Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2)

Taxonomy: Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus; Human immunodeficiency virus 2; HIV-2 subtype A

Average proteome isoelectric point is 7.79

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 10 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P18100|VPR_HV2BE Protein Vpr OS=Human immunodeficiency virus type 2 subtype A (isolate BEN) OX=11714 GN=vpr PE=3 SV=1
MM1 pKa = 7.57TDD3 pKa = 2.86PRR5 pKa = 11.84EE6 pKa = 3.98RR7 pKa = 11.84VPPGNSGEE15 pKa = 4.16EE16 pKa = 4.26TIGEE20 pKa = 3.94AFEE23 pKa = 4.02WLEE26 pKa = 3.94RR27 pKa = 11.84TIEE30 pKa = 4.07ALNRR34 pKa = 11.84EE35 pKa = 4.72AVNHH39 pKa = 6.54LPRR42 pKa = 11.84EE43 pKa = 4.32LIFQVWQRR51 pKa = 11.84SWRR54 pKa = 11.84YY55 pKa = 6.52WHH57 pKa = 7.46DD58 pKa = 3.69EE59 pKa = 3.79QGMSASYY66 pKa = 9.62TKK68 pKa = 10.67YY69 pKa = 10.44RR70 pKa = 11.84YY71 pKa = 9.72LCLMQKK77 pKa = 10.7AIFTHH82 pKa = 6.37FKK84 pKa = 10.41RR85 pKa = 11.84GCTCWGEE92 pKa = 4.01DD93 pKa = 3.23MGRR96 pKa = 11.84EE97 pKa = 4.12GLEE100 pKa = 4.27DD101 pKa = 3.7QGPPPPPPPGLVV113 pKa = 3.04

Molecular weight: 13.21 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P18094|ENV_HV2BE Envelope glycoprotein gp160 OS=Human immunodeficiency virus type 2 subtype A (isolate BEN) OX=11714 GN=env PE=3 SV=1
MM1 pKa = 7.63SEE3 pKa = 3.94RR4 pKa = 11.84ADD6 pKa = 3.66EE7 pKa = 4.6EE8 pKa = 4.44GLQGKK13 pKa = 8.85LRR15 pKa = 11.84LLRR18 pKa = 11.84LLHH21 pKa = 5.3QTNPYY26 pKa = 8.44PQGPGTASQRR36 pKa = 11.84RR37 pKa = 11.84NRR39 pKa = 11.84RR40 pKa = 11.84RR41 pKa = 11.84RR42 pKa = 11.84RR43 pKa = 11.84RR44 pKa = 11.84RR45 pKa = 11.84QWLRR49 pKa = 11.84LVALANKK56 pKa = 9.41LCAVPDD62 pKa = 4.36PPTDD66 pKa = 3.6SPLDD70 pKa = 3.42RR71 pKa = 11.84AIQHH75 pKa = 6.13LQRR78 pKa = 11.84LTIQEE83 pKa = 4.5LPDD86 pKa = 4.43PPTDD90 pKa = 3.76LPEE93 pKa = 4.69SNSNQGLAEE102 pKa = 4.07TT103 pKa = 4.76

Molecular weight: 11.79 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

9

1

10

3935

87

1550

393.5

44.78

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

6.531 ± 0.257

2.389 ± 0.416

3.99 ± 0.25

7.395 ± 0.579

2.567 ± 0.256

7.243 ± 0.552

2.236 ± 0.257

5.311 ± 0.767

6.658 ± 0.833

8.463 ± 0.439

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

2.084 ± 0.191

4.269 ± 0.466

6.277 ± 0.657

5.896 ± 0.354

7.039 ± 0.884

4.752 ± 0.571

5.845 ± 0.711

5.464 ± 0.641

2.49 ± 0.407

3.1 ± 0.373
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski