Amino acid dipepetide frequency for Colletotrichum sublineola (Sorghum anthracnose fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.857AlaAla: 10.857 ± 0.079	1.145AlaCys: 1.145 ± 0.016	4.704AlaAsp: 4.704 ± 0.033	5.38AlaGlu: 5.38 ± 0.045	3.227AlaPhe: 3.227 ± 0.024	6.36AlaGly: 6.36 ± 0.04	1.842AlaHis: 1.842 ± 0.019	4.22AlaIle: 4.22 ± 0.031	4.207AlaLys: 4.207 ± 0.035	7.893AlaLeu: 7.893 ± 0.044	2.104AlaMet: 2.104 ± 0.019	3.12AlaAsn: 3.12 ± 0.024	5.325AlaPro: 5.325 ± 0.045	3.469AlaGln: 3.469 ± 0.025	5.271AlaArg: 5.271 ± 0.036	7.634AlaSer: 7.634 ± 0.05	5.612AlaThr: 5.612 ± 0.04	6.017AlaVal: 6.017 ± 0.041	1.279AlaTrp: 1.279 ± 0.015	2.233AlaTyr: 2.233 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.972CysAla: 0.972 ± 0.014	0.255CysCys: 0.255 ± 0.008	0.678CysAsp: 0.678 ± 0.011	0.58CysGlu: 0.58 ± 0.01	0.537CysPhe: 0.537 ± 0.009	1.0CysGly: 1.0 ± 0.017	0.342CysHis: 0.342 ± 0.008	0.673CysIle: 0.673 ± 0.01	0.517CysLys: 0.517 ± 0.009	1.211CysLeu: 1.211 ± 0.012	0.266CysMet: 0.266 ± 0.007	0.453CysAsn: 0.453 ± 0.009	0.703CysPro: 0.703 ± 0.014	0.464CysGln: 0.464 ± 0.009	0.792CysArg: 0.792 ± 0.012	0.903CysSer: 0.903 ± 0.014	0.673CysThr: 0.673 ± 0.011	0.8CysVal: 0.8 ± 0.012	0.208CysTrp: 0.208 ± 0.006	0.341CysTyr: 0.341 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.149AspAla: 5.149 ± 0.033	0.657AspCys: 0.657 ± 0.012	4.585AspAsp: 4.585 ± 0.043	4.427AspGlu: 4.427 ± 0.035	2.257AspPhe: 2.257 ± 0.02	4.418AspGly: 4.418 ± 0.03	1.227AspHis: 1.227 ± 0.017	2.923AspIle: 2.923 ± 0.026	2.488AspLys: 2.488 ± 0.025	4.964AspLeu: 4.964 ± 0.028	1.337AspMet: 1.337 ± 0.016	1.926AspAsn: 1.926 ± 0.021	3.358AspPro: 3.358 ± 0.024	1.831AspGln: 1.831 ± 0.018	3.109AspArg: 3.109 ± 0.028	3.956AspSer: 3.956 ± 0.029	2.866AspThr: 2.866 ± 0.024	3.83AspVal: 3.83 ± 0.026	0.909AspTrp: 0.909 ± 0.014	1.551AspTyr: 1.551 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.761GluAla: 5.761 ± 0.047	0.61GluCys: 0.61 ± 0.012	4.126GluAsp: 4.126 ± 0.035	5.146GluGlu: 5.146 ± 0.051	1.863GluPhe: 1.863 ± 0.019	3.756GluGly: 3.756 ± 0.027	1.388GluHis: 1.388 ± 0.017	2.725GluIle: 2.725 ± 0.023	3.538GluLys: 3.538 ± 0.034	4.932GluLeu: 4.932 ± 0.034	1.435GluMet: 1.435 ± 0.017	2.153GluAsn: 2.153 ± 0.02	2.923GluPro: 2.923 ± 0.041	2.302GluGln: 2.302 ± 0.022	3.845GluArg: 3.845 ± 0.029	3.994GluSer: 3.994 ± 0.033	3.475GluThr: 3.475 ± 0.027	3.586GluVal: 3.586 ± 0.026	0.881GluTrp: 0.881 ± 0.013	1.558GluTyr: 1.558 ± 0.017	0.001GluXaa: 0.001 ± 0.0
Phe	3.146PheAla: 3.146 ± 0.028	0.561PheCys: 0.561 ± 0.009	2.303PheAsp: 2.303 ± 0.02	2.084PheGlu: 2.084 ± 0.019	1.626PhePhe: 1.626 ± 0.017	2.894PheGly: 2.894 ± 0.03	0.881PheHis: 0.881 ± 0.012	1.671PheIle: 1.671 ± 0.018	1.499PheLys: 1.499 ± 0.016	3.329PheLeu: 3.329 ± 0.025	0.78PheMet: 0.78 ± 0.012	1.44PheAsn: 1.44 ± 0.017	1.959PhePro: 1.959 ± 0.018	1.349PheGln: 1.349 ± 0.015	1.997PheArg: 1.997 ± 0.019	2.868PheSer: 2.868 ± 0.023	2.12PheThr: 2.12 ± 0.018	2.436PheVal: 2.436 ± 0.024	0.643PheTrp: 0.643 ± 0.011	1.077PheTyr: 1.077 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.9GlyAla: 5.9 ± 0.043	0.92GlyCys: 0.92 ± 0.013	3.832GlyAsp: 3.832 ± 0.028	3.626GlyGlu: 3.626 ± 0.028	2.834GlyPhe: 2.834 ± 0.023	6.438GlyGly: 6.438 ± 0.06	1.772GlyHis: 1.772 ± 0.021	3.446GlyIle: 3.446 ± 0.026	3.413GlyLys: 3.413 ± 0.028	6.167GlyLeu: 6.167 ± 0.043	1.628GlyMet: 1.628 ± 0.017	2.673GlyAsn: 2.673 ± 0.025	3.641GlyPro: 3.641 ± 0.027	2.6GlyGln: 2.6 ± 0.023	4.364GlyArg: 4.364 ± 0.034	5.814GlySer: 5.814 ± 0.037	4.149GlyThr: 4.149 ± 0.034	4.523GlyVal: 4.523 ± 0.036	1.203GlyTrp: 1.203 ± 0.017	2.089GlyTyr: 2.089 ± 0.019	0.001GlyXaa: 0.001 ± 0.0
His	1.906HisAla: 1.906 ± 0.018	0.335HisCys: 0.335 ± 0.008	1.325HisAsp: 1.325 ± 0.016	1.308HisGlu: 1.308 ± 0.014	0.903HisPhe: 0.903 ± 0.01	1.755HisGly: 1.755 ± 0.016	0.903HisHis: 0.903 ± 0.018	1.137HisIle: 1.137 ± 0.015	0.902HisLys: 0.902 ± 0.013	2.149HisLeu: 2.149 ± 0.021	0.512HisMet: 0.512 ± 0.008	0.831HisAsn: 0.831 ± 0.01	1.672HisPro: 1.672 ± 0.018	1.023HisGln: 1.023 ± 0.016	1.565HisArg: 1.565 ± 0.018	1.728HisSer: 1.728 ± 0.016	1.219HisThr: 1.219 ± 0.015	1.501HisVal: 1.501 ± 0.018	0.345HisTrp: 0.345 ± 0.009	0.675HisTyr: 0.675 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.111IleAla: 4.111 ± 0.029	0.677IleCys: 0.677 ± 0.01	2.722IleAsp: 2.722 ± 0.023	2.693IleGlu: 2.693 ± 0.022	1.828IlePhe: 1.828 ± 0.02	3.058IleGly: 3.058 ± 0.025	1.12IleHis: 1.12 ± 0.014	2.325IleIle: 2.325 ± 0.026	2.119IleLys: 2.119 ± 0.02	4.172IleLeu: 4.172 ± 0.028	0.99IleMet: 0.99 ± 0.014	1.709IleAsn: 1.709 ± 0.018	2.884IlePro: 2.884 ± 0.026	1.771IleGln: 1.771 ± 0.019	2.709IleArg: 2.709 ± 0.021	3.497IleSer: 3.497 ± 0.029	2.709IleThr: 2.709 ± 0.024	3.129IleVal: 3.129 ± 0.025	0.694IleTrp: 0.694 ± 0.012	1.264IleTyr: 1.264 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	4.443LysAla: 4.443 ± 0.037	0.481LysCys: 0.481 ± 0.011	2.779LysAsp: 2.779 ± 0.027	3.25LysGlu: 3.25 ± 0.032	1.407LysPhe: 1.407 ± 0.015	2.983LysGly: 2.983 ± 0.024	1.093LysHis: 1.093 ± 0.015	2.062LysIle: 2.062 ± 0.022	3.313LysLys: 3.313 ± 0.048	3.911LysLeu: 3.911 ± 0.029	1.033LysMet: 1.033 ± 0.016	1.702LysAsn: 1.702 ± 0.018	2.761LysPro: 2.761 ± 0.028	1.768LysGln: 1.768 ± 0.019	3.27LysArg: 3.27 ± 0.029	3.335LysSer: 3.335 ± 0.029	2.901LysThr: 2.901 ± 0.025	2.77LysVal: 2.77 ± 0.023	0.677LysTrp: 0.677 ± 0.01	1.295LysTyr: 1.295 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.176LeuAla: 8.176 ± 0.046	1.193LeuCys: 1.193 ± 0.013	5.061LeuAsp: 5.061 ± 0.031	5.3LeuGlu: 5.3 ± 0.033	3.204LeuPhe: 3.204 ± 0.027	6.051LeuGly: 6.051 ± 0.039	2.133LeuHis: 2.133 ± 0.021	3.594LeuIle: 3.594 ± 0.028	3.924LeuLys: 3.924 ± 0.028	8.046LeuLeu: 8.046 ± 0.046	1.775LeuMet: 1.775 ± 0.016	2.957LeuAsn: 2.957 ± 0.023	5.565LeuPro: 5.565 ± 0.042	3.616LeuGln: 3.616 ± 0.026	5.747LeuArg: 5.747 ± 0.034	6.909LeuSer: 6.909 ± 0.04	4.76LeuThr: 4.76 ± 0.025	5.571LeuVal: 5.571 ± 0.032	1.229LeuTrp: 1.229 ± 0.015	2.208LeuTyr: 2.208 ± 0.019	0.001LeuXaa: 0.001 ± 0.0
Met	2.397MetAla: 2.397 ± 0.018	0.236MetCys: 0.236 ± 0.007	1.265MetAsp: 1.265 ± 0.013	1.259MetGlu: 1.259 ± 0.016	0.745MetPhe: 0.745 ± 0.011	1.494MetGly: 1.494 ± 0.017	0.463MetHis: 0.463 ± 0.008	0.935MetIle: 0.935 ± 0.013	1.008MetLys: 1.008 ± 0.015	1.835MetLeu: 1.835 ± 0.02	0.592MetMet: 0.592 ± 0.009	0.779MetAsn: 0.779 ± 0.012	1.37MetPro: 1.37 ± 0.018	0.824MetGln: 0.824 ± 0.013	1.313MetArg: 1.313 ± 0.014	1.858MetSer: 1.858 ± 0.018	1.352MetThr: 1.352 ± 0.014	1.33MetVal: 1.33 ± 0.014	0.279MetTrp: 0.279 ± 0.007	0.526MetTyr: 0.526 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.174AsnAla: 3.174 ± 0.022	0.441AsnCys: 0.441 ± 0.01	1.97AsnAsp: 1.97 ± 0.021	1.93AsnGlu: 1.93 ± 0.018	1.342AsnPhe: 1.342 ± 0.014	3.09AsnGly: 3.09 ± 0.032	0.853AsnHis: 0.853 ± 0.015	1.904AsnIle: 1.904 ± 0.02	1.576AsnLys: 1.576 ± 0.02	3.132AsnLeu: 3.132 ± 0.021	0.848AsnMet: 0.848 ± 0.012	1.58AsnAsn: 1.58 ± 0.025	2.439AsnPro: 2.439 ± 0.022	1.32AsnGln: 1.32 ± 0.015	1.91AsnArg: 1.91 ± 0.019	2.584AsnSer: 2.584 ± 0.021	2.156AsnThr: 2.156 ± 0.021	2.302AsnVal: 2.302 ± 0.02	0.552AsnTrp: 0.552 ± 0.01	1.022AsnTyr: 1.022 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.89ProAla: 5.89 ± 0.048	0.557ProCys: 0.557 ± 0.012	3.352ProAsp: 3.352 ± 0.023	3.841ProGlu: 3.841 ± 0.035	2.088ProPhe: 2.088 ± 0.018	4.258ProGly: 4.258 ± 0.033	1.331ProHis: 1.331 ± 0.017	2.454ProIle: 2.454 ± 0.022	2.707ProLys: 2.707 ± 0.027	4.805ProLeu: 4.805 ± 0.027	1.109ProMet: 1.109 ± 0.014	2.214ProAsn: 2.214 ± 0.021	5.606ProPro: 5.606 ± 0.077	2.505ProGln: 2.505 ± 0.028	3.667ProArg: 3.667 ± 0.031	5.986ProSer: 5.986 ± 0.05	4.106ProThr: 4.106 ± 0.034	3.833ProVal: 3.833 ± 0.029	0.781ProTrp: 0.781 ± 0.012	1.487ProTyr: 1.487 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	3.548GlnAla: 3.548 ± 0.03	0.448GlnCys: 0.448 ± 0.009	2.043GlnAsp: 2.043 ± 0.019	2.301GlnGlu: 2.301 ± 0.021	1.221GlnPhe: 1.221 ± 0.015	2.467GlnGly: 2.467 ± 0.024	1.093GlnHis: 1.093 ± 0.017	1.711GlnIle: 1.711 ± 0.016	1.895GlnLys: 1.895 ± 0.019	3.344GlnLeu: 3.344 ± 0.03	0.893GlnMet: 0.893 ± 0.015	1.426GlnAsn: 1.426 ± 0.017	2.634GlnPro: 2.634 ± 0.033	2.771GlnGln: 2.771 ± 0.065	2.633GlnArg: 2.633 ± 0.02	2.943GlnSer: 2.943 ± 0.027	2.309GlnThr: 2.309 ± 0.03	2.149GlnVal: 2.149 ± 0.019	0.571GlnTrp: 0.571 ± 0.01	1.12GlnTyr: 1.12 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	4.944ArgAla: 4.944 ± 0.033	0.74ArgCys: 0.74 ± 0.011	3.56ArgAsp: 3.56 ± 0.032	3.778ArgGlu: 3.778 ± 0.029	2.159ArgPhe: 2.159 ± 0.019	3.918ArgGly: 3.918 ± 0.032	1.658ArgHis: 1.658 ± 0.017	2.766ArgIle: 2.766 ± 0.021	3.304ArgLys: 3.304 ± 0.027	5.582ArgLeu: 5.582 ± 0.035	1.332ArgMet: 1.332 ± 0.015	2.245ArgAsn: 2.245 ± 0.021	3.837ArgPro: 3.837 ± 0.031	2.719ArgGln: 2.719 ± 0.023	5.362ArgArg: 5.362 ± 0.044	4.654ArgSer: 4.654 ± 0.038	3.314ArgThr: 3.314 ± 0.026	3.493ArgVal: 3.493 ± 0.024	0.954ArgTrp: 0.954 ± 0.013	1.633ArgTyr: 1.633 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.789SerAla: 6.789 ± 0.039	0.889SerCys: 0.889 ± 0.013	4.168SerAsp: 4.168 ± 0.032	3.877SerGlu: 3.877 ± 0.032	2.989SerPhe: 2.989 ± 0.023	5.611SerGly: 5.611 ± 0.035	1.873SerHis: 1.873 ± 0.019	3.694SerIle: 3.694 ± 0.028	3.501SerLys: 3.501 ± 0.028	6.908SerLeu: 6.908 ± 0.039	1.697SerMet: 1.697 ± 0.016	2.825SerAsn: 2.825 ± 0.021	5.505SerPro: 5.505 ± 0.044	3.142SerGln: 3.142 ± 0.03	4.987SerArg: 4.987 ± 0.036	8.297SerSer: 8.297 ± 0.082	5.297SerThr: 5.297 ± 0.047	4.658SerVal: 4.658 ± 0.034	1.114SerTrp: 1.114 ± 0.014	1.96SerTyr: 1.96 ± 0.023	0.001SerXaa: 0.001 ± 0.0
Thr	5.588ThrAla: 5.588 ± 0.037	0.758ThrCys: 0.758 ± 0.013	2.883ThrAsp: 2.883 ± 0.022	3.083ThrGlu: 3.083 ± 0.027	2.194ThrPhe: 2.194 ± 0.02	4.268ThrGly: 4.268 ± 0.031	1.229ThrHis: 1.229 ± 0.015	2.991ThrIle: 2.991 ± 0.031	2.596ThrLys: 2.596 ± 0.021	5.061ThrLeu: 5.061 ± 0.039	1.216ThrMet: 1.216 ± 0.014	2.106ThrAsn: 2.106 ± 0.02	4.461ThrPro: 4.461 ± 0.037	2.084ThrGln: 2.084 ± 0.022	3.189ThrArg: 3.189 ± 0.021	5.147ThrSer: 5.147 ± 0.051	4.398ThrThr: 4.398 ± 0.058	3.889ThrVal: 3.889 ± 0.052	0.892ThrTrp: 0.892 ± 0.013	1.582ThrTyr: 1.582 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.791ValAla: 5.791 ± 0.033	0.857ValCys: 0.857 ± 0.014	3.836ValAsp: 3.836 ± 0.03	3.811ValGlu: 3.811 ± 0.026	2.528ValPhe: 2.528 ± 0.026	4.177ValGly: 4.177 ± 0.035	1.388ValHis: 1.388 ± 0.018	2.919ValIle: 2.919 ± 0.027	2.884ValLys: 2.884 ± 0.029	5.707ValLeu: 5.707 ± 0.039	1.338ValMet: 1.338 ± 0.014	2.235ValAsn: 2.235 ± 0.019	3.827ValPro: 3.827 ± 0.029	2.353ValGln: 2.353 ± 0.026	3.637ValArg: 3.637 ± 0.025	4.726ValSer: 4.726 ± 0.027	3.722ValThr: 3.722 ± 0.039	4.581ValVal: 4.581 ± 0.037	0.921ValTrp: 0.921 ± 0.013	1.706ValTyr: 1.706 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	1.218TrpAla: 1.218 ± 0.014	0.202TrpCys: 0.202 ± 0.006	0.918TrpAsp: 0.918 ± 0.013	0.854TrpGlu: 0.854 ± 0.013	0.561TrpPhe: 0.561 ± 0.011	0.966TrpGly: 0.966 ± 0.015	0.378TrpHis: 0.378 ± 0.007	0.75TrpIle: 0.75 ± 0.014	0.785TrpLys: 0.785 ± 0.012	1.37TrpLeu: 1.37 ± 0.015	0.382TrpMet: 0.382 ± 0.008	0.659TrpAsn: 0.659 ± 0.011	0.673TrpPro: 0.673 ± 0.011	0.571TrpGln: 0.571 ± 0.009	0.973TrpArg: 0.973 ± 0.012	1.028TrpSer: 1.028 ± 0.014	0.942TrpThr: 0.942 ± 0.012	0.92TrpVal: 0.92 ± 0.011	0.296TrpTrp: 0.296 ± 0.007	0.431TrpTyr: 0.431 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.137TyrAla: 2.137 ± 0.021	0.405TyrCys: 0.405 ± 0.008	1.659TyrAsp: 1.659 ± 0.017	1.469TyrGlu: 1.469 ± 0.017	1.148TyrPhe: 1.148 ± 0.016	2.067TyrGly: 2.067 ± 0.021	0.732TyrHis: 0.732 ± 0.013	1.283TyrIle: 1.283 ± 0.014	1.058TyrLys: 1.058 ± 0.014	2.501TyrLeu: 2.501 ± 0.02	0.594TyrMet: 0.594 ± 0.01	1.09TyrAsn: 1.09 ± 0.015	1.437TyrPro: 1.437 ± 0.018	1.038TyrGln: 1.038 ± 0.012	1.611TyrArg: 1.611 ± 0.019	1.921TyrSer: 1.921 ± 0.02	1.534TyrThr: 1.534 ± 0.023	1.629TyrVal: 1.629 ± 0.017	0.448TyrTrp: 0.448 ± 0.009	0.876TyrTyr: 0.876 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.23XaaXaa: 0.23 ± 0.044

Statistics based on 12697 proteins (6235361 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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