Amino acid dipepetide frequency for Salinisphaera shabanensis E1L3A

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.453AlaAla: 15.453 ± 0.17	1.291AlaCys: 1.291 ± 0.038	8.059AlaAsp: 8.059 ± 0.088	7.382AlaGlu: 7.382 ± 0.08	4.176AlaPhe: 4.176 ± 0.074	10.441AlaGly: 10.441 ± 0.108	2.772AlaHis: 2.772 ± 0.054	6.158AlaIle: 6.158 ± 0.095	3.048AlaLys: 3.048 ± 0.062	13.772AlaLeu: 13.772 ± 0.153	3.209AlaMet: 3.209 ± 0.062	3.259AlaAsn: 3.259 ± 0.051	5.263AlaPro: 5.263 ± 0.078	4.635AlaGln: 4.635 ± 0.076	9.416AlaArg: 9.416 ± 0.104	6.426AlaSer: 6.426 ± 0.09	6.064AlaThr: 6.064 ± 0.073	8.337AlaVal: 8.337 ± 0.096	1.621AlaTrp: 1.621 ± 0.044	2.736AlaTyr: 2.736 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.176CysAla: 1.176 ± 0.037	0.151CysCys: 0.151 ± 0.012	0.587CysAsp: 0.587 ± 0.027	0.518CysGlu: 0.518 ± 0.022	0.34CysPhe: 0.34 ± 0.019	0.907CysGly: 0.907 ± 0.03	0.288CysHis: 0.288 ± 0.017	0.403CysIle: 0.403 ± 0.019	0.19CysLys: 0.19 ± 0.015	0.893CysLeu: 0.893 ± 0.03	0.18CysMet: 0.18 ± 0.012	0.256CysAsn: 0.256 ± 0.018	0.471CysPro: 0.471 ± 0.021	0.254CysGln: 0.254 ± 0.013	0.696CysArg: 0.696 ± 0.025	0.492CysSer: 0.492 ± 0.02	0.47CysThr: 0.47 ± 0.02	0.794CysVal: 0.794 ± 0.029	0.112CysTrp: 0.112 ± 0.011	0.245CysTyr: 0.245 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.059AspAla: 8.059 ± 0.098	0.577AspCys: 0.577 ± 0.026	4.674AspAsp: 4.674 ± 0.078	4.282AspGlu: 4.282 ± 0.067	2.32AspPhe: 2.32 ± 0.044	5.16AspGly: 5.16 ± 0.08	1.415AspHis: 1.415 ± 0.034	3.566AspIle: 3.566 ± 0.063	1.816AspLys: 1.816 ± 0.05	5.473AspLeu: 5.473 ± 0.082	1.677AspMet: 1.677 ± 0.039	2.097AspAsn: 2.097 ± 0.043	2.896AspPro: 2.896 ± 0.057	1.93AspGln: 1.93 ± 0.043	4.434AspArg: 4.434 ± 0.066	3.316AspSer: 3.316 ± 0.066	3.884AspThr: 3.884 ± 0.064	4.493AspVal: 4.493 ± 0.066	1.085AspTrp: 1.085 ± 0.027	2.111AspTyr: 2.111 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.926GluAla: 6.926 ± 0.098	0.42GluCys: 0.42 ± 0.021	2.841GluAsp: 2.841 ± 0.064	2.511GluGlu: 2.511 ± 0.061	1.773GluPhe: 1.773 ± 0.042	3.635GluGly: 3.635 ± 0.065	1.671GluHis: 1.671 ± 0.038	3.274GluIle: 3.274 ± 0.062	1.912GluLys: 1.912 ± 0.045	5.853GluLeu: 5.853 ± 0.085	1.284GluMet: 1.284 ± 0.038	1.884GluAsn: 1.884 ± 0.042	2.823GluPro: 2.823 ± 0.054	2.953GluGln: 2.953 ± 0.061	5.726GluArg: 5.726 ± 0.088	3.272GluSer: 3.272 ± 0.06	3.31GluThr: 3.31 ± 0.059	3.418GluVal: 3.418 ± 0.061	0.677GluTrp: 0.677 ± 0.029	1.437GluTyr: 1.437 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.307PheAla: 4.307 ± 0.062	0.418PheCys: 0.418 ± 0.017	2.961PheAsp: 2.961 ± 0.053	2.442PheGlu: 2.442 ± 0.05	1.438PhePhe: 1.438 ± 0.041	3.357PheGly: 3.357 ± 0.061	0.68PheHis: 0.68 ± 0.024	1.661PheIle: 1.661 ± 0.038	0.915PheLys: 0.915 ± 0.024	2.819PheLeu: 2.819 ± 0.058	0.879PheMet: 0.879 ± 0.034	1.136PheAsn: 1.136 ± 0.036	1.246PhePro: 1.246 ± 0.032	0.894PheGln: 0.894 ± 0.028	1.744PheArg: 1.744 ± 0.042	2.134PheSer: 2.134 ± 0.044	1.838PheThr: 1.838 ± 0.046	2.962PheVal: 2.962 ± 0.064	0.537PheTrp: 0.537 ± 0.027	1.059PheTyr: 1.059 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	8.672GlyAla: 8.672 ± 0.117	0.89GlyCys: 0.89 ± 0.031	5.089GlyAsp: 5.089 ± 0.078	4.973GlyGlu: 4.973 ± 0.066	3.217GlyPhe: 3.217 ± 0.056	6.53GlyGly: 6.53 ± 0.103	2.03GlyHis: 2.03 ± 0.051	4.128GlyIle: 4.128 ± 0.068	2.58GlyLys: 2.58 ± 0.057	8.554GlyLeu: 8.554 ± 0.107	2.406GlyMet: 2.406 ± 0.057	2.202GlyAsn: 2.202 ± 0.046	2.91GlyPro: 2.91 ± 0.052	2.87GlyGln: 2.87 ± 0.058	5.386GlyArg: 5.386 ± 0.075	4.046GlySer: 4.046 ± 0.066	4.072GlyThr: 4.072 ± 0.069	6.528GlyVal: 6.528 ± 0.081	1.344GlyTrp: 1.344 ± 0.034	2.57GlyTyr: 2.57 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	2.889HisAla: 2.889 ± 0.056	0.269HisCys: 0.269 ± 0.016	1.464HisAsp: 1.464 ± 0.042	1.294HisGlu: 1.294 ± 0.034	0.874HisPhe: 0.874 ± 0.029	2.175HisGly: 2.175 ± 0.045	0.624HisHis: 0.624 ± 0.029	1.123HisIle: 1.123 ± 0.039	0.518HisLys: 0.518 ± 0.022	1.982HisLeu: 1.982 ± 0.05	0.527HisMet: 0.527 ± 0.023	0.601HisAsn: 0.601 ± 0.023	1.251HisPro: 1.251 ± 0.034	0.648HisGln: 0.648 ± 0.023	1.655HisArg: 1.655 ± 0.042	1.085HisSer: 1.085 ± 0.032	1.121HisThr: 1.121 ± 0.035	1.643HisVal: 1.643 ± 0.04	0.4HisTrp: 0.4 ± 0.022	0.703HisTyr: 0.703 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.082IleAla: 7.082 ± 0.093	0.487IleCys: 0.487 ± 0.021	4.377IleAsp: 4.377 ± 0.074	3.965IleGlu: 3.965 ± 0.068	1.473IlePhe: 1.473 ± 0.038	4.789IleGly: 4.789 ± 0.073	1.038IleHis: 1.038 ± 0.03	1.842IleIle: 1.842 ± 0.047	1.37IleLys: 1.37 ± 0.037	3.415IleLeu: 3.415 ± 0.067	0.912IleMet: 0.912 ± 0.029	1.611IleAsn: 1.611 ± 0.048	1.916IlePro: 1.916 ± 0.048	1.413IleGln: 1.413 ± 0.036	3.103IleArg: 3.103 ± 0.06	2.562IleSer: 2.562 ± 0.052	2.736IleThr: 2.736 ± 0.054	4.088IleVal: 4.088 ± 0.06	0.536IleTrp: 0.536 ± 0.022	1.187IleTyr: 1.187 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.32LysAla: 3.32 ± 0.064	0.163LysCys: 0.163 ± 0.014	1.328LysAsp: 1.328 ± 0.04	1.108LysGlu: 1.108 ± 0.039	0.682LysPhe: 0.682 ± 0.023	1.767LysGly: 1.767 ± 0.044	0.669LysHis: 0.669 ± 0.023	1.362LysIle: 1.362 ± 0.036	1.115LysLys: 1.115 ± 0.042	2.686LysLeu: 2.686 ± 0.053	0.571LysMet: 0.571 ± 0.023	0.857LysAsn: 0.857 ± 0.029	1.75LysPro: 1.75 ± 0.037	1.263LysGln: 1.263 ± 0.044	2.542LysArg: 2.542 ± 0.059	1.574LysSer: 1.574 ± 0.045	1.697LysThr: 1.697 ± 0.047	1.656LysVal: 1.656 ± 0.041	0.279LysTrp: 0.279 ± 0.016	0.613LysTyr: 0.613 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	13.681LeuAla: 13.681 ± 0.148	1.071LeuCys: 1.071 ± 0.028	6.898LeuAsp: 6.898 ± 0.099	5.626LeuGlu: 5.626 ± 0.079	3.774LeuPhe: 3.774 ± 0.071	8.202LeuGly: 8.202 ± 0.102	2.045LeuHis: 2.045 ± 0.043	5.076LeuIle: 5.076 ± 0.078	2.844LeuLys: 2.844 ± 0.054	9.825LeuLeu: 9.825 ± 0.133	2.307LeuMet: 2.307 ± 0.048	2.628LeuAsn: 2.628 ± 0.048	4.908LeuPro: 4.908 ± 0.073	2.793LeuGln: 2.793 ± 0.052	6.868LeuArg: 6.868 ± 0.105	5.968LeuSer: 5.968 ± 0.079	5.363LeuThr: 5.363 ± 0.071	7.384LeuVal: 7.384 ± 0.108	1.229LeuTrp: 1.229 ± 0.037	2.324LeuTyr: 2.324 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.058MetAla: 3.058 ± 0.059	0.181MetCys: 0.181 ± 0.013	1.215MetAsp: 1.215 ± 0.032	0.96MetGlu: 0.96 ± 0.034	0.724MetPhe: 0.724 ± 0.028	1.802MetGly: 1.802 ± 0.045	0.621MetHis: 0.621 ± 0.02	1.172MetIle: 1.172 ± 0.03	0.788MetLys: 0.788 ± 0.029	2.493MetLeu: 2.493 ± 0.055	0.579MetMet: 0.579 ± 0.028	0.824MetAsn: 0.824 ± 0.03	1.496MetPro: 1.496 ± 0.045	0.964MetGln: 0.964 ± 0.026	1.862MetArg: 1.862 ± 0.042	1.765MetSer: 1.765 ± 0.036	1.554MetThr: 1.554 ± 0.039	1.513MetVal: 1.513 ± 0.045	0.181MetTrp: 0.181 ± 0.014	0.394MetTyr: 0.394 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.671AsnAla: 3.671 ± 0.06	0.214AsnCys: 0.214 ± 0.016	2.01AsnAsp: 2.01 ± 0.042	1.67AsnGlu: 1.67 ± 0.04	0.893AsnPhe: 0.893 ± 0.03	2.465AsnGly: 2.465 ± 0.06	0.585AsnHis: 0.585 ± 0.024	1.392AsnIle: 1.392 ± 0.033	0.762AsnLys: 0.762 ± 0.026	2.534AsnLeu: 2.534 ± 0.048	0.621AsnMet: 0.621 ± 0.026	0.865AsnAsn: 0.865 ± 0.035	1.704AsnPro: 1.704 ± 0.04	0.892AsnGln: 0.892 ± 0.03	1.993AsnArg: 1.993 ± 0.037	1.353AsnSer: 1.353 ± 0.038	1.682AsnThr: 1.682 ± 0.042	2.069AsnVal: 2.069 ± 0.039	0.444AsnTrp: 0.444 ± 0.02	0.754AsnTyr: 0.754 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	5.863ProAla: 5.863 ± 0.079	0.316ProCys: 