Amino acid dipepetide frequency for Gordonia phage Savage

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.303AlaAla: 18.303 ± 2.087
0.807AlaCys: 0.807 ± 0.241
8.277AlaAsp: 8.277 ± 0.877
9.084AlaGlu: 9.084 ± 0.977
2.624AlaPhe: 2.624 ± 0.494
9.353AlaGly: 9.353 ± 0.851
2.288AlaHis: 2.288 ± 0.43
7.133AlaIle: 7.133 ± 0.613
3.903AlaLys: 3.903 ± 0.513
8.882AlaLeu: 8.882 ± 0.94
3.634AlaMet: 3.634 ± 0.465
4.172AlaAsn: 4.172 ± 0.684
5.518AlaPro: 5.518 ± 0.609
4.643AlaGln: 4.643 ± 0.567
7.873AlaArg: 7.873 ± 0.711
7.065AlaSer: 7.065 ± 0.754
8.008AlaThr: 8.008 ± 0.946
7.806AlaVal: 7.806 ± 0.849
1.682AlaTrp: 1.682 ± 0.26
2.422AlaTyr: 2.422 ± 0.326
0.0AlaXaa: 0.0 ± 0.0
Cys
1.077CysAla: 1.077 ± 0.261
0.135CysCys: 0.135 ± 0.098
0.538CysAsp: 0.538 ± 0.261
0.538CysGlu: 0.538 ± 0.189
0.135CysPhe: 0.135 ± 0.092
0.875CysGly: 0.875 ± 0.309
0.135CysHis: 0.135 ± 0.107
0.067CysIle: 0.067 ± 0.064
0.202CysLys: 0.202 ± 0.101
0.404CysLeu: 0.404 ± 0.152
0.067CysMet: 0.067 ± 0.063
0.135CysAsn: 0.135 ± 0.097
0.471CysPro: 0.471 ± 0.169
0.269CysGln: 0.269 ± 0.168
0.875CysArg: 0.875 ± 0.263
0.606CysSer: 0.606 ± 0.245
0.538CysThr: 0.538 ± 0.201
0.404CysVal: 0.404 ± 0.158
0.269CysTrp: 0.269 ± 0.161
0.202CysTyr: 0.202 ± 0.111
0.0CysXaa: 0.0 ± 0.0
Asp
7.738AspAla: 7.738 ± 0.958
0.74AspCys: 0.74 ± 0.241
4.979AspAsp: 4.979 ± 0.775
4.508AspGlu: 4.508 ± 0.604
2.086AspPhe: 2.086 ± 0.339
6.46AspGly: 6.46 ± 0.659
1.548AspHis: 1.548 ± 0.354
2.692AspIle: 2.692 ± 0.467
1.413AspLys: 1.413 ± 0.261
7.133AspLeu: 7.133 ± 0.742
1.346AspMet: 1.346 ± 0.316
2.019AspAsn: 2.019 ± 0.396
5.047AspPro: 5.047 ± 0.505
1.884AspGln: 1.884 ± 0.38
4.979AspArg: 4.979 ± 0.556
2.759AspSer: 2.759 ± 0.357
3.97AspThr: 3.97 ± 0.483
4.508AspVal: 4.508 ± 0.476
1.548AspTrp: 1.548 ± 0.322
1.48AspTyr: 1.48 ± 0.329
0.0AspXaa: 0.0 ± 0.0
Glu
7.335GluAla: 7.335 ± 0.787
0.807GluCys: 0.807 ± 0.251
2.557GluAsp: 2.557 ± 0.426
2.826GluGlu: 2.826 ± 0.566
1.951GluPhe: 1.951 ± 0.426
4.105GluGly: 4.105 ± 0.53
1.144GluHis: 1.144 ± 0.283
3.297GluIle: 3.297 ± 0.444
1.817GluLys: 1.817 ± 0.339
5.518GluLeu: 5.518 ± 0.679
1.48GluMet: 1.48 ± 0.308
1.413GluAsn: 1.413 ± 0.282
3.365GluPro: 3.365 ± 0.477
3.23GluGln: 3.23 ± 0.544
5.249GluArg: 5.249 ± 0.731
3.499GluSer: 3.499 ± 0.614
3.365GluThr: 3.365 ± 0.456
2.826GluVal: 2.826 ± 0.472
0.807GluTrp: 0.807 ± 0.241
1.817GluTyr: 1.817 ± 0.42
0.0GluXaa: 0.0 ± 0.0
Phe
3.566PheAla: 3.566 ± 0.437
0.135PheCys: 0.135 ± 0.116
2.759PheAsp: 2.759 ± 0.483
1.346PheGlu: 1.346 ± 0.339
0.807PhePhe: 0.807 ± 0.211
3.095PheGly: 3.095 ± 0.497
0.269PheHis: 0.269 ± 0.145
0.807PheIle: 0.807 ± 0.261
0.673PheLys: 0.673 ± 0.199
1.48PheLeu: 1.48 ± 0.268
0.404PheMet: 0.404 ± 0.147
0.538PheAsn: 0.538 ± 0.198
0.942PhePro: 0.942 ± 0.236
0.538PheGln: 0.538 ± 0.172
1.75PheArg: 1.75 ± 0.325
1.346PheSer: 1.346 ± 0.286
2.288PheThr: 2.288 ± 0.402
1.884PheVal: 1.884 ± 0.468
1.48PheTrp: 1.48 ± 0.347
0.269PheTyr: 0.269 ± 0.125
0.0PheXaa: 0.0 ± 0.0
Gly
8.142GlyAla: 8.142 ± 0.955
0.336GlyCys: 0.336 ± 0.178
6.46GlyAsp: 6.46 ± 0.632
4.845GlyGlu: 4.845 ± 0.584
2.153GlyPhe: 2.153 ± 0.464
7.873GlyGly: 7.873 ± 1.245
1.548GlyHis: 1.548 ± 0.293
4.508GlyIle: 4.508 ± 0.556
3.566GlyLys: 3.566 ± 0.509
6.46GlyLeu: 6.46 ± 0.71
1.817GlyMet: 1.817 ± 0.375
2.893GlyAsn: 2.893 ± 0.586
4.105GlyPro: 4.105 ± 0.509
3.028GlyGln: 3.028 ± 0.469
6.796GlyArg: 6.796 ± 0.634
5.181GlySer: 5.181 ± 0.785
5.652GlyThr: 5.652 ± 0.757
6.46GlyVal: 6.46 ± 0.641
1.211GlyTrp: 1.211 ± 0.327
2.557GlyTyr: 2.557 ± 0.393
0.0GlyXaa: 0.0 ± 0.0
His
1.615HisAla: 1.615 ± 0.373
0.336HisCys: 0.336 ± 0.164
1.346HisAsp: 1.346 ± 0.293
1.077HisGlu: 1.077 ± 0.381
0.404HisPhe: 0.404 ± 0.152
1.817HisGly: 1.817 ± 0.421
0.673HisHis: 0.673 ± 0.237
0.673HisIle: 0.673 ± 0.225
0.606HisLys: 0.606 ± 0.199
1.884HisLeu: 1.884 ± 0.399
0.202HisMet: 0.202 ± 0.099
0.471HisAsn: 0.471 ± 0.18
1.548HisPro: 1.548 ± 0.324
0.942HisGln: 0.942 ± 0.258
1.009HisArg: 1.009 ± 0.291
0.606HisSer: 0.606 ± 0.22
1.144HisThr: 1.144 ± 0.234
0.942HisVal: 0.942 ± 0.259
0.673HisTrp: 0.673 ± 0.237
0.606HisTyr: 0.606 ± 0.218
0.0HisXaa: 0.0 ± 0.0
Ile
5.989IleAla: 5.989 ± 0.706
0.269IleCys: 0.269 ± 0.145
4.71IleAsp: 4.71 ± 0.491
3.028IleGlu: 3.028 ± 0.461
1.48IlePhe: 1.48 ± 0.351
4.71IleGly: 4.71 ± 0.484
0.942IleHis: 0.942 ± 0.245
1.615IleIle: 1.615 ± 0.307
1.144IleLys: 1.144 ± 0.329
3.095IleLeu: 3.095 ± 0.537
0.538IleMet: 0.538 ± 0.191
1.279IleAsn: 1.279 ± 0.329
2.355IlePro: 2.355 ± 0.343
2.49IleGln: 2.49 ± 0.474
3.566IleArg: 3.566 ± 0.459
2.893IleSer: 2.893 ± 0.415
3.297IleThr: 3.297 ± 0.501
4.239IleVal: 4.239 ± 0.513
0.336IleTrp: 0.336 ± 0.147
1.48IleTyr: 1.48 ± 0.38
0.0IleXaa: 0.0 ± 0.0
Lys
3.836LysAla: 3.836 ± 0.536
0.067LysCys: 0.067 ± 0.06
2.086LysAsp: 2.086 ± 0.358
1.279LysGlu: 1.279 ± 0.352
0.74LysPhe: 0.74 ± 0.28
2.153LysGly: 2.153 ± 0.384
0.538LysHis: 0.538 ± 0.211
1.211LysIle: 1.211 ± 0.25
0.74LysLys: 0.74 ± 0.295
2.961LysLeu: 2.961 ± 0.502
0.807LysMet: 0.807 ± 0.235
0.807LysAsn: 0.807 ± 0.195
1.951LysPro: 1.951 ± 0.401
1.144LysGln: 1.144 ± 0.265
2.086LysArg: 2.086 ± 0.34
1.817LysSer: 1.817 ± 0.444
1.951LysThr: 1.951 ± 0.375
2.557LysVal: 2.557 ± 0.381
0.538LysTrp: 0.538 ± 0.212
0.74LysTyr: 0.74 ± 0.254
0.0LysXaa: 0.0 ± 0.0
Leu
10.565LeuAla: 10.565 ± 1.005
0.673LeuCys: 0.673 ± 0.254
5.181LeuAsp: 5.181 ± 0.57
3.768LeuGlu: 3.768 ± 0.41
1.817LeuPhe: 1.817 ± 0.486
7.671LeuGly: 7.671 ± 0.776
1.211LeuHis: 1.211 ± 0.308
3.634LeuIle: 3.634 ± 0.547
1.951LeuLys: 1.951 ± 0.373
5.249LeuLeu: 5.249 ± 0.659
1.615LeuMet: 1.615 ± 0.33
2.019LeuAsn: 2.019 ± 0.365
4.979LeuPro: 4.979 ± 0.519
2.221LeuGln: 2.221 ± 0.422
5.518LeuArg: 5.518 ± 0.808
4.508LeuSer: 4.508 ± 0.496
5.585LeuThr: 5.585 ± 0.794
6.258LeuVal: 6.258 ± 0.615
1.211LeuTrp: 1.211 ± 0.297
1.413LeuTyr: 1.413 ± 0.265
0.0LeuXaa: 0.0 ± 0.0
Met
2.961MetAla: 2.961 ± 0.578
0.404MetCys: 0.404 ± 0.163
0.942MetAsp: 0.942 ± 0.252
0.807MetGlu: 0.807 ± 0.211
0.471MetPhe: 0.471 ± 0.17
1.615MetGly: 1.615 ± 0.339
0.336MetHis: 0.336 ± 0.158
1.346MetIle: 1.346 ± 0.324
0.538MetLys: 0.538 ± 0.209
1.75MetLeu: 1.75 ± 0.346
0.606MetMet: 0.606 ± 0.207
0.74MetAsn: 0.74 ± 0.26
1.211MetPro: 1.211 ± 0.238
0.606MetGln: 0.606 ± 0.243
1.346MetArg: 1.346 ± 0.307
1.817MetSer: 1.817 ± 0.351
2.355MetThr: 2.355 ± 0.377
0.942MetVal: 0.942 ± 0.246
0.269MetTrp: 0.269 ± 0.134
0.269MetTyr: 0.269 ± 0.125
0.0MetXaa: 0.0 ± 0.0
Asn
3.701AsnAla: 3.701 ± 0.625
0.067AsnCys: 0.067 ± 0.07
1.48AsnAsp: 1.48 ± 0.316
1.413AsnGlu: 1.413 ± 0.333
0.875AsnPhe: 0.875 ± 0.381
2.759AsnGly: 2.759 ± 0.464
0.673AsnHis: 0.673 ± 0.374
1.346AsnIle: 1.346 ± 0.275
0.942AsnLys: 0.942 ± 0.251
1.884AsnLeu: 1.884 ± 0.367
0.404AsnMet: 0.404 ± 0.174
0.606AsnAsn: 0.606 ± 0.191
2.221AsnPro: 2.221 ± 0.482
1.279AsnGln: 1.279 ± 0.347
2.557AsnArg: 2.557 ± 0.517
1.615AsnSer: 1.615 ± 0.3
1.951AsnThr: 1.951 ± 0.476
1.48AsnVal: 1.48 ± 0.333
0.404AsnTrp: 0.404 ± 0.178
0.875AsnTyr: 0.875 ± 0.239
0.0AsnXaa: 0.0 ± 0.0
Pro
7.335ProAla: 7.335 ± 0.813
0.471ProCys: 0.471 ± 0.21
4.912ProAsp: 4.912 ± 0.698
4.576ProGlu: 4.576 ± 0.704
0.875ProPhe: 0.875 ± 0.223
5.181ProGly: 5.181 ± 0.696
1.144ProHis: 1.144 ± 0.309
2.49ProIle: 2.49 ± 0.418
1.817ProLys: 1.817 ± 0.399
3.297ProLeu: 3.297 ± 0.429
1.077ProMet: 1.077 ± 0.275
1.951ProAsn: 1.951 ± 0.385
3.365ProPro: 3.365 ± 0.393
1.615ProGln: 1.615 ± 0.257
4.105ProArg: 4.105 ± 0.68
2.692ProSer: 2.692 ± 0.377
3.499ProThr: 3.499 ± 0.564
3.566ProVal: 3.566 ± 0.488
1.48ProTrp: 1.48 ± 0.29
1.009ProTyr: 1.009 ± 0.249
0.0ProXaa: 0.0 ± 0.0
Gln
3.97GlnAla: 3.97 ± 0.643
0.269GlnCys: 0.269 ± 0.125
1.615GlnAsp: 1.615 ± 0.294
1.413GlnGlu: 1.413 ± 0.353
1.144GlnPhe: 1.144 ± 0.259
2.019GlnGly: 2.019 ± 0.398
0.807GlnHis: 0.807 ± 0.232
2.759GlnIle: 2.759 ± 0.398
1.211GlnLys: 1.211 ± 0.286
2.759GlnLeu: 2.759 ± 0.362
1.615GlnMet: 1.615 ± 0.285
1.077GlnAsn: 1.077 ± 0.254
2.086GlnPro: 2.086 ± 0.343
2.086GlnGln: 2.086 ± 0.475
3.566GlnArg: 3.566 ± 0.776
1.884GlnSer: 1.884 ± 0.364
2.49GlnThr: 2.49 ± 0.346
2.961GlnVal: 2.961 ± 0.4
0.807GlnTrp: 0.807 ± 0.231
0.606GlnTyr: 0.606 ± 0.231
0.0GlnXaa: 0.0 ± 0.0
Arg
7.738ArgAla: 7.738 ± 0.622
0.606ArgCys: 0.606 ± 0.256
3.903ArgAsp: 3.903 ± 0.496
4.912ArgGlu: 4.912 ± 0.709
2.624ArgPhe: 2.624 ± 0.419
4.845ArgGly: 4.845 ± 0.59
1.144ArgHis: 1.144 ± 0.341
4.374ArgIle: 4.374 ± 0.56
3.23ArgLys: 3.23 ± 0.491
5.922ArgLeu: 5.922 ± 0.609
1.817ArgMet: 1.817 ± 0.316
2.49ArgAsn: 2.49 ± 0.323
4.172ArgPro: 4.172 ± 0.644
2.557ArgGln: 2.557 ± 0.479
6.46ArgArg: 6.46 ± 0.954
4.037ArgSer: 4.037 ± 0.615
4.979ArgThr: 4.979 ± 0.659
5.854ArgVal: 5.854 ± 0.613
1.615ArgTrp: 1.615 ± 0.4
1.817ArgTyr: 1.817 ± 0.366
0.0ArgXaa: 0.0 ± 0.0
Ser
7.267SerAla: 7.267 ± 0.843
0.471SerCys: 0.471 ± 0.166
3.163SerAsp: 3.163 ± 0.39
2.826SerGlu: 2.826 ± 0.372
1.75SerPhe: 1.75 ± 0.365
6.191SerGly: 6.191 ± 0.899
0.606SerHis: 0.606 ± 0.221
3.095SerIle: 3.095 ± 0.49
1.615SerLys: 1.615 ± 0.337
4.576SerLeu: 4.576 ± 0.615
0.673SerMet: 0.673 ± 0.247
1.279SerAsn: 1.279 ± 0.284
3.365SerPro: 3.365 ± 0.472
2.019SerGln: 2.019 ± 0.402
3.701SerArg: 3.701 ± 0.622
2.826SerSer: 2.826 ± 0.492
3.634SerThr: 3.634 ± 0.47
3.365SerVal: 3.365 ± 0.388
1.817SerTrp: 1.817 ± 0.359
1.144SerTyr: 1.144 ± 0.257
0.0SerXaa: 0.0 ± 0.0
Thr
9.488ThrAla: 9.488 ± 1.35
0.471ThrCys: 0.471 ± 0.201
4.643ThrAsp: 4.643 ± 0.639
3.634ThrGlu: 3.634 ± 0.476
1.144ThrPhe: 1.144 ± 0.317
6.258ThrGly: 6.258 ± 0.809
1.077ThrHis: 1.077 ± 0.281
4.576ThrIle: 4.576 ± 0.578
1.413ThrLys: 1.413 ± 0.282
5.518ThrLeu: 5.518 ± 0.489
1.009ThrMet: 1.009 ± 0.28
1.817ThrAsn: 1.817 ± 0.407
3.499ThrPro: 3.499 ± 0.47
2.086ThrGln: 2.086 ± 0.33
3.836ThrArg: 3.836 ± 0.497
4.239ThrSer: 4.239 ± 0.579
4.845ThrThr: 4.845 ± 0.72
5.518ThrVal: 5.518 ± 0.623
1.48ThrTrp: 1.48 ± 0.265
0.875ThrTyr: 0.875 ± 0.194
0.0ThrXaa: 0.0 ± 0.0
Val
8.411ValAla: 8.411 ± 0.801
0.606ValCys: 0.606 ± 0.228
6.729ValAsp: 6.729 ± 0.617
4.307ValGlu: 4.307 ± 0.414
2.221ValPhe: 2.221 ± 0.431
5.047ValGly: 5.047 ± 0.654
1.144ValHis: 1.144 ± 0.338
2.961ValIle: 2.961 ± 0.424
1.884ValLys: 1.884 ± 0.34
4.508ValLeu: 4.508 ± 0.484
1.346ValMet: 1.346 ± 0.32
1.951ValAsn: 1.951 ± 0.39
4.037ValPro: 4.037 ± 0.542
2.557ValGln: 2.557 ± 0.443
6.191ValArg: 6.191 ± 0.67
3.903ValSer: 3.903 ± 0.616
5.047ValThr: 5.047 ± 0.686
6.325ValVal: 6.325 ± 0.821
1.077ValTrp: 1.077 ± 0.254
1.211ValTyr: 1.211 ± 0.26
0.0ValXaa: 0.0 ± 0.0
Trp
1.951TrpAla: 1.951 ± 0.344
0.202TrpCys: 0.202 ± 0.128
1.279TrpAsp: 1.279 ± 0.313
1.009TrpGlu: 1.009 ± 0.212
0.74TrpPhe: 0.74 ± 0.307
1.682TrpGly: 1.682 ± 0.384
0.404TrpHis: 0.404 ± 0.195
0.404TrpIle: 0.404 ± 0.187
0.404TrpLys: 0.404 ± 0.153
2.49TrpLeu: 2.49 ± 0.432
0.606TrpMet: 0.606 ± 0.192
0.471TrpAsn: 0.471 ± 0.202
1.211TrpPro: 1.211 ± 0.288
0.807TrpGln: 0.807 ± 0.216
1.884TrpArg: 1.884 ± 0.352
1.144TrpSer: 1.144 ± 0.23
1.211TrpThr: 1.211 ± 0.298
1.077TrpVal: 1.077 ± 0.232
0.74TrpTrp: 0.74 ± 0.283
0.269TrpTyr: 0.269 ± 0.136
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.49TyrAla: 2.49 ± 0.466
0.067TyrCys: 0.067 ± 0.058
1.279TyrAsp: 1.279 ± 0.362
1.211TyrGlu: 1.211 ± 0.362
0.336TyrPhe: 0.336 ± 0.117
1.951TyrGly: 1.951 ± 0.358
0.942TyrHis: 0.942 ± 0.305
0.471TyrIle: 0.471 ± 0.158
0.942TyrLys: 0.942 ± 0.248
1.279TyrLeu: 1.279 ± 0.238
0.202TyrMet: 0.202 ± 0.104
0.404TyrAsn: 0.404 ± 0.138
1.009TyrPro: 1.009 ± 0.301
1.144TyrGln: 1.144 ± 0.298
1.75TyrArg: 1.75 ± 0.477
0.942TyrSer: 0.942 ± 0.196
1.615TyrThr: 1.615 ± 0.277
2.49TyrVal: 2.49 ± 0.433
0.538TyrTrp: 0.538 ± 0.187
0.404TyrTyr: 0.404 ± 0.138
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (14862 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski