAsn: 2.936 ± 0.054	7.049LeuPro: 7.049 ± 0.079	5.391LeuGln: 5.391 ± 0.076	10.007LeuArg: 10.007 ± 0.133	7.834LeuSer: 7.834 ± 0.098	4.644LeuThr: 4.644 ± 0.064	6.554LeuVal: 6.554 ± 0.076	1.456LeuTrp: 1.456 ± 0.039	2.492LeuTyr: 2.492 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.453MetAla: 2.453 ± 0.045	0.141MetCys: 0.141 ± 0.01	0.928MetAsp: 0.928 ± 0.027	0.849MetGlu: 0.849 ± 0.027	0.669MetPhe: 0.669 ± 0.025	1.488MetGly: 1.488 ± 0.036	0.462MetHis: 0.462 ± 0.016	0.906MetIle: 0.906 ± 0.028	0.849MetLys: 0.849 ± 0.024	2.506MetLeu: 2.506 ± 0.051	0.489MetMet: 0.489 ± 0.02	0.846MetAsn: 0.846 ± 0.023	1.302MetPro: 1.302 ± 0.033	0.972MetGln: 0.972 ± 0.026	1.628MetArg: 1.628 ± 0.037	1.741MetSer: 1.741 ± 0.041	1.057MetThr: 1.057 ± 0.03	1.258MetVal: 1.258 ± 0.033	0.178MetTrp: 0.178 ± 0.012	0.313MetTyr: 0.313 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.198AsnAla: 3.198 ± 0.063	0.29AsnCys: 0.29 ± 0.015	1.222AsnAsp: 1.222 ± 0.052	1.252AsnGlu: 1.252 ± 0.032	0.998AsnPhe: 0.998 ± 0.026	2.19AsnGly: 2.19 ± 0.059	0.511AsnHis: 0.511 ± 0.019	1.202AsnIle: 1.202 ± 0.035	0.783AsnLys: 0.783 ± 0.025	3.013AsnLeu: 3.013 ± 0.05	0.501AsnMet: 0.501 ± 0.018	0.762AsnAsn: 0.762 ± 0.028	1.799AsnPro: 1.799 ± 0.039	0.961AsnGln: 0.961 ± 0.026	1.689AsnArg: 1.689 ± 0.038	1.364AsnSer: 1.364 ± 0.041	1.41AsnThr: 1.41 ± 0.043	1.717AsnVal: 1.717 ± 0.039	0.434AsnTrp: 0.434 ± 0.018	0.723AsnTyr: 0.723 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	7.146ProAla: 7.146 ± 0.097	0.362ProCys: 0.362 ± 0.015	2.952ProAsp: 2.952 ± 0.051	3.497ProGlu: 3.497 ± 0.056	1.563ProPhe: 1.563 ± 0.035	4.617ProGly: 4.617 ± 0.074	1.04ProHis: 1.04 ± 0.028	1.769ProIle: 1.769 ± 0.04	1.461ProLys: 1.461 ± 0.037	5.882ProLeu: 5.882 ± 0.077	1.239ProMet: 1.239 ± 0.033	1.137ProAsn: 1.137 ± 0.033	2.988ProPro: 2.988 ± 0.064	2.825ProGln: 2.825 ± 0.05	3.403ProArg: 3.403 ± 0.051	2.547ProSer: 2.547 ± 0.048	2.013ProThr: 2.013 ± 0.042	3.727ProVal: 3.727 ± 0.059	0.714ProTrp: 0.714 ± 0.024	1.337ProTyr: 1.337 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	6.664GlnAla: 6.664 ± 0.093	0.334GlnCys: 0.334 ± 0.016	2.041GlnAsp: 2.041 ± 0.04	1.853GlnGlu: 1.853 ± 0.044	1.349GlnPhe: 1.349 ± 0.038	3.207GlnGly: 3.207 ± 0.053	1.052GlnHis: 1.052 ± 0.029	1.98GlnIle: 1.98 ± 0.04	1.28GlnLys: 1.28 ± 0.032	6.221GlnLeu: 6.221 ± 0.088	0.909GlnMet: 0.909 ± 0.03	1.127GlnAsn: 1.127 ± 0.031	2.324GlnPro: 2.324 ± 0.047	2.629GlnGln: 2.629 ± 0.055	4.215GlnArg: 4.215 ± 0.07	2.28GlnSer: 2.28 ± 0.041	2.107GlnThr: 2.107 ± 0.044	2.757GlnVal: 2.757 ± 0.047	0.692GlnTrp: 0.692 ± 0.027	1.049GlnTyr: 1.049 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.386ArgAla: 8.386 ± 0.106	0.741ArgCys: 0.741 ± 0.025	3.723ArgAsp: 3.723 ± 0.051	5.34ArgGlu: 5.34 ± 0.081	2.815ArgPhe: 2.815 ± 0.047	5.179ArgGly: 5.179 ± 0.067	1.883ArgHis: 1.883 ± 0.047	3.665ArgIle: 3.665 ± 0.056	2.164ArgLys: 2.164 ± 0.047	9.243ArgLeu: 9.243 ± 0.103	1.632ArgMet: 1.632 ± 0.031	1.863ArgAsn: 1.863 ± 0.037	3.077ArgPro: 3.077 ± 0.045	3.263ArgGln: 3.263 ± 0.057	5.883ArgArg: 5.883 ± 0.098	3.902ArgSer: 3.902 ± 0.058	2.568ArgThr: 2.568 ± 0.049	5.122ArgVal: 5.122 ± 0.072	1.255ArgTrp: 1.255 ± 0.031	2.545ArgTyr: 2.545 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	7.151SerAla: 7.151 ± 0.092	0.623SerCys: 0.623 ± 0.021	2.799SerAsp: 2.799 ± 0.058	2.99SerGlu: 2.99 ± 0.048	2.263SerPhe: 2.263 ± 0.043	5.843SerGly: 5.843 ± 0.128	1.058SerHis: 1.058 ± 0.031	2.236SerIle: 2.236 ± 0.046	1.409SerLys: 1.409 ± 0.033	6.55SerLeu: 6.55 ± 0.081	1.149SerMet: 1.149 ± 0.028	1.405SerAsn: 1.405 ± 0.041	2.724SerPro: 2.724 ± 0.047	2.0SerGln: 2.0 ± 0.038	3.672SerArg: 3.672 ± 0.05	3.532SerSer: 3.532 ± 0.075	2.614SerThr: 2.614 ± 0.056	3.896SerVal: 3.896 ± 0.065	0.937SerTrp: 0.937 ± 0.026	1.501SerTyr: 1.501 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.298ThrAla: 5.298 ± 0.078	0.316ThrCys: 0.316 ± 0.016	1.888ThrAsp: 1.888 ± 0.046	2.057ThrGlu: 2.057 ± 0.044	1.278ThrPhe: 1.278 ± 0.034	4.002ThrGly: 4.002 ± 0.076	1.052ThrHis: 1.052 ± 0.028	1.782ThrIle: 1.782 ± 0.048	0.968ThrLys: 0.968 ± 0.026	6.129ThrLeu: 6.129 ± 0.085	0.838ThrMet: 0.838 ± 0.025	0.904ThrAsn: 0.904 ± 0.03	3.257ThrPro: 3.257 ± 0.063	2.234ThrGln: 2.234 ± 0.04	3.283ThrArg: 3.283 ± 0.047	2.024ThrSer: 2.024 ± 0.045	2.013ThrThr: 2.013 ± 0.05	3.618ThrVal: 3.618 ± 0.08	0.522ThrTrp: 0.522 ± 0.022	1.004ThrTyr: 1.004 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	7.767ValAla: 7.767 ± 0.09	0.74ValCys: 0.74 ± 0.024	3.737ValAsp: 3.737 ± 0.056	3.708ValGlu: 3.708 ± 0.059	2.427ValPhe: 2.427 ± 0.044	4.776ValGly: 4.776 ± 0.069	1.431ValHis: 1.431 ± 0.03	3.139ValIle: 3.139 ± 0.055	2.097ValLys: 2.097 ± 0.044	8.08ValLeu: 8.08 ± 0.078	1.57ValMet: 1.57 ± 0.033	2.049ValAsn: 2.049 ± 0.044	3.55ValPro: 3.55 ± 0.055	2.911ValGln: 2.911 ± 0.043	4.525ValArg: 4.525 ± 0.059	4.053ValSer: 4.053 ± 0.073	3.158ValThr: 3.158 ± 0.07	4.808ValVal: 4.808 ± 0.068	0.812ValTrp: 0.812 ± 0.027	1.695ValTyr: 1.695 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.243TrpAla: 1.243 ± 0.033	0.17TrpCys: 0.17 ± 0.01	0.636TrpAsp: 0.636 ± 0.021	0.534TrpGlu: 0.534 ± 0.02	0.516TrpPhe: 0.516 ± 0.022	0.857TrpGly: 0.857 ± 0.029	0.39TrpHis: 0.39 ± 0.017	0.551TrpIle: 0.551 ± 0.021	0.384TrpLys: 0.384 ± 0.016	2.179TrpLeu: 2.179 ± 0.043	0.285TrpMet: 0.285 ± 0.016	0.492TrpAsn: 0.492 ± 0.018	0.759TrpPro: 0.759 ± 0.022	1.016TrpGln: 1.016 ± 0.031	1.348TrpArg: 1.348 ± 0.034	0.834TrpSer: 0.834 ± 0.029	0.676TrpThr: 0.676 ± 0.022	0.86TrpVal: 0.86 ± 0.027	0.251TrpTrp: 0.251 ± 0.014	0.379TrpTyr: 0.379 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.181TyrAla: 3.181 ± 0.049	0.277TyrCys: 0.277 ± 0.014	1.376TyrAsp: 1.376 ± 0.034	1.526TyrGlu: 1.526 ± 0.037	1.047TyrPhe: 1.047 ± 0.031	2.399TyrGly: 2.399 ± 0.045	0.571TyrHis: 0.571 ± 0.02	0.876TyrIle: 0.876 ± 0.027	0.691TyrLys: 0.691 ± 0.024	2.894TyrLeu: 2.894 ± 0.054	0.399TyrMet: 0.399 ± 0.017	0.706TyrAsn: 0.706 ± 0.026	1.191TyrPro: 1.191 ± 0.03	1.224TyrGln: 1.224 ± 0.034	2.223TyrArg: 2.223 ± 0.044	1.39TyrSer: 1.39 ± 0.034	1.295TyrThr: 1.295 ± 0.037	1.709TyrVal: 1.709 ± 0.036	0.422TyrTrp: 0.422 ± 0.019	0.75TyrTyr: 0.75 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3891 proteins (1330244 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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