Amino acid dipepetide frequency for Isoptericola variabilis (strain 225)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.003AlaAla: 23.003 ± 0.3	0.798AlaCys: 0.798 ± 0.03	8.958AlaAsp: 8.958 ± 0.112	9.068AlaGlu: 9.068 ± 0.119	3.551AlaPhe: 3.551 ± 0.07	13.879AlaGly: 13.879 ± 0.16	2.739AlaHis: 2.739 ± 0.053	3.908AlaIle: 3.908 ± 0.076	2.028AlaLys: 2.028 ± 0.059	14.399AlaLeu: 14.399 ± 0.174	2.561AlaMet: 2.561 ± 0.05	1.854AlaAsn: 1.854 ± 0.049	7.696AlaPro: 7.696 ± 0.123	3.673AlaGln: 3.673 ± 0.074	11.574AlaArg: 11.574 ± 0.169	6.487AlaSer: 6.487 ± 0.09	8.187AlaThr: 8.187 ± 0.101	13.632AlaVal: 13.632 ± 0.156	2.365AlaTrp: 2.365 ± 0.048	2.414AlaTyr: 2.414 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.779CysAla: 0.779 ± 0.032	0.074CysCys: 0.074 ± 0.01	0.301CysAsp: 0.301 ± 0.017	0.296CysGlu: 0.296 ± 0.019	0.163CysPhe: 0.163 ± 0.014	0.636CysGly: 0.636 ± 0.028	0.121CysHis: 0.121 ± 0.012	0.112CysIle: 0.112 ± 0.012	0.058CysLys: 0.058 ± 0.007	0.472CysLeu: 0.472 ± 0.021	0.077CysMet: 0.077 ± 0.008	0.084CysAsn: 0.084 ± 0.01	0.37CysPro: 0.37 ± 0.022	0.111CysGln: 0.111 ± 0.011	0.369CysArg: 0.369 ± 0.024	0.344CysSer: 0.344 ± 0.018	0.373CysThr: 0.373 ± 0.019	0.488CysVal: 0.488 ± 0.03	0.078CysTrp: 0.078 ± 0.008	0.105CysTyr: 0.105 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	9.899AspAla: 9.899 ± 0.114	0.281AspCys: 0.281 ± 0.018	5.074AspAsp: 5.074 ± 0.085	4.443AspGlu: 4.443 ± 0.085	1.341AspPhe: 1.341 ± 0.039	7.41AspGly: 7.41 ± 0.129	1.34AspHis: 1.34 ± 0.037	1.314AspIle: 1.314 ± 0.035	0.813AspLys: 0.813 ± 0.032	6.637AspLeu: 6.637 ± 0.093	0.731AspMet: 0.731 ± 0.028	0.741AspAsn: 0.741 ± 0.034	4.796AspPro: 4.796 ± 0.075	1.419AspGln: 1.419 ± 0.039	4.558AspArg: 4.558 ± 0.084	1.854AspSer: 1.854 ± 0.049	2.802AspThr: 2.802 ± 0.055	7.671AspVal: 7.671 ± 0.098	0.867AspTrp: 0.867 ± 0.028	1.088AspTyr: 1.088 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	7.992GluAla: 7.992 ± 0.113	0.277GluCys: 0.277 ± 0.022	3.177GluAsp: 3.177 ± 0.06	3.325GluGlu: 3.325 ± 0.069	1.333GluPhe: 1.333 ± 0.041	4.407GluGly: 4.407 ± 0.071	1.891GluHis: 1.891 ± 0.042	2.293GluIle: 2.293 ± 0.053	1.129GluLys: 1.129 ± 0.041	7.012GluLeu: 7.012 ± 0.102	0.797GluMet: 0.797 ± 0.031	1.004GluAsn: 1.004 ± 0.037	4.133GluPro: 4.133 ± 0.079	2.286GluGln: 2.286 ± 0.052	6.001GluArg: 6.001 ± 0.079	2.342GluSer: 2.342 ± 0.052	3.009GluThr: 3.009 ± 0.059	5.532GluVal: 5.532 ± 0.089	0.826GluTrp: 0.826 ± 0.037	1.088GluTyr: 1.088 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.5PheAla: 3.5 ± 0.065	0.198PheCys: 0.198 ± 0.014	2.014PheAsp: 2.014 ± 0.044	1.548PheGlu: 1.548 ± 0.039	0.862PhePhe: 0.862 ± 0.036	2.779PheGly: 2.779 ± 0.061	0.524PheHis: 0.524 ± 0.023	0.547PheIle: 0.547 ± 0.027	0.328PheLys: 0.328 ± 0.023	2.467PheLeu: 2.467 ± 0.058	0.371PheMet: 0.371 ± 0.019	0.457PheAsn: 0.457 ± 0.022	1.248PhePro: 1.248 ± 0.042	0.585PheGln: 0.585 ± 0.028	1.694PheArg: 1.694 ± 0.044	1.325PheSer: 1.325 ± 0.038	1.781PheThr: 1.781 ± 0.046	2.666PheVal: 2.666 ± 0.058	0.483PheTrp: 0.483 ± 0.023	0.552PheTyr: 0.552 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	11.897GlyAla: 11.897 ± 0.136	0.56GlyCys: 0.56 ± 0.025	5.517GlyAsp: 5.517 ± 0.086	5.445GlyGlu: 5.445 ± 0.08	2.761GlyPhe: 2.761 ± 0.058	8.522GlyGly: 8.522 ± 0.131	2.07GlyHis: 2.07 ± 0.046	3.223GlyIle: 3.223 ± 0.065	1.752GlyLys: 1.752 ± 0.049	9.058GlyLeu: 9.058 ± 0.098	1.937GlyMet: 1.937 ± 0.047	1.499GlyAsn: 1.499 ± 0.046	5.14GlyPro: 5.14 ± 0.089	2.382GlyGln: 2.382 ± 0.059	7.483GlyArg: 7.483 ± 0.097	4.964GlySer: 4.964 ± 0.084	6.508GlyThr: 6.508 ± 0.094	8.943GlyVal: 8.943 ± 0.111	1.748GlyTrp: 1.748 ± 0.047	2.136GlyTyr: 2.136 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.877HisAla: 2.877 ± 0.061	0.126HisCys: 0.126 ± 0.012	1.616HisAsp: 1.616 ± 0.046	1.286HisGlu: 1.286 ± 0.034	0.479HisPhe: 0.479 ± 0.023	2.232HisGly: 2.232 ± 0.056	0.653HisHis: 0.653 ± 0.03	0.379HisIle: 0.379 ± 0.022	0.245HisLys: 0.245 ± 0.017	2.397HisLeu: 2.397 ± 0.054	0.272HisMet: 0.272 ± 0.018	0.314HisAsn: 0.314 ± 0.019	1.591HisPro: 1.591 ± 0.048	0.494HisGln: 0.494 ± 0.023	1.911HisArg: 1.911 ± 0.047	0.746HisSer: 0.746 ± 0.028	1.001HisThr: 1.001 ± 0.033	2.216HisVal: 2.216 ± 0.046	0.31HisTrp: 0.31 ± 0.02	0.363HisTyr: 0.363 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	4.097IleAla: 4.097 ± 0.076	0.166IleCys: 0.166 ± 0.013	2.191IleAsp: 2.191 ± 0.047	1.927IleGlu: 1.927 ± 0.052	0.753IlePhe: 0.753 ± 0.03	2.775IleGly: 2.775 ± 0.057	0.465IleHis: 0.465 ± 0.021	0.838IleIle: 0.838 ± 0.036	0.525IleLys: 0.525 ± 0.024	2.444IleLeu: 2.444 ± 0.057	0.408IleMet: 0.408 ± 0.02	0.577IleAsn: 0.577 ± 0.025	1.565IlePro: 1.565 ± 0.041	0.603IleGln: 0.603 ± 0.03	1.716IleArg: 1.716 ± 0.042	1.29IleSer: 1.29 ± 0.043	1.911IleThr: 1.911 ± 0.05	2.932IleVal: 2.932 ± 0.062	0.308IleTrp: 0.308 ± 0.018	0.492IleTyr: 0.492 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	1.988LysAla: 1.988 ± 0.057	0.06LysCys: 0.06 ± 0.009	0.947LysAsp: 0.947 ± 0.035	0.816LysGlu: 0.816 ± 0.034	0.317LysPhe: 0.317 ± 0.019	1.293LysGly: 1.293 ± 0.044	0.411LysHis: 0.411 ± 0.022	0.659LysIle: 0.659 ± 0.029	0.497LysLys: 0.497 ± 0.029	1.258LysLeu: 1.258 ± 0.04	0.281LysMet: 0.281 ± 0.019	0.361LysAsn: 0.361 ± 0.021	0.907LysPro: 0.907 ± 0.032	0.47LysGln: 0.47 ± 0.024	1.101LysArg: 1.101 ± 0.041	0.763LysSer: 0.763 ± 0.033	0.901LysThr: 0.901 ± 0.03	1.612LysVal: 1.612 ± 0.042	0.146LysTrp: 0.146 ± 0.013	0.347LysTyr: 0.347 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	16.362LeuAla: 16.362 ± 0.18	0.501LeuCys: 0.501 ± 0.023	7.262LeuAsp: 7.262 ± 0.099	5.934LeuGlu: 5.934 ± 0.086	2.266LeuPhe: 2.266 ± 0.054	9.517LeuGly: 9.517 ± 0.119	1.99LeuHis: 1.99 ± 0.047	1.989LeuIle: 1.989 ± 0.046	1.292LeuLys: 1.292 ± 0.044	10.249LeuLeu: 10.249 ± 0.149	1.359LeuMet: 1.359 ± 0.043	1.325LeuAsn: 1.325 ± 0.038	5.93LeuPro: 5.93 ± 0.082	2.181LeuGln: 2.181 ± 0.049	8.165LeuArg: 8.165 ± 0.117	4.424LeuSer: 4.424 ± 0.066	6.0LeuThr: 6.0 ± 0.078	11.103LeuVal: 11.103 ± 0.143	1.26LeuTrp: 1.26 ± 0.04	1.477LeuTyr: 1.477 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	1.968MetAla: 1.968 ± 0.051	0.096MetCys: 0.096 ± 0.01	0.764MetAsp: 0.764 ± 0.024	0.607MetGlu: 0.607 ± 0.026	0.445MetPhe: 0.445 ± 0.023	1.18MetGly: 1.18 ± 0.036	0.35MetHis: 0.35 ± 0.021	0.577MetIle: 0.577 ± 0.026	0.276MetLys: 0.276 ± 0.019	1.682MetLeu: 1.682 ± 0.042	0.225MetMet: 0.225 ± 0.016	0.363MetAsn: 0.363 ± 0.02	1.042MetPro: 1.042 ± 0.034	0.371MetGln: 0.371 ± 0.018	1.261MetArg: 1.261 ± 0.034	1.281MetSer: 1.281 ± 0.035	1.68MetThr: 1.68 ± 0.038	1.352MetVal: 1.352 ± 0.036	0.152MetTrp: 0.152 ± 0.01	0.244MetTyr: 0.244 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	1.923AsnAla: 1.923 ± 0.045	0.081AsnCys: 0.081 ± 0.011	0.885AsnAsp: 0.885 ± 0.035	0.713AsnGlu: 0.713 ± 0.031	0.428AsnPhe: 0.428 ± 0.022	1.399AsnGly: 1.399 ± 0.045	0.356AsnHis: 0.356 ± 0.019	0.523AsnIle: 0.523 ± 0.025	0.281AsnLys: 0.281 ± 0.018	1.578AsnLeu: 1.578 ± 0.04	0.247AsnMet: 0.247 ± 0.015	0.362AsnAsn: 0.362 ± 0.022	1.345AsnPro: 1.345 ± 0.04	0.434AsnGln: 0.434 ± 0.022	1.009AsnArg: 1.009 ± 0.037	0.621AsnSer: 0.621 ± 0.024	0.905AsnThr: 0.905 ± 0.032	1.516AsnVal: 1.516 ± 0.04	0.217AsnTrp: 0.217 ± 0.017	0.394AsnTyr: 0.394 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	8.962ProAla: 8.962 ± 0.127	0.236ProCys: 0.236 ± 0.022	5.046ProAsp: 5.046 ± 0.085	4.552ProGlu: 4.552 ± 0.08	1.536ProPhe: 1.536 ± 0.039	6.516ProGly: 6.516 ± 0.098	1.257ProHis: 1.257 ± 0.038	1.302ProIle: 1.302 ± 0.037	0.798ProLys: 0.798 ± 0.036	5.099ProLeu: 5.099 ± 0.082	0.871ProMet: 0.871 ± 0.032	0.8ProAsn: 0.8 ± 0.03	3.14ProPro: 3.14 ± 0.068	1.456ProGln: 1.456 ± 0.043	4.051ProArg: 4.051 ± 0.075	3.281ProSer: 3.281 ± 0.076	3.648ProThr: 3.648 ± 0.077	5.97ProVal: 5.97 ± 0.085	0.922ProTrp: 0.922 ± 0.032	1.132ProTyr: 1.132 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.546GlnAla: 3.546 ± 0.067	0.107GlnCys: 0.107 ± 0.011	1.28GlnAsp: 1.28 ± 0.042	1.314GlnGlu: 1.314 ± 0.041	0.642GlnPhe: 0.642 ± 0.025	1.966GlnGly: 1.966 ± 0.049	0.631GlnHis: 0.631 ± 0.027	0.956GlnIle: 0.956 ± 0.031	0.452GlnLys: 0.452 ± 0.021	2.621GlnLeu: 2.621 ± 0.051	0.422GlnMet: 0.422 ± 0.023	0.445GlnAsn: 0.445 ± 0.024	1.447GlnPro: 1.447 ± 0.045	0.956GlnGln: 0.956 ± 0.034	2.092GlnArg: 2.092 ± 0.043	0.943GlnSer: 0.943 ± 0.036	1.226GlnThr: 1.226 ± 0.04	2.958GlnVal: 2.958 ± 0.057	0.4GlnTrp: 0.4 ± 0.021	0.55GlnTyr: 0.55 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	10.572ArgAla: 10.572 ± 0.137	0.412ArgCys: 0.412 ± 0.025	4.522ArgAsp: 4.522 ± 0.068	4.818ArgGlu: 4.818 ± 0.084	2.208ArgPhe: 2.208 ± 0.054	6.065ArgGly: 6.065 ± 0.087	1.802ArgHis: 1.802 ± 0.051	2.625ArgIle: 2.625 ± 0.053	1.216ArgLys: 1.216 ± 0.041	8.261ArgLeu: 8.261 ± 0.112	1.564ArgMet: 1.564 ± 0.037	1.031ArgAsn: 1.031 ± 0.034	4.861ArgPro: 4.861 ± 0.087	1.919ArgGln: 1.919 ± 0.049	8.195ArgArg: 8.195 ± 0.131	4.013ArgSer: 4.013 ± 0.074	5.362ArgThr: 5.362 ± 0.076	7.079ArgVal: 7.079 ± 0.083	1.586ArgTrp: 1.586 ± 0.04	1.722ArgTyr: 1.722 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.09SerAla: 6.09 ± 0.079	0.266SerCys: 0.266 ± 0.018	2.808SerAsp: 2.808 ± 0.057	2.352SerGlu: 2.352 ± 0.045	1.446SerPhe: 1.446 ± 0.039	5.169SerGly: 5.169 ± 0.074	0.908SerHis: 0.908 ± 0.032	1.445SerIle: 1.445 ± 0.043	0.696SerLys: 0.696 ± 0.031	4.33SerLeu: 4.33 ± 0.066	0.954SerMet: 0.954 ± 0.03	0.807SerAsn: 0.807 ± 0.031	3.068SerPro: 3.068 ± 0.064	1.084SerGln: 1.084 ± 0.031	3.506SerArg: 3.506 ± 0.065	2.792SerSer: 2.792 ± 0.058	3.279SerThr: 3.279 ± 0.06	4.215SerVal: 4.215 ± 0.073	0.829SerTrp: 0.829 ± 0.036	0.979SerTyr: 0.979 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	8.217ThrAla: 8.217 ± 0.099	0.351ThrCys: 0.351 ± 0.022	3.584ThrAsp: 3.584 ± 0.067	3.223ThrGlu: 3.223 ± 0.077	1.94ThrPhe: 1.94 ± 0.048	6.185ThrGly: 6.185 ± 0.087	1.168ThrHis: 1.168 ± 0.038	1.978ThrIle: 1.978 ± 0.045	0.876ThrLys: 0.876 ± 0.031	6.035ThrLeu: 6.035 ± 0.092	0.922ThrMet: 0.922 ± 0.029	1.004ThrAsn: 1.004 ± 0.033	4.27ThrPro: 4.27 ± 0.065	1.392ThrGln: 1.392 ± 0.042	3.986ThrArg: 3.986 ± 0.062	3.371ThrSer: 3.371 ± 0.066	4.547ThrThr: 4.547 ± 0.078	6.483ThrVal: 6.483 ± 0.123	1.036ThrTrp: 1.036 ± 0.044	1.336ThrTyr: 1.336 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	14.828ValAla: 14.828 ± 0.135	0.584ValCys: 0.584 ± 0.027	6.82ValAsp: 6.82 ± 0.101	6.267ValGlu: 6.267 ± 0.083	2.312ValPhe: 2.312 ± 0.048	8.604ValGly: 8.604 ± 0.115	2.135ValHis: 2.135 ± 0.052	2.523ValIle: 2.523 ± 0.057	1.352ValLys: 1.352 ± 0.045	10.965ValLeu: 10.965 ± 0.132	1.427ValMet: 1.427 ± 0.046	1.498ValAsn: 1.498 ± 0.038	6.237ValPro: 6.237 ± 0.099	2.157ValGln: 2.157 ± 0.046	8.163ValArg: 8.163 ± 0.101	4.29ValSer: 4.29 ± 0.057	6.611ValThr: 6.611 ± 0.109	12.91ValVal: 12.91 ± 0.151	1.287ValTrp: 1.287 ± 0.042	1.566ValTyr: 1.566 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.784TrpAla: 1.784 ± 0.045	0.123TrpCys: 0.123 ± 0.013	0.934TrpAsp: 0.934 ± 0.037	0.768TrpGlu: 0.768 ± 0.028	0.604TrpPhe: 0.604 ± 0.026	1.124TrpGly: 1.124 ± 0.037	0.319TrpHis: 0.319 ± 0.018	0.466TrpIle: 0.466 ± 0.022	0.246TrpLys: 0.246 ± 0.018	1.686TrpLeu: 1.686 ± 0.046	0.273TrpMet: 0.273 ± 0.018	0.346TrpAsn: 0.346 ± 0.02	0.803TrpPro: 0.803 ± 0.029	0.488TrpGln: 0.488 ± 0.026	1.409TrpArg: 1.409 ± 0.048	0.968TrpSer: 0.968 ± 0.033	1.046TrpThr: 1.046 ± 0.031	1.391TrpVal: 1.391 ± 0.044	0.386TrpTrp: 0.386 ± 0.02	0.346TrpTyr: 0.346 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.491TyrAla: 2.491 ± 0.054	0.111TyrCys: 0.111 ± 0.01	1.378TyrAsp: 1.378 ± 0.04	1.149TyrGlu: 1.149 ± 0.035	0.542TyrPhe: 0.542 ± 0.028	1.891TyrGly: 1.891 ± 0.037	0.379TyrHis: 0.379 ± 0.019	0.326TyrIle: 0.326 ± 0.02	0.274TyrLys: 0.274 ± 0.017	1.938TyrLeu: 1.938 ± 0.048	0.215TyrMet: 0.215 ± 0.014	0.346TyrAsn: 0.346 ± 0.021	0.984TyrPro: 0.984 ± 0.03	0.493TyrGln: 0.493 ± 0.024	1.589TyrArg: 1.589 ± 0.039	0.925TyrSer: 0.925 ± 0.03	1.126TyrThr: 1.126 ± 0.042	1.866TyrVal: 1.866 ± 0.047	0.306TyrTrp: 0.306 ± 0.018	0.404TyrTyr: 0.404 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2879 proteins (987482 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---