Amino acid dipepetide frequency for Parasaccharibacter apium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.903AlaAla: 11.903 ± 0.206
1.283AlaCys: 1.283 ± 0.056
5.051AlaAsp: 5.051 ± 0.104
6.757AlaGlu: 6.757 ± 0.138
3.905AlaPhe: 3.905 ± 0.087
9.109AlaGly: 9.109 ± 0.163
3.121AlaHis: 3.121 ± 0.08
5.422AlaIle: 5.422 ± 0.1
3.171AlaLys: 3.171 ± 0.089
13.84AlaLeu: 13.84 ± 0.221
2.927AlaMet: 2.927 ± 0.063
2.391AlaAsn: 2.391 ± 0.076
5.214AlaPro: 5.214 ± 0.107
4.926AlaGln: 4.926 ± 0.126
7.643AlaArg: 7.643 ± 0.139
5.828AlaSer: 5.828 ± 0.118
5.178AlaThr: 5.178 ± 0.106
6.995AlaVal: 6.995 ± 0.15
1.215AlaTrp: 1.215 ± 0.051
2.543AlaTyr: 2.543 ± 0.077
0.0AlaXaa: 0.0 ± 0.0
Cys
1.188CysAla: 1.188 ± 0.052
0.165CysCys: 0.165 ± 0.018
0.571CysAsp: 0.571 ± 0.034
0.431CysGlu: 0.431 ± 0.031
0.409CysPhe: 0.409 ± 0.028
1.001CysGly: 1.001 ± 0.046
0.338CysHis: 0.338 ± 0.028
0.492CysIle: 0.492 ± 0.035
0.207CysLys: 0.207 ± 0.021
1.294CysLeu: 1.294 ± 0.058
0.193CysMet: 0.193 ± 0.017
0.228CysAsn: 0.228 ± 0.022
0.562CysPro: 0.562 ± 0.032
0.411CysGln: 0.411 ± 0.029
0.687CysArg: 0.687 ± 0.036
0.566CysSer: 0.566 ± 0.037
0.503CysThr: 0.503 ± 0.031
0.804CysVal: 0.804 ± 0.043
0.143CysTrp: 0.143 ± 0.018
0.22CysTyr: 0.22 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
5.051AspAla: 5.051 ± 0.096
0.512AspCys: 0.512 ± 0.036
2.789AspAsp: 2.789 ± 0.088
3.586AspGlu: 3.586 ± 0.094
1.689AspPhe: 1.689 ± 0.057
4.445AspGly: 4.445 ± 0.106
1.425AspHis: 1.425 ± 0.051
3.097AspIle: 3.097 ± 0.077
1.809AspLys: 1.809 ± 0.067
4.816AspLeu: 4.816 ± 0.11
1.37AspMet: 1.37 ± 0.047
1.401AspAsn: 1.401 ± 0.051
2.708AspPro: 2.708 ± 0.076
1.517AspGln: 1.517 ± 0.053
2.84AspArg: 2.84 ± 0.07
2.236AspSer: 2.236 ± 0.068
2.302AspThr: 2.302 ± 0.066
4.127AspVal: 4.127 ± 0.089
0.797AspTrp: 0.797 ± 0.043
1.504AspTyr: 1.504 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
7.702GluAla: 7.702 ± 0.161
0.387GluCys: 0.387 ± 0.028
3.156GluAsp: 3.156 ± 0.088
4.017GluGlu: 4.017 ± 0.112
1.346GluPhe: 1.346 ± 0.054
5.198GluGly: 5.198 ± 0.115
1.73GluHis: 1.73 ± 0.069
2.927GluIle: 2.927 ± 0.081
2.29GluLys: 2.29 ± 0.073
4.614GluLeu: 4.614 ± 0.099
1.482GluMet: 1.482 ± 0.049
1.498GluAsn: 1.498 ± 0.053
2.148GluPro: 2.148 ± 0.081
3.006GluGln: 3.006 ± 0.088
4.717GluArg: 4.717 ± 0.116
2.734GluSer: 2.734 ± 0.068
3.312GluThr: 3.312 ± 0.089
3.674GluVal: 3.674 ± 0.098
0.615GluTrp: 0.615 ± 0.032
0.896GluTyr: 0.896 ± 0.039
0.0GluXaa: 0.0 ± 0.0
Phe
3.531PheAla: 3.531 ± 0.086
0.566PheCys: 0.566 ± 0.031
1.904PheAsp: 1.904 ± 0.065
1.66PheGlu: 1.66 ± 0.065
1.542PhePhe: 1.542 ± 0.071
3.129PheGly: 3.129 ± 0.092
1.019PheHis: 1.019 ± 0.043
1.932PheIle: 1.932 ± 0.067
0.913PheLys: 0.913 ± 0.046
3.813PheLeu: 3.813 ± 0.108
0.964PheMet: 0.964 ± 0.046
1.098PheAsn: 1.098 ± 0.045
1.577PhePro: 1.577 ± 0.059
1.214PheGln: 1.214 ± 0.045
2.036PheArg: 2.036 ± 0.057
2.508PheSer: 2.508 ± 0.067
2.1PheThr: 2.1 ± 0.064
2.236PheVal: 2.236 ± 0.076
0.582PheTrp: 0.582 ± 0.037
1.025PheTyr: 1.025 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
7.629GlyAla: 7.629 ± 0.135
0.953GlyCys: 0.953 ± 0.038
3.779GlyAsp: 3.779 ± 0.096
4.478GlyGlu: 4.478 ± 0.112
3.145GlyPhe: 3.145 ± 0.075
6.933GlyGly: 6.933 ± 0.191
2.508GlyHis: 2.508 ± 0.073
4.285GlyIle: 4.285 ± 0.109
3.208GlyLys: 3.208 ± 0.091
8.916GlyLeu: 8.916 ± 0.146
2.613GlyMet: 2.613 ± 0.078
2.099GlyAsn: 2.099 ± 0.088
3.32GlyPro: 3.32 ± 0.073
3.847GlyGln: 3.847 ± 0.1
5.982GlyArg: 5.982 ± 0.118
4.21GlySer: 4.21 ± 0.109
4.733GlyThr: 4.733 ± 0.123
5.947GlyVal: 5.947 ± 0.138
1.294GlyTrp: 1.294 ± 0.051
2.258GlyTyr: 2.258 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
3.039HisAla: 3.039 ± 0.084
0.316HisCys: 0.316 ± 0.026
1.583HisAsp: 1.583 ± 0.052
1.432HisGlu: 1.432 ± 0.061
1.182HisPhe: 1.182 ± 0.055
2.266HisGly: 2.266 ± 0.069
1.313HisHis: 1.313 ± 0.063
1.843HisIle: 1.843 ± 0.061
1.025HisLys: 1.025 ± 0.041
2.965HisLeu: 2.965 ± 0.085
0.758HisMet: 0.758 ± 0.039
1.041HisAsn: 1.041 ± 0.04
1.853HisPro: 1.853 ± 0.052
1.083HisGln: 1.083 ± 0.047
1.656HisArg: 1.656 ± 0.056
1.43HisSer: 1.43 ± 0.056
1.506HisThr: 1.506 ± 0.052
1.915HisVal: 1.915 ± 0.059
0.472HisTrp: 0.472 ± 0.026
1.004HisTyr: 1.004 ± 0.053
0.0HisXaa: 0.0 ± 0.0
Ile
6.202IleAla: 6.202 ± 0.116
0.641IleCys: 0.641 ± 0.033
2.754IleAsp: 2.754 ± 0.071
3.119IleGlu: 3.119 ± 0.081
1.777IlePhe: 1.777 ± 0.06
4.631IleGly: 4.631 ± 0.117
1.261IleHis: 1.261 ± 0.048
3.261IleIle: 3.261 ± 0.089
1.542IleLys: 1.542 ± 0.059
5.504IleLeu: 5.504 ± 0.112
1.179IleMet: 1.179 ± 0.055
1.588IleAsn: 1.588 ± 0.062
2.881IlePro: 2.881 ± 0.084
1.597IleGln: 1.597 ± 0.055
3.316IleArg: 3.316 ± 0.093
3.228IleSer: 3.228 ± 0.073
3.645IleThr: 3.645 ± 0.103
3.553IleVal: 3.553 ± 0.086
0.588IleTrp: 0.588 ± 0.032
1.127IleTyr: 1.127 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.627LysAla: 4.627 ± 0.113
0.169LysCys: 0.169 ± 0.016
1.981LysAsp: 1.981 ± 0.066
2.315LysGlu: 2.315 ± 0.08
0.573LysPhe: 0.573 ± 0.036
3.033LysGly: 3.033 ± 0.072
0.795LysHis: 0.795 ± 0.039
1.739LysIle: 1.739 ± 0.055
1.731LysLys: 1.731 ± 0.074
3.175LysLeu: 3.175 ± 0.085
0.898LysMet: 0.898 ± 0.04
0.991LysAsn: 0.991 ± 0.047
1.9LysPro: 1.9 ± 0.063
1.449LysGln: 1.449 ± 0.052
2.541LysArg: 2.541 ± 0.075
1.531LysSer: 1.531 ± 0.057
2.268LysThr: 2.268 ± 0.067
1.994LysVal: 1.994 ± 0.074
0.237LysTrp: 0.237 ± 0.022
0.542LysTyr: 0.542 ± 0.035
0.0LysXaa: 0.0 ± 0.0
Leu
11.989LeuAla: 11.989 ± 0.193
1.539LeuCys: 1.539 ± 0.062
5.314LeuAsp: 5.314 ± 0.099
5.727LeuGlu: 5.727 ± 0.114
3.986LeuPhe: 3.986 ± 0.095
8.005LeuGly: 8.005 ± 0.135
3.189LeuHis: 3.189 ± 0.088
5.499LeuIle: 5.499 ± 0.112
4.082LeuLys: 4.082 ± 0.1
11.222LeuLeu: 11.222 ± 0.209
2.589LeuMet: 2.589 ± 0.079
3.033LeuAsn: 3.033 ± 0.089
6.885LeuPro: 6.885 ± 0.121
3.819LeuGln: 3.819 ± 0.098
7.003LeuArg: 7.003 ± 0.113
7.487LeuSer: 7.487 ± 0.134
6.648LeuThr: 6.648 ± 0.14
6.165LeuVal: 6.165 ± 0.114
1.498LeuTrp: 1.498 ± 0.061
2.629LeuTyr: 2.629 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
3.151MetAla: 3.151 ± 0.079
0.16MetCys: 0.16 ± 0.017
1.175MetAsp: 1.175 ± 0.047
1.441MetGlu: 1.441 ± 0.055
0.655MetPhe: 0.655 ± 0.033
2.2MetGly: 2.2 ± 0.063
0.534MetHis: 0.534 ± 0.031
1.271MetIle: 1.271 ± 0.049
1.085MetLys: 1.085 ± 0.04
2.609MetLeu: 2.609 ± 0.083
0.823MetMet: 0.823 ± 0.041
0.778MetAsn: 0.778 ± 0.036
1.594MetPro: 1.594 ± 0.055
1.078MetGln: 1.078 ± 0.044
1.656MetArg: 1.656 ± 0.053
1.676MetSer: 1.676 ± 0.06
1.753MetThr: 1.753 ± 0.057
1.834MetVal: 1.834 ± 0.065
0.202MetTrp: 0.202 ± 0.017
0.288MetTyr: 0.288 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.081AsnAla: 3.081 ± 0.095
0.207AsnCys: 0.207 ± 0.02
1.37AsnAsp: 1.37 ± 0.061
1.333AsnGlu: 1.333 ± 0.053
0.901AsnPhe: 0.901 ± 0.043
2.444AsnGly: 2.444 ± 0.102
0.767AsnHis: 0.767 ± 0.034
1.847AsnIle: 1.847 ± 0.065
0.914AsnLys: 0.914 ± 0.044
2.651AsnLeu: 2.651 ± 0.076
0.69AsnMet: 0.69 ± 0.034
0.99AsnAsn: 0.99 ± 0.056
1.9AsnPro: 1.9 ± 0.062
0.964AsnGln: 0.964 ± 0.048
1.768AsnArg: 1.768 ± 0.059
1.487AsnSer: 1.487 ± 0.068
1.55AsnThr: 1.55 ± 0.062
1.788AsnVal: 1.788 ± 0.061
0.406AsnTrp: 0.406 ± 0.031
0.742AsnTyr: 0.742 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
5.776ProAla: 5.776 ± 0.107
0.461ProCys: 0.461 ± 0.032
2.916ProAsp: 2.916 ± 0.077
3.718ProGlu: 3.718 ± 0.088
2.126ProPhe: 2.126 ± 0.066
3.85ProGly: 3.85 ± 0.095
1.939ProHis: 1.939 ± 0.065
2.501ProIle: 2.501 ± 0.078
1.577ProLys: 1.577 ± 0.052
5.978ProLeu: 5.978 ± 0.112
1.223ProMet: 1.223 ± 0.048
1.421ProAsn: 1.421 ± 0.057
3.175ProPro: 3.175 ± 0.106
2.168ProGln: 2.168 ± 0.059
2.668ProArg: 2.668 ± 0.059
3.461ProSer: 3.461 ± 0.078
3.167ProThr: 3.167 ± 0.087
3.722ProVal: 3.722 ± 0.105
0.734ProTrp: 0.734 ± 0.036
1.37ProTyr: 1.37 ± 0.059
0.0ProXaa: 0.0 ± 0.0
Gln
5.135GlnAla: 5.135 ± 0.124
0.253GlnCys: 0.253 ± 0.023
2.033GlnAsp: 2.033 ± 0.055
2.521GlnGlu: 2.521 ± 0.081
1.234GlnPhe: 1.234 ± 0.048
2.996GlnGly: 2.996 ± 0.088
1.311GlnHis: 1.311 ± 0.056
2.009GlnIle: 2.009 ± 0.064
1.924GlnLys: 1.924 ± 0.064
3.773GlnLeu: 3.773 ± 0.094
0.993GlnMet: 0.993 ± 0.041
1.373GlnAsn: 1.373 ± 0.056
2.212GlnPro: 2.212 ± 0.075
2.253GlnGln: 2.253 ± 0.092
2.917GlnArg: 2.917 ± 0.091
2.297GlnSer: 2.297 ± 0.071
2.356GlnThr: 2.356 ± 0.073
2.189GlnVal: 2.189 ± 0.067
0.534GlnTrp: 0.534 ± 0.036
0.797GlnTyr: 0.797 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
6.612ArgAla: 6.612 ± 0.115
0.549ArgCys: 0.549 ± 0.036
3.2ArgAsp: 3.2 ± 0.087
3.674ArgGlu: 3.674 ± 0.086
2.8ArgPhe: 2.8 ± 0.081
4.427ArgGly: 4.427 ± 0.116
2.302ArgHis: 2.302 ± 0.071
3.555ArgIle: 3.555 ± 0.084
2.425ArgLys: 2.425 ± 0.075
7.954ArgLeu: 7.954 ± 0.139
1.702ArgMet: 1.702 ± 0.05
1.836ArgAsn: 1.836 ± 0.063
3.367ArgPro: 3.367 ± 0.075
3.09ArgGln: 3.09 ± 0.094
4.7ArgArg: 4.7 ± 0.117
3.4ArgSer: 3.4 ± 0.085
3.107ArgThr: 3.107 ± 0.08
4.192ArgVal: 4.192 ± 0.093
0.907ArgTrp: 0.907 ± 0.048
2.038ArgTyr: 2.038 ± 0.062
0.0ArgXaa: 0.0 ± 0.0
Ser
5.396SerAla: 5.396 ± 0.105
0.644SerCys: 0.644 ± 0.04
2.545SerAsp: 2.545 ± 0.079
2.495SerGlu: 2.495 ± 0.071
2.662SerPhe: 2.662 ± 0.072
5.058SerGly: 5.058 ± 0.129
1.733SerHis: 1.733 ± 0.057
3.052SerIle: 3.052 ± 0.075
1.438SerLys: 1.438 ± 0.048
7.063SerLeu: 7.063 ± 0.143
1.447SerMet: 1.447 ± 0.051
1.489SerAsn: 1.489 ± 0.067
3.241SerPro: 3.241 ± 0.071
2.014SerGln: 2.014 ± 0.066
3.577SerArg: 3.577 ± 0.086
3.74SerSer: 3.74 ± 0.096
3.053SerThr: 3.053 ± 0.085
3.755SerVal: 3.755 ± 0.093
0.92SerTrp: 0.92 ± 0.041
1.496SerTyr: 1.496 ± 0.058
0.0SerXaa: 0.0 ± 0.0
Thr
6.118ThrAla: 6.118 ± 0.117
0.411ThrCys: 0.411 ± 0.027
2.583ThrAsp: 2.583 ± 0.074
2.572ThrGlu: 2.572 ± 0.07
1.801ThrPhe: 1.801 ± 0.064
4.926ThrGly: 4.926 ± 0.121
1.761ThrHis: 1.761 ± 0.052
3.239ThrIle: 3.239 ± 0.092
1.573ThrLys: 1.573 ± 0.053
7.184ThrLeu: 7.184 ± 0.132
1.344ThrMet: 1.344 ± 0.048
1.513ThrAsn: 1.513 ± 0.068
4.006ThrPro: 4.006 ± 0.092
2.244ThrGln: 2.244 ± 0.075
3.145ThrArg: 3.145 ± 0.081
3.107ThrSer: 3.107 ± 0.093
3.237ThrThr: 3.237 ± 0.101
3.619ThrVal: 3.619 ± 0.095
0.577ThrTrp: 0.577 ± 0.035
1.135ThrTyr: 1.135 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
6.755ValAla: 6.755 ± 0.132
0.745ValCys: 0.745 ± 0.036
3.268ValAsp: 3.268 ± 0.084
4.227ValGlu: 4.227 ± 0.099
2.26ValPhe: 2.26 ± 0.068
5.029ValGly: 5.029 ± 0.122
1.491ValHis: 1.491 ± 0.054
3.802ValIle: 3.802 ± 0.09
2.256ValLys: 2.256 ± 0.073
6.937ValLeu: 6.937 ± 0.14
1.966ValMet: 1.966 ± 0.065
1.871ValAsn: 1.871 ± 0.067
3.597ValPro: 3.597 ± 0.084
2.602ValGln: 2.602 ± 0.068
4.179ValArg: 4.179 ± 0.099
3.966ValSer: 3.966 ± 0.102
4.039ValThr: 4.039 ± 0.104
4.816ValVal: 4.816 ± 0.124
0.749ValTrp: 0.749 ± 0.039
1.25ValTyr: 1.25 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.162TrpAla: 1.162 ± 0.049
0.18TrpCys: 0.18 ± 0.017
0.567TrpAsp: 0.567 ± 0.031
0.562TrpGlu: 0.562 ± 0.031
0.521TrpPhe: 0.521 ± 0.034
0.988TrpGly: 0.988 ± 0.051
0.422TrpHis: 0.422 ± 0.03
0.474TrpIle: 0.474 ± 0.027
0.441TrpLys: 0.441 ± 0.033
1.761TrpLeu: 1.761 ± 0.064
0.323TrpMet: 0.323 ± 0.028
0.393TrpAsn: 0.393 ± 0.032
0.624TrpPro: 0.624 ± 0.041
0.778TrpGln: 0.778 ± 0.037
1.105TrpArg: 1.105 ± 0.046
0.716TrpSer: 0.716 ± 0.035
0.547TrpThr: 0.547 ± 0.034
0.947TrpVal: 0.947 ± 0.04
0.23TrpTrp: 0.23 ± 0.021
0.332TrpTyr: 0.332 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.376TyrAla: 2.376 ± 0.072
0.272TyrCys: 0.272 ± 0.022
1.485TyrAsp: 1.485 ± 0.046
1.383TyrGlu: 1.383 ± 0.06
0.83TyrPhe: 0.83 ± 0.041
2.469TyrGly: 2.469 ± 0.076
0.722TyrHis: 0.722 ± 0.039
1.149TyrIle: 1.149 ± 0.052
0.878TyrLys: 0.878 ± 0.043
2.238TyrLeu: 2.238 ± 0.069
0.479TyrMet: 0.479 ± 0.029
0.769TyrAsn: 0.769 ± 0.039
1.186TyrPro: 1.186 ± 0.049
1.052TyrGln: 1.052 ± 0.048
1.7TyrArg: 1.7 ± 0.06
1.21TyrSer: 1.21 ± 0.046
1.091TyrThr: 1.091 ± 0.056
1.533TyrVal: 1.533 ± 0.055
0.375TyrTrp: 0.375 ± 0.03
0.687TyrTyr: 0.687 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1608 proteins (544650 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski