Amino acid dipepetide frequency for Actinoplanes teichomyceticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
25.548AlaAla: 25.548 ± 0.19
1.028AlaCys: 1.028 ± 0.023
8.821AlaAsp: 8.821 ± 0.065
8.59AlaGlu: 8.59 ± 0.078
3.337AlaPhe: 3.337 ± 0.039
16.375AlaGly: 16.375 ± 0.122
2.597AlaHis: 2.597 ± 0.038
4.107AlaIle: 4.107 ± 0.046
2.324AlaLys: 2.324 ± 0.044
14.177AlaLeu: 14.177 ± 0.116
2.537AlaMet: 2.537 ± 0.034
2.169AlaAsn: 2.169 ± 0.036
7.792AlaPro: 7.792 ± 0.087
3.791AlaGln: 3.791 ± 0.045
11.002AlaArg: 11.002 ± 0.103
5.652AlaSer: 5.652 ± 0.058
8.325AlaThr: 8.325 ± 0.068
12.879AlaVal: 12.879 ± 0.082
2.003AlaTrp: 2.003 ± 0.034
2.819AlaTyr: 2.819 ± 0.035
0.0AlaXaa: 0.0 ± 0.0
Cys
1.049CysAla: 1.049 ± 0.025
0.096CysCys: 0.096 ± 0.006
0.493CysAsp: 0.493 ± 0.014
0.309CysGlu: 0.309 ± 0.011
0.194CysPhe: 0.194 ± 0.011
0.934CysGly: 0.934 ± 0.023
0.181CysHis: 0.181 ± 0.009
0.156CysIle: 0.156 ± 0.008
0.099CysLys: 0.099 ± 0.006
0.701CysLeu: 0.701 ± 0.019
0.107CysMet: 0.107 ± 0.006
0.148CysAsn: 0.148 ± 0.008
0.513CysPro: 0.513 ± 0.015
0.169CysGln: 0.169 ± 0.008
0.681CysArg: 0.681 ± 0.02
0.407CysSer: 0.407 ± 0.014
0.459CysThr: 0.459 ± 0.015
0.59CysVal: 0.59 ± 0.017
0.126CysTrp: 0.126 ± 0.008
0.162CysTyr: 0.162 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
7.485AspAla: 7.485 ± 0.065
0.393AspCys: 0.393 ± 0.012
3.655AspAsp: 3.655 ± 0.052
3.623AspGlu: 3.623 ± 0.051
1.505AspPhe: 1.505 ± 0.027
6.081AspGly: 6.081 ± 0.062
1.313AspHis: 1.313 ± 0.027
1.72AspIle: 1.72 ± 0.031
0.844AspLys: 0.844 ± 0.021
6.439AspLeu: 6.439 ± 0.057
0.772AspMet: 0.772 ± 0.017
0.973AspAsn: 0.973 ± 0.025
4.836AspPro: 4.836 ± 0.058
1.568AspGln: 1.568 ± 0.025
5.673AspArg: 5.673 ± 0.053
2.275AspSer: 2.275 ± 0.033
2.963AspThr: 2.963 ± 0.04
4.769AspVal: 4.769 ± 0.047
0.974AspTrp: 0.974 ± 0.023
1.143AspTyr: 1.143 ± 0.026
0.0AspXaa: 0.0 ± 0.0
Glu
6.259GluAla: 6.259 ± 0.066
0.305GluCys: 0.305 ± 0.008
2.055GluAsp: 2.055 ± 0.032
2.302GluGlu: 2.302 ± 0.039
1.398GluPhe: 1.398 ± 0.024
2.905GluGly: 2.905 ± 0.041
1.471GluHis: 1.471 ± 0.026
2.241GluIle: 2.241 ± 0.034
1.041GluLys: 1.041 ± 0.024
6.105GluLeu: 6.105 ± 0.063
0.892GluMet: 0.892 ± 0.021
0.86GluAsn: 0.86 ± 0.023
3.534GluPro: 3.534 ± 0.054
2.195GluGln: 2.195 ± 0.031
4.982GluArg: 4.982 ± 0.059
2.211GluSer: 2.211 ± 0.028
2.538GluThr: 2.538 ± 0.039
4.131GluVal: 4.131 ± 0.047
0.658GluTrp: 0.658 ± 0.017
0.977GluTyr: 0.977 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
3.892PheAla: 3.892 ± 0.042
0.247PheCys: 0.247 ± 0.01
1.924PheAsp: 1.924 ± 0.032
1.201PheGlu: 1.201 ± 0.023
0.824PhePhe: 0.824 ± 0.021
2.961PheGly: 2.961 ± 0.036
0.604PheHis: 0.604 ± 0.017
0.634PheIle: 0.634 ± 0.017
0.404PheLys: 0.404 ± 0.014
2.46PheLeu: 2.46 ± 0.034
0.334PheMet: 0.334 ± 0.012
0.53PheAsn: 0.53 ± 0.016
1.392PhePro: 1.392 ± 0.028
0.67PheGln: 0.67 ± 0.017
1.941PheArg: 1.941 ± 0.031
1.256PheSer: 1.256 ± 0.025
1.961PheThr: 1.961 ± 0.027
2.246PheVal: 2.246 ± 0.032
0.413PheTrp: 0.413 ± 0.013
0.594PheTyr: 0.594 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
12.038GlyAla: 12.038 ± 0.087
0.85GlyCys: 0.85 ± 0.021
5.51GlyAsp: 5.51 ± 0.055
4.504GlyGlu: 4.504 ± 0.053
2.855GlyPhe: 2.855 ± 0.04
8.781GlyGly: 8.781 ± 0.074
2.315GlyHis: 2.315 ± 0.033
3.202GlyIle: 3.202 ± 0.04
1.906GlyLys: 1.906 ± 0.034
9.253GlyLeu: 9.253 ± 0.076
1.904GlyMet: 1.904 ± 0.03
1.785GlyAsn: 1.785 ± 0.033
5.531GlyPro: 5.531 ± 0.065
2.56GlyGln: 2.56 ± 0.036
8.461GlyArg: 8.461 ± 0.077
5.1GlySer: 5.1 ± 0.057
5.908GlyThr: 5.908 ± 0.064
7.873GlyVal: 7.873 ± 0.07
1.934GlyTrp: 1.934 ± 0.036
2.48GlyTyr: 2.48 ± 0.034
0.0GlyXaa: 0.0 ± 0.0
His
2.67HisAla: 2.67 ± 0.038
0.192HisCys: 0.192 ± 0.008
1.38HisAsp: 1.38 ± 0.026
1.08HisGlu: 1.08 ± 0.022
0.568HisPhe: 0.568 ± 0.019
2.28HisGly: 2.28 ± 0.037
0.655HisHis: 0.655 ± 0.019
0.564HisIle: 0.564 ± 0.015
0.239HisLys: 0.239 ± 0.012
2.452HisLeu: 2.452 ± 0.037
0.298HisMet: 0.298 ± 0.012
0.378HisAsn: 0.378 ± 0.014
1.819HisPro: 1.819 ± 0.032
0.618HisGln: 0.618 ± 0.015
2.299HisArg: 2.299 ± 0.035
0.836HisSer: 0.836 ± 0.02
1.182HisThr: 1.182 ± 0.025
1.681HisVal: 1.681 ± 0.029
0.325HisTrp: 0.325 ± 0.011
0.412HisTyr: 0.412 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
5.121IleAla: 5.121 ± 0.048
0.321IleCys: 0.321 ± 0.012
2.446IleAsp: 2.446 ± 0.031
1.988IleGlu: 1.988 ± 0.034
0.82IlePhe: 0.82 ± 0.02
3.674IleGly: 3.674 ± 0.039
0.565IleHis: 0.565 ± 0.015
0.956IleIle: 0.956 ± 0.023
0.642IleLys: 0.642 ± 0.019
2.527IleLeu: 2.527 ± 0.036
0.464IleMet: 0.464 ± 0.014
0.777IleAsn: 0.777 ± 0.019
1.776IlePro: 1.776 ± 0.031
0.721IleGln: 0.721 ± 0.017
2.681IleArg: 2.681 ± 0.035
1.771IleSer: 1.771 ± 0.033
2.414IleThr: 2.414 ± 0.04
2.883IleVal: 2.883 ± 0.037
0.447IleTrp: 0.447 ± 0.014
0.577IleTyr: 0.577 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
2.183LysAla: 2.183 ± 0.048
0.105LysCys: 0.105 ± 0.007
0.827LysAsp: 0.827 ± 0.023
0.702LysGlu: 0.702 ± 0.02
0.366LysPhe: 0.366 ± 0.014
1.214LysGly: 1.214 ± 0.025
0.353LysHis: 0.353 ± 0.013
0.793LysIle: 0.793 ± 0.018
0.522LysLys: 0.522 ± 0.02
1.713LysLeu: 1.713 ± 0.028
0.31LysMet: 0.31 ± 0.011
0.414LysAsn: 0.414 ± 0.015
1.128LysPro: 1.128 ± 0.026
0.59LysGln: 0.59 ± 0.015
1.264LysArg: 1.264 ± 0.027
0.912LysSer: 0.912 ± 0.027
0.985LysThr: 0.985 ± 0.02
1.464LysVal: 1.464 ± 0.028
0.218LysTrp: 0.218 ± 0.011
0.377LysTyr: 0.377 ± 0.013
0.0LysXaa: 0.0 ± 0.0
Leu
16.13LeuAla: 16.13 ± 0.131
0.754LeuCys: 0.754 ± 0.018
6.553LeuAsp: 6.553 ± 0.067
3.772LeuGlu: 3.772 ± 0.045
2.607LeuPhe: 2.607 ± 0.038
9.111LeuGly: 9.111 ± 0.065
2.213LeuHis: 2.213 ± 0.029
3.831LeuIle: 3.831 ± 0.044
1.444LeuLys: 1.444 ± 0.027
11.316LeuLeu: 11.316 ± 0.106
1.4LeuMet: 1.4 ± 0.03
1.692LeuAsn: 1.692 ± 0.029
6.489LeuPro: 6.489 ± 0.055
2.182LeuGln: 2.182 ± 0.032
9.143LeuArg: 9.143 ± 0.081
5.162LeuSer: 5.162 ± 0.054
7.005LeuThr: 7.005 ± 0.066
8.637LeuVal: 8.637 ± 0.071
1.239LeuTrp: 1.239 ± 0.027
1.681LeuTyr: 1.681 ± 0.028
0.0LeuXaa: 0.0 ± 0.0
Met
2.164MetAla: 2.164 ± 0.033
0.123MetCys: 0.123 ± 0.007
0.767MetAsp: 0.767 ± 0.018
0.558MetGlu: 0.558 ± 0.016
0.456MetPhe: 0.456 ± 0.014
1.054MetGly: 1.054 ± 0.026
0.319MetHis: 0.319 ± 0.012
0.768MetIle: 0.768 ± 0.019
0.322MetLys: 0.322 ± 0.014
1.802MetLeu: 1.802 ± 0.027
0.288MetMet: 0.288 ± 0.011
0.391MetAsn: 0.391 ± 0.013
1.188MetPro: 1.188 ± 0.024
0.421MetGln: 0.421 ± 0.012
1.482MetArg: 1.482 ± 0.023
1.253MetSer: 1.253 ± 0.026
1.574MetThr: 1.574 ± 0.026
1.261MetVal: 1.261 ± 0.027
0.203MetTrp: 0.203 ± 0.009
0.304MetTyr: 0.304 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
2.251AsnAla: 2.251 ± 0.042
0.161AsnCys: 0.161 ± 0.008
0.969AsnAsp: 0.969 ± 0.025
0.748AsnGlu: 0.748 ± 0.016
0.484AsnPhe: 0.484 ± 0.014
1.875AsnGly: 1.875 ± 0.038
0.376AsnHis: 0.376 ± 0.014
0.613AsnIle: 0.613 ± 0.018
0.308AsnLys: 0.308 ± 0.014
1.737AsnLeu: 1.737 ± 0.029
0.29AsnMet: 0.29 ± 0.013
0.446AsnAsn: 0.446 ± 0.017
1.396AsnPro: 1.396 ± 0.026
0.522AsnGln: 0.522 ± 0.017
1.506AsnArg: 1.506 ± 0.029
0.834AsnSer: 0.834 ± 0.021
1.075AsnThr: 1.075 ± 0.026
1.412AsnVal: 1.412 ± 0.028
0.305AsnTrp: 0.305 ± 0.012
0.447AsnTyr: 0.447 ± 0.016
0.0AsnXaa: 0.0 ± 0.0
Pro
11.237ProAla: 11.237 ± 0.118
0.322ProCys: 0.322 ± 0.013
4.701ProAsp: 4.701 ± 0.054
3.785ProGlu: 3.785 ± 0.049
1.455ProPhe: 1.455 ± 0.027
7.455ProGly: 7.455 ± 0.082
1.244ProHis: 1.244 ± 0.028
1.725ProIle: 1.725 ± 0.027
0.861ProLys: 0.861 ± 0.02
5.123ProLeu: 5.123 ± 0.055
1.004ProMet: 1.004 ± 0.022
0.934ProAsn: 0.934 ± 0.023
4.226ProPro: 4.226 ± 0.073
1.711ProGln: 1.711 ± 0.028
4.272ProArg: 4.272 ± 0.058
3.04ProSer: 3.04 ± 0.047
3.144ProThr: 3.144 ± 0.046
5.924ProVal: 5.924 ± 0.054
0.923ProTrp: 0.923 ± 0.02
1.245ProTyr: 1.245 ± 0.022
0.0ProXaa: 0.0 ± 0.0
Gln
3.809GlnAla: 3.809 ± 0.043
0.16GlnCys: 0.16 ± 0.008
1.126GlnAsp: 1.126 ± 0.02
1.145GlnGlu: 1.145 ± 0.023
0.711GlnPhe: 0.711 ± 0.018
1.767GlnGly: 1.767 ± 0.029
0.663GlnHis: 0.663 ± 0.019
1.166GlnIle: 1.166 ± 0.023
0.487GlnLys: 0.487 ± 0.017
3.132GlnLeu: 3.132 ± 0.044
0.487GlnMet: 0.487 ± 0.013
0.498GlnAsn: 0.498 ± 0.018
1.966GlnPro: 1.966 ± 0.036
1.159GlnGln: 1.159 ± 0.027
2.759GlnArg: 2.759 ± 0.031
1.153GlnSer: 1.153 ± 0.023
1.36GlnThr: 1.36 ± 0.025
2.557GlnVal: 2.557 ± 0.033
0.484GlnTrp: 0.484 ± 0.015
0.535GlnTyr: 0.535 ± 0.016
0.0GlnXaa: 0.0 ± 0.0
Arg
10.967ArgAla: 10.967 ± 0.094
0.675ArgCys: 0.675 ± 0.018
4.853ArgAsp: 4.853 ± 0.057
4.158ArgGlu: 4.158 ± 0.05
2.441ArgPhe: 2.441 ± 0.036
5.949ArgGly: 5.949 ± 0.062
2.318ArgHis: 2.318 ± 0.037
3.477ArgIle: 3.477 ± 0.037
1.371ArgLys: 1.371 ± 0.027
9.538ArgLeu: 9.538 ± 0.085
1.963ArgMet: 1.963 ± 0.029
1.508ArgAsn: 1.508 ± 0.026
5.783ArgPro: 5.783 ± 0.074
2.557ArgGln: 2.557 ± 0.036
8.892ArgArg: 8.892 ± 0.089
4.176ArgSer: 4.176 ± 0.048
5.105ArgThr: 5.105 ± 0.049
6.489ArgVal: 6.489 ± 0.064
1.602ArgTrp: 1.602 ± 0.027
2.056ArgTyr: 2.056 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
6.89SerAla: 6.89 ± 0.061
0.378SerCys: 0.378 ± 0.012
2.39SerAsp: 2.39 ± 0.033
1.909SerGlu: 1.909 ± 0.029
1.396SerPhe: 1.396 ± 0.025
5.721SerGly: 5.721 ± 0.061
0.898SerHis: 0.898 ± 0.024
1.601SerIle: 1.601 ± 0.029
0.745SerLys: 0.745 ± 0.02
4.246SerLeu: 4.246 ± 0.047
0.987SerMet: 0.987 ± 0.022
0.8SerAsn: 0.8 ± 0.022
3.179SerPro: 3.179 ± 0.043
1.076SerGln: 1.076 ± 0.023
3.852SerArg: 3.852 ± 0.048
2.669SerSer: 2.669 ± 0.041
2.977SerThr: 2.977 ± 0.042
3.946SerVal: 3.946 ± 0.042
0.941SerTrp: 0.941 ± 0.022
1.148SerTyr: 1.148 ± 0.025
0.0SerXaa: 0.0 ± 0.0
Thr
9.107ThrAla: 9.107 ± 0.081
0.435ThrCys: 0.435 ± 0.014
3.406ThrAsp: 3.406 ± 0.044
2.842ThrGlu: 2.842 ± 0.04
1.702ThrPhe: 1.702 ± 0.031
7.304ThrGly: 7.304 ± 0.074
1.059ThrHis: 1.059 ± 0.023
2.002ThrIle: 2.002 ± 0.033
0.902ThrLys: 0.902 ± 0.027
5.716ThrLeu: 5.716 ± 0.057
0.945ThrMet: 0.945 ± 0.02
1.008ThrAsn: 1.008 ± 0.027
4.185ThrPro: 4.185 ± 0.053
1.188ThrGln: 1.188 ± 0.022
4.178ThrArg: 4.178 ± 0.04
2.948ThrSer: 2.948 ± 0.044
3.861ThrThr: 3.861 ± 0.053
6.334ThrVal: 6.334 ± 0.058
0.956ThrTrp: 0.956 ± 0.022
1.283ThrTyr: 1.283 ± 0.029
0.0ThrXaa: 0.0 ± 0.0
Val
12.417ValAla: 12.417 ± 0.092
0.71ValCys: 0.71 ± 0.018
5.029ValAsp: 5.029 ± 0.041
4.284ValGlu: 4.284 ± 0.046
2.239ValPhe: 2.239 ± 0.036
6.308ValGly: 6.308 ± 0.066
1.898ValHis: 1.898 ± 0.028
3.032ValIle: 3.032 ± 0.035
1.438ValLys: 1.438 ± 0.028
9.728ValLeu: 9.728 ± 0.089
1.215ValMet: 1.215 ± 0.025
1.635ValAsn: 1.635 ± 0.029
5.511ValPro: 5.511 ± 0.058
2.086ValGln: 2.086 ± 0.033
7.201ValArg: 7.201 ± 0.063
4.217ValSer: 4.217 ± 0.042
6.221ValThr: 6.221 ± 0.067
8.172ValVal: 8.172 ± 0.078
1.099ValTrp: 1.099 ± 0.021
1.484ValTyr: 1.484 ± 0.025
0.0ValXaa: 0.0 ± 0.0
Trp
1.817TrpAla: 1.817 ± 0.03
0.151TrpCys: 0.151 ± 0.008
0.767TrpAsp: 0.767 ± 0.017
0.588TrpGlu: 0.588 ± 0.021
0.485TrpPhe: 0.485 ± 0.017
0.977TrpGly: 0.977 ± 0.02
0.41TrpHis: 0.41 ± 0.013
0.556TrpIle: 0.556 ± 0.017
0.263TrpLys: 0.263 ± 0.011
1.873TrpLeu: 1.873 ± 0.033
0.296TrpMet: 0.296 ± 0.012
0.425TrpAsn: 0.425 ± 0.013
0.924TrpPro: 0.924 ± 0.02
0.649TrpGln: 0.649 ± 0.016
1.534TrpArg: 1.534 ± 0.025
1.008TrpSer: 1.008 ± 0.02
1.081TrpThr: 1.081 ± 0.023
1.035TrpVal: 1.035 ± 0.023
0.401TrpTrp: 0.401 ± 0.013
0.35TrpTyr: 0.35 ± 0.013
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.84TyrAla: 2.84 ± 0.034
0.168TyrCys: 0.168 ± 0.009
1.332TyrAsp: 1.332 ± 0.026
0.971TyrGlu: 0.971 ± 0.022
0.644TyrPhe: 0.644 ± 0.015
2.022TyrGly: 2.022 ± 0.032
0.475TyrHis: 0.475 ± 0.014
0.427TyrIle: 0.427 ± 0.016
0.277TyrLys: 0.277 ± 0.011
2.323TyrLeu: 2.323 ± 0.033
0.205TyrMet: 0.205 ± 0.01
0.384TyrAsn: 0.384 ± 0.015
1.165TyrPro: 1.165 ± 0.022
0.69TyrGln: 0.69 ± 0.018
2.077TyrArg: 2.077 ± 0.028
0.868TyrSer: 0.868 ± 0.02
1.225TyrThr: 1.225 ± 0.027
1.642TyrVal: 1.642 ± 0.029
0.338TyrTrp: 0.338 ± 0.012
0.469TyrTyr: 0.469 ± 0.016
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7203 proteins (2375611 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski