Amino acid dipepetide frequency for Pachysolen tannophilus NRRL Y-2460

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.13AlaAla: 4.13 ± 0.068	0.596AlaCys: 0.596 ± 0.015	2.598AlaAsp: 2.598 ± 0.033	3.135AlaGlu: 3.135 ± 0.041	2.038AlaPhe: 2.038 ± 0.031	2.848AlaGly: 2.848 ± 0.04	0.903AlaHis: 0.903 ± 0.021	3.77AlaIle: 3.77 ± 0.04	3.831AlaLys: 3.831 ± 0.042	4.801AlaLeu: 4.801 ± 0.049	0.957AlaMet: 0.957 ± 0.02	3.107AlaAsn: 3.107 ± 0.04	2.195AlaPro: 2.195 ± 0.045	1.942AlaGln: 1.942 ± 0.037	2.055AlaArg: 2.055 ± 0.029	4.75AlaSer: 4.75 ± 0.058	3.128AlaThr: 3.128 ± 0.04	3.001AlaVal: 3.001 ± 0.04	0.398AlaTrp: 0.398 ± 0.013	1.521AlaTyr: 1.521 ± 0.027	0.0AlaXaa: 0.0 ± 0.0
Cys	0.536CysAla: 0.536 ± 0.017	0.28CysCys: 0.28 ± 0.011	0.653CysAsp: 0.653 ± 0.018	0.562CysGlu: 0.562 ± 0.015	0.725CysPhe: 0.725 ± 0.017	0.798CysGly: 0.798 ± 0.018	0.267CysHis: 0.267 ± 0.011	0.965CysIle: 0.965 ± 0.021	0.706CysLys: 0.706 ± 0.017	1.237CysLeu: 1.237 ± 0.022	0.196CysMet: 0.196 ± 0.009	0.608CysAsn: 0.608 ± 0.017	0.421CysPro: 0.421 ± 0.015	0.332CysGln: 0.332 ± 0.012	0.396CysArg: 0.396 ± 0.012	0.974CysSer: 0.974 ± 0.018	0.487CysThr: 0.487 ± 0.015	0.581CysVal: 0.581 ± 0.014	0.147CysTrp: 0.147 ± 0.008	0.496CysTyr: 0.496 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	2.75AspAla: 2.75 ± 0.035	0.62AspCys: 0.62 ± 0.016	5.274AspAsp: 5.274 ± 0.071	5.502AspGlu: 5.502 ± 0.056	2.998AspPhe: 2.998 ± 0.035	2.943AspGly: 2.943 ± 0.037	1.095AspHis: 1.095 ± 0.021	4.384AspIle: 4.384 ± 0.044	4.011AspLys: 4.011 ± 0.046	6.023AspLeu: 6.023 ± 0.049	0.912AspMet: 0.912 ± 0.017	4.022AspAsn: 4.022 ± 0.046	2.158AspPro: 2.158 ± 0.033	1.921AspGln: 1.921 ± 0.027	1.843AspArg: 1.843 ± 0.028	4.869AspSer: 4.869 ± 0.047	2.45AspThr: 2.45 ± 0.029	3.204AspVal: 3.204 ± 0.043	0.55AspTrp: 0.55 ± 0.015	2.341AspTyr: 2.341 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	3.205GluAla: 3.205 ± 0.039	0.565GluCys: 0.565 ± 0.014	4.6GluAsp: 4.6 ± 0.059	6.712GluGlu: 6.712 ± 0.093	3.01GluPhe: 3.01 ± 0.036	2.56GluGly: 2.56 ± 0.03	1.038GluHis: 1.038 ± 0.02	5.246GluIle: 5.246 ± 0.052	5.954GluLys: 5.954 ± 0.062	6.712GluLeu: 6.712 ± 0.062	1.173GluMet: 1.173 ± 0.023	5.571GluAsn: 5.571 ± 0.057	1.727GluPro: 1.727 ± 0.029	2.453GluGln: 2.453 ± 0.035	2.504GluArg: 2.504 ± 0.038	4.674GluSer: 4.674 ± 0.049	3.289GluThr: 3.289 ± 0.036	3.338GluVal: 3.338 ± 0.037	0.582GluTrp: 0.582 ± 0.016	2.157GluTyr: 2.157 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	2.237PheAla: 2.237 ± 0.031	0.56PheCys: 0.56 ± 0.014	2.785PheAsp: 2.785 ± 0.029	3.113PheGlu: 3.113 ± 0.036	2.376PhePhe: 2.376 ± 0.036	2.714PheGly: 2.714 ± 0.043	0.911PheHis: 0.911 ± 0.02	3.478PheIle: 3.478 ± 0.042	3.894PheLys: 3.894 ± 0.043	4.474PheLeu: 4.474 ± 0.042	0.823PheMet: 0.823 ± 0.017	3.291PheAsn: 3.291 ± 0.034	1.724PhePro: 1.724 ± 0.029	1.883PheGln: 1.883 ± 0.029	1.462PheArg: 1.462 ± 0.026	3.759PheSer: 3.759 ± 0.045	2.302PheThr: 2.302 ± 0.028	2.475PheVal: 2.475 ± 0.032	0.477PheTrp: 0.477 ± 0.016	1.687PheTyr: 1.687 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	2.79GlyAla: 2.79 ± 0.041	0.67GlyCys: 0.67 ± 0.019	2.853GlyAsp: 2.853 ± 0.036	2.859GlyGlu: 2.859 ± 0.035	2.571GlyPhe: 2.571 ± 0.042	3.679GlyGly: 3.679 ± 0.054	0.999GlyHis: 0.999 ± 0.021	3.837GlyIle: 3.837 ± 0.045	3.69GlyLys: 3.69 ± 0.044	4.617GlyLeu: 4.617 ± 0.046	0.831GlyMet: 0.831 ± 0.019	3.699GlyAsn: 3.699 ± 0.049	1.436GlyPro: 1.436 ± 0.028	1.336GlyGln: 1.336 ± 0.024	1.978GlyArg: 1.978 ± 0.032	4.792GlySer: 4.792 ± 0.053	2.728GlyThr: 2.728 ± 0.034	3.024GlyVal: 3.024 ± 0.047	0.558GlyTrp: 0.558 ± 0.016	1.919GlyTyr: 1.919 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	0.839HisAla: 0.839 ± 0.02	0.254HisCys: 0.254 ± 0.01	1.103HisAsp: 1.103 ± 0.021	1.135HisGlu: 1.135 ± 0.021	0.845HisPhe: 0.845 ± 0.019	1.028HisGly: 1.028 ± 0.023	0.77HisHis: 0.77 ± 0.026	1.227HisIle: 1.227 ± 0.023	1.209HisLys: 1.209 ± 0.022	1.823HisLeu: 1.823 ± 0.028	0.309HisMet: 0.309 ± 0.011	1.228HisAsn: 1.228 ± 0.021	0.925HisPro: 0.925 ± 0.023	0.962HisGln: 0.962 ± 0.025	0.846HisArg: 0.846 ± 0.017	1.652HisSer: 1.652 ± 0.029	0.849HisThr: 0.849 ± 0.018	0.869HisVal: 0.869 ± 0.017	0.172HisTrp: 0.172 ± 0.007	0.763HisTyr: 0.763 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	3.683IleAla: 3.683 ± 0.036	0.898IleCys: 0.898 ± 0.021	4.825IleAsp: 4.825 ± 0.05	4.789IleGlu: 4.789 ± 0.047	3.507IlePhe: 3.507 ± 0.04	3.745IleGly: 3.745 ± 0.042	1.314IleHis: 1.314 ± 0.021	5.349IleIle: 5.349 ± 0.061	5.474IleLys: 5.474 ± 0.052	7.212IleLeu: 7.212 ± 0.066	1.277IleMet: 1.277 ± 0.025	5.284IleAsn: 5.284 ± 0.053	3.328IlePro: 3.328 ± 0.042	2.389IleGln: 2.389 ± 0.034	2.724IleArg: 2.724 ± 0.033	6.718IleSer: 6.718 ± 0.048	3.872IleThr: 3.872 ± 0.038	3.994IleVal: 3.994 ± 0.039	0.705IleTrp: 0.705 ± 0.017	2.527IleTyr: 2.527 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.495LysAla: 3.495 ± 0.042	0.706LysCys: 0.706 ± 0.019	4.579LysAsp: 4.579 ± 0.045	5.637LysGlu: 5.637 ± 0.056	3.74LysPhe: 3.74 ± 0.042	2.73LysGly: 2.73 ± 0.036	1.285LysHis: 1.285 ± 0.019	6.647LysIle: 6.647 ± 0.063	7.219LysLys: 7.219 ± 0.074	8.183LysLeu: 8.183 ± 0.062	1.341LysMet: 1.341 ± 0.022	6.281LysAsn: 6.281 ± 0.063	2.656LysPro: 2.656 ± 0.039	2.744LysGln: 2.744 ± 0.036	3.439LysArg: 3.439 ± 0.042	5.758LysSer: 5.758 ± 0.049	3.878LysThr: 3.878 ± 0.037	3.742LysVal: 3.742 ± 0.04	0.697LysTrp: 0.697 ± 0.015	2.758LysTyr: 2.758 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	5.126LeuAla: 5.126 ± 0.049	1.108LeuCys: 1.108 ± 0.024	5.21LeuAsp: 5.21 ± 0.047	6.095LeuGlu: 6.095 ± 0.058	4.052LeuPhe: 4.052 ± 0.043	4.293LeuGly: 4.293 ± 0.049	1.696LeuHis: 1.696 ± 0.027	7.467LeuIle: 7.467 ± 0.074	8.718LeuLys: 8.718 ± 0.081	9.247LeuLeu: 9.247 ± 0.082	1.751LeuMet: 1.751 ± 0.024	7.056LeuAsn: 7.056 ± 0.057	4.235LeuPro: 4.235 ± 0.044	3.882LeuGln: 3.882 ± 0.041	3.826LeuArg: 3.826 ± 0.043	8.686LeuSer: 8.686 ± 0.071	5.154LeuThr: 5.154 ± 0.044	4.919LeuVal: 4.919 ± 0.042	0.801LeuTrp: 0.801 ± 0.02	3.085LeuTyr: 3.085 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	1.08MetAla: 1.08 ± 0.018	0.204MetCys: 0.204 ± 0.009	1.063MetAsp: 1.063 ± 0.023	1.066MetGlu: 1.066 ± 0.02	0.756MetPhe: 0.756 ± 0.017	0.951MetGly: 0.951 ± 0.022	0.243MetHis: 0.243 ± 0.009	1.26MetIle: 1.26 ± 0.022	1.274MetLys: 1.274 ± 0.024	1.538MetLeu: 1.538 ± 0.029	0.387MetMet: 0.387 ± 0.014	1.134MetAsn: 1.134 ± 0.02	0.597MetPro: 0.597 ± 0.015	0.484MetGln: 0.484 ± 0.013	0.644MetArg: 0.644 ± 0.017	1.75MetSer: 1.75 ± 0.025	0.921MetThr: 0.921 ± 0.02	1.021MetVal: 1.021 ± 0.02	0.145MetTrp: 0.145 ± 0.007	0.491MetTyr: 0.491 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.967AsnAla: 2.967 ± 0.037	0.846AsnCys: 0.846 ± 0.019	4.971AsnAsp: 4.971 ± 0.052	4.861AsnGlu: 4.861 ± 0.055	3.668AsnPhe: 3.668 ± 0.046	4.294AsnGly: 4.294 ± 0.051	1.479AsnHis: 1.479 ± 0.024	4.827AsnIle: 4.827 ± 0.047	5.181AsnLys: 5.181 ± 0.053	6.718AsnLeu: 6.718 ± 0.075	1.023AsnMet: 1.023 ± 0.019	9.022AsnAsn: 9.022 ± 0.155	2.385AsnPro: 2.385 ± 0.031	2.385AsnGln: 2.385 ± 0.035	2.32AsnArg: 2.32 ± 0.03	7.109AsnSer: 7.109 ± 0.078	3.402AsnThr: 3.402 ± 0.045	3.335AsnVal: 3.335 ± 0.036	0.683AsnTrp: 0.683 ± 0.015	2.833AsnTyr: 2.833 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	2.086ProAla: 2.086 ± 0.037	0.309ProCys: 0.309 ± 0.013	1.906ProAsp: 1.906 ± 0.028	2.606ProGlu: 2.606 ± 0.034	1.819ProPhe: 1.819 ± 0.027	1.74ProGly: 1.74 ± 0.028	0.723ProHis: 0.723 ± 0.018	3.053ProIle: 3.053 ± 0.034	2.677ProLys: 2.677 ± 0.032	3.678ProLeu: 3.678 ± 0.046	0.625ProMet: 0.625 ± 0.015	2.393ProAsn: 2.393 ± 0.032	2.222ProPro: 2.222 ± 0.061	1.645ProGln: 1.645 ± 0.04	1.459ProArg: 1.459 ± 0.026	3.796ProSer: 3.796 ± 0.048	2.349ProThr: 2.349 ± 0.036	2.302ProVal: 2.302 ± 0.034	0.361ProTrp: 0.361 ± 0.011	1.286ProTyr: 1.286 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	1.977GlnAla: 1.977 ± 0.036	0.324GlnCys: 0.324 ± 0.01	2.027GlnAsp: 2.027 ± 0.028	2.719GlnGlu: 2.719 ± 0.04	1.621GlnPhe: 1.621 ± 0.025	1.39GlnGly: 1.39 ± 0.025	0.903GlnHis: 0.903 ± 0.021	2.452GlnIle: 2.452 ± 0.03	2.798GlnLys: 2.798 ± 0.034	3.676GlnLeu: 3.676 ± 0.041	0.66GlnMet: 0.66 ± 0.018	2.436GlnAsn: 2.436 ± 0.034	1.458GlnPro: 1.458 ± 0.034	4.355GlnGln: 4.355 ± 0.15	1.62GlnArg: 1.62 ± 0.029	2.655GlnSer: 2.655 ± 0.04	1.663GlnThr: 1.663 ± 0.028	1.823GlnVal: 1.823 ± 0.029	0.307GlnTrp: 0.307 ± 0.012	1.235GlnTyr: 1.235 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	1.974ArgAla: 1.974 ± 0.03	0.473ArgCys: 0.473 ± 0.015	2.019ArgAsp: 2.019 ± 0.029	2.427ArgGlu: 2.427 ± 0.033	1.801ArgPhe: 1.801 ± 0.024	1.849ArgGly: 1.849 ± 0.034	0.824ArgHis: 0.824 ± 0.016	2.671ArgIle: 2.671 ± 0.035	3.372ArgLys: 3.372 ± 0.037	3.73ArgLeu: 3.73 ± 0.039	0.675ArgMet: 0.675 ± 0.017	2.522ArgAsn: 2.522 ± 0.035	1.469ArgPro: 1.469 ± 0.027	1.509ArgGln: 1.509 ± 0.024	2.226ArgArg: 2.226 ± 0.039	3.318ArgSer: 3.318 ± 0.044	1.854ArgThr: 1.854 ± 0.028	1.894ArgVal: 1.894 ± 0.029	0.384ArgTrp: 0.384 ± 0.011	1.389ArgTyr: 1.389 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	4.761SerAla: 4.761 ± 0.058	0.966SerCys: 0.966 ± 0.018	4.557SerAsp: 4.557 ± 0.054	4.615SerGlu: 4.615 ± 0.045	4.047SerPhe: 4.047 ± 0.05	4.859SerGly: 4.859 ± 0.063	1.557SerHis: 1.557 ± 0.026	6.485SerIle: 6.485 ± 0.045	6.802SerLys: 6.802 ± 0.056	8.57SerLeu: 8.57 ± 0.072	1.485SerMet: 1.485 ± 0.027	6.85SerAsn: 6.85 ± 0.069	3.585SerPro: 3.585 ± 0.049	2.981SerGln: 2.981 ± 0.045	3.342SerArg: 3.342 ± 0.042	12.195SerSer: 12.195 ± 0.192	5.655SerThr: 5.655 ± 0.083	4.35SerVal: 4.35 ± 0.046	0.775SerTrp: 0.775 ± 0.018	2.752SerTyr: 2.752 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	3.055ThrAla: 3.055 ± 0.035	0.593ThrCys: 0.593 ± 0.017	2.691ThrAsp: 2.691 ± 0.037	2.913ThrGlu: 2.913 ± 0.031	2.205ThrPhe: 2.205 ± 0.034	3.09ThrGly: 3.09 ± 0.039	0.909ThrHis: 0.909 ± 0.019	3.785ThrIle: 3.785 ± 0.042	3.718ThrLys: 3.718 ± 0.038	4.681ThrLeu: 4.681 ± 0.048	0.871ThrMet: 0.871 ± 0.019	3.693ThrAsn: 3.693 ± 0.041	2.551ThrPro: 2.551 ± 0.037	1.601ThrGln: 1.601 ± 0.026	2.039ThrArg: 2.039 ± 0.03	5.421ThrSer: 5.421 ± 0.09	3.839ThrThr: 3.839 ± 0.053	2.838ThrVal: 2.838 ± 0.039	0.475ThrTrp: 0.475 ± 0.014	1.561ThrTyr: 1.561 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	3.014ValAla: 3.014 ± 0.036	0.623ValCys: 0.623 ± 0.017	3.332ValAsp: 3.332 ± 0.037	3.619ValGlu: 3.619 ± 0.04	2.433ValPhe: 2.433 ± 0.036	2.899ValGly: 2.899 ± 0.044	0.948ValHis: 0.948 ± 0.018	3.716ValIle: 3.716 ± 0.043	3.766ValLys: 3.766 ± 0.038	4.916ValLeu: 4.916 ± 0.051	0.942ValMet: 0.942 ± 0.019	3.127ValAsn: 3.127 ± 0.034	2.419ValPro: 2.419 ± 0.034	1.653ValGln: 1.653 ± 0.025	1.919ValArg: 1.919 ± 0.028	4.6ValSer: 4.6 ± 0.042	2.738ValThr: 2.738 ± 0.032	3.28ValVal: 3.28 ± 0.042	0.471ValTrp: 0.471 ± 0.013	1.716ValTyr: 1.716 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.427TrpAla: 0.427 ± 0.013	0.211TrpCys: 0.211 ± 0.008	0.574TrpAsp: 0.574 ± 0.016	0.552TrpGlu: 0.552 ± 0.015	0.498TrpPhe: 0.498 ± 0.014	0.485TrpGly: 0.485 ± 0.015	0.165TrpHis: 0.165 ± 0.008	0.656TrpIle: 0.656 ± 0.018	0.783TrpLys: 0.783 ± 0.016	0.927TrpLeu: 0.927 ± 0.018	0.185TrpMet: 0.185 ± 0.009	0.599TrpAsn: 0.599 ± 0.017	0.254TrpPro: 0.254 ± 0.01	0.268TrpGln: 0.268 ± 0.01	0.433TrpArg: 0.433 ± 0.014	0.769TrpSer: 0.769 ± 0.017	0.446TrpThr: 0.446 ± 0.014	0.493TrpVal: 0.493 ± 0.016	0.136TrpTrp: 0.136 ± 0.007	0.363TrpTyr: 0.363 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.573TyrAla: 1.573 ± 0.023	0.564TyrCys: 0.564 ± 0.015	2.251TyrAsp: 2.251 ± 0.033	2.153TyrGlu: 2.153 ± 0.03	1.715TyrPhe: 1.715 ± 0.028	1.968TyrGly: 1.968 ± 0.032	0.778TyrHis: 0.778 ± 0.017	2.34TyrIle: 2.34 ± 0.033	2.437TyrLys: 2.437 ± 0.029	3.643TyrLeu: 3.643 ± 0.038	0.587TyrMet: 0.587 ± 0.016	2.387TyrAsn: 2.387 ± 0.03	1.29TyrPro: 1.29 ± 0.026	1.373TyrGln: 1.373 ± 0.022	1.307TyrArg: 1.307 ± 0.021	2.944TyrSer: 2.944 ± 0.036	1.522TyrThr: 1.522 ± 0.026	1.648TyrVal: 1.648 ± 0.026	0.4TyrTrp: 0.4 ± 0.013	1.575TyrTyr: 1.575 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5645 proteins (2707834 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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