Amino acid dipepetide frequency for Pseudomonas phage YMC12/01/R960

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.821AlaAla: 17.821 ± 2.498
1.279AlaCys: 1.279 ± 0.379
7.333AlaAsp: 7.333 ± 0.907
8.441AlaGlu: 8.441 ± 1.031
4.008AlaPhe: 4.008 ± 0.481
9.55AlaGly: 9.55 ± 1.227
1.791AlaHis: 1.791 ± 0.366
5.969AlaIle: 5.969 ± 0.744
4.775AlaLys: 4.775 ± 0.661
11.937AlaLeu: 11.937 ± 1.12
4.093AlaMet: 4.093 ± 0.677
3.325AlaAsn: 3.325 ± 0.637
4.945AlaPro: 4.945 ± 0.809
6.48AlaGln: 6.48 ± 0.872
9.209AlaArg: 9.209 ± 1.076
7.418AlaSer: 7.418 ± 1.125
6.651AlaThr: 6.651 ± 0.715
6.992AlaVal: 6.992 ± 0.862
2.046AlaTrp: 2.046 ± 0.32
2.984AlaTyr: 2.984 ± 0.496
0.0AlaXaa: 0.0 ± 0.0
Cys
0.853CysAla: 0.853 ± 0.279
0.085CysCys: 0.085 ± 0.079
0.682CysAsp: 0.682 ± 0.208
0.682CysGlu: 0.682 ± 0.324
0.597CysPhe: 0.597 ± 0.238
0.597CysGly: 0.597 ± 0.246
0.341CysHis: 0.341 ± 0.196
0.085CysIle: 0.085 ± 0.089
0.085CysLys: 0.085 ± 0.092
0.256CysLeu: 0.256 ± 0.173
0.256CysMet: 0.256 ± 0.179
0.256CysAsn: 0.256 ± 0.136
0.682CysPro: 0.682 ± 0.26
0.085CysGln: 0.085 ± 0.1
0.853CysArg: 0.853 ± 0.327
0.512CysSer: 0.512 ± 0.218
0.426CysThr: 0.426 ± 0.218
0.341CysVal: 0.341 ± 0.195
0.171CysTrp: 0.171 ± 0.136
0.171CysTyr: 0.171 ± 0.124
0.0CysXaa: 0.0 ± 0.0
Asp
6.992AspAla: 6.992 ± 0.887
0.171AspCys: 0.171 ± 0.122
3.325AspAsp: 3.325 ± 0.59
4.008AspGlu: 4.008 ± 0.668
1.791AspPhe: 1.791 ± 0.324
6.224AspGly: 6.224 ± 0.826
1.194AspHis: 1.194 ± 0.328
2.132AspIle: 2.132 ± 0.379
1.108AspLys: 1.108 ± 0.339
5.372AspLeu: 5.372 ± 0.691
1.62AspMet: 1.62 ± 0.461
1.791AspAsn: 1.791 ± 0.324
2.643AspPro: 2.643 ± 0.492
4.008AspGln: 4.008 ± 0.821
3.581AspArg: 3.581 ± 0.471
3.496AspSer: 3.496 ± 0.472
2.899AspThr: 2.899 ± 0.441
3.922AspVal: 3.922 ± 0.685
1.279AspTrp: 1.279 ± 0.276
1.535AspTyr: 1.535 ± 0.451
0.0AspXaa: 0.0 ± 0.0
Glu
7.333GluAla: 7.333 ± 0.886
0.512GluCys: 0.512 ± 0.25
2.984GluAsp: 2.984 ± 0.731
2.643GluGlu: 2.643 ± 0.447
2.387GluPhe: 2.387 ± 0.472
3.24GluGly: 3.24 ± 0.409
0.767GluHis: 0.767 ± 0.27
2.558GluIle: 2.558 ± 0.416
2.473GluLys: 2.473 ± 0.396
6.395GluLeu: 6.395 ± 0.833
1.364GluMet: 1.364 ± 0.415
1.279GluAsn: 1.279 ± 0.356
3.155GluPro: 3.155 ± 0.547
3.325GluGln: 3.325 ± 0.532
5.286GluArg: 5.286 ± 0.732
2.643GluSer: 2.643 ± 0.419
2.729GluThr: 2.729 ± 0.456
4.178GluVal: 4.178 ± 0.598
0.853GluTrp: 0.853 ± 0.24
1.535GluTyr: 1.535 ± 0.334
0.0GluXaa: 0.0 ± 0.0
Phe
3.922PheAla: 3.922 ± 0.481
0.256PheCys: 0.256 ± 0.126
2.302PheAsp: 2.302 ± 0.384
1.535PheGlu: 1.535 ± 0.441
0.938PhePhe: 0.938 ± 0.267
2.729PheGly: 2.729 ± 0.495
0.512PheHis: 0.512 ± 0.233
1.194PheIle: 1.194 ± 0.293
1.023PheLys: 1.023 ± 0.318
1.791PheLeu: 1.791 ± 0.368
0.853PheMet: 0.853 ± 0.321
1.279PheAsn: 1.279 ± 0.361
1.364PhePro: 1.364 ± 0.46
1.45PheGln: 1.45 ± 0.313
1.961PheArg: 1.961 ± 0.429
1.279PheSer: 1.279 ± 0.379
1.791PheThr: 1.791 ± 0.42
1.45PheVal: 1.45 ± 0.301
0.426PheTrp: 0.426 ± 0.195
0.767PheTyr: 0.767 ± 0.251
0.0PheXaa: 0.0 ± 0.0
Gly
8.186GlyAla: 8.186 ± 1.266
0.426GlyCys: 0.426 ± 0.175
4.178GlyAsp: 4.178 ± 0.727
4.604GlyGlu: 4.604 ± 0.545
2.814GlyPhe: 2.814 ± 0.442
7.077GlyGly: 7.077 ± 0.829
0.767GlyHis: 0.767 ± 0.253
3.837GlyIle: 3.837 ± 0.537
2.814GlyLys: 2.814 ± 0.589
7.503GlyLeu: 7.503 ± 0.825
1.62GlyMet: 1.62 ± 0.446
1.961GlyAsn: 1.961 ± 0.389
2.814GlyPro: 2.814 ± 0.42
4.86GlyGln: 4.86 ± 0.662
6.992GlyArg: 6.992 ± 0.838
5.031GlySer: 5.031 ± 0.672
4.178GlyThr: 4.178 ± 0.489
5.286GlyVal: 5.286 ± 0.694
2.046GlyTrp: 2.046 ± 0.402
2.387GlyTyr: 2.387 ± 0.608
0.0GlyXaa: 0.0 ± 0.0
His
1.705HisAla: 1.705 ± 0.323
0.085HisCys: 0.085 ± 0.083
0.767HisAsp: 0.767 ± 0.213
0.426HisGlu: 0.426 ± 0.208
0.341HisPhe: 0.341 ± 0.211
1.023HisGly: 1.023 ± 0.282
0.341HisHis: 0.341 ± 0.259
0.682HisIle: 0.682 ± 0.238
0.341HisLys: 0.341 ± 0.17
1.876HisLeu: 1.876 ± 0.364
0.767HisMet: 0.767 ± 0.307
0.853HisAsn: 0.853 ± 0.286
1.45HisPro: 1.45 ± 0.365
0.597HisGln: 0.597 ± 0.227
1.023HisArg: 1.023 ± 0.276
0.341HisSer: 0.341 ± 0.161
0.682HisThr: 0.682 ± 0.23
0.853HisVal: 0.853 ± 0.258
0.341HisTrp: 0.341 ± 0.184
0.767HisTyr: 0.767 ± 0.254
0.0HisXaa: 0.0 ± 0.0
Ile
5.286IleAla: 5.286 ± 0.822
0.426IleCys: 0.426 ± 0.197
3.07IleAsp: 3.07 ± 0.36
2.814IleGlu: 2.814 ± 0.544
0.853IlePhe: 0.853 ± 0.247
3.155IleGly: 3.155 ± 0.495
0.767IleHis: 0.767 ± 0.241
1.194IleIle: 1.194 ± 0.275
1.364IleLys: 1.364 ± 0.341
2.473IleLeu: 2.473 ± 0.447
0.341IleMet: 0.341 ± 0.174
1.194IleAsn: 1.194 ± 0.35
1.876IlePro: 1.876 ± 0.391
2.132IleGln: 2.132 ± 0.562
3.752IleArg: 3.752 ± 0.497
2.473IleSer: 2.473 ± 0.415
2.984IleThr: 2.984 ± 0.542
2.899IleVal: 2.899 ± 0.507
0.512IleTrp: 0.512 ± 0.232
1.108IleTyr: 1.108 ± 0.347
0.0IleXaa: 0.0 ± 0.0
Lys
4.945LysAla: 4.945 ± 0.841
0.085LysCys: 0.085 ± 0.1
1.535LysAsp: 1.535 ± 0.351
1.791LysGlu: 1.791 ± 0.447
0.597LysPhe: 0.597 ± 0.213
3.155LysGly: 3.155 ± 0.443
0.512LysHis: 0.512 ± 0.206
1.023LysIle: 1.023 ± 0.366
1.535LysLys: 1.535 ± 0.407
3.325LysLeu: 3.325 ± 0.583
0.767LysMet: 0.767 ± 0.343
1.108LysAsn: 1.108 ± 0.297
2.643LysPro: 2.643 ± 0.556
1.194LysGln: 1.194 ± 0.303
2.814LysArg: 2.814 ± 0.571
2.046LysSer: 2.046 ± 0.451
2.302LysThr: 2.302 ± 0.366
2.302LysVal: 2.302 ± 0.495
0.426LysTrp: 0.426 ± 0.17
1.108LysTyr: 1.108 ± 0.258
0.0LysXaa: 0.0 ± 0.0
Leu
12.534LeuAla: 12.534 ± 1.271
0.853LeuCys: 0.853 ± 0.238
6.907LeuAsp: 6.907 ± 0.857
6.395LeuGlu: 6.395 ± 0.824
2.302LeuPhe: 2.302 ± 0.559
7.589LeuGly: 7.589 ± 0.77
1.876LeuHis: 1.876 ± 0.432
3.07LeuIle: 3.07 ± 0.538
3.752LeuLys: 3.752 ± 0.798
8.441LeuLeu: 8.441 ± 1.008
1.961LeuMet: 1.961 ± 0.461
2.899LeuAsn: 2.899 ± 0.442
4.86LeuPro: 4.86 ± 0.836
3.922LeuGln: 3.922 ± 0.739
5.969LeuArg: 5.969 ± 0.604
4.945LeuSer: 4.945 ± 0.758
5.116LeuThr: 5.116 ± 0.76
6.821LeuVal: 6.821 ± 0.855
1.364LeuTrp: 1.364 ± 0.268
2.217LeuTyr: 2.217 ± 0.471
0.0LeuXaa: 0.0 ± 0.0
Met
3.496MetAla: 3.496 ± 0.415
0.171MetCys: 0.171 ± 0.122
2.217MetAsp: 2.217 ± 0.407
1.364MetGlu: 1.364 ± 0.35
0.512MetPhe: 0.512 ± 0.198
1.62MetGly: 1.62 ± 0.358
0.341MetHis: 0.341 ± 0.17
0.426MetIle: 0.426 ± 0.18
1.108MetLys: 1.108 ± 0.283
1.45MetLeu: 1.45 ± 0.297
0.426MetMet: 0.426 ± 0.23
0.682MetAsn: 0.682 ± 0.223
1.194MetPro: 1.194 ± 0.31
1.45MetGln: 1.45 ± 0.382
1.364MetArg: 1.364 ± 0.333
1.705MetSer: 1.705 ± 0.363
1.45MetThr: 1.45 ± 0.364
1.023MetVal: 1.023 ± 0.397
0.426MetTrp: 0.426 ± 0.256
0.341MetTyr: 0.341 ± 0.175
0.0MetXaa: 0.0 ± 0.0
Asn
3.581AsnAla: 3.581 ± 0.7
0.085AsnCys: 0.085 ± 0.092
1.62AsnAsp: 1.62 ± 0.371
1.194AsnGlu: 1.194 ± 0.334
0.512AsnPhe: 0.512 ± 0.199
2.984AsnGly: 2.984 ± 0.631
0.767AsnHis: 0.767 ± 0.203
1.023AsnIle: 1.023 ± 0.289
1.279AsnLys: 1.279 ± 0.395
2.899AsnLeu: 2.899 ± 0.629
0.682AsnMet: 0.682 ± 0.227
1.876AsnAsn: 1.876 ± 0.53
2.217AsnPro: 2.217 ± 0.531
0.938AsnGln: 0.938 ± 0.278
2.984AsnArg: 2.984 ± 0.509
1.45AsnSer: 1.45 ± 0.437
1.194AsnThr: 1.194 ± 0.3
1.023AsnVal: 1.023 ± 0.278
0.597AsnTrp: 0.597 ± 0.216
1.023AsnTyr: 1.023 ± 0.289
0.0AsnXaa: 0.0 ± 0.0
Pro
6.736ProAla: 6.736 ± 0.764
0.767ProCys: 0.767 ± 0.379
3.837ProAsp: 3.837 ± 0.518
2.558ProGlu: 2.558 ± 0.438
1.535ProPhe: 1.535 ± 0.381
4.093ProGly: 4.093 ± 0.515
0.512ProHis: 0.512 ± 0.184
1.791ProIle: 1.791 ± 0.397
1.961ProLys: 1.961 ± 0.434
4.263ProLeu: 4.263 ± 0.56
0.938ProMet: 0.938 ± 0.356
1.535ProAsn: 1.535 ± 0.364
2.558ProPro: 2.558 ± 0.603
2.473ProGln: 2.473 ± 0.538
3.496ProArg: 3.496 ± 0.619
3.24ProSer: 3.24 ± 0.484
2.558ProThr: 2.558 ± 0.423
3.24ProVal: 3.24 ± 0.618
0.426ProTrp: 0.426 ± 0.196
1.705ProTyr: 1.705 ± 0.416
0.0ProXaa: 0.0 ± 0.0
Gln
6.224GlnAla: 6.224 ± 0.854
0.171GlnCys: 0.171 ± 0.126
1.791GlnAsp: 1.791 ± 0.418
1.961GlnGlu: 1.961 ± 0.517
1.364GlnPhe: 1.364 ± 0.314
4.093GlnGly: 4.093 ± 0.568
0.767GlnHis: 0.767 ± 0.253
2.387GlnIle: 2.387 ± 0.446
1.364GlnLys: 1.364 ± 0.409
6.907GlnLeu: 6.907 ± 0.58
1.108GlnMet: 1.108 ± 0.296
0.767GlnAsn: 0.767 ± 0.214
2.046GlnPro: 2.046 ± 0.376
4.178GlnGln: 4.178 ± 1.045
4.86GlnArg: 4.86 ± 0.887
2.899GlnSer: 2.899 ± 0.417
2.217GlnThr: 2.217 ± 0.435
4.604GlnVal: 4.604 ± 0.456
0.512GlnTrp: 0.512 ± 0.223
1.108GlnTyr: 1.108 ± 0.342
0.0GlnXaa: 0.0 ± 0.0
Arg
8.1ArgAla: 8.1 ± 0.997
0.512ArgCys: 0.512 ± 0.207
4.69ArgAsp: 4.69 ± 0.608
4.69ArgGlu: 4.69 ± 0.521
2.046ArgPhe: 2.046 ± 0.385
4.86ArgGly: 4.86 ± 0.693
0.938ArgHis: 0.938 ± 0.244
3.496ArgIle: 3.496 ± 0.632
2.558ArgLys: 2.558 ± 0.491
7.503ArgLeu: 7.503 ± 0.867
1.279ArgMet: 1.279 ± 0.257
2.046ArgAsn: 2.046 ± 0.421
3.752ArgPro: 3.752 ± 0.819
4.178ArgGln: 4.178 ± 0.672
5.798ArgArg: 5.798 ± 0.901
4.945ArgSer: 4.945 ± 0.597
3.411ArgThr: 3.411 ± 0.438
4.945ArgVal: 4.945 ± 0.837
1.791ArgTrp: 1.791 ± 0.407
2.558ArgTyr: 2.558 ± 0.505
0.0ArgXaa: 0.0 ± 0.0
Ser
8.186SerAla: 8.186 ± 0.899
0.597SerCys: 0.597 ± 0.247
3.581SerAsp: 3.581 ± 0.679
2.729SerGlu: 2.729 ± 0.481
1.108SerPhe: 1.108 ± 0.301
5.031SerGly: 5.031 ± 0.742
0.682SerHis: 0.682 ± 0.299
2.899SerIle: 2.899 ± 0.409
1.876SerLys: 1.876 ± 0.453
5.713SerLeu: 5.713 ± 0.698
1.108SerMet: 1.108 ± 0.372
1.961SerAsn: 1.961 ± 0.453
3.325SerPro: 3.325 ± 0.707
2.729SerGln: 2.729 ± 0.442
3.325SerArg: 3.325 ± 0.697
4.349SerSer: 4.349 ± 0.605
3.07SerThr: 3.07 ± 0.538
3.325SerVal: 3.325 ± 0.552
1.705SerTrp: 1.705 ± 0.375
1.961SerTyr: 1.961 ± 0.367
0.0SerXaa: 0.0 ± 0.0
Thr
7.077ThrAla: 7.077 ± 0.826
0.341ThrCys: 0.341 ± 0.273
2.984ThrAsp: 2.984 ± 0.463
2.643ThrGlu: 2.643 ± 0.511
1.62ThrPhe: 1.62 ± 0.338
4.434ThrGly: 4.434 ± 0.657
0.767ThrHis: 0.767 ± 0.253
2.046ThrIle: 2.046 ± 0.422
1.791ThrLys: 1.791 ± 0.498
5.116ThrLeu: 5.116 ± 0.891
0.767ThrMet: 0.767 ± 0.248
1.535ThrAsn: 1.535 ± 0.274
2.899ThrPro: 2.899 ± 0.396
1.62ThrGln: 1.62 ± 0.306
3.24ThrArg: 3.24 ± 0.555
3.581ThrSer: 3.581 ± 0.553
3.496ThrThr: 3.496 ± 0.643
6.139ThrVal: 6.139 ± 0.875
0.938ThrTrp: 0.938 ± 0.274
1.194ThrTyr: 1.194 ± 0.288
0.0ThrXaa: 0.0 ± 0.0
Val
9.209ValAla: 9.209 ± 0.788
0.597ValCys: 0.597 ± 0.218
3.155ValAsp: 3.155 ± 0.542
5.031ValGlu: 5.031 ± 0.782
1.705ValPhe: 1.705 ± 0.341
4.86ValGly: 4.86 ± 0.621
0.853ValHis: 0.853 ± 0.199
2.899ValIle: 2.899 ± 0.443
2.387ValLys: 2.387 ± 0.409
6.139ValLeu: 6.139 ± 0.723
1.45ValMet: 1.45 ± 0.424
1.791ValAsn: 1.791 ± 0.372
3.325ValPro: 3.325 ± 0.563
3.155ValGln: 3.155 ± 0.545
4.434ValArg: 4.434 ± 0.676
3.837ValSer: 3.837 ± 0.623
4.69ValThr: 4.69 ± 0.727
4.69ValVal: 4.69 ± 0.586
1.279ValTrp: 1.279 ± 0.273
2.302ValTyr: 2.302 ± 0.519
0.0ValXaa: 0.0 ± 0.0
Trp
1.535TrpAla: 1.535 ± 0.345
0.341TrpCys: 0.341 ± 0.163
0.938TrpAsp: 0.938 ± 0.273
0.597TrpGlu: 0.597 ± 0.248
0.767TrpPhe: 0.767 ± 0.223
0.767TrpGly: 0.767 ± 0.28
0.085TrpHis: 0.085 ± 0.092
0.853TrpIle: 0.853 ± 0.248
0.853TrpLys: 0.853 ± 0.25
2.046TrpLeu: 2.046 ± 0.377
0.938TrpMet: 0.938 ± 0.27
0.597TrpAsn: 0.597 ± 0.227
1.023TrpPro: 1.023 ± 0.322
1.108TrpGln: 1.108 ± 0.312
1.279TrpArg: 1.279 ± 0.34
1.194TrpSer: 1.194 ± 0.329
0.938TrpThr: 0.938 ± 0.291
1.62TrpVal: 1.62 ± 0.413
0.512TrpTrp: 0.512 ± 0.194
0.085TrpTyr: 0.085 ± 0.08
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.325TyrAla: 3.325 ± 0.413
0.341TyrCys: 0.341 ± 0.183
1.194TyrAsp: 1.194 ± 0.346
1.535TyrGlu: 1.535 ± 0.444
1.023TyrPhe: 1.023 ± 0.266
2.302TyrGly: 2.302 ± 0.519
0.682TyrHis: 0.682 ± 0.279
1.108TyrIle: 1.108 ± 0.276
0.767TyrLys: 0.767 ± 0.271
2.387TyrLeu: 2.387 ± 0.471
0.341TyrMet: 0.341 ± 0.167
1.194TyrAsn: 1.194 ± 0.287
1.45TyrPro: 1.45 ± 0.487
1.45TyrGln: 1.45 ± 0.333
1.876TyrArg: 1.876 ± 0.371
1.876TyrSer: 1.876 ± 0.377
1.45TyrThr: 1.45 ± 0.439
2.132TyrVal: 2.132 ± 0.493
0.426TyrTrp: 0.426 ± 0.243
0.512TyrTyr: 0.512 ± 0.222
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 56 proteins (11729 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski