Amino acid dipepetide frequency for Gloeomargarita lithophora Alchichica-D10

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.69AlaAla: 7.69 ± 0.12	0.892AlaCys: 0.892 ± 0.029	4.098AlaAsp: 4.098 ± 0.079	5.116AlaGlu: 5.116 ± 0.089	2.498AlaPhe: 2.498 ± 0.065	7.268AlaGly: 7.268 ± 0.107	1.76AlaHis: 1.76 ± 0.052	5.042AlaIle: 5.042 ± 0.077	2.917AlaLys: 2.917 ± 0.066	10.561AlaLeu: 10.561 ± 0.148	2.031AlaMet: 2.031 ± 0.057	3.098AlaAsn: 3.098 ± 0.091	4.222AlaPro: 4.222 ± 0.077	6.968AlaGln: 6.968 ± 0.111	4.23AlaArg: 4.23 ± 0.081	3.995AlaSer: 3.995 ± 0.066	5.215AlaThr: 5.215 ± 0.086	7.081AlaVal: 7.081 ± 0.108	1.53AlaTrp: 1.53 ± 0.053	2.349AlaTyr: 2.349 ± 0.057	0.0AlaXaa: 0.0 ± 0.0
Cys	0.782CysAla: 0.782 ± 0.034	0.123CysCys: 0.123 ± 0.012	0.565CysAsp: 0.565 ± 0.025	0.487CysGlu: 0.487 ± 0.021	0.36CysPhe: 0.36 ± 0.021	0.945CysGly: 0.945 ± 0.035	0.317CysHis: 0.317 ± 0.022	0.469CysIle: 0.469 ± 0.023	0.239CysLys: 0.239 ± 0.019	1.221CysLeu: 1.221 ± 0.037	0.133CysMet: 0.133 ± 0.012	0.306CysAsn: 0.306 ± 0.022	0.715CysPro: 0.715 ± 0.027	0.695CysGln: 0.695 ± 0.025	0.714CysArg: 0.714 ± 0.028	0.489CysSer: 0.489 ± 0.022	0.541CysThr: 0.541 ± 0.027	0.595CysVal: 0.595 ± 0.03	0.176CysTrp: 0.176 ± 0.015	0.382CysTyr: 0.382 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.196AspAla: 3.196 ± 0.066	0.524AspCys: 0.524 ± 0.025	1.773AspAsp: 1.773 ± 0.043	2.459AspGlu: 2.459 ± 0.057	2.204AspPhe: 2.204 ± 0.054	3.289AspGly: 3.289 ± 0.069	0.896AspHis: 0.896 ± 0.037	2.703AspIle: 2.703 ± 0.068	1.447AspLys: 1.447 ± 0.046	5.893AspLeu: 5.893 ± 0.099	0.922AspMet: 0.922 ± 0.03	1.349AspAsn: 1.349 ± 0.04	2.87AspPro: 2.87 ± 0.06	2.381AspGln: 2.381 ± 0.046	2.641AspArg: 2.641 ± 0.059	2.1AspSer: 2.1 ± 0.052	2.249AspThr: 2.249 ± 0.052	3.033AspVal: 3.033 ± 0.064	1.132AspTrp: 1.132 ± 0.042	1.777AspTyr: 1.777 ± 0.049	0.0AspXaa: 0.0 ± 0.0
Glu	4.972GluAla: 4.972 ± 0.094	0.478GluCys: 0.478 ± 0.029	2.005GluAsp: 2.005 ± 0.052	2.749GluGlu: 2.749 ± 0.077	2.315GluPhe: 2.315 ± 0.055	2.962GluGly: 2.962 ± 0.072	1.041GluHis: 1.041 ± 0.034	3.783GluIle: 3.783 ± 0.073	1.971GluLys: 1.971 ± 0.063	7.557GluLeu: 7.557 ± 0.093	1.371GluMet: 1.371 ± 0.042	1.808GluAsn: 1.808 ± 0.042	2.91GluPro: 2.91 ± 0.069	3.796GluGln: 3.796 ± 0.07	4.326GluArg: 4.326 ± 0.074	2.575GluSer: 2.575 ± 0.064	3.156GluThr: 3.156 ± 0.07	3.956GluVal: 3.956 ± 0.075	0.853GluTrp: 0.853 ± 0.034	1.563GluTyr: 1.563 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.134PheAla: 3.134 ± 0.064	0.483PheCys: 0.483 ± 0.024	1.92PheAsp: 1.92 ± 0.045	1.559PheGlu: 1.559 ± 0.052	1.402PhePhe: 1.402 ± 0.041	2.79PheGly: 2.79 ± 0.059	0.731PheHis: 0.731 ± 0.029	1.838PheIle: 1.838 ± 0.055	0.836PheLys: 0.836 ± 0.032	3.882PheLeu: 3.882 ± 0.074	0.694PheMet: 0.694 ± 0.03	1.368PheAsn: 1.368 ± 0.045	1.917PhePro: 1.917 ± 0.051	1.862PheGln: 1.862 ± 0.045	1.909PheArg: 1.909 ± 0.045	2.251PheSer: 2.251 ± 0.055	2.243PheThr: 2.243 ± 0.054	2.145PheVal: 2.145 ± 0.05	0.82PheTrp: 0.82 ± 0.037	1.316PheTyr: 1.316 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.584GlyAla: 6.584 ± 0.122	0.964GlyCys: 0.964 ± 0.036	3.546GlyAsp: 3.546 ± 0.082	4.74GlyGlu: 4.74 ± 0.086	3.143GlyPhe: 3.143 ± 0.063	6.17GlyGly: 6.17 ± 0.146	1.574GlyHis: 1.574 ± 0.046	4.825GlyIle: 4.825 ± 0.1	2.975GlyLys: 2.975 ± 0.064	9.222GlyLeu: 9.222 ± 0.133	2.135GlyMet: 2.135 ± 0.054	2.697GlyAsn: 2.697 ± 0.1	1.429GlyPro: 1.429 ± 0.046	4.59GlyGln: 4.59 ± 0.077	4.597GlyArg: 4.597 ± 0.079	3.746GlySer: 3.746 ± 0.072	4.511GlyThr: 4.511 ± 0.106	6.348GlyVal: 6.348 ± 0.099	1.68GlyTrp: 1.68 ± 0.05	2.567GlyTyr: 2.567 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	1.287HisAla: 1.287 ± 0.037	0.366HisCys: 0.366 ± 0.023	0.745HisAsp: 0.745 ± 0.03	0.805HisGlu: 0.805 ± 0.03	0.761HisPhe: 0.761 ± 0.03	1.354HisGly: 1.354 ± 0.038	0.74HisHis: 0.74 ± 0.032	1.089HisIle: 1.089 ± 0.038	0.491HisLys: 0.491 ± 0.026	3.042HisLeu: 3.042 ± 0.074	0.224HisMet: 0.224 ± 0.016	0.627HisAsn: 0.627 ± 0.026	1.81HisPro: 1.81 ± 0.054	1.577HisGln: 1.577 ± 0.05	1.665HisArg: 1.665 ± 0.054	1.06HisSer: 1.06 ± 0.037	1.133HisThr: 1.133 ± 0.033	0.853HisVal: 0.853 ± 0.033	0.566HisTrp: 0.566 ± 0.028	0.846HisTyr: 0.846 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	4.931IleAla: 4.931 ± 0.083	0.62IleCys: 0.62 ± 0.027	2.759IleAsp: 2.759 ± 0.057	2.928IleGlu: 2.928 ± 0.063	2.038IlePhe: 2.038 ± 0.058	3.708IleGly: 3.708 ± 0.078	1.381IleHis: 1.381 ± 0.041	2.734IleIle: 2.734 ± 0.069	1.693IleLys: 1.693 ± 0.056	6.365IleLeu: 6.365 ± 0.09	0.765IleMet: 0.765 ± 0.032	2.059IleAsn: 2.059 ± 0.068	3.488IlePro: 3.488 ± 0.072	3.041IleGln: 3.041 ± 0.072	3.051IleArg: 3.051 ± 0.052	3.04IleSer: 3.04 ± 0.063	3.807IleThr: 3.807 ± 0.108	3.232IleVal: 3.232 ± 0.065	0.752IleTrp: 0.752 ± 0.033	1.688IleTyr: 1.688 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	2.575LysAla: 2.575 ± 0.063	0.232LysCys: 0.232 ± 0.018	1.301LysAsp: 1.301 ± 0.041	1.652LysGlu: 1.652 ± 0.056	1.104LysPhe: 1.104 ± 0.042	1.946LysGly: 1.946 ± 0.061	0.623LysHis: 0.623 ± 0.027	2.334LysIle: 2.334 ± 0.062	1.395LysLys: 1.395 ± 0.05	3.579LysLeu: 3.579 ± 0.072	0.705LysMet: 0.705 ± 0.031	1.366LysAsn: 1.366 ± 0.045	1.833LysPro: 1.833 ± 0.045	1.805LysGln: 1.805 ± 0.055	1.913LysArg: 1.913 ± 0.048	1.774LysSer: 1.774 ± 0.053	2.077LysThr: 2.077 ± 0.047	2.203LysVal: 2.203 ± 0.052	0.386LysTrp: 0.386 ± 0.023	0.958LysTyr: 0.958 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	12.649LeuAla: 12.649 ± 0.153	1.087LeuCys: 1.087 ± 0.04	5.453LeuAsp: 5.453 ± 0.083	6.836LeuGlu: 6.836 ± 0.106	3.581LeuPhe: 3.581 ± 0.077	10.173LeuGly: 10.173 ± 0.142	2.371LeuHis: 2.371 ± 0.062	5.685LeuIle: 5.685 ± 0.096	3.955LeuLys: 3.955 ± 0.07	12.27LeuLeu: 12.27 ± 0.168	2.117LeuMet: 2.117 ± 0.052	3.793LeuAsn: 3.793 ± 0.071	6.782LeuPro: 6.782 ± 0.102	6.025LeuGln: 6.025 ± 0.109	6.913LeuArg: 6.913 ± 0.113	6.365LeuSer: 6.365 ± 0.101	7.814LeuThr: 7.814 ± 0.115	9.226LeuVal: 9.226 ± 0.109	1.947LeuTrp: 1.947 ± 0.05	2.752LeuTyr: 2.752 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	2.244MetAla: 2.244 ± 0.05	0.118MetCys: 0.118 ± 0.012	0.868MetAsp: 0.868 ± 0.031	1.038MetGlu: 1.038 ± 0.035	0.512MetPhe: 0.512 ± 0.025	1.725MetGly: 1.725 ± 0.051	0.315MetHis: 0.315 ± 0.016	1.054MetIle: 1.054 ± 0.033	0.704MetLys: 0.704 ± 0.027	1.762MetLeu: 1.762 ± 0.047	0.436MetMet: 0.436 ± 0.022	0.815MetAsn: 0.815 ± 0.033	1.204MetPro: 1.204 ± 0.035	1.061MetGln: 1.061 ± 0.033	1.197MetArg: 1.197 ± 0.037	1.052MetSer: 1.052 ± 0.035	1.466MetThr: 1.466 ± 0.046	1.729MetVal: 1.729 ± 0.041	0.148MetTrp: 0.148 ± 0.013	0.406MetTyr: 0.406 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.42AsnAla: 2.42 ± 0.065	0.418AsnCys: 0.418 ± 0.025	1.309AsnAsp: 1.309 ± 0.039	1.337AsnGlu: 1.337 ± 0.04	1.415AsnPhe: 1.415 ± 0.046	2.273AsnGly: 2.273 ± 0.084	0.839AsnHis: 0.839 ± 0.038	1.724AsnIle: 1.724 ± 0.07	0.867AsnLys: 0.867 ± 0.032	4.844AsnLeu: 4.844 ± 0.104	0.555AsnMet: 0.555 ± 0.025	1.153AsnAsn: 1.153 ± 0.061	2.711AsnPro: 2.711 ± 0.07	2.197AsnGln: 2.197 ± 0.049	2.203AsnArg: 2.203 ± 0.053	1.675AsnSer: 1.675 ± 0.067	1.64AsnThr: 1.64 ± 0.077	1.899AsnVal: 1.899 ± 0.057	0.617AsnTrp: 0.617 ± 0.027	1.274AsnTyr: 1.274 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	5.063ProAla: 5.063 ± 0.085	0.458ProCys: 0.458 ± 0.03	3.147ProAsp: 3.147 ± 0.065	4.417ProGlu: 4.417 ± 0.068	1.628ProPhe: 1.628 ± 0.04	4.407ProGly: 4.407 ± 0.077	1.199ProHis: 1.199 ± 0.035	2.51ProIle: 2.51 ± 0.06	1.647ProLys: 1.647 ± 0.053	5.935ProLeu: 5.935 ± 0.085	1.059ProMet: 1.059 ± 0.034	1.693ProAsn: 1.693 ± 0.049	3.639ProPro: 3.639 ± 0.096	3.652ProGln: 3.652 ± 0.078	2.535ProArg: 2.535 ± 0.065	2.571ProSer: 2.571 ± 0.055	3.255ProThr: 3.255 ± 0.078	4.523ProVal: 4.523 ± 0.073	1.084ProTrp: 1.084 ± 0.037	1.459ProTyr: 1.459 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	6.586GlnAla: 6.586 ± 0.098	0.455GlnCys: 0.455 ± 0.023	2.492GlnAsp: 2.492 ± 0.053	4.225GlnGlu: 4.225 ± 0.069	1.855GlnPhe: 1.855 ± 0.047	5.236GlnGly: 5.236 ± 0.095	1.06GlnHis: 1.06 ± 0.038	3.524GlnIle: 3.524 ± 0.072	2.581GlnLys: 2.581 ± 0.062	5.796GlnLeu: 5.796 ± 0.101	1.331GlnMet: 1.331 ± 0.038	1.946GlnAsn: 1.946 ± 0.052	3.351GlnPro: 3.351 ± 0.077	3.945GlnGln: 3.945 ± 0.113	4.388GlnArg: 4.388 ± 0.08	2.68GlnSer: 2.68 ± 0.061	3.559GlnThr: 3.559 ± 0.08	5.598GlnVal: 5.598 ± 0.101	1.063GlnTrp: 1.063 ± 0.038	1.402GlnTyr: 1.402 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	4.236ArgAla: 4.236 ± 0.084	0.671ArgCys: 0.671 ± 0.028	2.629ArgAsp: 2.629 ± 0.058	3.755ArgGlu: 3.755 ± 0.071	2.278ArgPhe: 2.278 ± 0.054	4.083ArgGly: 4.083 ± 0.08	1.265ArgHis: 1.265 ± 0.036	2.932ArgIle: 2.932 ± 0.061	1.741ArgLys: 1.741 ± 0.051	7.697ArgLeu: 7.697 ± 0.117	1.197ArgMet: 1.197 ± 0.037	1.73ArgAsn: 1.73 ± 0.049	3.073ArgPro: 3.073 ± 0.075	4.412ArgGln: 4.412 ± 0.083	4.089ArgArg: 4.089 ± 0.078	2.965ArgSer: 2.965 ± 0.066	2.983ArgThr: 2.983 ± 0.071	4.893ArgVal: 4.893 ± 0.086	1.511ArgTrp: 1.511 ± 0.042	2.061ArgTyr: 2.061 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	3.78SerAla: 3.78 ± 0.072	0.441SerCys: 0.441 ± 0.019	2.258SerAsp: 2.258 ± 0.052	2.702SerGlu: 2.702 ± 0.064	1.864SerPhe: 1.864 ± 0.054	4.241SerGly: 4.241 ± 0.086	1.147SerHis: 1.147 ± 0.041	2.419SerIle: 2.419 ± 0.053	1.417SerLys: 1.417 ± 0.044	6.058SerLeu: 6.058 ± 0.093	0.94SerMet: 0.94 ± 0.03	1.607SerAsn: 1.607 ± 0.05	3.381SerPro: 3.381 ± 0.065	3.134SerGln: 3.134 ± 0.061	3.13SerArg: 3.13 ± 0.072	2.435SerSer: 2.435 ± 0.056	2.688SerThr: 2.688 ± 0.073	3.219SerVal: 3.219 ± 0.067	0.864SerTrp: 0.864 ± 0.035	1.564SerTyr: 1.564 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	5.628ThrAla: 5.628 ± 0.084	0.578ThrCys: 0.578 ± 0.023	2.478ThrAsp: 2.478 ± 0.062	2.884ThrGlu: 2.884 ± 0.051	1.794ThrPhe: 1.794 ± 0.044	5.282ThrGly: 5.282 ± 0.136	1.251ThrHis: 1.251 ± 0.037	3.062ThrIle: 3.062 ± 0.078	1.447ThrLys: 1.447 ± 0.044	7.466ThrLeu: 7.466 ± 0.118	0.906ThrMet: 0.906 ± 0.031	1.791ThrAsn: 1.791 ± 0.062	4.317ThrPro: 4.317 ± 0.096	3.667ThrGln: 3.667 ± 0.071	2.879ThrArg: 2.879 ± 0.058	2.586ThrSer: 2.586 ± 0.066	3.299ThrThr: 3.299 ± 0.094	4.448ThrVal: 4.448 ± 0.09	1.104ThrTrp: 1.104 ± 0.04	1.515ThrTyr: 1.515 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	7.388ValAla: 7.388 ± 0.106	0.749ValCys: 0.749 ± 0.028	3.365ValAsp: 3.365 ± 0.068	3.83ValGlu: 3.83 ± 0.075	2.512ValPhe: 2.512 ± 0.056	6.082ValGly: 6.082 ± 0.097	1.226ValHis: 1.226 ± 0.037	4.338ValIle: 4.338 ± 0.084	2.351ValLys: 2.351 ± 0.054	8.35ValLeu: 8.35 ± 0.121	1.607ValMet: 1.607 ± 0.049	2.858ValAsn: 2.858 ± 0.08	3.691ValPro: 3.691 ± 0.066	4.203ValGln: 4.203 ± 0.078	4.326ValArg: 4.326 ± 0.085	3.7ValSer: 3.7 ± 0.072	4.759ValThr: 4.759 ± 0.091	6.334ValVal: 6.334 ± 0.117	1.135ValTrp: 1.135 ± 0.039	1.892ValTyr: 1.892 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.302TrpAla: 1.302 ± 0.042	0.213TrpCys: 0.213 ± 0.015	0.759TrpAsp: 0.759 ± 0.03	1.084TrpGlu: 1.084 ± 0.039	0.672TrpPhe: 0.672 ± 0.033	1.714TrpGly: 1.714 ± 0.053	0.516TrpHis: 0.516 ± 0.022	0.666TrpIle: 0.666 ± 0.028	0.331TrpLys: 0.331 ± 0.022	2.627TrpLeu: 2.627 ± 0.07	0.342TrpMet: 0.342 ± 0.02	0.454TrpAsn: 0.454 ± 0.024	0.795TrpPro: 0.795 ± 0.035	1.854TrpGln: 1.854 ± 0.053	1.251TrpArg: 1.251 ± 0.04	0.784TrpSer: 0.784 ± 0.031	0.589TrpThr: 0.589 ± 0.026	1.638TrpVal: 1.638 ± 0.047	0.484TrpTrp: 0.484 ± 0.031	0.407TrpTyr: 0.407 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.116TyrAla: 2.116 ± 0.053	0.384TyrCys: 0.384 ± 0.021	1.369TyrAsp: 1.369 ± 0.038	1.543TyrGlu: 1.543 ± 0.05	1.161TyrPhe: 1.161 ± 0.04	2.396TyrGly: 2.396 ± 0.055	0.79TyrHis: 0.79 ± 0.032	1.348TyrIle: 1.348 ± 0.042	0.755TyrLys: 0.755 ± 0.032	3.667TyrLeu: 3.667 ± 0.073	0.381TyrMet: 0.381 ± 0.023	0.854TyrAsn: 0.854 ± 0.032	1.738TyrPro: 1.738 ± 0.045	2.21TyrGln: 2.21 ± 0.051	2.243TyrArg: 2.243 ± 0.059	1.448TyrSer: 1.448 ± 0.048	1.399TyrThr: 1.399 ± 0.045	1.746TyrVal: 1.746 ± 0.038	0.629TyrTrp: 0.629 ± 0.027	0.981TyrTyr: 0.981 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3022 proteins (879357 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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