0.316 ± 0.018	3.514ProAsp: 3.514 ± 0.056	3.243ProGlu: 3.243 ± 0.056	1.553ProPhe: 1.553 ± 0.037	4.053ProGly: 4.053 ± 0.064	0.967ProHis: 0.967 ± 0.028	2.242ProIle: 2.242 ± 0.05	1.198ProLys: 1.198 ± 0.034	4.532ProLeu: 4.532 ± 0.068	1.104ProMet: 1.104 ± 0.03	1.409ProAsn: 1.409 ± 0.038	2.028ProPro: 2.028 ± 0.046	1.608ProGln: 1.608 ± 0.042	2.894ProArg: 2.894 ± 0.049	2.469ProSer: 2.469 ± 0.049	2.294ProThr: 2.294 ± 0.048	3.727ProVal: 3.727 ± 0.052	0.679ProTrp: 0.679 ± 0.026	1.164ProTyr: 1.164 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.9GlnAla: 4.9 ± 0.081	0.265GlnCys: 0.265 ± 0.016	1.476GlnAsp: 1.476 ± 0.041	1.237GlnGlu: 1.237 ± 0.036	1.133GlnPhe: 1.133 ± 0.033	2.453GlnGly: 2.453 ± 0.047	0.801GlnHis: 0.801 ± 0.029	1.945GlnIle: 1.945 ± 0.049	0.897GlnLys: 0.897 ± 0.029	3.502GlnLeu: 3.502 ± 0.068	0.901GlnMet: 0.901 ± 0.03	0.944GlnAsn: 0.944 ± 0.028	1.936GlnPro: 1.936 ± 0.046	1.602GlnGln: 1.602 ± 0.044	3.251GlnArg: 3.251 ± 0.066	1.992GlnSer: 1.992 ± 0.042	1.996GlnThr: 1.996 ± 0.046	2.475GlnVal: 2.475 ± 0.049	0.454GlnTrp: 0.454 ± 0.021	0.843GlnTyr: 0.843 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	8.281ArgAla: 8.281 ± 0.105	0.695ArgCys: 0.695 ± 0.027	4.773ArgAsp: 4.773 ± 0.067	4.723ArgGlu: 4.723 ± 0.074	2.966ArgPhe: 2.966 ± 0.054	4.776ArgGly: 4.776 ± 0.084	1.836ArgHis: 1.836 ± 0.044	3.845ArgIle: 3.845 ± 0.062	1.89ArgLys: 1.89 ± 0.046	8.348ArgLeu: 8.348 ± 0.101	1.976ArgMet: 1.976 ± 0.038	1.943ArgAsn: 1.943 ± 0.044	2.999ArgPro: 2.999 ± 0.055	2.753ArgGln: 2.753 ± 0.048	5.943ArgArg: 5.943 ± 0.096	3.579ArgSer: 3.579 ± 0.069	3.135ArgThr: 3.135 ± 0.056	5.335ArgVal: 5.335 ± 0.068	1.212ArgTrp: 1.212 ± 0.038	2.436ArgTyr: 2.436 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	6.686SerAla: 6.686 ± 0.085	0.4SerCys: 0.4 ± 0.019	3.477SerAsp: 3.477 ± 0.061	2.941SerGlu: 2.941 ± 0.052	1.878SerPhe: 1.878 ± 0.047	4.893SerGly: 4.893 ± 0.073	1.142SerHis: 1.142 ± 0.033	2.56SerIle: 2.56 ± 0.048	1.403SerLys: 1.403 ± 0.039	5.451SerLeu: 5.451 ± 0.068	1.395SerMet: 1.395 ± 0.035	1.621SerAsn: 1.621 ± 0.037	2.421SerPro: 2.421 ± 0.05	1.936SerGln: 1.936 ± 0.044	3.836SerArg: 3.836 ± 0.06	3.083SerSer: 3.083 ± 0.072	2.752SerThr: 2.752 ± 0.053	3.904SerVal: 3.904 ± 0.062	0.712SerTrp: 0.712 ± 0.023	1.339SerTyr: 1.339 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.99ThrAla: 5.99 ± 0.086	0.409ThrCys: 0.409 ± 0.019	3.132ThrAsp: 3.132 ± 0.065	2.509ThrGlu: 2.509 ± 0.046	1.678ThrPhe: 1.678 ± 0.04	4.839ThrGly: 4.839 ± 0.068	1.2ThrHis: 1.2 ± 0.035	2.545ThrIle: 2.545 ± 0.045	1.024ThrLys: 1.024 ± 0.037	6.517ThrLeu: 6.517 ± 0.096	1.026ThrMet: 1.026 ± 0.038	1.262ThrAsn: 1.262 ± 0.036	3.45ThrPro: 3.45 ± 0.052	1.835ThrGln: 1.835 ± 0.041	3.913ThrArg: 3.913 ± 0.071	2.582ThrSer: 2.582 ± 0.056	2.825ThrThr: 2.825 ± 0.053	4.067ThrVal: 4.067 ± 0.061	0.586ThrTrp: 0.586 ± 0.023	1.147ThrTyr: 1.147 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.317ValAla: 9.317 ± 0.109	0.777ValCys: 0.777 ± 0.027	5.005ValAsp: 5.005 ± 0.058	4.304ValGlu: 4.304 ± 0.077	2.954ValPhe: 2.954 ± 0.054	5.613ValGly: 5.613 ± 0.082	1.499ValHis: 1.499 ± 0.038	3.869ValIle: 3.869 ± 0.057	1.702ValLys: 1.702 ± 0.047	7.573ValLeu: 7.573 ± 0.103	1.761ValMet: 1.761 ± 0.045	2.081ValAsn: 2.081 ± 0.051	3.431ValPro: 3.431 ± 0.057	2.005ValGln: 2.005 ± 0.047	4.623ValArg: 4.623 ± 0.07	4.091ValSer: 4.091 ± 0.066	3.85ValThr: 3.85 ± 0.064	6.073ValVal: 6.073 ± 0.086	0.898ValTrp: 0.898 ± 0.028	1.794ValTyr: 1.794 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.337TrpAla: 1.337 ± 0.038	0.139TrpCys: 0.139 ± 0.01	0.596TrpAsp: 0.596 ± 0.025	0.474TrpGlu: 0.474 ± 0.024	0.543TrpPhe: 0.543 ± 0.021	0.836TrpGly: 0.836 ± 0.024	0.423TrpHis: 0.423 ± 0.02	0.659TrpIle: 0.659 ± 0.026	0.312TrpLys: 0.312 ± 0.018	2.075TrpLeu: 2.075 ± 0.051	0.339TrpMet: 0.339 ± 0.016	0.379TrpAsn: 0.379 ± 0.019	0.729TrpPro: 0.729 ± 0.027	0.85TrpGln: 0.85 ± 0.031	1.257TrpArg: 1.257 ± 0.04	0.648TrpSer: 0.648 ± 0.025	0.578TrpThr: 0.578 ± 0.026	0.923TrpVal: 0.923 ± 0.032	0.231TrpTrp: 0.231 ± 0.014	0.32TrpTyr: 0.32 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.849TyrAla: 2.849 ± 0.053	0.289TyrCys: 0.289 ± 0.017	1.788TyrAsp: 1.788 ± 0.043	1.439TyrGlu: 1.439 ± 0.04	1.036TyrPhe: 1.036 ± 0.031	2.305TyrGly: 2.305 ± 0.048	0.538TyrHis: 0.538 ± 0.027	1.079TyrIle: 1.079 ± 0.031	0.717TyrLys: 0.717 ± 0.026	2.519TyrLeu: 2.519 ± 0.048	0.494TyrMet: 0.494 ± 0.022	0.715TyrAsn: 0.715 ± 0.026	1.228TyrPro: 1.228 ± 0.035	0.903TyrGln: 0.903 ± 0.029	2.303TyrArg: 2.303 ± 0.044	1.395TyrSer: 1.395 ± 0.045	1.315TyrThr: 1.315 ± 0.033	1.832TyrVal: 1.832 ± 0.048	0.431TyrTrp: 0.431 ± 0.02	0.779TyrTyr: 0.779 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3524 proteins (1120061 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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