Amino acid dipepetide frequency for Rikenella microfusus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.556AlaAla: 11.556 ± 0.165
1.04AlaCys: 1.04 ± 0.037
5.92AlaAsp: 5.92 ± 0.1
6.967AlaGlu: 6.967 ± 0.114
3.502AlaPhe: 3.502 ± 0.078
8.312AlaGly: 8.312 ± 0.122
1.409AlaHis: 1.409 ± 0.045
4.639AlaIle: 4.639 ± 0.083
3.786AlaLys: 3.786 ± 0.079
8.671AlaLeu: 8.671 ± 0.114
2.309AlaMet: 2.309 ± 0.056
2.655AlaAsn: 2.655 ± 0.065
3.566AlaPro: 3.566 ± 0.071
3.112AlaGln: 3.112 ± 0.073
5.47AlaArg: 5.47 ± 0.088
4.876AlaSer: 4.876 ± 0.091
4.561AlaThr: 4.561 ± 0.084
7.664AlaVal: 7.664 ± 0.104
1.079AlaTrp: 1.079 ± 0.042
2.943AlaTyr: 2.943 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.979CysAla: 0.979 ± 0.038
0.222CysCys: 0.222 ± 0.018
0.651CysAsp: 0.651 ± 0.029
0.575CysGlu: 0.575 ± 0.031
0.478CysPhe: 0.478 ± 0.027
1.254CysGly: 1.254 ± 0.045
0.206CysHis: 0.206 ± 0.017
0.565CysIle: 0.565 ± 0.028
0.436CysLys: 0.436 ± 0.025
0.952CysLeu: 0.952 ± 0.034
0.22CysMet: 0.22 ± 0.018
0.41CysAsn: 0.41 ± 0.026
0.621CysPro: 0.621 ± 0.029
0.244CysGln: 0.244 ± 0.018
0.901CysArg: 0.901 ± 0.034
0.67CysSer: 0.67 ± 0.03
0.667CysThr: 0.667 ± 0.031
0.693CysVal: 0.693 ± 0.03
0.128CysTrp: 0.128 ± 0.012
0.431CysTyr: 0.431 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.633AspAla: 4.633 ± 0.079
0.559AspCys: 0.559 ± 0.026
2.902AspAsp: 2.902 ± 0.061
3.491AspGlu: 3.491 ± 0.082
2.81AspPhe: 2.81 ± 0.06
4.864AspGly: 4.864 ± 0.098
0.846AspHis: 0.846 ± 0.033
3.612AspIle: 3.612 ± 0.068
2.826AspLys: 2.826 ± 0.072
4.712AspLeu: 4.712 ± 0.079
1.428AspMet: 1.428 ± 0.048
2.256AspAsn: 2.256 ± 0.051
2.82AspPro: 2.82 ± 0.065
1.116AspGln: 1.116 ± 0.044
3.868AspArg: 3.868 ± 0.07
3.28AspSer: 3.28 ± 0.08
3.383AspThr: 3.383 ± 0.065
3.147AspVal: 3.147 ± 0.073
0.861AspTrp: 0.861 ± 0.034
2.658AspTyr: 2.658 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
6.148GluAla: 6.148 ± 0.111
0.558GluCys: 0.558 ± 0.027
2.662GluAsp: 2.662 ± 0.059
3.89GluGlu: 3.89 ± 0.088
2.212GluPhe: 2.212 ± 0.049
4.361GluGly: 4.361 ± 0.088
1.182GluHis: 1.182 ± 0.04
4.175GluIle: 4.175 ± 0.079
3.771GluLys: 3.771 ± 0.075
5.973GluLeu: 5.973 ± 0.103
1.95GluMet: 1.95 ± 0.047
2.871GluAsn: 2.871 ± 0.067
2.438GluPro: 2.438 ± 0.057
2.499GluGln: 2.499 ± 0.058
4.796GluArg: 4.796 ± 0.087
2.881GluSer: 2.881 ± 0.06
3.71GluThr: 3.71 ± 0.077
4.127GluVal: 4.127 ± 0.078
0.948GluTrp: 0.948 ± 0.037
2.401GluTyr: 2.401 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.889PheAla: 3.889 ± 0.072
0.572PheCys: 0.572 ± 0.026
2.954PheAsp: 2.954 ± 0.073
2.269PheGlu: 2.269 ± 0.056
1.857PhePhe: 1.857 ± 0.061
3.772PheGly: 3.772 ± 0.084
0.731PheHis: 0.731 ± 0.031
2.281PheIle: 2.281 ± 0.054
1.443PheLys: 1.443 ± 0.045
3.363PheLeu: 3.363 ± 0.077
1.056PheMet: 1.056 ± 0.033
1.557PheAsn: 1.557 ± 0.05
1.86PhePro: 1.86 ± 0.049
0.946PheGln: 0.946 ± 0.035
3.11PheArg: 3.11 ± 0.075
2.745PheSer: 2.745 ± 0.068
2.496PheThr: 2.496 ± 0.058
3.098PheVal: 3.098 ± 0.074
0.528PheTrp: 0.528 ± 0.029
1.483PheTyr: 1.483 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
6.428GlyAla: 6.428 ± 0.1
1.018GlyCys: 1.018 ± 0.045
4.228GlyAsp: 4.228 ± 0.082
4.893GlyGlu: 4.893 ± 0.066
3.377GlyPhe: 3.377 ± 0.068
6.568GlyGly: 6.568 ± 0.137
1.53GlyHis: 1.53 ± 0.043
5.414GlyIle: 5.414 ± 0.091
4.473GlyLys: 4.473 ± 0.079
6.661GlyLeu: 6.661 ± 0.104
2.284GlyMet: 2.284 ± 0.053
3.178GlyAsn: 3.178 ± 0.074
2.033GlyPro: 2.033 ± 0.058
2.355GlyGln: 2.355 ± 0.061
5.373GlyArg: 5.373 ± 0.094
4.346GlySer: 4.346 ± 0.075
5.081GlyThr: 5.081 ± 0.087
5.441GlyVal: 5.441 ± 0.088
1.135GlyTrp: 1.135 ± 0.044
3.337GlyTyr: 3.337 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.366HisAla: 1.366 ± 0.048
0.242HisCys: 0.242 ± 0.019
0.94HisAsp: 0.94 ± 0.036
0.83HisGlu: 0.83 ± 0.032
0.889HisPhe: 0.889 ± 0.031
1.408HisGly: 1.408 ± 0.047
0.363HisHis: 0.363 ± 0.021
1.271HisIle: 1.271 ± 0.045
0.817HisLys: 0.817 ± 0.033
1.534HisLeu: 1.534 ± 0.046
0.352HisMet: 0.352 ± 0.021
0.687HisAsn: 0.687 ± 0.031
1.127HisPro: 1.127 ± 0.046
0.41HisGln: 0.41 ± 0.021
1.214HisArg: 1.214 ± 0.037
0.993HisSer: 0.993 ± 0.039
1.128HisThr: 1.128 ± 0.041
0.993HisVal: 0.993 ± 0.036
0.226HisTrp: 0.226 ± 0.018
0.813HisTyr: 0.813 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.892IleAla: 5.892 ± 0.095
0.711IleCys: 0.711 ± 0.027
4.139IleAsp: 4.139 ± 0.082
4.055IleGlu: 4.055 ± 0.077
2.386IlePhe: 2.386 ± 0.066
4.663IleGly: 4.663 ± 0.084
0.971IleHis: 0.971 ± 0.037
2.877IleIle: 2.877 ± 0.068
2.325IleLys: 2.325 ± 0.061
5.011IleLeu: 5.011 ± 0.101
1.157IleMet: 1.157 ± 0.039
1.976IleAsn: 1.976 ± 0.059
3.055IlePro: 3.055 ± 0.061
1.479IleGln: 1.479 ± 0.044
4.262IleArg: 4.262 ± 0.073
3.307IleSer: 3.307 ± 0.081
3.0IleThr: 3.0 ± 0.068
4.644IleVal: 4.644 ± 0.088
0.556IleTrp: 0.556 ± 0.029
2.135IleTyr: 2.135 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.298LysAla: 4.298 ± 0.09
0.368LysCys: 0.368 ± 0.021
2.332LysAsp: 2.332 ± 0.056
3.443LysGlu: 3.443 ± 0.079
1.607LysPhe: 1.607 ± 0.045
3.496LysGly: 3.496 ± 0.068
0.815LysHis: 0.815 ± 0.03
3.244LysIle: 3.244 ± 0.071
2.918LysLys: 2.918 ± 0.073
4.06LysLeu: 4.06 ± 0.081
1.498LysMet: 1.498 ± 0.043
1.985LysAsn: 1.985 ± 0.056
2.002LysPro: 2.002 ± 0.053
1.624LysGln: 1.624 ± 0.049
3.036LysArg: 3.036 ± 0.064
2.396LysSer: 2.396 ± 0.056
2.928LysThr: 2.928 ± 0.067
3.17LysVal: 3.17 ± 0.07
0.575LysTrp: 0.575 ± 0.03
1.952LysTyr: 1.952 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
8.563LeuAla: 8.563 ± 0.108
1.279LeuCys: 1.279 ± 0.045
4.838LeuAsp: 4.838 ± 0.086
5.086LeuGlu: 5.086 ± 0.085
4.17LeuPhe: 4.17 ± 0.103
6.291LeuGly: 6.291 ± 0.111
1.645LeuHis: 1.645 ± 0.05
4.663LeuIle: 4.663 ± 0.112
4.52LeuLys: 4.52 ± 0.075
9.063LeuLeu: 9.063 ± 0.163
2.199LeuMet: 2.199 ± 0.052
3.364LeuAsn: 3.364 ± 0.066
4.659LeuPro: 4.659 ± 0.075
2.744LeuGln: 2.744 ± 0.055
6.272LeuArg: 6.272 ± 0.099
5.993LeuSer: 5.993 ± 0.099
5.649LeuThr: 5.649 ± 0.087
5.714LeuVal: 5.714 ± 0.09
1.142LeuTrp: 1.142 ± 0.04
3.27LeuTyr: 3.27 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.396MetAla: 2.396 ± 0.058
0.193MetCys: 0.193 ± 0.015
1.305MetAsp: 1.305 ± 0.042
1.658MetGlu: 1.658 ± 0.045
0.911MetPhe: 0.911 ± 0.032
1.837MetGly: 1.837 ± 0.048
0.398MetHis: 0.398 ± 0.02
1.467MetIle: 1.467 ± 0.045
1.703MetLys: 1.703 ± 0.039
2.428MetLeu: 2.428 ± 0.055
0.684MetMet: 0.684 ± 0.029
1.13MetAsn: 1.13 ± 0.04
1.252MetPro: 1.252 ± 0.04
1.004MetGln: 1.004 ± 0.04
1.634MetArg: 1.634 ± 0.045
1.311MetSer: 1.311 ± 0.035
1.519MetThr: 1.519 ± 0.041
1.585MetVal: 1.585 ± 0.049
0.249MetTrp: 0.249 ± 0.018
0.65MetTyr: 0.65 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.054AsnAla: 3.054 ± 0.066
0.414AsnCys: 0.414 ± 0.025
1.987AsnAsp: 1.987 ± 0.052
1.951AsnGlu: 1.951 ± 0.049
1.49AsnPhe: 1.49 ± 0.042
3.192AsnGly: 3.192 ± 0.07
0.716AsnHis: 0.716 ± 0.031
2.635AsnIle: 2.635 ± 0.066
1.658AsnLys: 1.658 ± 0.046
3.412AsnLeu: 3.412 ± 0.067
0.889AsnMet: 0.889 ± 0.036
1.499AsnAsn: 1.499 ± 0.055
2.288AsnPro: 2.288 ± 0.059
0.915AsnGln: 0.915 ± 0.041
2.724AsnArg: 2.724 ± 0.063
1.864AsnSer: 1.864 ± 0.063
2.088AsnThr: 2.088 ± 0.052
2.441AsnVal: 2.441 ± 0.058
0.452AsnTrp: 0.452 ± 0.026
1.535AsnTyr: 1.535 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.912ProAla: 4.912 ± 0.094
0.421ProCys: 0.421 ± 0.021
3.352ProAsp: 3.352 ± 0.08
4.038ProGlu: 4.038 ± 0.073
1.889ProPhe: 1.889 ± 0.047
3.448ProGly: 3.448 ± 0.068
0.785ProHis: 0.785 ± 0.028
1.936ProIle: 1.936 ± 0.057
1.952ProLys: 1.952 ± 0.061
3.889ProLeu: 3.889 ± 0.064
0.995ProMet: 0.995 ± 0.034
1.503ProAsn: 1.503 ± 0.043
1.289ProPro: 1.289 ± 0.045
1.797ProGln: 1.797 ± 0.047
2.199ProArg: 2.199 ± 0.055
2.308ProSer: 2.308 ± 0.057
2.126ProThr: 2.126 ± 0.061
3.835ProVal: 3.835 ± 0.062
0.548ProTrp: 0.548 ± 0.029
1.643ProTyr: 1.643 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
2.942GlnAla: 2.942 ± 0.058
0.282GlnCys: 0.282 ± 0.02
1.351GlnAsp: 1.351 ± 0.04
1.933GlnGlu: 1.933 ± 0.053
1.173GlnPhe: 1.173 ± 0.039
2.11GlnGly: 2.11 ± 0.056
0.551GlnHis: 0.551 ± 0.027
1.995GlnIle: 1.995 ± 0.051
1.645GlnLys: 1.645 ± 0.05
2.727GlnLeu: 2.727 ± 0.071
0.931GlnMet: 0.931 ± 0.032
1.188GlnAsn: 1.188 ± 0.042
1.324GlnPro: 1.324 ± 0.045
1.384GlnGln: 1.384 ± 0.056
2.001GlnArg: 2.001 ± 0.055
1.632GlnSer: 1.632 ± 0.042
1.949GlnThr: 1.949 ± 0.053
2.079GlnVal: 2.079 ± 0.046
0.44GlnTrp: 0.44 ± 0.025
1.157GlnTyr: 1.157 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
4.826ArgAla: 4.826 ± 0.089
0.666ArgCys: 0.666 ± 0.029
3.046ArgAsp: 3.046 ± 0.061
4.601ArgGlu: 4.601 ± 0.088
3.144ArgPhe: 3.144 ± 0.06
4.05ArgGly: 4.05 ± 0.061
1.433ArgHis: 1.433 ± 0.043
4.801ArgIle: 4.801 ± 0.077
3.573ArgLys: 3.573 ± 0.07
6.384ArgLeu: 6.384 ± 0.102
2.058ArgMet: 2.058 ± 0.051
2.785ArgAsn: 2.785 ± 0.074
2.945ArgPro: 2.945 ± 0.082
2.589ArgGln: 2.589 ± 0.065
4.708ArgArg: 4.708 ± 0.097
3.48ArgSer: 3.48 ± 0.073
3.827ArgThr: 3.827 ± 0.075
3.835ArgVal: 3.835 ± 0.076
0.921ArgTrp: 0.921 ± 0.037
2.872ArgTyr: 2.872 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
5.24SerAla: 5.24 ± 0.088
0.651SerCys: 0.651 ± 0.028
3.167SerAsp: 3.167 ± 0.063
3.209SerGlu: 3.209 ± 0.068
2.534SerPhe: 2.534 ± 0.063
5.154SerGly: 5.154 ± 0.093
0.964SerHis: 0.964 ± 0.034
2.922SerIle: 2.922 ± 0.072
2.206SerLys: 2.206 ± 0.056
5.488SerLeu: 5.488 ± 0.09
1.28SerMet: 1.28 ± 0.048
1.746SerAsn: 1.746 ± 0.058
2.63SerPro: 2.63 ± 0.061
1.515SerGln: 1.515 ± 0.042
3.328SerArg: 3.328 ± 0.068
3.114SerSer: 3.114 ± 0.077
2.851SerThr: 2.851 ± 0.073
4.497SerVal: 4.497 ± 0.078
0.739SerTrp: 0.739 ± 0.033
2.123SerTyr: 2.123 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
6.039ThrAla: 6.039 ± 0.087
0.498ThrCys: 0.498 ± 0.029
3.629ThrAsp: 3.629 ± 0.075
3.385ThrGlu: 3.385 ± 0.073
2.343ThrPhe: 2.343 ± 0.058
5.002ThrGly: 5.002 ± 0.097
0.926ThrHis: 0.926 ± 0.033
3.225ThrIle: 3.225 ± 0.072
2.082ThrLys: 2.082 ± 0.055
5.701ThrLeu: 5.701 ± 0.099
1.155ThrMet: 1.155 ± 0.041
1.679ThrAsn: 1.679 ± 0.052
3.167ThrPro: 3.167 ± 0.058
1.546ThrGln: 1.546 ± 0.044
2.822ThrArg: 2.822 ± 0.049
2.78ThrSer: 2.78 ± 0.072
3.097ThrThr: 3.097 ± 0.068
5.463ThrVal: 5.463 ± 0.094
0.565ThrTrp: 0.565 ± 0.028
2.015ThrTyr: 2.015 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
6.693ValAla: 6.693 ± 0.095
0.952ValCys: 0.952 ± 0.034
3.515ValAsp: 3.515 ± 0.069
4.382ValGlu: 4.382 ± 0.083
2.928ValPhe: 2.928 ± 0.065
5.165ValGly: 5.165 ± 0.089
1.146ValHis: 1.146 ± 0.041
3.996ValIle: 3.996 ± 0.082
3.25ValLys: 3.25 ± 0.067
6.301ValLeu: 6.301 ± 0.099
1.596ValMet: 1.596 ± 0.051
2.568ValAsn: 2.568 ± 0.068
3.582ValPro: 3.582 ± 0.067
2.032ValGln: 2.032 ± 0.045
5.094ValArg: 5.094 ± 0.091
4.728ValSer: 4.728 ± 0.084
4.207ValThr: 4.207 ± 0.084
5.339ValVal: 5.339 ± 0.097
0.894ValTrp: 0.894 ± 0.038
2.504ValTyr: 2.504 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.902TrpAla: 0.902 ± 0.039
0.211TrpCys: 0.211 ± 0.017
0.665TrpAsp: 0.665 ± 0.028
0.746TrpGlu: 0.746 ± 0.032
0.549TrpPhe: 0.549 ± 0.029
1.085TrpGly: 1.085 ± 0.036
0.263TrpHis: 0.263 ± 0.019
0.787TrpIle: 0.787 ± 0.035
0.606TrpLys: 0.606 ± 0.033
1.304TrpLeu: 1.304 ± 0.045
0.406TrpMet: 0.406 ± 0.024
0.605TrpAsn: 0.605 ± 0.033
0.372TrpPro: 0.372 ± 0.023
0.527TrpGln: 0.527 ± 0.027
0.824TrpArg: 0.824 ± 0.032
0.661TrpSer: 0.661 ± 0.032
0.687TrpThr: 0.687 ± 0.03
0.774TrpVal: 0.774 ± 0.033
0.214TrpTrp: 0.214 ± 0.018
0.481TrpTyr: 0.481 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.282TyrAla: 3.282 ± 0.064
0.449TyrCys: 0.449 ± 0.023
2.491TyrAsp: 2.491 ± 0.053
2.151TyrGlu: 2.151 ± 0.057
1.76TyrPhe: 1.76 ± 0.053
3.119TyrGly: 3.119 ± 0.058
0.722TyrHis: 0.722 ± 0.028
2.098TyrIle: 2.098 ± 0.045
1.757TyrLys: 1.757 ± 0.053
3.491TyrLeu: 3.491 ± 0.065
0.864TyrMet: 0.864 ± 0.033
1.561TyrAsn: 1.561 ± 0.047
1.836TyrPro: 1.836 ± 0.045
0.954TyrGln: 0.954 ± 0.031
2.909TyrArg: 2.909 ± 0.07
1.995TyrSer: 1.995 ± 0.051
2.166TyrThr: 2.166 ± 0.059
2.328TyrVal: 2.328 ± 0.059
0.47TyrTrp: 0.47 ± 0.023
1.652TyrTyr: 1.652 ± 0.049
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2358 proteins (804626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski