Amino acid dipepetide frequency for Moraxella phage Mcat23

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.605AlaAla: 5.605 ± 1.138
1.45AlaCys: 1.45 ± 0.384
5.509AlaAsp: 5.509 ± 0.623
6.185AlaGlu: 6.185 ± 0.9
2.706AlaPhe: 2.706 ± 0.491
5.605AlaGly: 5.605 ± 0.75
1.16AlaHis: 1.16 ± 0.323
5.026AlaIle: 5.026 ± 0.58
7.828AlaLys: 7.828 ± 0.967
8.988AlaLeu: 8.988 ± 1.531
1.933AlaMet: 1.933 ± 0.547
3.189AlaAsn: 3.189 ± 0.501
2.899AlaPro: 2.899 ± 0.598
4.156AlaGln: 4.156 ± 0.735
3.866AlaArg: 3.866 ± 0.534
5.992AlaSer: 5.992 ± 0.673
6.185AlaThr: 6.185 ± 1.233
4.349AlaVal: 4.349 ± 0.65
0.773AlaTrp: 0.773 ± 0.301
2.706AlaTyr: 2.706 ± 0.455
0.0AlaXaa: 0.0 ± 0.0
Cys
0.387CysAla: 0.387 ± 0.217
0.097CysCys: 0.097 ± 0.087
0.58CysAsp: 0.58 ± 0.259
0.677CysGlu: 0.677 ± 0.313
0.193CysPhe: 0.193 ± 0.117
1.063CysGly: 1.063 ± 0.446
0.387CysHis: 0.387 ± 0.219
0.483CysIle: 0.483 ± 0.208
0.387CysLys: 0.387 ± 0.251
1.256CysLeu: 1.256 ± 0.374
0.193CysMet: 0.193 ± 0.134
0.387CysAsn: 0.387 ± 0.17
0.387CysPro: 0.387 ± 0.218
0.677CysGln: 0.677 ± 0.315
0.773CysArg: 0.773 ± 0.302
0.773CysSer: 0.773 ± 0.27
0.29CysThr: 0.29 ± 0.186
0.773CysVal: 0.773 ± 0.415
0.0CysTrp: 0.0 ± 0.0
0.483CysTyr: 0.483 ± 0.259
0.0CysXaa: 0.0 ± 0.0
Asp
5.316AspAla: 5.316 ± 0.61
0.29AspCys: 0.29 ± 0.152
5.122AspAsp: 5.122 ± 0.763
4.736AspGlu: 4.736 ± 0.566
3.093AspPhe: 3.093 ± 0.587
5.799AspGly: 5.799 ± 0.598
0.87AspHis: 0.87 ± 0.271
4.446AspIle: 4.446 ± 0.703
4.832AspLys: 4.832 ± 0.601
5.316AspLeu: 5.316 ± 0.644
1.353AspMet: 1.353 ± 0.305
3.963AspAsn: 3.963 ± 0.62
2.223AspPro: 2.223 ± 0.579
0.773AspGln: 0.773 ± 0.249
2.126AspArg: 2.126 ± 0.4
4.156AspSer: 4.156 ± 0.51
3.189AspThr: 3.189 ± 0.506
4.252AspVal: 4.252 ± 0.589
0.87AspTrp: 0.87 ± 0.324
2.416AspTyr: 2.416 ± 0.481
0.0AspXaa: 0.0 ± 0.0
Glu
4.059GluAla: 4.059 ± 0.557
0.677GluCys: 0.677 ± 0.295
3.383GluAsp: 3.383 ± 0.702
2.223GluGlu: 2.223 ± 0.746
3.576GluPhe: 3.576 ± 0.5
2.32GluGly: 2.32 ± 0.356
1.353GluHis: 1.353 ± 0.374
3.576GluIle: 3.576 ± 0.574
4.349GluLys: 4.349 ± 0.682
7.635GluLeu: 7.635 ± 0.905
2.223GluMet: 2.223 ± 0.426
3.286GluAsn: 3.286 ± 0.565
2.32GluPro: 2.32 ± 0.501
3.479GluGln: 3.479 ± 0.458
4.252GluArg: 4.252 ± 0.544
2.899GluSer: 2.899 ± 0.589
2.803GluThr: 2.803 ± 0.433
3.576GluVal: 3.576 ± 0.477
0.773GluTrp: 0.773 ± 0.283
2.996GluTyr: 2.996 ± 0.513
0.0GluXaa: 0.0 ± 0.0
Phe
2.706PheAla: 2.706 ± 0.683
1.16PheCys: 1.16 ± 0.338
3.866PheAsp: 3.866 ± 0.536
3.383PheGlu: 3.383 ± 0.615
1.256PhePhe: 1.256 ± 0.332
3.093PheGly: 3.093 ± 0.531
0.87PheHis: 0.87 ± 0.277
2.899PheIle: 2.899 ± 0.472
2.32PheLys: 2.32 ± 0.52
2.803PheLeu: 2.803 ± 0.603
0.677PheMet: 0.677 ± 0.267
2.126PheAsn: 2.126 ± 0.394
0.87PhePro: 0.87 ± 0.326
0.677PheGln: 0.677 ± 0.335
1.546PheArg: 1.546 ± 0.405
2.126PheSer: 2.126 ± 0.423
2.609PheThr: 2.609 ± 0.486
2.513PheVal: 2.513 ± 0.5
0.58PheTrp: 0.58 ± 0.246
1.063PheTyr: 1.063 ± 0.343
0.0PheXaa: 0.0 ± 0.0
Gly
4.639GlyAla: 4.639 ± 0.791
0.29GlyCys: 0.29 ± 0.166
4.639GlyAsp: 4.639 ± 0.756
4.349GlyGlu: 4.349 ± 0.667
3.576GlyPhe: 3.576 ± 0.537
5.219GlyGly: 5.219 ± 1.09
1.16GlyHis: 1.16 ± 0.364
4.059GlyIle: 4.059 ± 0.453
5.992GlyLys: 5.992 ± 0.713
5.219GlyLeu: 5.219 ± 0.543
1.546GlyMet: 1.546 ± 0.413
3.189GlyAsn: 3.189 ± 0.536
0.193GlyPro: 0.193 ± 0.141
1.836GlyGln: 1.836 ± 0.374
4.639GlyArg: 4.639 ± 0.606
3.189GlySer: 3.189 ± 0.571
3.383GlyThr: 3.383 ± 0.704
5.702GlyVal: 5.702 ± 0.702
0.58GlyTrp: 0.58 ± 0.19
1.74GlyTyr: 1.74 ± 0.433
0.0GlyXaa: 0.0 ± 0.0
His
1.74HisAla: 1.74 ± 0.391
0.387HisCys: 0.387 ± 0.197
1.546HisAsp: 1.546 ± 0.411
1.353HisGlu: 1.353 ± 0.318
1.063HisPhe: 1.063 ± 0.233
1.643HisGly: 1.643 ± 0.406
0.966HisHis: 0.966 ± 0.456
1.063HisIle: 1.063 ± 0.279
0.87HisLys: 0.87 ± 0.274
2.706HisLeu: 2.706 ± 0.563
0.58HisMet: 0.58 ± 0.293
0.966HisAsn: 0.966 ± 0.279
0.773HisPro: 0.773 ± 0.231
0.87HisGln: 0.87 ± 0.177
0.58HisArg: 0.58 ± 0.203
0.966HisSer: 0.966 ± 0.351
1.74HisThr: 1.74 ± 0.38
0.773HisVal: 0.773 ± 0.3
0.193HisTrp: 0.193 ± 0.135
1.063HisTyr: 1.063 ± 0.369
0.0HisXaa: 0.0 ± 0.0
Ile
5.316IleAla: 5.316 ± 0.509
0.773IleCys: 0.773 ± 0.301
4.929IleAsp: 4.929 ± 0.558
3.866IleGlu: 3.866 ± 0.617
2.126IlePhe: 2.126 ± 0.627
4.639IleGly: 4.639 ± 0.69
1.16IleHis: 1.16 ± 0.337
5.992IleIle: 5.992 ± 0.925
5.702IleLys: 5.702 ± 0.901
4.252IleLeu: 4.252 ± 0.608
1.546IleMet: 1.546 ± 0.346
3.383IleAsn: 3.383 ± 0.624
1.16IlePro: 1.16 ± 0.327
3.383IleGln: 3.383 ± 0.626
1.836IleArg: 1.836 ± 0.393
3.286IleSer: 3.286 ± 0.53
4.542IleThr: 4.542 ± 0.621
2.03IleVal: 2.03 ± 0.307
0.29IleTrp: 0.29 ± 0.131
2.126IleTyr: 2.126 ± 0.347
0.0IleXaa: 0.0 ± 0.0
Lys
8.022LysAla: 8.022 ± 1.549
0.097LysCys: 0.097 ± 0.094
4.059LysAsp: 4.059 ± 0.598
2.996LysGlu: 2.996 ± 0.549
2.416LysPhe: 2.416 ± 0.526
3.866LysGly: 3.866 ± 0.616
1.74LysHis: 1.74 ± 0.516
3.189LysIle: 3.189 ± 0.505
4.736LysLys: 4.736 ± 0.835
6.475LysLeu: 6.475 ± 0.895
2.416LysMet: 2.416 ± 0.518
4.252LysAsn: 4.252 ± 0.748
2.996LysPro: 2.996 ± 0.535
2.996LysGln: 2.996 ± 0.636
4.156LysArg: 4.156 ± 0.677
4.542LysSer: 4.542 ± 0.778
4.929LysThr: 4.929 ± 0.819
2.803LysVal: 2.803 ± 0.6
0.773LysTrp: 0.773 ± 0.307
2.126LysTyr: 2.126 ± 0.466
0.0LysXaa: 0.0 ± 0.0
Leu
9.761LeuAla: 9.761 ± 1.118
0.966LeuCys: 0.966 ± 0.369
6.669LeuAsp: 6.669 ± 0.693
4.929LeuGlu: 4.929 ± 0.862
2.996LeuPhe: 2.996 ± 0.503
6.475LeuGly: 6.475 ± 0.753
2.03LeuHis: 2.03 ± 0.658
4.832LeuIle: 4.832 ± 0.539
6.862LeuLys: 6.862 ± 0.913
7.635LeuLeu: 7.635 ± 1.06
2.126LeuMet: 2.126 ± 0.525
4.736LeuAsn: 4.736 ± 0.587
3.576LeuPro: 3.576 ± 0.706
3.189LeuGln: 3.189 ± 0.572
4.252LeuArg: 4.252 ± 0.544
6.379LeuSer: 6.379 ± 0.631
5.702LeuThr: 5.702 ± 0.854
4.252LeuVal: 4.252 ± 0.617
1.353LeuTrp: 1.353 ± 0.274
3.093LeuTyr: 3.093 ± 0.483
0.0LeuXaa: 0.0 ± 0.0
Met
2.513MetAla: 2.513 ± 0.417
0.097MetCys: 0.097 ± 0.092
1.933MetAsp: 1.933 ± 0.35
1.16MetGlu: 1.16 ± 0.251
0.87MetPhe: 0.87 ± 0.304
1.933MetGly: 1.933 ± 0.381
0.87MetHis: 0.87 ± 0.339
2.32MetIle: 2.32 ± 0.618
1.353MetLys: 1.353 ± 0.315
2.03MetLeu: 2.03 ± 0.426
1.063MetMet: 1.063 ± 0.309
1.256MetAsn: 1.256 ± 0.453
0.966MetPro: 0.966 ± 0.288
1.643MetGln: 1.643 ± 0.359
1.256MetArg: 1.256 ± 0.411
2.513MetSer: 2.513 ± 0.451
2.03MetThr: 2.03 ± 0.4
2.03MetVal: 2.03 ± 0.562
0.29MetTrp: 0.29 ± 0.156
0.677MetTyr: 0.677 ± 0.34
0.0MetXaa: 0.0 ± 0.0
Asn
3.963AsnAla: 3.963 ± 0.611
0.483AsnCys: 0.483 ± 0.238
2.609AsnAsp: 2.609 ± 0.544
3.866AsnGlu: 3.866 ± 0.435
1.643AsnPhe: 1.643 ± 0.376
2.416AsnGly: 2.416 ± 0.397
1.063AsnHis: 1.063 ± 0.477
3.576AsnIle: 3.576 ± 0.512
2.996AsnLys: 2.996 ± 0.65
5.122AsnLeu: 5.122 ± 0.709
1.45AsnMet: 1.45 ± 0.469
2.609AsnAsn: 2.609 ± 0.482
2.803AsnPro: 2.803 ± 0.595
2.03AsnGln: 2.03 ± 0.425
2.126AsnArg: 2.126 ± 0.557
3.189AsnSer: 3.189 ± 0.446
2.899AsnThr: 2.899 ± 0.533
2.03AsnVal: 2.03 ± 0.494
0.387AsnTrp: 0.387 ± 0.16
2.03AsnTyr: 2.03 ± 0.414
0.0AsnXaa: 0.0 ± 0.0
Pro
1.836ProAla: 1.836 ± 0.407
0.483ProCys: 0.483 ± 0.183
2.32ProAsp: 2.32 ± 0.449
1.74ProGlu: 1.74 ± 0.39
1.836ProPhe: 1.836 ± 0.588
1.063ProGly: 1.063 ± 0.252
0.87ProHis: 0.87 ± 0.3
2.706ProIle: 2.706 ± 0.417
2.03ProLys: 2.03 ± 0.519
1.836ProLeu: 1.836 ± 0.493
1.353ProMet: 1.353 ± 0.378
2.223ProAsn: 2.223 ± 0.482
1.353ProPro: 1.353 ± 0.344
0.966ProGln: 0.966 ± 0.323
1.353ProArg: 1.353 ± 0.474
2.996ProSer: 2.996 ± 0.598
1.643ProThr: 1.643 ± 0.389
2.706ProVal: 2.706 ± 0.508
0.58ProTrp: 0.58 ± 0.227
0.677ProTyr: 0.677 ± 0.258
0.0ProXaa: 0.0 ± 0.0
Gln
5.605GlnAla: 5.605 ± 0.677
0.29GlnCys: 0.29 ± 0.172
1.933GlnAsp: 1.933 ± 0.491
2.609GlnGlu: 2.609 ± 0.481
1.063GlnPhe: 1.063 ± 0.296
2.32GlnGly: 2.32 ± 0.508
0.677GlnHis: 0.677 ± 0.218
2.513GlnIle: 2.513 ± 0.567
4.059GlnLys: 4.059 ± 0.537
3.479GlnLeu: 3.479 ± 0.679
1.546GlnMet: 1.546 ± 0.348
2.126GlnAsn: 2.126 ± 0.589
1.256GlnPro: 1.256 ± 0.365
2.223GlnGln: 2.223 ± 0.609
2.223GlnArg: 2.223 ± 0.453
2.609GlnSer: 2.609 ± 0.464
3.769GlnThr: 3.769 ± 0.542
2.609GlnVal: 2.609 ± 0.575
0.29GlnTrp: 0.29 ± 0.149
1.256GlnTyr: 1.256 ± 0.311
0.0GlnXaa: 0.0 ± 0.0
Arg
4.639ArgAla: 4.639 ± 0.566
0.483ArgCys: 0.483 ± 0.23
2.513ArgAsp: 2.513 ± 0.352
2.996ArgGlu: 2.996 ± 0.467
2.513ArgPhe: 2.513 ± 0.576
2.706ArgGly: 2.706 ± 0.468
1.256ArgHis: 1.256 ± 0.273
2.609ArgIle: 2.609 ± 0.471
1.836ArgLys: 1.836 ± 0.443
5.702ArgLeu: 5.702 ± 0.855
0.966ArgMet: 0.966 ± 0.293
2.03ArgAsn: 2.03 ± 0.502
1.353ArgPro: 1.353 ± 0.329
3.286ArgGln: 3.286 ± 0.564
2.609ArgArg: 2.609 ± 0.528
2.609ArgSer: 2.609 ± 0.575
2.126ArgThr: 2.126 ± 0.455
2.803ArgVal: 2.803 ± 0.454
0.87ArgTrp: 0.87 ± 0.233
2.803ArgTyr: 2.803 ± 0.528
0.0ArgXaa: 0.0 ± 0.0
Ser
4.542SerAla: 4.542 ± 0.744
0.29SerCys: 0.29 ± 0.15
4.059SerAsp: 4.059 ± 0.792
4.736SerGlu: 4.736 ± 0.613
2.706SerPhe: 2.706 ± 0.606
3.286SerGly: 3.286 ± 0.411
1.353SerHis: 1.353 ± 0.254
3.479SerIle: 3.479 ± 0.696
3.576SerLys: 3.576 ± 0.511
5.992SerLeu: 5.992 ± 0.849
1.546SerMet: 1.546 ± 0.371
3.576SerAsn: 3.576 ± 0.524
1.643SerPro: 1.643 ± 0.603
3.963SerGln: 3.963 ± 0.577
2.996SerArg: 2.996 ± 0.478
2.996SerSer: 2.996 ± 0.596
2.803SerThr: 2.803 ± 0.487
3.769SerVal: 3.769 ± 0.665
0.483SerTrp: 0.483 ± 0.177
1.933SerTyr: 1.933 ± 0.372
0.0SerXaa: 0.0 ± 0.0
Thr
7.248ThrAla: 7.248 ± 0.863
0.58ThrCys: 0.58 ± 0.256
3.383ThrAsp: 3.383 ± 0.531
3.383ThrGlu: 3.383 ± 0.627
1.546ThrPhe: 1.546 ± 0.31
4.736ThrGly: 4.736 ± 0.569
1.353ThrHis: 1.353 ± 0.395
3.576ThrIle: 3.576 ± 0.579
3.479ThrLys: 3.479 ± 0.721
5.316ThrLeu: 5.316 ± 0.706
1.933ThrMet: 1.933 ± 0.467
2.03ThrAsn: 2.03 ± 0.411
2.803ThrPro: 2.803 ± 0.654
2.223ThrGln: 2.223 ± 0.375
1.74ThrArg: 1.74 ± 0.404
2.899ThrSer: 2.899 ± 0.631
4.349ThrThr: 4.349 ± 0.68
4.639ThrVal: 4.639 ± 0.669
0.966ThrTrp: 0.966 ± 0.298
1.16ThrTyr: 1.16 ± 0.254
0.0ThrXaa: 0.0 ± 0.0
Val
4.639ValAla: 4.639 ± 0.863
0.87ValCys: 0.87 ± 0.291
3.286ValAsp: 3.286 ± 0.556
3.576ValGlu: 3.576 ± 0.501
2.03ValPhe: 2.03 ± 0.429
3.383ValGly: 3.383 ± 0.527
1.353ValHis: 1.353 ± 0.373
3.866ValIle: 3.866 ± 0.665
3.576ValLys: 3.576 ± 0.652
5.895ValLeu: 5.895 ± 0.685
2.706ValMet: 2.706 ± 0.419
2.996ValAsn: 2.996 ± 0.423
1.74ValPro: 1.74 ± 0.347
2.803ValGln: 2.803 ± 0.395
3.673ValArg: 3.673 ± 0.561
3.189ValSer: 3.189 ± 0.533
2.609ValThr: 2.609 ± 0.504
2.899ValVal: 2.899 ± 0.445
0.773ValTrp: 0.773 ± 0.291
2.126ValTyr: 2.126 ± 0.518
0.0ValXaa: 0.0 ± 0.0
Trp
0.87TrpAla: 0.87 ± 0.336
0.29TrpCys: 0.29 ± 0.15
0.87TrpAsp: 0.87 ± 0.297
0.87TrpGlu: 0.87 ± 0.312
0.387TrpPhe: 0.387 ± 0.187
0.773TrpGly: 0.773 ± 0.243
0.387TrpHis: 0.387 ± 0.172
0.483TrpIle: 0.483 ± 0.212
0.387TrpLys: 0.387 ± 0.216
1.256TrpLeu: 1.256 ± 0.44
0.193TrpMet: 0.193 ± 0.129
0.193TrpAsn: 0.193 ± 0.149
0.097TrpPro: 0.097 ± 0.092
1.45TrpGln: 1.45 ± 0.403
0.387TrpArg: 0.387 ± 0.217
0.58TrpSer: 0.58 ± 0.267
0.387TrpThr: 0.387 ± 0.172
0.87TrpVal: 0.87 ± 0.233
0.097TrpTrp: 0.097 ± 0.109
0.58TrpTyr: 0.58 ± 0.265
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.706TyrAla: 2.706 ± 0.74
0.193TyrCys: 0.193 ± 0.138
1.933TyrAsp: 1.933 ± 0.428
2.126TyrGlu: 2.126 ± 0.46
1.546TyrPhe: 1.546 ± 0.41
2.803TyrGly: 2.803 ± 0.498
0.966TyrHis: 0.966 ± 0.427
1.643TyrIle: 1.643 ± 0.422
2.416TyrLys: 2.416 ± 0.475
2.899TyrLeu: 2.899 ± 0.732
1.353TyrMet: 1.353 ± 0.357
0.87TyrAsn: 0.87 ± 0.301
1.16TyrPro: 1.16 ± 0.427
1.836TyrGln: 1.836 ± 0.414
2.32TyrArg: 2.32 ± 0.421
1.836TyrSer: 1.836 ± 0.457
1.353TyrThr: 1.353 ± 0.253
2.609TyrVal: 2.609 ± 0.635
0.483TyrTrp: 0.483 ± 0.229
1.546TyrTyr: 1.546 ± 0.376
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 49 proteins (10348 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski