Amino acid dipepetide frequency for Helicobacter phage Pt1918U

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.418AlaAla: 1.418 ± 0.383
0.654AlaCys: 0.654 ± 0.294
1.963AlaAsp: 1.963 ± 0.365
3.598AlaGlu: 3.598 ± 0.88
4.471AlaPhe: 4.471 ± 0.905
2.617AlaGly: 2.617 ± 0.545
1.09AlaHis: 1.09 ± 0.351
5.234AlaIle: 5.234 ± 0.829
7.306AlaLys: 7.306 ± 1.134
11.122AlaLeu: 11.122 ± 1.101
1.09AlaMet: 1.09 ± 0.343
6.324AlaAsn: 6.324 ± 0.779
1.418AlaPro: 1.418 ± 0.464
2.835AlaGln: 2.835 ± 0.439
3.707AlaArg: 3.707 ± 0.762
2.617AlaSer: 2.617 ± 0.643
2.399AlaThr: 2.399 ± 0.598
1.745AlaVal: 1.745 ± 0.596
0.436AlaTrp: 0.436 ± 0.192
1.854AlaTyr: 1.854 ± 0.478
0.0AlaXaa: 0.0 ± 0.0
Cys
0.654CysAla: 0.654 ± 0.332
0.218CysCys: 0.218 ± 0.226
0.763CysAsp: 0.763 ± 0.353
0.872CysGlu: 0.872 ± 0.26
0.654CysPhe: 0.654 ± 0.314
0.436CysGly: 0.436 ± 0.265
0.109CysHis: 0.109 ± 0.119
0.545CysIle: 0.545 ± 0.227
0.436CysLys: 0.436 ± 0.222
0.763CysLeu: 0.763 ± 0.425
0.0CysMet: 0.0 ± 0.0
0.218CysAsn: 0.218 ± 0.174
0.327CysPro: 0.327 ± 0.17
0.109CysGln: 0.109 ± 0.095
0.109CysArg: 0.109 ± 0.095
0.109CysSer: 0.109 ± 0.117
0.654CysThr: 0.654 ± 0.299
0.763CysVal: 0.763 ± 0.355
0.0CysTrp: 0.0 ± 0.0
0.327CysTyr: 0.327 ± 0.183
0.0CysXaa: 0.0 ± 0.0
Asp
3.816AspAla: 3.816 ± 0.602
0.327AspCys: 0.327 ± 0.228
1.854AspAsp: 1.854 ± 0.525
4.143AspGlu: 4.143 ± 0.709
5.125AspPhe: 5.125 ± 0.992
1.963AspGly: 1.963 ± 0.378
0.218AspHis: 0.218 ± 0.17
2.29AspIle: 2.29 ± 0.444
5.561AspLys: 5.561 ± 0.923
6.979AspLeu: 6.979 ± 0.815
1.09AspMet: 1.09 ± 0.305
4.362AspAsn: 4.362 ± 0.608
1.199AspPro: 1.199 ± 0.414
0.872AspGln: 0.872 ± 0.375
1.745AspArg: 1.745 ± 0.345
2.29AspSer: 2.29 ± 0.467
1.854AspThr: 1.854 ± 0.44
1.308AspVal: 1.308 ± 0.412
0.0AspTrp: 0.0 ± 0.0
3.271AspTyr: 3.271 ± 0.572
0.0AspXaa: 0.0 ± 0.0
Glu
5.452GluAla: 5.452 ± 0.588
0.327GluCys: 0.327 ± 0.172
2.181GluAsp: 2.181 ± 0.489
3.925GluGlu: 3.925 ± 0.83
3.707GluPhe: 3.707 ± 0.568
1.963GluGly: 1.963 ± 0.453
1.199GluHis: 1.199 ± 0.465
7.306GluIle: 7.306 ± 0.844
10.359GluLys: 10.359 ± 1.218
10.686GluLeu: 10.686 ± 1.416
1.418GluMet: 1.418 ± 0.425
8.832GluAsn: 8.832 ± 0.943
1.527GluPro: 1.527 ± 0.465
4.689GluGln: 4.689 ± 0.688
5.016GluArg: 5.016 ± 0.57
7.415GluSer: 7.415 ± 0.983
3.925GluThr: 3.925 ± 0.573
3.925GluVal: 3.925 ± 0.814
0.327GluTrp: 0.327 ± 0.188
2.399GluTyr: 2.399 ± 0.416
0.0GluXaa: 0.0 ± 0.0
Phe
2.508PheAla: 2.508 ± 0.544
0.872PheCys: 0.872 ± 0.442
3.271PheAsp: 3.271 ± 0.598
2.944PheGlu: 2.944 ± 0.553
2.944PhePhe: 2.944 ± 0.619
1.636PheGly: 1.636 ± 0.317
0.545PheHis: 0.545 ± 0.165
2.835PheIle: 2.835 ± 0.568
7.633PheLys: 7.633 ± 0.88
6.651PheLeu: 6.651 ± 0.752
0.545PheMet: 0.545 ± 0.253
4.034PheAsn: 4.034 ± 0.72
0.436PhePro: 0.436 ± 0.231
1.418PheGln: 1.418 ± 0.521
1.636PheArg: 1.636 ± 0.468
4.907PheSer: 4.907 ± 0.83
2.29PheThr: 2.29 ± 0.421
2.072PheVal: 2.072 ± 0.573
0.0PheTrp: 0.0 ± 0.0
2.181PheTyr: 2.181 ± 0.558
0.0PheXaa: 0.0 ± 0.0
Gly
3.38GlyAla: 3.38 ± 0.861
0.327GlyCys: 0.327 ± 0.18
1.308GlyAsp: 1.308 ± 0.416
2.617GlyGlu: 2.617 ± 0.531
3.38GlyPhe: 3.38 ± 0.67
2.835GlyGly: 2.835 ± 0.658
0.436GlyHis: 0.436 ± 0.204
2.835GlyIle: 2.835 ± 0.53
2.944GlyLys: 2.944 ± 0.882
4.907GlyLeu: 4.907 ± 0.641
1.418GlyMet: 1.418 ± 0.39
2.617GlyAsn: 2.617 ± 0.525
0.0GlyPro: 0.0 ± 0.0
1.199GlyGln: 1.199 ± 0.388
1.636GlyArg: 1.636 ± 0.443
2.726GlySer: 2.726 ± 0.579
0.981GlyThr: 0.981 ± 0.294
3.816GlyVal: 3.816 ± 0.93
0.218GlyTrp: 0.218 ± 0.153
1.418GlyTyr: 1.418 ± 0.34
0.0GlyXaa: 0.0 ± 0.0
His
0.654HisAla: 0.654 ± 0.246
0.109HisCys: 0.109 ± 0.113
1.308HisAsp: 1.308 ± 0.431
0.872HisGlu: 0.872 ± 0.297
0.327HisPhe: 0.327 ± 0.142
0.327HisGly: 0.327 ± 0.165
0.0HisHis: 0.0 ± 0.0
1.418HisIle: 1.418 ± 0.48
1.745HisLys: 1.745 ± 0.343
0.872HisLeu: 0.872 ± 0.33
0.109HisMet: 0.109 ± 0.119
1.09HisAsn: 1.09 ± 0.423
0.109HisPro: 0.109 ± 0.079
0.109HisGln: 0.109 ± 0.108
0.327HisArg: 0.327 ± 0.18
0.545HisSer: 0.545 ± 0.246
0.872HisThr: 0.872 ± 0.313
0.327HisVal: 0.327 ± 0.181
0.0HisTrp: 0.0 ± 0.0
0.763HisTyr: 0.763 ± 0.231
0.0HisXaa: 0.0 ± 0.0
Ile
4.143IleAla: 4.143 ± 0.675
0.327IleCys: 0.327 ± 0.176
3.925IleAsp: 3.925 ± 0.566
5.125IleGlu: 5.125 ± 0.742
2.835IlePhe: 2.835 ± 0.536
1.745IleGly: 1.745 ± 0.498
0.763IleHis: 0.763 ± 0.32
4.034IleIle: 4.034 ± 0.778
8.396IleLys: 8.396 ± 1.082
8.396IleLeu: 8.396 ± 0.807
0.981IleMet: 0.981 ± 0.279
5.67IleAsn: 5.67 ± 1.008
1.527IlePro: 1.527 ± 0.373
3.707IleGln: 3.707 ± 0.987
3.707IleArg: 3.707 ± 0.529
4.034IleSer: 4.034 ± 0.487
5.016IleThr: 5.016 ± 0.962
3.707IleVal: 3.707 ± 0.44
0.218IleTrp: 0.218 ± 0.156
2.508IleTyr: 2.508 ± 0.586
0.0IleXaa: 0.0 ± 0.0
Lys
7.524LysAla: 7.524 ± 0.956
0.872LysCys: 0.872 ± 0.394
8.287LysAsp: 8.287 ± 1.234
13.521LysGlu: 13.521 ± 1.288
3.489LysPhe: 3.489 ± 0.59
3.38LysGly: 3.38 ± 0.58
2.181LysHis: 2.181 ± 0.6
9.595LysIle: 9.595 ± 1.063
10.468LysLys: 10.468 ± 1.539
7.415LysLeu: 7.415 ± 0.799
2.399LysMet: 2.399 ± 0.403
8.287LysAsn: 8.287 ± 1.022
2.835LysPro: 2.835 ± 0.607
6.106LysGln: 6.106 ± 0.862
3.925LysArg: 3.925 ± 0.72
5.888LysSer: 5.888 ± 0.786
4.58LysThr: 4.58 ± 0.49
5.125LysVal: 5.125 ± 0.771
0.763LysTrp: 0.763 ± 0.248
3.38LysTyr: 3.38 ± 0.576
0.0LysXaa: 0.0 ± 0.0
Leu
5.125LeuAla: 5.125 ± 0.592
1.308LeuCys: 1.308 ± 0.516
4.253LeuAsp: 4.253 ± 0.524
13.739LeuGlu: 13.739 ± 1.364
4.471LeuPhe: 4.471 ± 0.657
5.234LeuGly: 5.234 ± 0.831
0.436LeuHis: 0.436 ± 0.181
6.324LeuIle: 6.324 ± 0.986
16.574LeuLys: 16.574 ± 1.38
6.76LeuLeu: 6.76 ± 0.808
1.527LeuMet: 1.527 ± 0.45
11.34LeuAsn: 11.34 ± 1.301
1.527LeuPro: 1.527 ± 0.362
4.798LeuGln: 4.798 ± 1.053
4.58LeuArg: 4.58 ± 0.898
7.306LeuSer: 7.306 ± 0.853
3.162LeuThr: 3.162 ± 0.516
3.925LeuVal: 3.925 ± 0.769
0.654LeuTrp: 0.654 ± 0.273
1.963LeuTyr: 1.963 ± 0.394
0.0LeuXaa: 0.0 ± 0.0
Met
0.872MetAla: 0.872 ± 0.389
0.109MetCys: 0.109 ± 0.106
1.418MetAsp: 1.418 ± 0.407
0.981MetGlu: 0.981 ± 0.279
0.763MetPhe: 0.763 ± 0.293
1.199MetGly: 1.199 ± 0.42
0.327MetHis: 0.327 ± 0.219
1.636MetIle: 1.636 ± 0.361
1.199MetLys: 1.199 ± 0.38
1.636MetLeu: 1.636 ± 0.381
0.218MetMet: 0.218 ± 0.165
1.745MetAsn: 1.745 ± 0.35
1.09MetPro: 1.09 ± 0.269
1.418MetGln: 1.418 ± 0.389
0.872MetArg: 0.872 ± 0.303
1.418MetSer: 1.418 ± 0.291
0.436MetThr: 0.436 ± 0.226
0.545MetVal: 0.545 ± 0.232
0.218MetTrp: 0.218 ± 0.161
0.436MetTyr: 0.436 ± 0.219
0.0MetXaa: 0.0 ± 0.0
Asn
8.396AsnAla: 8.396 ± 0.954
0.109AsnCys: 0.109 ± 0.12
4.253AsnAsp: 4.253 ± 0.646
7.633AsnGlu: 7.633 ± 1.186
3.162AsnPhe: 3.162 ± 0.618
3.053AsnGly: 3.053 ± 0.551
0.872AsnHis: 0.872 ± 0.258
4.907AsnIle: 4.907 ± 0.851
7.851AsnLys: 7.851 ± 0.873
6.979AsnLeu: 6.979 ± 1.016
1.09AsnMet: 1.09 ± 0.348
7.633AsnAsn: 7.633 ± 1.318
1.745AsnPro: 1.745 ± 0.528
4.471AsnGln: 4.471 ± 0.632
2.835AsnArg: 2.835 ± 0.649
5.888AsnSer: 5.888 ± 0.758
5.016AsnThr: 5.016 ± 0.729
2.399AsnVal: 2.399 ± 0.582
0.436AsnTrp: 0.436 ± 0.209
4.689AsnTyr: 4.689 ± 0.701
0.0AsnXaa: 0.0 ± 0.0
Pro
0.436ProAla: 0.436 ± 0.209
0.109ProCys: 0.109 ± 0.113
0.436ProAsp: 0.436 ± 0.254
1.09ProGlu: 1.09 ± 0.424
2.181ProPhe: 2.181 ± 0.59
0.327ProGly: 0.327 ± 0.255
0.109ProHis: 0.109 ± 0.112
1.636ProIle: 1.636 ± 0.435
2.617ProLys: 2.617 ± 0.657
2.617ProLeu: 2.617 ± 0.609
0.327ProMet: 0.327 ± 0.194
1.745ProAsn: 1.745 ± 0.395
0.872ProPro: 0.872 ± 0.275
0.436ProGln: 0.436 ± 0.242
1.308ProArg: 1.308 ± 0.403
2.181ProSer: 2.181 ± 0.447
1.199ProThr: 1.199 ± 0.27
0.872ProVal: 0.872 ± 0.366
0.0ProTrp: 0.0 ± 0.0
1.418ProTyr: 1.418 ± 0.449
0.0ProXaa: 0.0 ± 0.0
Gln
5.67GlnAla: 5.67 ± 0.808
0.327GlnCys: 0.327 ± 0.246
1.854GlnAsp: 1.854 ± 0.495
5.016GlnGlu: 5.016 ± 0.758
1.636GlnPhe: 1.636 ± 0.339
2.29GlnGly: 2.29 ± 0.47
0.109GlnHis: 0.109 ± 0.113
2.726GlnIle: 2.726 ± 0.47
4.362GlnLys: 4.362 ± 0.759
3.598GlnLeu: 3.598 ± 0.544
0.872GlnMet: 0.872 ± 0.257
3.162GlnAsn: 3.162 ± 0.815
0.436GlnPro: 0.436 ± 0.237
1.418GlnGln: 1.418 ± 0.696
1.854GlnArg: 1.854 ± 0.475
2.29GlnSer: 2.29 ± 0.506
1.963GlnThr: 1.963 ± 0.442
2.181GlnVal: 2.181 ± 0.341
0.0GlnTrp: 0.0 ± 0.0
0.545GlnTyr: 0.545 ± 0.262
0.0GlnXaa: 0.0 ± 0.0
Arg
3.162ArgAla: 3.162 ± 0.592
0.218ArgCys: 0.218 ± 0.159
2.726ArgAsp: 2.726 ± 0.453
5.234ArgGlu: 5.234 ± 1.064
2.29ArgPhe: 2.29 ± 0.464
1.636ArgGly: 1.636 ± 0.37
1.09ArgHis: 1.09 ± 0.296
2.29ArgIle: 2.29 ± 0.523
3.925ArgLys: 3.925 ± 0.647
5.125ArgLeu: 5.125 ± 0.674
1.09ArgMet: 1.09 ± 0.321
2.29ArgAsn: 2.29 ± 0.403
0.872ArgPro: 0.872 ± 0.369
1.745ArgGln: 1.745 ± 0.395
1.745ArgArg: 1.745 ± 0.616
1.963ArgSer: 1.963 ± 0.458
1.636ArgThr: 1.636 ± 0.473
1.527ArgVal: 1.527 ± 0.446
0.0ArgTrp: 0.0 ± 0.0
1.199ArgTyr: 1.199 ± 0.368
0.0ArgXaa: 0.0 ± 0.0
Ser
4.362SerAla: 4.362 ± 0.664
0.436SerCys: 0.436 ± 0.278
5.234SerAsp: 5.234 ± 0.642
5.67SerGlu: 5.67 ± 0.781
3.925SerPhe: 3.925 ± 0.746
4.253SerGly: 4.253 ± 0.687
0.654SerHis: 0.654 ± 0.284
3.598SerIle: 3.598 ± 0.659
5.779SerLys: 5.779 ± 0.637
6.76SerLeu: 6.76 ± 1.083
1.527SerMet: 1.527 ± 0.483
2.944SerAsn: 2.944 ± 0.494
1.854SerPro: 1.854 ± 0.355
2.399SerGln: 2.399 ± 0.418
1.854SerArg: 1.854 ± 0.506
3.598SerSer: 3.598 ± 0.788
2.072SerThr: 2.072 ± 0.436
4.58SerVal: 4.58 ± 0.892
0.327SerTrp: 0.327 ± 0.162
3.053SerTyr: 3.053 ± 0.55
0.0SerXaa: 0.0 ± 0.0
Thr
2.508ThrAla: 2.508 ± 0.493
0.436ThrCys: 0.436 ± 0.221
2.072ThrAsp: 2.072 ± 0.507
3.707ThrGlu: 3.707 ± 0.522
0.763ThrPhe: 0.763 ± 0.226
2.181ThrGly: 2.181 ± 0.587
0.872ThrHis: 0.872 ± 0.313
4.253ThrIle: 4.253 ± 0.626
4.253ThrLys: 4.253 ± 0.779
3.816ThrLeu: 3.816 ± 0.587
0.872ThrMet: 0.872 ± 0.233
3.925ThrAsn: 3.925 ± 0.733
2.29ThrPro: 2.29 ± 0.423
1.963ThrGln: 1.963 ± 0.487
1.418ThrArg: 1.418 ± 0.368
3.053ThrSer: 3.053 ± 0.626
3.38ThrThr: 3.38 ± 0.735
0.763ThrVal: 0.763 ± 0.278
0.545ThrTrp: 0.545 ± 0.21
1.308ThrTyr: 1.308 ± 0.37
0.0ThrXaa: 0.0 ± 0.0
Val
1.963ValAla: 1.963 ± 0.552
0.654ValCys: 0.654 ± 0.296
1.527ValAsp: 1.527 ± 0.384
2.29ValGlu: 2.29 ± 0.447
2.726ValPhe: 2.726 ± 0.509
2.508ValGly: 2.508 ± 0.651
0.218ValHis: 0.218 ± 0.154
3.816ValIle: 3.816 ± 0.586
4.907ValLys: 4.907 ± 0.857
5.452ValLeu: 5.452 ± 1.055
0.872ValMet: 0.872 ± 0.33
2.944ValAsn: 2.944 ± 0.665
0.763ValPro: 0.763 ± 0.302
0.763ValGln: 0.763 ± 0.291
1.854ValArg: 1.854 ± 0.461
4.253ValSer: 4.253 ± 0.814
1.308ValThr: 1.308 ± 0.303
2.726ValVal: 2.726 ± 0.805
0.327ValTrp: 0.327 ± 0.169
1.418ValTyr: 1.418 ± 0.671
0.0ValXaa: 0.0 ± 0.0
Trp
0.109TrpAla: 0.109 ± 0.112
0.0TrpCys: 0.0 ± 0.0
0.109TrpAsp: 0.109 ± 0.079
0.654TrpGlu: 0.654 ± 0.327
0.109TrpPhe: 0.109 ± 0.114
0.327TrpGly: 0.327 ± 0.148
0.218TrpHis: 0.218 ± 0.135
0.218TrpIle: 0.218 ± 0.186
0.218TrpLys: 0.218 ± 0.125
0.109TrpLeu: 0.109 ± 0.108
0.218TrpMet: 0.218 ± 0.166
0.654TrpAsn: 0.654 ± 0.39
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.218TrpArg: 0.218 ± 0.15
0.436TrpSer: 0.436 ± 0.24
0.109TrpThr: 0.109 ± 0.125
0.545TrpVal: 0.545 ± 0.294
0.0TrpTrp: 0.0 ± 0.0
0.327TrpTyr: 0.327 ± 0.258
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.745TyrAla: 1.745 ± 0.375
0.327TyrCys: 0.327 ± 0.187
1.527TyrAsp: 1.527 ± 0.418
2.944TyrGlu: 2.944 ± 0.599
2.399TyrPhe: 2.399 ± 0.678
1.09TyrGly: 1.09 ± 0.263
0.436TyrHis: 0.436 ± 0.196
3.271TyrIle: 3.271 ± 0.662
3.489TyrLys: 3.489 ± 0.665
4.362TyrLeu: 4.362 ± 0.923
0.763TyrMet: 0.763 ± 0.297
3.707TyrAsn: 3.707 ± 0.666
1.09TyrPro: 1.09 ± 0.351
1.854TyrGln: 1.854 ± 0.498
1.418TyrArg: 1.418 ± 0.343
1.963TyrSer: 1.963 ± 0.492
1.527TyrThr: 1.527 ± 0.318
0.436TyrVal: 0.436 ± 0.245
0.109TyrTrp: 0.109 ± 0.118
1.636TyrTyr: 1.636 ± 0.396
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 34 proteins (9172 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski