Amino acid dipepetide frequency for Thiobacillus denitrificans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.0AlaAla: 17.0 ± 0.232	1.271AlaCys: 1.271 ± 0.038	6.719AlaAsp: 6.719 ± 0.095	7.298AlaGlu: 7.298 ± 0.109	3.976AlaPhe: 3.976 ± 0.077	10.141AlaGly: 10.141 ± 0.136	2.829AlaHis: 2.829 ± 0.062	5.576AlaIle: 5.576 ± 0.078	3.705AlaLys: 3.705 ± 0.08	14.226AlaLeu: 14.226 ± 0.177	3.274AlaMet: 3.274 ± 0.064	3.059AlaAsn: 3.059 ± 0.064	5.419AlaPro: 5.419 ± 0.089	5.196AlaGln: 5.196 ± 0.085	8.947AlaArg: 8.947 ± 0.122	6.051AlaSer: 6.051 ± 0.082	5.571AlaThr: 5.571 ± 0.09	8.357AlaVal: 8.357 ± 0.106	1.915AlaTrp: 1.915 ± 0.053	2.702AlaTyr: 2.702 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.016CysAla: 1.016 ± 0.033	0.118CysCys: 0.118 ± 0.012	0.507CysAsp: 0.507 ± 0.026	0.502CysGlu: 0.502 ± 0.027	0.275CysPhe: 0.275 ± 0.018	0.916CysGly: 0.916 ± 0.035	0.323CysHis: 0.323 ± 0.02	0.358CysIle: 0.358 ± 0.021	0.259CysLys: 0.259 ± 0.016	0.802CysLeu: 0.802 ± 0.027	0.186CysMet: 0.186 ± 0.015	0.25CysAsn: 0.25 ± 0.016	0.568CysPro: 0.568 ± 0.027	0.271CysGln: 0.271 ± 0.017	0.605CysArg: 0.605 ± 0.031	0.453CysSer: 0.453 ± 0.023	0.458CysThr: 0.458 ± 0.024	0.657CysVal: 0.657 ± 0.03	0.102CysTrp: 0.102 ± 0.011	0.248CysTyr: 0.248 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	7.53AspAla: 7.53 ± 0.105	0.494AspCys: 0.494 ± 0.025	2.953AspAsp: 2.953 ± 0.065	3.4AspGlu: 3.4 ± 0.075	2.34AspPhe: 2.34 ± 0.053	4.304AspGly: 4.304 ± 0.075	1.205AspHis: 1.205 ± 0.035	2.837AspIle: 2.837 ± 0.06	1.964AspLys: 1.964 ± 0.054	5.457AspLeu: 5.457 ± 0.088	1.389AspMet: 1.389 ± 0.04	1.424AspAsn: 1.424 ± 0.044	2.901AspPro: 2.901 ± 0.052	1.753AspGln: 1.753 ± 0.047	3.185AspArg: 3.185 ± 0.06	2.629AspSer: 2.629 ± 0.052	2.986AspThr: 2.986 ± 0.053	3.99AspVal: 3.99 ± 0.079	1.039AspTrp: 1.039 ± 0.033	1.741AspTyr: 1.741 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	7.495GluAla: 7.495 ± 0.109	0.403GluCys: 0.403 ± 0.026	2.368GluAsp: 2.368 ± 0.053	2.451GluGlu: 2.451 ± 0.069	1.979GluPhe: 1.979 ± 0.047	3.571GluGly: 3.571 ± 0.061	1.405GluHis: 1.405 ± 0.043	3.247GluIle: 3.247 ± 0.069	2.293GluLys: 2.293 ± 0.056	6.132GluLeu: 6.132 ± 0.098	1.425GluMet: 1.425 ± 0.049	1.635GluAsn: 1.635 ± 0.04	2.301GluPro: 2.301 ± 0.051	2.442GluGln: 2.442 ± 0.057	4.306GluArg: 4.306 ± 0.081	2.745GluSer: 2.745 ± 0.053	3.231GluThr: 3.231 ± 0.063	4.049GluVal: 4.049 ± 0.089	0.73GluTrp: 0.73 ± 0.027	1.282GluTyr: 1.282 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.027PheAla: 4.027 ± 0.081	0.36PheCys: 0.36 ± 0.02	2.525PheAsp: 2.525 ± 0.058	2.133PheGlu: 2.133 ± 0.05	1.465PhePhe: 1.465 ± 0.046	3.165PheGly: 3.165 ± 0.063	0.822PheHis: 0.822 ± 0.027	1.858PheIle: 1.858 ± 0.044	1.294PheLys: 1.294 ± 0.042	3.286PheLeu: 3.286 ± 0.08	0.913PheMet: 0.913 ± 0.031	1.208PheAsn: 1.208 ± 0.037	1.573PhePro: 1.573 ± 0.041	1.016PheGln: 1.016 ± 0.028	2.063PheArg: 2.063 ± 0.048	2.288PheSer: 2.288 ± 0.053	1.815PheThr: 1.815 ± 0.046	2.777PheVal: 2.777 ± 0.06	0.496PheTrp: 0.496 ± 0.026	0.942PheTyr: 0.942 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	7.943GlyAla: 7.943 ± 0.115	0.88GlyCys: 0.88 ± 0.036	4.1GlyAsp: 4.1 ± 0.077	4.656GlyGlu: 4.656 ± 0.064	3.311GlyPhe: 3.311 ± 0.072	6.436GlyGly: 6.436 ± 0.114	1.937GlyHis: 1.937 ± 0.048	4.308GlyIle: 4.308 ± 0.067	3.455GlyLys: 3.455 ± 0.073	8.692GlyLeu: 8.692 ± 0.128	2.541GlyMet: 2.541 ± 0.054	2.276GlyAsn: 2.276 ± 0.058	2.261GlyPro: 2.261 ± 0.052	3.188GlyGln: 3.188 ± 0.064	5.14GlyArg: 5.14 ± 0.081	4.111GlySer: 4.111 ± 0.075	3.866GlyThr: 3.866 ± 0.078	6.439GlyVal: 6.439 ± 0.098	1.362GlyTrp: 1.362 ± 0.047	2.306GlyTyr: 2.306 ± 0.056	0.001GlyXaa: 0.001 ± 0.001
His	3.097HisAla: 3.097 ± 0.066	0.286HisCys: 0.286 ± 0.019	1.318HisAsp: 1.318 ± 0.037	1.224HisGlu: 1.224 ± 0.04	0.976HisPhe: 0.976 ± 0.034	2.165HisGly: 2.165 ± 0.054	0.711HisHis: 0.711 ± 0.028	1.07HisIle: 1.07 ± 0.035	0.659HisLys: 0.659 ± 0.026	2.445HisLeu: 2.445 ± 0.057	0.521HisMet: 0.521 ± 0.024	0.586HisAsn: 0.586 ± 0.026	1.641HisPro: 1.641 ± 0.04	0.745HisGln: 0.745 ± 0.029	1.459HisArg: 1.459 ± 0.038	1.091HisSer: 1.091 ± 0.036	1.227HisThr: 1.227 ± 0.034	1.581HisVal: 1.581 ± 0.043	0.369HisTrp: 0.369 ± 0.019	0.779HisTyr: 0.779 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.305IleAla: 6.305 ± 0.102	0.381IleCys: 0.381 ± 0.02	3.381IleAsp: 3.381 ± 0.065	3.495IleGlu: 3.495 ± 0.061	1.441IlePhe: 1.441 ± 0.048	4.138IleGly: 4.138 ± 0.073	1.083IleHis: 1.083 ± 0.038	1.939IleIle: 1.939 ± 0.05	1.788IleLys: 1.788 ± 0.049	4.348IleLeu: 4.348 ± 0.071	0.887IleMet: 0.887 ± 0.031	1.614IleAsn: 1.614 ± 0.045	2.433IlePro: 2.433 ± 0.047	1.557IleGln: 1.557 ± 0.041	3.139IleArg: 3.139 ± 0.063	2.52IleSer: 2.52 ± 0.057	2.529IleThr: 2.529 ± 0.047	3.636IleVal: 3.636 ± 0.061	0.447IleTrp: 0.447 ± 0.026	1.098IleTyr: 1.098 ± 0.041	0.0IleXaa: 0.0 ± 0.0
Lys	3.757LysAla: 3.757 ± 0.079	0.2LysCys: 0.2 ± 0.014	1.823LysAsp: 1.823 ± 0.056	1.557LysGlu: 1.557 ± 0.049	0.925LysPhe: 0.925 ± 0.037	2.444LysGly: 2.444 ± 0.055	0.826LysHis: 0.826 ± 0.027	1.775LysIle: 1.775 ± 0.053	1.627LysLys: 1.627 ± 0.058	4.108LysLeu: 4.108 ± 0.074	0.995LysMet: 0.995 ± 0.038	1.206LysAsn: 1.206 ± 0.035	2.208LysPro: 2.208 ± 0.055	1.652LysGln: 1.652 ± 0.043	2.412LysArg: 2.412 ± 0.061	1.952LysSer: 1.952 ± 0.048	2.184LysThr: 2.184 ± 0.056	2.468LysVal: 2.468 ± 0.063	0.4LysTrp: 0.4 ± 0.024	0.752LysTyr: 0.752 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	15.355LeuAla: 15.355 ± 0.184	0.844LeuCys: 0.844 ± 0.029	6.739LeuAsp: 6.739 ± 0.091	5.672LeuGlu: 5.672 ± 0.091	3.889LeuPhe: 3.889 ± 0.079	8.372LeuGly: 8.372 ± 0.107	2.512LeuHis: 2.512 ± 0.05	5.234LeuIle: 5.234 ± 0.094	4.475LeuLys: 4.475 ± 0.073	11.896LeuLeu: 11.896 ± 0.184	2.525LeuMet: 2.525 ± 0.057	3.269LeuAsn: 3.269 ± 0.06	6.35LeuPro: 6.35 ± 0.094	3.794LeuGln: 3.794 ± 0.075	7.076LeuArg: 7.076 ± 0.109	6.072LeuSer: 6.072 ± 0.089	5.981LeuThr: 5.981 ± 0.096	7.447LeuVal: 7.447 ± 0.117	1.27LeuTrp: 1.27 ± 0.033	2.312LeuTyr: 2.312 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	2.991MetAla: 2.991 ± 0.063	0.165MetCys: 0.165 ± 0.013	1.288MetAsp: 1.288 ± 0.043	1.212MetGlu: 1.212 ± 0.039	0.684MetPhe: 0.684 ± 0.029	1.85MetGly: 1.85 ± 0.041	0.552MetHis: 0.552 ± 0.026	1.067MetIle: 1.067 ± 0.036	1.174MetLys: 1.174 ± 0.039	2.829MetLeu: 2.829 ± 0.056	0.666MetMet: 0.666 ± 0.032	0.954MetAsn: 0.954 ± 0.039	1.435MetPro: 1.435 ± 0.034	1.214MetGln: 1.214 ± 0.038	1.786MetArg: 1.786 ± 0.047	1.506MetSer: 1.506 ± 0.04	1.52MetThr: 1.52 ± 0.044	1.68MetVal: 1.68 ± 0.04	0.192MetTrp: 0.192 ± 0.016	0.375MetTyr: 0.375 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.214AsnAla: 3.214 ± 0.062	0.3AsnCys: 0.3 ± 0.02	1.434AsnAsp: 1.434 ± 0.043	1.424AsnGlu: 1.424 ± 0.043	1.047AsnPhe: 1.047 ± 0.032	2.263AsnGly: 2.263 ± 0.052	0.608AsnHis: 0.608 ± 0.025	1.37AsnIle: 1.37 ± 0.04	0.962AsnLys: 0.962 ± 0.034	3.203AsnLeu: 3.203 ± 0.064	0.649AsnMet: 0.649 ± 0.029	0.782AsnAsn: 0.782 ± 0.03	2.052AsnPro: 2.052 ± 0.049	1.119AsnGln: 1.119 ± 0.033	1.89AsnArg: 1.89 ± 0.048	1.244AsnSer: 1.244 ± 0.041	1.546AsnThr: 1.546 ± 0.053	2.039AsnVal: 2.039 ± 0.049	0.453AsnTrp: 0.453 ± 0.022	0.714AsnTyr: 0.714 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	6.424ProAla: 6.424 ± 0.1	0.358ProCys: 0.358 ± 0.021	3.476ProAsp: 3.476 ± 0.058	3.308ProGlu: 3.308 ± 0.064	1.781ProPhe: 1.781 ± 0.047	4.482ProGly: 4.482 ± 0.073	1.2ProHis: 1.2 ± 0.038	1.985ProIle: 1.985 ± 0.051	1.491ProLys: 1.491 ± 0.038	5.302ProLeu: 5.302 ± 0.082	1.195ProMet: 1.195 ± 0.034	1.346ProAsn: 1.346 ± 0.035	2.533ProPro: 2.533 ± 0.065	1.949ProGln: 1.949 ± 0.047	2.707ProArg: 2.707 ± 0.052	2.187ProSer: 2.187 ± 0.055	2.295ProThr: 2.295 ± 0.054	4.245ProVal: 4.245 ± 0.078	0.727ProTrp: 0.727 ± 0.031	1.238ProTyr: 1.238 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.518GlnAla: 5.518 ± 0.101	0.304GlnCys: 0.304 ± 0.02	1.749GlnAsp: 1.749 ± 0.043	1.626GlnGlu: 1.626 ± 0.044	1.262GlnPhe: 1.262 ± 0.039	2.743GlnGly: 2.743 ± 0.062	0.987GlnHis: 0.987 ± 0.037	1.899GlnIle: 1.899 ± 0.045	1.269GlnLys: 1.269 ± 0.042	4.24GlnLeu: 4.24 ± 0.078	1.015GlnMet: 1.015 ± 0.036	0.917GlnAsn: 0.917 ± 0.032	2.232GlnPro: 2.232 ± 0.049	1.891GlnGln: 1.891 ± 0.055	2.875GlnArg: 2.875 ± 0.063	1.954GlnSer: 1.954 ± 0.056	2.178GlnThr: 2.178 ± 0.052	3.033GlnVal: 3.033 ± 0.069	0.495GlnTrp: 0.495 ± 0.02	0.841GlnTyr: 0.841 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	7.395ArgAla: 7.395 ± 0.099	0.517ArgCys: 0.517 ± 0.025	3.88ArgAsp: 3.88 ± 0.061	4.188ArgGlu: 4.188 ± 0.079	2.777ArgPhe: 2.777 ± 0.054	4.433ArgGly: 4.433 ± 0.076	1.88ArgHis: 1.88 ± 0.055	3.734ArgIle: 3.734 ± 0.068	1.99ArgLys: 1.99 ± 0.047	8.017ArgLeu: 8.017 ± 0.13	1.804ArgMet: 1.804 ± 0.042	1.861ArgAsn: 1.861 ± 0.046	2.942ArgPro: 2.942 ± 0.068	3.006ArgGln: 3.006 ± 0.059	4.655ArgArg: 4.655 ± 0.09	2.951ArgSer: 2.951 ± 0.064	2.86ArgThr: 2.86 ± 0.059	5.027ArgVal: 5.027 ± 0.074	1.002ArgTrp: 1.002 ± 0.035	1.964ArgTyr: 1.964 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.686SerAla: 5.686 ± 0.084	0.448SerCys: 0.448 ± 0.023	2.666SerAsp: 2.666 ± 0.052	2.676SerGlu: 2.676 ± 0.06	1.897SerPhe: 1.897 ± 0.049	5.204SerGly: 5.204 ± 0.089	1.253SerHis: 1.253 ± 0.038	2.346SerIle: 2.346 ± 0.053	1.553SerLys: 1.553 ± 0.038	5.816SerLeu: 5.816 ± 0.1	1.308SerMet: 1.308 ± 0.042	1.388SerAsn: 1.388 ± 0.04	2.516SerPro: 2.516 ± 0.052	1.894SerGln: 1.894 ± 0.052	3.402SerArg: 3.402 ± 0.059	2.506SerSer: 2.506 ± 0.06	2.508SerThr: 2.508 ± 0.061	3.775SerVal: 3.775 ± 0.064	0.676SerTrp: 0.676 ± 0.028	1.12SerTyr: 1.12 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	5.671ThrAla: 5.671 ± 0.09	0.441ThrCys: 0.441 ± 0.025	2.621ThrAsp: 2.621 ± 0.05	2.532ThrGlu: 2.532 ± 0.057	1.594ThrPhe: 1.594 ± 0.049	4.443ThrGly: 4.443 ± 0.076	1.351ThrHis: 1.351 ± 0.039	2.149ThrIle: 2.149 ± 0.053	1.222ThrLys: 1.222 ± 0.043	7.219ThrLeu: 7.219 ± 0.113	0.993ThrMet: 0.993 ± 0.036	1.159ThrAsn: 1.159 ± 0.042	3.478ThrPro: 3.478 ± 0.072	2.052ThrGln: 2.052 ± 0.052	3.541ThrArg: 3.541 ± 0.054	2.34ThrSer: 2.34 ± 0.052	2.541ThrThr: 2.541 ± 0.067	3.962ThrVal: 3.962 ± 0.069	0.57ThrTrp: 0.57 ± 0.026	1.176ThrTyr: 1.176 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	8.762ValAla: 8.762 ± 0.1	0.705ValCys: 0.705 ± 0.025	4.036ValAsp: 4.036 ± 0.06	4.386ValGlu: 4.386 ± 0.078	2.786ValPhe: 2.786 ± 0.053	5.199ValGly: 5.199 ± 0.08	1.486ValHis: 1.486 ± 0.045	3.878ValIle: 3.878 ± 0.068	2.865ValLys: 2.865 ± 0.064	8.112ValLeu: 8.112 ± 0.108	2.008ValMet: 2.008 ± 0.046	2.318ValAsn: 2.318 ± 0.06	3.464ValPro: 3.464 ± 0.063	2.401ValGln: 2.401 ± 0.057	4.669ValArg: 4.669 ± 0.087	4.122ValSer: 4.122 ± 0.066	3.973ValThr: 3.973 ± 0.086	5.956ValVal: 5.956 ± 0.098	0.997ValTrp: 0.997 ± 0.038	1.691ValTyr: 1.691 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.228TrpAla: 1.228 ± 0.039	0.145TrpCys: 0.145 ± 0.012	0.637TrpAsp: 0.637 ± 0.027	0.573TrpGlu: 0.573 ± 0.027	0.53TrpPhe: 0.53 ± 0.025	0.866TrpGly: 0.866 ± 0.035	0.404TrpHis: 0.404 ± 0.021	0.642TrpIle: 0.642 ± 0.026	0.504TrpLys: 0.504 ± 0.025	2.201TrpLeu: 2.201 ± 0.055	0.402TrpMet: 0.402 ± 0.022	0.397TrpAsn: 0.397 ± 0.02	0.659TrpPro: 0.659 ± 0.028	0.786TrpGln: 0.786 ± 0.031	1.121TrpArg: 1.121 ± 0.041	0.621TrpSer: 0.621 ± 0.026	0.544TrpThr: 0.544 ± 0.026	1.073TrpVal: 1.073 ± 0.033	0.244TrpTrp: 0.244 ± 0.017	0.285TrpTyr: 0.285 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.814TyrAla: 2.814 ± 0.069	0.255TyrCys: 0.255 ± 0.019	1.302TyrAsp: 1.302 ± 0.039	1.176TyrGlu: 1.176 ± 0.041	1.092TyrPhe: 1.092 ± 0.034	2.073TyrGly: 2.073 ± 0.048	0.578TyrHis: 0.578 ± 0.025	0.887TyrIle: 0.887 ± 0.031	0.721TyrLys: 0.721 ± 0.03	2.754TyrLeu: 2.754 ± 0.064	0.446TyrMet: 0.446 ± 0.02	0.664TyrAsn: 0.664 ± 0.028	1.262TyrPro: 1.262 ± 0.043	1.1TyrGln: 1.1 ± 0.034	1.905TyrArg: 1.905 ± 0.054	1.294TyrSer: 1.294 ± 0.04	1.244TyrThr: 1.244 ± 0.043	1.623TyrVal: 1.623 ± 0.044	0.375TyrTrp: 0.375 ± 0.021	0.656TyrTyr: 0.656 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.003

Statistics based on 3078 proteins (919040 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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