Amino acid dipepetide frequency for Melghirimyces profundicolus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.709AlaAla: 7.709 ± 0.113	0.738AlaCys: 0.738 ± 0.027	4.158AlaAsp: 4.158 ± 0.07	5.875AlaGlu: 5.875 ± 0.08	3.303AlaPhe: 3.303 ± 0.056	7.466AlaGly: 7.466 ± 0.108	1.529AlaHis: 1.529 ± 0.045	4.298AlaIle: 4.298 ± 0.075	3.517AlaLys: 3.517 ± 0.063	8.274AlaLeu: 8.274 ± 0.099	2.142AlaMet: 2.142 ± 0.045	1.882AlaAsn: 1.882 ± 0.042	2.852AlaPro: 2.852 ± 0.054	2.157AlaGln: 2.157 ± 0.054	5.241AlaArg: 5.241 ± 0.072	3.961AlaSer: 3.961 ± 0.065	3.281AlaThr: 3.281 ± 0.057	7.343AlaVal: 7.343 ± 0.107	1.106AlaTrp: 1.106 ± 0.034	2.168AlaTyr: 2.168 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.539CysAla: 0.539 ± 0.025	0.116CysCys: 0.116 ± 0.013	0.433CysAsp: 0.433 ± 0.02	0.477CysGlu: 0.477 ± 0.022	0.345CysPhe: 0.345 ± 0.019	0.875CysGly: 0.875 ± 0.029	0.244CysHis: 0.244 ± 0.016	0.434CysIle: 0.434 ± 0.021	0.261CysLys: 0.261 ± 0.015	0.854CysLeu: 0.854 ± 0.029	0.194CysMet: 0.194 ± 0.015	0.235CysAsn: 0.235 ± 0.017	0.498CysPro: 0.498 ± 0.021	0.213CysGln: 0.213 ± 0.016	0.686CysArg: 0.686 ± 0.03	0.47CysSer: 0.47 ± 0.02	0.459CysThr: 0.459 ± 0.021	0.48CysVal: 0.48 ± 0.027	0.092CysTrp: 0.092 ± 0.009	0.231CysTyr: 0.231 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.582AspAla: 3.582 ± 0.067	0.406AspCys: 0.406 ± 0.022	2.144AspAsp: 2.144 ± 0.05	3.705AspGlu: 3.705 ± 0.068	2.009AspPhe: 2.009 ± 0.044	4.236AspGly: 4.236 ± 0.07	1.321AspHis: 1.321 ± 0.032	2.609AspIle: 2.609 ± 0.057	1.962AspLys: 1.962 ± 0.059	5.454AspLeu: 5.454 ± 0.073	1.115AspMet: 1.115 ± 0.032	1.141AspAsn: 1.141 ± 0.035	3.578AspPro: 3.578 ± 0.063	1.86AspGln: 1.86 ± 0.046	4.579AspArg: 4.579 ± 0.067	2.362AspSer: 2.362 ± 0.052	2.282AspThr: 2.282 ± 0.053	3.66AspVal: 3.66 ± 0.06	0.933AspTrp: 0.933 ± 0.027	1.662AspTyr: 1.662 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	6.791GluAla: 6.791 ± 0.083	0.463GluCys: 0.463 ± 0.024	3.634GluAsp: 3.634 ± 0.063	8.118GluGlu: 8.118 ± 0.124	1.906GluPhe: 1.906 ± 0.046	5.976GluGly: 5.976 ± 0.085	1.477GluHis: 1.477 ± 0.043	4.19GluIle: 4.19 ± 0.07	5.673GluLys: 5.673 ± 0.085	6.496GluLeu: 6.496 ± 0.091	2.166GluMet: 2.166 ± 0.045	2.433GluAsn: 2.433 ± 0.052	2.904GluPro: 2.904 ± 0.052	2.84GluGln: 2.84 ± 0.055	5.4GluArg: 5.4 ± 0.087	3.448GluSer: 3.448 ± 0.059	4.078GluThr: 4.078 ± 0.063	5.622GluVal: 5.622 ± 0.081	1.162GluTrp: 1.162 ± 0.037	1.81GluTyr: 1.81 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	2.894PheAla: 2.894 ± 0.057	0.386PheCys: 0.386 ± 0.021	2.061PheAsp: 2.061 ± 0.048	2.156PheGlu: 2.156 ± 0.045	2.017PhePhe: 2.017 ± 0.053	3.436PheGly: 3.436 ± 0.062	1.139PheHis: 1.139 ± 0.035	2.136PheIle: 2.136 ± 0.052	1.295PheLys: 1.295 ± 0.034	4.401PheLeu: 4.401 ± 0.081	0.86PheMet: 0.86 ± 0.029	1.161PheAsn: 1.161 ± 0.033	2.008PhePro: 2.008 ± 0.051	1.312PheGln: 1.312 ± 0.03	2.757PheArg: 2.757 ± 0.056	2.644PheSer: 2.644 ± 0.048	2.162PheThr: 2.162 ± 0.051	2.586PheVal: 2.586 ± 0.049	0.522PheTrp: 0.522 ± 0.026	1.222PheTyr: 1.222 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	6.012GlyAla: 6.012 ± 0.094	0.896GlyCys: 0.896 ± 0.031	3.98GlyAsp: 3.98 ± 0.07	6.233GlyGlu: 6.233 ± 0.083	3.417GlyPhe: 3.417 ± 0.061	6.507GlyGly: 6.507 ± 0.095	1.645GlyHis: 1.645 ± 0.038	5.385GlyIle: 5.385 ± 0.083	5.225GlyLys: 5.225 ± 0.071	7.968GlyLeu: 7.968 ± 0.105	2.635GlyMet: 2.635 ± 0.054	2.538GlyAsn: 2.538 ± 0.055	2.795GlyPro: 2.795 ± 0.049	2.241GlyGln: 2.241 ± 0.048	5.072GlyArg: 5.072 ± 0.083	4.572GlySer: 4.572 ± 0.073	4.664GlyThr: 4.664 ± 0.077	6.596GlyVal: 6.596 ± 0.089	1.427GlyTrp: 1.427 ± 0.041	2.696GlyTyr: 2.696 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.507HisAla: 1.507 ± 0.042	0.232HisCys: 0.232 ± 0.015	0.947HisAsp: 0.947 ± 0.029	1.226HisGlu: 1.226 ± 0.034	1.002HisPhe: 1.002 ± 0.032	1.786HisGly: 1.786 ± 0.047	0.777HisHis: 0.777 ± 0.033	1.182HisIle: 1.182 ± 0.034	0.708HisLys: 0.708 ± 0.026	2.619HisLeu: 2.619 ± 0.07	0.506HisMet: 0.506 ± 0.025	0.548HisAsn: 0.548 ± 0.025	1.831HisPro: 1.831 ± 0.048	0.861HisGln: 0.861 ± 0.032	2.072HisArg: 2.072 ± 0.05	1.288HisSer: 1.288 ± 0.034	1.131HisThr: 1.131 ± 0.031	1.494HisVal: 1.494 ± 0.037	0.353HisTrp: 0.353 ± 0.018	0.781HisTyr: 0.781 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	4.522IleAla: 4.522 ± 0.075	0.53IleCys: 0.53 ± 0.02	2.849IleAsp: 2.849 ± 0.058	3.009IleGlu: 3.009 ± 0.059	1.99IlePhe: 1.99 ± 0.051	4.876IleGly: 4.876 ± 0.077	1.768IleHis: 1.768 ± 0.042	2.677IleIle: 2.677 ± 0.06	1.944IleLys: 1.944 ± 0.045	5.973IleLeu: 5.973 ± 0.099	1.121IleMet: 1.121 ± 0.034	1.625IleAsn: 1.625 ± 0.034	3.404IlePro: 3.404 ± 0.053	2.265IleGln: 2.265 ± 0.053	5.113IleArg: 5.113 ± 0.08	3.142IleSer: 3.142 ± 0.061	2.942IleThr: 2.942 ± 0.058	3.639IleVal: 3.639 ± 0.071	0.604IleTrp: 0.604 ± 0.024	1.508IleTyr: 1.508 ± 0.039	0.0IleXaa: 0.0 ± 0.0
Lys	4.105LysAla: 4.105 ± 0.066	0.212LysCys: 0.212 ± 0.014	2.623LysAsp: 2.623 ± 0.054	5.565LysGlu: 5.565 ± 0.081	1.087LysPhe: 1.087 ± 0.035	4.442LysGly: 4.442 ± 0.074	1.014LysHis: 1.014 ± 0.03	2.591LysIle: 2.591 ± 0.054	4.156LysLys: 4.156 ± 0.079	4.061LysLeu: 4.061 ± 0.07	1.511LysMet: 1.511 ± 0.036	1.93LysAsn: 1.93 ± 0.043	2.299LysPro: 2.299 ± 0.049	1.948LysGln: 1.948 ± 0.051	3.682LysArg: 3.682 ± 0.062	2.339LysSer: 2.339 ± 0.054	2.865LysThr: 2.865 ± 0.054	3.916LysVal: 3.916 ± 0.077	0.734LysTrp: 0.734 ± 0.028	1.25LysTyr: 1.25 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	8.667LeuAla: 8.667 ± 0.096	0.811LeuCys: 0.811 ± 0.031	5.223LeuAsp: 5.223 ± 0.078	7.349LeuGlu: 7.349 ± 0.105	4.543LeuPhe: 4.543 ± 0.079	7.406LeuGly: 7.406 ± 0.096	2.192LeuHis: 2.192 ± 0.048	5.735LeuIle: 5.735 ± 0.092	5.864LeuLys: 5.864 ± 0.082	10.322LeuLeu: 10.322 ± 0.134	2.521LeuMet: 2.521 ± 0.048	3.348LeuAsn: 3.348 ± 0.056	5.039LeuPro: 5.039 ± 0.075	2.967LeuGln: 2.967 ± 0.056	5.903LeuArg: 5.903 ± 0.08	6.514LeuSer: 6.514 ± 0.091	5.728LeuThr: 5.728 ± 0.081	6.927LeuVal: 6.927 ± 0.101	1.164LeuTrp: 1.164 ± 0.04	2.763LeuTyr: 2.763 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.432MetAla: 2.432 ± 0.054	0.125MetCys: 0.125 ± 0.011	1.631MetAsp: 1.631 ± 0.039	2.459MetGlu: 2.459 ± 0.046	0.828MetPhe: 0.828 ± 0.031	2.166MetGly: 2.166 ± 0.044	0.404MetHis: 0.404 ± 0.021	1.618MetIle: 1.618 ± 0.042	2.01MetLys: 2.01 ± 0.041	2.156MetLeu: 2.156 ± 0.049	0.829MetMet: 0.829 ± 0.031	1.055MetAsn: 1.055 ± 0.033	1.034MetPro: 1.034 ± 0.038	0.72MetGln: 0.72 ± 0.023	1.363MetArg: 1.363 ± 0.034	1.382MetSer: 1.382 ± 0.04	1.573MetThr: 1.573 ± 0.036	2.075MetVal: 2.075 ± 0.05	0.256MetTrp: 0.256 ± 0.016	0.568MetTyr: 0.568 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.165AsnAla: 2.165 ± 0.048	0.226AsnCys: 0.226 ± 0.018	1.3AsnAsp: 1.3 ± 0.037	1.854AsnGlu: 1.854 ± 0.045	0.938AsnPhe: 0.938 ± 0.033	2.659AsnGly: 2.659 ± 0.056	0.804AsnHis: 0.804 ± 0.03	1.654AsnIle: 1.654 ± 0.041	1.254AsnLys: 1.254 ± 0.038	3.049AsnLeu: 3.049 ± 0.056	0.762AsnMet: 0.762 ± 0.028	0.91AsnAsn: 0.91 ± 0.034	2.128AsnPro: 2.128 ± 0.044	1.235AsnGln: 1.235 ± 0.038	2.898AsnArg: 2.898 ± 0.054	1.319AsnSer: 1.319 ± 0.039	1.505AsnThr: 1.505 ± 0.039	2.075AsnVal: 2.075 ± 0.045	0.424AsnTrp: 0.424 ± 0.019	0.792AsnTyr: 0.792 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	3.644ProAla: 3.644 ± 0.062	0.324ProCys: 0.324 ± 0.018	3.303ProAsp: 3.303 ± 0.064	4.622ProGlu: 4.622 ± 0.081	2.223ProPhe: 2.223 ± 0.052	4.475ProGly: 4.475 ± 0.076	1.17ProHis: 1.17 ± 0.034	2.084ProIle: 2.084 ± 0.047	2.078ProLys: 2.078 ± 0.05	4.652ProLeu: 4.652 ± 0.071	1.119ProMet: 1.119 ± 0.036	1.187ProAsn: 1.187 ± 0.033	2.072ProPro: 2.072 ± 0.049	1.296ProGln: 1.296 ± 0.033	2.707ProArg: 2.707 ± 0.053	2.77ProSer: 2.77 ± 0.054	2.02ProThr: 2.02 ± 0.048	4.537ProVal: 4.537 ± 0.072	0.683ProTrp: 0.683 ± 0.026	1.459ProTyr: 1.459 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.938GlnAla: 2.938 ± 0.057	0.212GlnCys: 0.212 ± 0.013	1.354GlnAsp: 1.354 ± 0.041	2.321GlnGlu: 2.321 ± 0.05	1.024GlnPhe: 1.024 ± 0.034	2.406GlnGly: 2.406 ± 0.049	0.627GlnHis: 0.627 ± 0.024	1.705GlnIle: 1.705 ± 0.041	1.965GlnLys: 1.965 ± 0.044	3.115GlnLeu: 3.115 ± 0.057	0.977GlnMet: 0.977 ± 0.029	1.137GlnAsn: 1.137 ± 0.035	1.613GlnPro: 1.613 ± 0.042	1.413GlnGln: 1.413 ± 0.064	1.994GlnArg: 1.994 ± 0.049	1.784GlnSer: 1.784 ± 0.044	1.803GlnThr: 1.803 ± 0.04	2.618GlnVal: 2.618 ± 0.045	0.51GlnTrp: 0.51 ± 0.024	0.983GlnTyr: 0.983 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	4.271ArgAla: 4.271 ± 0.066	0.566ArgCys: 0.566 ± 0.024	3.161ArgAsp: 3.161 ± 0.057	6.519ArgGlu: 6.519 ± 0.091	3.102ArgPhe: 3.102 ± 0.061	4.429ArgGly: 4.429 ± 0.074	1.537ArgHis: 1.537 ± 0.041	4.356ArgIle: 4.356 ± 0.068	4.223ArgLys: 4.223 ± 0.063	7.689ArgLeu: 7.689 ± 0.104	2.287ArgMet: 2.287 ± 0.047	2.155ArgAsn: 2.155 ± 0.042	2.966ArgPro: 2.966 ± 0.058	2.319ArgGln: 2.319 ± 0.054	4.901ArgArg: 4.901 ± 0.081	3.702ArgSer: 3.702 ± 0.062	3.186ArgThr: 3.186 ± 0.052	5.082ArgVal: 5.082 ± 0.07	1.266ArgTrp: 1.266 ± 0.036	2.318ArgTyr: 2.318 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	3.897SerAla: 3.897 ± 0.069	0.442SerCys: 0.442 ± 0.02	2.698SerAsp: 2.698 ± 0.055	3.358SerGlu: 3.358 ± 0.064	2.477SerPhe: 2.477 ± 0.048	5.173SerGly: 5.173 ± 0.079	1.303SerHis: 1.303 ± 0.042	2.979SerIle: 2.979 ± 0.058	2.248SerLys: 2.248 ± 0.05	5.991SerLeu: 5.991 ± 0.093	1.55SerMet: 1.55 ± 0.039	1.384SerAsn: 1.384 ± 0.038	2.888SerPro: 2.888 ± 0.058	1.555SerGln: 1.555 ± 0.039	4.067SerArg: 4.067 ± 0.072	3.004SerSer: 3.004 ± 0.059	2.58SerThr: 2.58 ± 0.047	4.121SerVal: 4.121 ± 0.065	0.741SerTrp: 0.741 ± 0.028	1.471SerTyr: 1.471 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.451ThrAla: 4.451 ± 0.072	0.415ThrCys: 0.415 ± 0.019	2.719ThrAsp: 2.719 ± 0.058	3.451ThrGlu: 3.451 ± 0.055	2.076ThrPhe: 2.076 ± 0.045	5.378ThrGly: 5.378 ± 0.078	1.099ThrHis: 1.099 ± 0.031	2.661ThrIle: 2.661 ± 0.057	1.854ThrLys: 1.854 ± 0.049	5.383ThrLeu: 5.383 ± 0.071	1.206ThrMet: 1.206 ± 0.033	1.298ThrAsn: 1.298 ± 0.035	2.851ThrPro: 2.851 ± 0.054	1.383ThrGln: 1.383 ± 0.035	3.228ThrArg: 3.228 ± 0.056	2.62ThrSer: 2.62 ± 0.052	2.421ThrThr: 2.421 ± 0.067	4.8ThrVal: 4.8 ± 0.07	0.633ThrTrp: 0.633 ± 0.026	1.567ThrTyr: 1.567 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	5.979ValAla: 5.979 ± 0.081	0.678ValCys: 0.678 ± 0.027	4.094ValAsp: 4.094 ± 0.066	5.571ValGlu: 5.571 ± 0.086	2.999ValPhe: 2.999 ± 0.064	5.343ValGly: 5.343 ± 0.086	1.725ValHis: 1.725 ± 0.039	4.731ValIle: 4.731 ± 0.075	4.083ValLys: 4.083 ± 0.078	7.817ValLeu: 7.817 ± 0.094	1.95ValMet: 1.95 ± 0.045	2.464ValAsn: 2.464 ± 0.054	3.664ValPro: 3.664 ± 0.063	2.384ValGln: 2.384 ± 0.049	5.002ValArg: 5.002 ± 0.071	4.456ValSer: 4.456 ± 0.064	4.567ValThr: 4.567 ± 0.075	5.853ValVal: 5.853 ± 0.095	0.967ValTrp: 0.967 ± 0.029	2.083ValTyr: 2.083 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.894TrpAla: 0.894 ± 0.029	0.109TrpCys: 0.109 ± 0.01	0.674TrpAsp: 0.674 ± 0.028	1.005TrpGlu: 1.005 ± 0.033	0.629TrpPhe: 0.629 ± 0.026	1.019TrpGly: 1.019 ± 0.035	0.245TrpHis: 0.245 ± 0.013	0.962TrpIle: 0.962 ± 0.03	0.917TrpLys: 0.917 ± 0.032	1.633TrpLeu: 1.633 ± 0.048	0.561TrpMet: 0.561 ± 0.024	0.611TrpAsn: 0.611 ± 0.026	0.467TrpPro: 0.467 ± 0.023	0.42TrpGln: 0.42 ± 0.021	0.754TrpArg: 0.754 ± 0.026	0.737TrpSer: 0.737 ± 0.028	0.742TrpThr: 0.742 ± 0.029	1.174TrpVal: 1.174 ± 0.038	0.25TrpTrp: 0.25 ± 0.016	0.381TrpTyr: 0.381 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.003TyrAla: 2.003 ± 0.052	0.248TyrCys: 0.248 ± 0.017	1.613TyrAsp: 1.613 ± 0.051	1.714TyrGlu: 1.714 ± 0.044	1.241TyrPhe: 1.241 ± 0.041	2.45TyrGly: 2.45 ± 0.048	0.831TyrHis: 0.831 ± 0.031	1.517TyrIle: 1.517 ± 0.042	1.094TyrLys: 1.094 ± 0.032	3.078TyrLeu: 3.078 ± 0.068	0.671TyrMet: 0.671 ± 0.025	0.909TyrAsn: 0.909 ± 0.034	1.536TyrPro: 1.536 ± 0.039	1.111TyrGln: 1.111 ± 0.035	2.619TyrArg: 2.619 ± 0.053	1.409TyrSer: 1.409 ± 0.033	1.505TyrThr: 1.505 ± 0.044	1.81TyrVal: 1.81 ± 0.045	0.356TyrTrp: 0.356 ± 0.018	1.023TyrTyr: 1.023 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3716 proteins (1052417 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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