Amino acid dipepetide frequency for Pseudomonas sp. DMKU_BBB3-04

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.15AlaAla: 14.15 ± 0.159	1.459AlaCys: 1.459 ± 0.04	6.79AlaAsp: 6.79 ± 0.086	7.55AlaGlu: 7.55 ± 0.083	4.193AlaPhe: 4.193 ± 0.058	10.002AlaGly: 10.002 ± 0.106	2.451AlaHis: 2.451 ± 0.048	4.798AlaIle: 4.798 ± 0.058	2.916AlaLys: 2.916 ± 0.054	15.864AlaLeu: 15.864 ± 0.135	2.732AlaMet: 2.732 ± 0.047	2.573AlaAsn: 2.573 ± 0.057	5.761AlaPro: 5.761 ± 0.096	4.781AlaGln: 4.781 ± 0.061	9.368AlaArg: 9.368 ± 0.116	6.273AlaSer: 6.273 ± 0.081	5.095AlaThr: 5.095 ± 0.07	7.867AlaVal: 7.867 ± 0.083	1.937AlaTrp: 1.937 ± 0.04	2.786AlaTyr: 2.786 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.153CysAla: 1.153 ± 0.03	0.14CysCys: 0.14 ± 0.01	0.535CysAsp: 0.535 ± 0.02	0.519CysGlu: 0.519 ± 0.02	0.336CysPhe: 0.336 ± 0.016	0.954CysGly: 0.954 ± 0.024	0.276CysHis: 0.276 ± 0.015	0.397CysIle: 0.397 ± 0.017	0.221CysLys: 0.221 ± 0.014	1.217CysLeu: 1.217 ± 0.037	0.169CysMet: 0.169 ± 0.013	0.212CysAsn: 0.212 ± 0.013	0.539CysPro: 0.539 ± 0.02	0.394CysGln: 0.394 ± 0.017	0.753CysArg: 0.753 ± 0.027	0.569CysSer: 0.569 ± 0.021	0.44CysThr: 0.44 ± 0.017	0.668CysVal: 0.668 ± 0.025	0.149CysTrp: 0.149 ± 0.01	0.241CysTyr: 0.241 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.176AspAla: 7.176 ± 0.1	0.545AspCys: 0.545 ± 0.023	3.379AspAsp: 3.379 ± 0.061	3.614AspGlu: 3.614 ± 0.067	2.009AspPhe: 2.009 ± 0.045	5.215AspGly: 5.215 ± 0.091	1.251AspHis: 1.251 ± 0.03	2.368AspIle: 2.368 ± 0.042	1.569AspLys: 1.569 ± 0.035	6.58AspLeu: 6.58 ± 0.076	1.092AspMet: 1.092 ± 0.027	1.275AspAsn: 1.275 ± 0.034	3.421AspPro: 3.421 ± 0.055	1.88AspGln: 1.88 ± 0.042	3.83AspArg: 3.83 ± 0.046	2.731AspSer: 2.731 ± 0.055	2.589AspThr: 2.589 ± 0.046	3.826AspVal: 3.826 ± 0.064	1.133AspTrp: 1.133 ± 0.031	1.842AspTyr: 1.842 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.617GluAla: 7.617 ± 0.1	0.42GluCys: 0.42 ± 0.017	2.809GluAsp: 2.809 ± 0.051	3.114GluGlu: 3.114 ± 0.067	1.523GluPhe: 1.523 ± 0.035	4.269GluGly: 4.269 ± 0.062	1.544GluHis: 1.544 ± 0.029	2.439GluIle: 2.439 ± 0.049	1.873GluLys: 1.873 ± 0.046	6.496GluLeu: 6.496 ± 0.085	1.095GluMet: 1.095 ± 0.03	1.331GluAsn: 1.331 ± 0.035	2.947GluPro: 2.947 ± 0.054	3.177GluGln: 3.177 ± 0.055	5.976GluArg: 5.976 ± 0.084	2.408GluSer: 2.408 ± 0.041	2.78GluThr: 2.78 ± 0.049	4.109GluVal: 4.109 ± 0.064	0.676GluTrp: 0.676 ± 0.023	1.131GluTyr: 1.131 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	4.239PheAla: 4.239 ± 0.063	0.452PheCys: 0.452 ± 0.016	2.481PheAsp: 2.481 ± 0.044	2.028PheGlu: 2.028 ± 0.035	1.397PhePhe: 1.397 ± 0.036	3.148PheGly: 3.148 ± 0.047	0.748PheHis: 0.748 ± 0.026	1.475PheIle: 1.475 ± 0.034	0.947PheLys: 0.947 ± 0.028	3.37PheLeu: 3.37 ± 0.059	0.706PheMet: 0.706 ± 0.027	1.081PheAsn: 1.081 ± 0.027	1.545PhePro: 1.545 ± 0.035	1.226PheGln: 1.226 ± 0.031	2.038PheArg: 2.038 ± 0.039	2.269PheSer: 2.269 ± 0.051	1.775PheThr: 1.775 ± 0.05	2.443PheVal: 2.443 ± 0.051	0.544PheTrp: 0.544 ± 0.016	0.995PheTyr: 0.995 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.302GlyAla: 8.302 ± 0.097	0.982GlyCys: 0.982 ± 0.028	4.478GlyAsp: 4.478 ± 0.066	5.388GlyGlu: 5.388 ± 0.072	3.341GlyPhe: 3.341 ± 0.055	6.43GlyGly: 6.43 ± 0.1	1.989GlyHis: 1.989 ± 0.038	3.808GlyIle: 3.808 ± 0.058	2.734GlyLys: 2.734 ± 0.052	10.17GlyLeu: 10.17 ± 0.093	2.033GlyMet: 2.033 ± 0.046	2.062GlyAsn: 2.062 ± 0.052	3.027GlyPro: 3.027 ± 0.054	3.568GlyGln: 3.568 ± 0.051	6.188GlyArg: 6.188 ± 0.08	4.431GlySer: 4.431 ± 0.069	3.954GlyThr: 3.954 ± 0.079	6.167GlyVal: 6.167 ± 0.084	1.361GlyTrp: 1.361 ± 0.032	2.542GlyTyr: 2.542 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	2.449HisAla: 2.449 ± 0.04	0.329HisCys: 0.329 ± 0.016	1.29HisAsp: 1.29 ± 0.031	1.185HisGlu: 1.185 ± 0.031	0.91HisPhe: 0.91 ± 0.022	2.256HisGly: 2.256 ± 0.045	0.612HisHis: 0.612 ± 0.026	0.828HisIle: 0.828 ± 0.027	0.505HisLys: 0.505 ± 0.02	2.911HisLeu: 2.911 ± 0.055	0.43HisMet: 0.43 ± 0.017	0.486HisAsn: 0.486 ± 0.019	1.595HisPro: 1.595 ± 0.036	0.865HisGln: 0.865 ± 0.026	1.641HisArg: 1.641 ± 0.039	1.051HisSer: 1.051 ± 0.027	0.982HisThr: 0.982 ± 0.03	1.379HisVal: 1.379 ± 0.031	0.46HisTrp: 0.46 ± 0.019	0.745HisTyr: 0.745 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.215IleAla: 5.215 ± 0.078	0.358IleCys: 0.358 ± 0.018	2.891IleAsp: 2.891 ± 0.051	2.84IleGlu: 2.84 ± 0.052	1.143IlePhe: 1.143 ± 0.04	4.023IleGly: 4.023 ± 0.066	0.886IleHis: 0.886 ± 0.025	1.409IleIle: 1.409 ± 0.04	1.224IleLys: 1.224 ± 0.037	3.751IleLeu: 3.751 ± 0.059	0.605IleMet: 0.605 ± 0.025	1.284IleAsn: 1.284 ± 0.036	2.099IlePro: 2.099 ± 0.043	1.421IleGln: 1.421 ± 0.033	2.905IleArg: 2.905 ± 0.054	2.182IleSer: 2.182 ± 0.049	2.008IleThr: 2.008 ± 0.048	2.949IleVal: 2.949 ± 0.049	0.377IleTrp: 0.377 ± 0.018	0.964IleTyr: 0.964 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.45LysAla: 3.45 ± 0.056	0.152LysCys: 0.152 ± 0.013	1.517LysAsp: 1.517 ± 0.037	1.339LysGlu: 1.339 ± 0.036	0.63LysPhe: 0.63 ± 0.022	2.253LysGly: 2.253 ± 0.047	0.564LysHis: 0.564 ± 0.021	1.147LysIle: 1.147 ± 0.035	1.068LysLys: 1.068 ± 0.039	2.819LysLeu: 2.819 ± 0.056	0.553LysMet: 0.553 ± 0.02	0.763LysAsn: 0.763 ± 0.027	1.677LysPro: 1.677 ± 0.037	1.192LysGln: 1.192 ± 0.032	2.189LysArg: 2.189 ± 0.041	1.35LysSer: 1.35 ± 0.031	1.514LysThr: 1.514 ± 0.031	2.317LysVal: 2.317 ± 0.053	0.267LysTrp: 0.267 ± 0.013	0.565LysTyr: 0.565 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	16.422LeuAla: 16.422 ± 0.159	1.24LeuCys: 1.24 ± 0.028	7.898LeuAsp: 7.898 ± 0.095	7.025LeuGlu: 7.025 ± 0.092	4.173LeuPhe: 4.173 ± 0.06	10.112LeuGly: 10.112 ± 0.102	2.641LeuHis: 2.641 ± 0.05	4.736LeuIle: 4.736 ± 0.08	3.672LeuLys: 3.672 ± 0.06	14.28LeuLeu: 14.28 ± 0.158	2.309LeuMet: 2.309 ± 0.047	3.128LeuAsn: 3.128 ± 0.057	6.945LeuPro: 6.945 ± 0.074	4.601LeuGln: 4.601 ± 0.065	8.641LeuArg: 8.641 ± 0.097	6.613LeuSer: 6.613 ± 0.072	5.463LeuThr: 5.463 ± 0.076	8.45LeuVal: 8.45 ± 0.09	1.474LeuTrp: 1.474 ± 0.036	2.702LeuTyr: 2.702 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.52MetAla: 2.52 ± 0.043	0.14MetCys: 0.14 ± 0.011	1.028MetAsp: 1.028 ± 0.03	0.862MetGlu: 0.862 ± 0.027	0.555MetPhe: 0.555 ± 0.019	1.543MetGly: 1.543 ± 0.039	0.425MetHis: 0.425 ± 0.016	0.91MetIle: 0.91 ± 0.033	0.732MetLys: 0.732 ± 0.026	2.306MetLeu: 2.306 ± 0.047	0.401MetMet: 0.401 ± 0.02	0.692MetAsn: 0.692 ± 0.023	1.279MetPro: 1.279 ± 0.035	0.865MetGln: 0.865 ± 0.025	1.472MetArg: 1.472 ± 0.031	1.441MetSer: 1.441 ± 0.035	1.227MetThr: 1.227 ± 0.032	1.345MetVal: 1.345 ± 0.036	0.147MetTrp: 0.147 ± 0.012	0.3MetTyr: 0.3 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.771AsnAla: 2.771 ± 0.048	0.242AsnCys: 0.242 ± 0.016	1.307AsnAsp: 1.307 ± 0.034	1.147AsnGlu: 1.147 ± 0.033	0.83AsnPhe: 0.83 ± 0.028	2.286AsnGly: 2.286 ± 0.058	0.529AsnHis: 0.529 ± 0.02	0.997AsnIle: 0.997 ± 0.031	0.662AsnLys: 0.662 ± 0.023	3.067AsnLeu: 3.067 ± 0.052	0.425AsnMet: 0.425 ± 0.016	0.646AsnAsn: 0.646 ± 0.027	1.747AsnPro: 1.747 ± 0.044	1.026AsnGln: 1.026 ± 0.031	1.84AsnArg: 1.84 ± 0.03	1.124AsnSer: 1.124 ± 0.033	1.172AsnThr: 1.172 ± 0.036	1.711AsnVal: 1.711 ± 0.038	0.34AsnTrp: 0.34 ± 0.016	0.642AsnTyr: 0.642 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.029ProAla: 7.029 ± 0.106	0.394ProCys: 0.394 ± 0.019	3.376ProAsp: 3.376 ± 0.068	3.416ProGlu: 3.416 ± 0.054	1.93ProPhe: 1.93 ± 0.037	4.583ProGly: 4.583 ± 0.071	1.119ProHis: 1.119 ± 0.032	1.753ProIle: 1.753 ± 0.039	1.298ProLys: 1.298 ± 0.037	6.588ProLeu: 6.588 ± 0.07	1.155ProMet: 1.155 ± 0.031	1.137ProAsn: 1.137 ± 0.029	2.666ProPro: 2.666 ± 0.059	2.083ProGln: 2.083 ± 0.039	3.605ProArg: 3.605 ± 0.06	2.773ProSer: 2.773 ± 0.048	2.346ProThr: 2.346 ± 0.045	4.087ProVal: 4.087 ± 0.06	0.825ProTrp: 0.825 ± 0.025	1.248ProTyr: 1.248 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	6.096GlnAla: 6.096 ± 0.082	0.283GlnCys: 0.283 ± 0.016	1.88GlnAsp: 1.88 ± 0.042	1.798GlnGlu: 1.798 ± 0.041	1.124GlnPhe: 1.124 ± 0.032	3.464GlnGly: 3.464 ± 0.06	0.983GlnHis: 0.983 ± 0.029	1.502GlnIle: 1.502 ± 0.037	0.965GlnLys: 0.965 ± 0.028	4.543GlnLeu: 4.543 ± 0.065	0.788GlnMet: 0.788 ± 0.027	0.886GlnAsn: 0.886 ± 0.026	2.508GlnPro: 2.508 ± 0.046	2.107GlnGln: 2.107 ± 0.05	4.017GlnArg: 4.017 ± 0.076	1.75GlnSer: 1.75 ± 0.039	1.652GlnThr: 1.652 ± 0.043	3.644GlnVal: 3.644 ± 0.056	0.547GlnTrp: 0.547 ± 0.021	0.867GlnTyr: 0.867 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	7.79ArgAla: 7.79 ± 0.099	0.726ArgCys: 0.726 ± 0.024	4.394ArgAsp: 4.394 ± 0.065	4.706ArgGlu: 4.706 ± 0.076	3.218ArgPhe: 3.218 ± 0.05	4.921ArgGly: 4.921 ± 0.059	2.192ArgHis: 2.192 ± 0.042	3.463ArgIle: 3.463 ± 0.049	1.734ArgLys: 1.734 ± 0.038	10.798ArgLeu: 10.798 ± 0.15	1.648ArgMet: 1.648 ± 0.036	1.778ArgAsn: 1.778 ± 0.036	3.772ArgPro: 3.772 ± 0.058	3.944ArgGln: 3.944 ± 0.064	6.008ArgArg: 6.008 ± 0.096	3.522ArgSer: 3.522 ± 0.053	3.037ArgThr: 3.037 ± 0.05	5.308ArgVal: 5.308 ± 0.064	1.201ArgTrp: 1.201 ± 0.032	2.376ArgTyr: 2.376 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	5.863SerAla: 5.863 ± 0.079	0.402SerCys: 0.402 ± 0.018	2.631SerAsp: 2.631 ± 0.053	2.681SerGlu: 2.681 ± 0.048	1.881SerPhe: 1.881 ± 0.045	5.039SerGly: 5.039 ± 0.08	1.177SerHis: 1.177 ± 0.031	2.197SerIle: 2.197 ± 0.052	1.294SerLys: 1.294 ± 0.034	6.796SerLeu: 6.796 ± 0.082	1.123SerMet: 1.123 ± 0.032	1.244SerAsn: 1.244 ± 0.037	2.768SerPro: 2.768 ± 0.047	2.003SerGln: 2.003 ± 0.04	3.784SerArg: 3.784 ± 0.049	2.825SerSer: 2.825 ± 0.057	2.482SerThr: 2.482 ± 0.054	3.613SerVal: 3.613 ± 0.058	0.673SerTrp: 0.673 ± 0.025	1.244SerTyr: 1.244 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	4.944ThrAla: 4.944 ± 0.079	0.468ThrCys: 0.468 ± 0.019	2.325ThrAsp: 2.325 ± 0.047	2.144ThrGlu: 2.144 ± 0.041	1.79ThrPhe: 1.79 ± 0.05	4.045ThrGly: 4.045 ± 0.059	1.06ThrHis: 1.06 ± 0.028	1.569ThrIle: 1.569 ± 0.042	0.864ThrLys: 0.864 ± 0.028	6.932ThrLeu: 6.932 ± 0.106	0.65ThrMet: 0.65 ± 0.025	0.932ThrAsn: 0.932 ± 0.027	3.394ThrPro: 3.394 ± 0.067	1.692ThrGln: 1.692 ± 0.041	3.469ThrArg: 3.469 ± 0.056	2.249ThrSer: 2.249 ± 0.05	2.118ThrThr: 2.118 ± 0.053	3.513ThrVal: 3.513 ± 0.079	0.687ThrTrp: 0.687 ± 0.027	1.239ThrTyr: 1.239 ± 0.055	0.0ThrXaa: 0.0 ± 0.0
Val	8.35ValAla: 8.35 ± 0.087	0.72ValCys: 0.72 ± 0.024	4.242ValAsp: 4.242 ± 0.05	4.645ValGlu: 4.645 ± 0.066	2.488ValPhe: 2.488 ± 0.048	5.415ValGly: 5.415 ± 0.078	1.457ValHis: 1.457 ± 0.032	3.303ValIle: 3.303 ± 0.054	2.066ValLys: 2.066 ± 0.048	8.475ValLeu: 8.475 ± 0.093	1.559ValMet: 1.559 ± 0.038	1.956ValAsn: 1.956 ± 0.044	3.605ValPro: 3.605 ± 0.061	2.619ValGln: 2.619 ± 0.046	5.03ValArg: 5.03 ± 0.065	3.996ValSer: 3.996 ± 0.065	3.586ValThr: 3.586 ± 0.08	5.404ValVal: 5.404 ± 0.078	0.845ValTrp: 0.845 ± 0.027	1.603ValTyr: 1.603 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.212TrpAla: 1.212 ± 0.034	0.153TrpCys: 0.153 ± 0.011	0.649TrpAsp: 0.649 ± 0.024	0.568TrpGlu: 0.568 ± 0.024	0.485TrpPhe: 0.485 ± 0.018	0.867TrpGly: 0.867 ± 0.027	0.407TrpHis: 0.407 ± 0.018	0.585TrpIle: 0.585 ± 0.021	0.384TrpLys: 0.384 ± 0.018	2.328TrpLeu: 2.328 ± 0.048	0.311TrpMet: 0.311 ± 0.015	0.398TrpAsn: 0.398 ± 0.018	0.753TrpPro: 0.753 ± 0.028	0.857TrpGln: 0.857 ± 0.03	1.385TrpArg: 1.385 ± 0.039	0.797TrpSer: 0.797 ± 0.025	0.63TrpThr: 0.63 ± 0.022	0.917TrpVal: 0.917 ± 0.031	0.231TrpTrp: 0.231 ± 0.016	0.362TrpTyr: 0.362 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.599TyrAla: 2.599 ± 0.046	0.279TyrCys: 0.279 ± 0.014	1.425TyrAsp: 1.425 ± 0.042	1.163TyrGlu: 1.163 ± 0.032	0.949TyrPhe: 0.949 ± 0.028	2.13TyrGly: 2.13 ± 0.042	0.598TyrHis: 0.598 ± 0.019	0.849TyrIle: 0.849 ± 0.031	0.597TyrLys: 0.597 ± 0.023	3.236TyrLeu: 3.236 ± 0.054	0.404TyrMet: 0.404 ± 0.018	0.647TyrAsn: 0.647 ± 0.025	1.361TyrPro: 1.361 ± 0.035	1.105TyrGln: 1.105 ± 0.032	2.398TyrArg: 2.398 ± 0.043	1.366TyrSer: 1.366 ± 0.036	1.233TyrThr: 1.233 ± 0.055	1.647TyrVal: 1.647 ± 0.034	0.407TyrTrp: 0.407 ± 0.018	0.664TyrTyr: 0.664 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4165 proteins (1375172 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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