Amino acid dipepetide frequency for Streptococcus phage Javan536

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.886AlaAla: 3.886 ± 1.089
0.086AlaCys: 0.086 ± 0.082
5.181AlaAsp: 5.181 ± 0.779
4.922AlaGlu: 4.922 ± 0.64
3.282AlaPhe: 3.282 ± 0.671
4.75AlaGly: 4.75 ± 0.855
0.691AlaHis: 0.691 ± 0.249
3.627AlaIle: 3.627 ± 0.742
6.304AlaLys: 6.304 ± 0.781
6.736AlaLeu: 6.736 ± 0.889
1.641AlaMet: 1.641 ± 0.394
3.8AlaAsn: 3.8 ± 0.673
2.073AlaPro: 2.073 ± 0.755
2.677AlaGln: 2.677 ± 0.568
3.195AlaArg: 3.195 ± 0.392
4.577AlaSer: 4.577 ± 0.738
5.354AlaThr: 5.354 ± 0.735
4.404AlaVal: 4.404 ± 0.745
1.209AlaTrp: 1.209 ± 0.31
2.073AlaTyr: 2.073 ± 0.341
0.0AlaXaa: 0.0 ± 0.0
Cys
0.259CysAla: 0.259 ± 0.136
0.0CysCys: 0.0 ± 0.0
0.604CysAsp: 0.604 ± 0.196
0.259CysGlu: 0.259 ± 0.143
0.259CysPhe: 0.259 ± 0.173
0.345CysGly: 0.345 ± 0.221
0.086CysHis: 0.086 ± 0.088
0.173CysIle: 0.173 ± 0.115
0.345CysLys: 0.345 ± 0.174
0.691CysLeu: 0.691 ± 0.287
0.0CysMet: 0.0 ± 0.0
0.173CysAsn: 0.173 ± 0.113
0.173CysPro: 0.173 ± 0.208
0.173CysGln: 0.173 ± 0.123
0.173CysArg: 0.173 ± 0.175
0.432CysSer: 0.432 ± 0.196
0.259CysThr: 0.259 ± 0.143
0.345CysVal: 0.345 ± 0.145
0.086CysTrp: 0.086 ± 0.082
0.345CysTyr: 0.345 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
3.109AspAla: 3.109 ± 0.693
0.259AspCys: 0.259 ± 0.127
3.109AspAsp: 3.109 ± 0.741
4.145AspGlu: 4.145 ± 0.637
3.368AspPhe: 3.368 ± 0.499
7.168AspGly: 7.168 ± 1.158
0.518AspHis: 0.518 ± 0.227
4.318AspIle: 4.318 ± 0.709
5.354AspLys: 5.354 ± 0.53
3.972AspLeu: 3.972 ± 0.657
2.332AspMet: 2.332 ± 0.448
3.972AspAsn: 3.972 ± 0.704
2.245AspPro: 2.245 ± 0.371
1.554AspGln: 1.554 ± 0.316
2.763AspArg: 2.763 ± 0.621
4.059AspSer: 4.059 ± 0.476
3.972AspThr: 3.972 ± 0.71
4.145AspVal: 4.145 ± 0.81
0.691AspTrp: 0.691 ± 0.237
2.591AspTyr: 2.591 ± 0.427
0.0AspXaa: 0.0 ± 0.0
Glu
3.627GluAla: 3.627 ± 0.633
0.345GluCys: 0.345 ± 0.184
3.8GluAsp: 3.8 ± 0.754
5.354GluGlu: 5.354 ± 1.142
1.727GluPhe: 1.727 ± 0.358
3.627GluGly: 3.627 ± 0.468
1.123GluHis: 1.123 ± 0.367
5.959GluIle: 5.959 ± 0.873
3.972GluLys: 3.972 ± 0.632
6.563GluLeu: 6.563 ± 0.946
1.641GluMet: 1.641 ± 0.427
4.059GluAsn: 4.059 ± 0.71
1.727GluPro: 1.727 ± 0.44
3.282GluGln: 3.282 ± 0.519
3.8GluArg: 3.8 ± 0.599
2.763GluSer: 2.763 ± 0.416
4.231GluThr: 4.231 ± 0.577
4.836GluVal: 4.836 ± 0.743
0.518GluTrp: 0.518 ± 0.271
3.109GluTyr: 3.109 ± 0.464
0.0GluXaa: 0.0 ± 0.0
Phe
3.109PheAla: 3.109 ± 0.533
0.259PheCys: 0.259 ± 0.139
3.282PheAsp: 3.282 ± 0.508
3.282PheGlu: 3.282 ± 0.679
1.813PhePhe: 1.813 ± 0.363
2.85PheGly: 2.85 ± 0.726
0.086PheHis: 0.086 ± 0.082
2.159PheIle: 2.159 ± 0.496
3.8PheLys: 3.8 ± 0.694
3.195PheLeu: 3.195 ± 0.549
0.604PheMet: 0.604 ± 0.21
3.282PheAsn: 3.282 ± 0.491
0.95PhePro: 0.95 ± 0.24
1.123PheGln: 1.123 ± 0.291
1.295PheArg: 1.295 ± 0.37
3.109PheSer: 3.109 ± 0.523
2.073PheThr: 2.073 ± 0.382
2.85PheVal: 2.85 ± 0.419
0.345PheTrp: 0.345 ± 0.151
1.295PheTyr: 1.295 ± 0.295
0.0PheXaa: 0.0 ± 0.0
Gly
3.886GlyAla: 3.886 ± 0.756
0.345GlyCys: 0.345 ± 0.169
4.663GlyAsp: 4.663 ± 0.673
3.713GlyGlu: 3.713 ± 0.518
3.195GlyPhe: 3.195 ± 0.411
5.44GlyGly: 5.44 ± 0.933
0.864GlyHis: 0.864 ± 0.31
5.095GlyIle: 5.095 ± 0.608
6.045GlyLys: 6.045 ± 0.758
6.477GlyLeu: 6.477 ± 0.657
2.245GlyMet: 2.245 ± 0.469
4.577GlyAsn: 4.577 ± 0.749
1.468GlyPro: 1.468 ± 0.597
2.936GlyGln: 2.936 ± 0.426
3.454GlyArg: 3.454 ± 0.563
3.886GlySer: 3.886 ± 0.678
4.836GlyThr: 4.836 ± 0.67
4.491GlyVal: 4.491 ± 0.722
1.382GlyTrp: 1.382 ± 0.397
2.936GlyTyr: 2.936 ± 0.413
0.0GlyXaa: 0.0 ± 0.0
His
0.864HisAla: 0.864 ± 0.285
0.086HisCys: 0.086 ± 0.099
0.518HisAsp: 0.518 ± 0.177
0.518HisGlu: 0.518 ± 0.244
0.864HisPhe: 0.864 ± 0.225
0.432HisGly: 0.432 ± 0.163
0.345HisHis: 0.345 ± 0.12
0.777HisIle: 0.777 ± 0.209
0.95HisLys: 0.95 ± 0.322
0.864HisLeu: 0.864 ± 0.179
0.518HisMet: 0.518 ± 0.189
0.95HisAsn: 0.95 ± 0.329
0.691HisPro: 0.691 ± 0.212
0.864HisGln: 0.864 ± 0.291
0.345HisArg: 0.345 ± 0.166
0.604HisSer: 0.604 ± 0.215
0.777HisThr: 0.777 ± 0.264
0.691HisVal: 0.691 ± 0.244
0.0HisTrp: 0.0 ± 0.0
0.345HisTyr: 0.345 ± 0.182
0.0HisXaa: 0.0 ± 0.0
Ile
5.181IleAla: 5.181 ± 0.738
0.432IleCys: 0.432 ± 0.221
4.318IleAsp: 4.318 ± 0.665
3.541IleGlu: 3.541 ± 0.797
1.554IlePhe: 1.554 ± 0.348
4.922IleGly: 4.922 ± 0.562
0.777IleHis: 0.777 ± 0.212
2.504IleIle: 2.504 ± 0.487
4.922IleLys: 4.922 ± 0.725
2.85IleLeu: 2.85 ± 0.53
1.295IleMet: 1.295 ± 0.43
3.627IleAsn: 3.627 ± 0.563
2.677IlePro: 2.677 ± 0.678
2.073IleGln: 2.073 ± 0.399
2.332IleArg: 2.332 ± 0.403
4.75IleSer: 4.75 ± 0.479
4.491IleThr: 4.491 ± 0.535
2.763IleVal: 2.763 ± 0.63
0.691IleTrp: 0.691 ± 0.196
1.468IleTyr: 1.468 ± 0.348
0.0IleXaa: 0.0 ± 0.0
Lys
6.39LysAla: 6.39 ± 0.822
0.173LysCys: 0.173 ± 0.142
4.318LysAsp: 4.318 ± 0.807
5.527LysGlu: 5.527 ± 0.947
2.85LysPhe: 2.85 ± 0.843
6.131LysGly: 6.131 ± 0.969
1.382LysHis: 1.382 ± 0.496
4.577LysIle: 4.577 ± 0.743
6.477LysLys: 6.477 ± 1.211
5.786LysLeu: 5.786 ± 0.888
1.9LysMet: 1.9 ± 0.425
5.095LysAsn: 5.095 ± 0.515
3.8LysPro: 3.8 ± 0.554
4.491LysGln: 4.491 ± 0.811
2.936LysArg: 2.936 ± 0.653
4.231LysSer: 4.231 ± 0.773
5.613LysThr: 5.613 ± 0.849
4.404LysVal: 4.404 ± 0.732
1.209LysTrp: 1.209 ± 0.269
2.85LysTyr: 2.85 ± 0.475
0.0LysXaa: 0.0 ± 0.0
Leu
5.872LeuAla: 5.872 ± 0.9
0.518LeuCys: 0.518 ± 0.217
5.613LeuAsp: 5.613 ± 0.625
5.527LeuGlu: 5.527 ± 0.753
2.763LeuPhe: 2.763 ± 0.418
4.75LeuGly: 4.75 ± 1.018
0.518LeuHis: 0.518 ± 0.205
3.886LeuIle: 3.886 ± 0.606
7.081LeuLys: 7.081 ± 0.581
5.613LeuLeu: 5.613 ± 0.676
2.245LeuMet: 2.245 ± 0.425
6.39LeuAsn: 6.39 ± 0.734
3.022LeuPro: 3.022 ± 0.487
2.936LeuGln: 2.936 ± 0.541
2.504LeuArg: 2.504 ± 0.611
5.44LeuSer: 5.44 ± 0.876
5.613LeuThr: 5.613 ± 0.616
4.491LeuVal: 4.491 ± 0.494
0.604LeuTrp: 0.604 ± 0.231
2.073LeuTyr: 2.073 ± 0.456
0.0LeuXaa: 0.0 ± 0.0
Met
2.245MetAla: 2.245 ± 0.461
0.173MetCys: 0.173 ± 0.166
1.036MetAsp: 1.036 ± 0.363
1.209MetGlu: 1.209 ± 0.297
1.295MetPhe: 1.295 ± 0.326
1.209MetGly: 1.209 ± 0.342
0.259MetHis: 0.259 ± 0.163
1.554MetIle: 1.554 ± 0.414
2.504MetLys: 2.504 ± 0.52
1.382MetLeu: 1.382 ± 0.359
0.259MetMet: 0.259 ± 0.126
0.691MetAsn: 0.691 ± 0.214
0.95MetPro: 0.95 ± 0.203
0.864MetGln: 0.864 ± 0.241
0.777MetArg: 0.777 ± 0.259
1.554MetSer: 1.554 ± 0.287
2.332MetThr: 2.332 ± 0.57
1.813MetVal: 1.813 ± 0.311
0.259MetTrp: 0.259 ± 0.137
1.036MetTyr: 1.036 ± 0.309
0.0MetXaa: 0.0 ± 0.0
Asn
5.354AsnAla: 5.354 ± 0.868
0.518AsnCys: 0.518 ± 0.232
2.936AsnAsp: 2.936 ± 0.449
2.763AsnGlu: 2.763 ± 0.674
2.332AsnPhe: 2.332 ± 0.411
7.081AsnGly: 7.081 ± 1.03
0.691AsnHis: 0.691 ± 0.207
3.282AsnIle: 3.282 ± 0.531
2.936AsnLys: 2.936 ± 0.515
5.268AsnLeu: 5.268 ± 0.656
1.295AsnMet: 1.295 ± 0.434
3.886AsnAsn: 3.886 ± 0.66
4.059AsnPro: 4.059 ± 0.595
2.936AsnGln: 2.936 ± 0.602
1.986AsnArg: 1.986 ± 0.445
4.404AsnSer: 4.404 ± 0.676
4.404AsnThr: 4.404 ± 0.61
4.404AsnVal: 4.404 ± 0.534
0.864AsnTrp: 0.864 ± 0.247
2.591AsnTyr: 2.591 ± 0.527
0.0AsnXaa: 0.0 ± 0.0
Pro
2.245ProAla: 2.245 ± 0.405
0.0ProCys: 0.0 ± 0.0
1.554ProAsp: 1.554 ± 0.392
2.936ProGlu: 2.936 ± 0.894
1.468ProPhe: 1.468 ± 0.329
1.641ProGly: 1.641 ± 0.586
0.345ProHis: 0.345 ± 0.146
1.295ProIle: 1.295 ± 0.353
2.936ProLys: 2.936 ± 0.457
2.763ProLeu: 2.763 ± 0.434
0.518ProMet: 0.518 ± 0.192
2.936ProAsn: 2.936 ± 0.429
0.95ProPro: 0.95 ± 0.339
1.641ProGln: 1.641 ± 0.421
0.777ProArg: 0.777 ± 0.23
2.418ProSer: 2.418 ± 0.513
3.627ProThr: 3.627 ± 0.659
2.763ProVal: 2.763 ± 0.839
0.173ProTrp: 0.173 ± 0.102
1.9ProTyr: 1.9 ± 0.479
0.0ProXaa: 0.0 ± 0.0
Gln
4.059GlnAla: 4.059 ± 0.678
0.173GlnCys: 0.173 ± 0.121
2.936GlnAsp: 2.936 ± 0.477
3.195GlnGlu: 3.195 ± 0.86
0.691GlnPhe: 0.691 ± 0.209
3.627GlnGly: 3.627 ± 0.922
0.604GlnHis: 0.604 ± 0.177
2.332GlnIle: 2.332 ± 0.512
3.368GlnLys: 3.368 ± 0.663
3.109GlnLeu: 3.109 ± 0.582
1.209GlnMet: 1.209 ± 0.361
3.109GlnAsn: 3.109 ± 0.476
1.209GlnPro: 1.209 ± 0.411
2.504GlnGln: 2.504 ± 0.567
1.727GlnArg: 1.727 ± 0.288
2.504GlnSer: 2.504 ± 0.309
2.677GlnThr: 2.677 ± 0.409
2.245GlnVal: 2.245 ± 0.388
0.777GlnTrp: 0.777 ± 0.314
1.986GlnTyr: 1.986 ± 0.372
0.0GlnXaa: 0.0 ± 0.0
Arg
1.986ArgAla: 1.986 ± 0.413
0.086ArgCys: 0.086 ± 0.088
2.418ArgAsp: 2.418 ± 0.516
2.677ArgGlu: 2.677 ± 0.475
2.504ArgPhe: 2.504 ± 0.441
2.073ArgGly: 2.073 ± 0.643
0.518ArgHis: 0.518 ± 0.184
2.504ArgIle: 2.504 ± 0.579
3.972ArgLys: 3.972 ± 0.94
3.368ArgLeu: 3.368 ± 0.519
0.864ArgMet: 0.864 ± 0.255
2.332ArgAsn: 2.332 ± 0.421
1.036ArgPro: 1.036 ± 0.247
1.813ArgGln: 1.813 ± 0.479
0.95ArgArg: 0.95 ± 0.311
1.813ArgSer: 1.813 ± 0.336
2.85ArgThr: 2.85 ± 0.528
2.073ArgVal: 2.073 ± 0.434
0.864ArgTrp: 0.864 ± 0.238
2.073ArgTyr: 2.073 ± 0.443
0.0ArgXaa: 0.0 ± 0.0
Ser
3.972SerAla: 3.972 ± 0.678
0.345SerCys: 0.345 ± 0.175
4.318SerAsp: 4.318 ± 0.819
4.318SerGlu: 4.318 ± 0.52
2.591SerPhe: 2.591 ± 0.586
4.145SerGly: 4.145 ± 0.621
0.345SerHis: 0.345 ± 0.146
3.454SerIle: 3.454 ± 0.689
5.354SerLys: 5.354 ± 0.51
4.231SerLeu: 4.231 ± 0.601
1.727SerMet: 1.727 ± 0.344
5.095SerAsn: 5.095 ± 0.582
2.159SerPro: 2.159 ± 0.343
3.368SerGln: 3.368 ± 0.71
2.504SerArg: 2.504 ± 0.405
3.627SerSer: 3.627 ± 0.631
4.663SerThr: 4.663 ± 0.755
4.491SerVal: 4.491 ± 0.867
0.864SerTrp: 0.864 ± 0.292
2.504SerTyr: 2.504 ± 0.652
0.0SerXaa: 0.0 ± 0.0
Thr
5.354ThrAla: 5.354 ± 0.865
0.173ThrCys: 0.173 ± 0.11
5.009ThrAsp: 5.009 ± 0.776
4.404ThrGlu: 4.404 ± 0.609
2.936ThrPhe: 2.936 ± 0.579
4.75ThrGly: 4.75 ± 1.033
0.777ThrHis: 0.777 ± 0.249
3.713ThrIle: 3.713 ± 0.658
4.663ThrLys: 4.663 ± 0.53
6.304ThrLeu: 6.304 ± 0.846
0.864ThrMet: 0.864 ± 0.308
4.922ThrAsn: 4.922 ± 0.905
2.85ThrPro: 2.85 ± 0.915
3.627ThrGln: 3.627 ± 0.537
2.332ThrArg: 2.332 ± 0.533
4.231ThrSer: 4.231 ± 0.544
4.318ThrThr: 4.318 ± 0.961
5.44ThrVal: 5.44 ± 0.853
1.9ThrTrp: 1.9 ± 0.318
2.418ThrTyr: 2.418 ± 0.743
0.0ThrXaa: 0.0 ± 0.0
Val
5.699ValAla: 5.699 ± 0.798
0.604ValCys: 0.604 ± 0.309
5.009ValAsp: 5.009 ± 0.713
4.577ValGlu: 4.577 ± 0.658
2.418ValPhe: 2.418 ± 0.413
4.059ValGly: 4.059 ± 0.442
0.864ValHis: 0.864 ± 0.316
3.195ValIle: 3.195 ± 0.558
5.786ValLys: 5.786 ± 0.716
4.059ValLeu: 4.059 ± 0.529
1.295ValMet: 1.295 ± 0.359
2.763ValAsn: 2.763 ± 0.584
1.9ValPro: 1.9 ± 0.488
2.159ValGln: 2.159 ± 0.462
2.504ValArg: 2.504 ± 0.476
5.527ValSer: 5.527 ± 0.683
4.75ValThr: 4.75 ± 1.139
3.8ValVal: 3.8 ± 0.695
0.777ValTrp: 0.777 ± 0.217
2.159ValTyr: 2.159 ± 0.432
0.0ValXaa: 0.0 ± 0.0
Trp
0.777TrpAla: 0.777 ± 0.184
0.086TrpCys: 0.086 ± 0.09
0.95TrpAsp: 0.95 ± 0.526
0.777TrpGlu: 0.777 ± 0.241
0.691TrpPhe: 0.691 ± 0.229
0.604TrpGly: 0.604 ± 0.154
0.518TrpHis: 0.518 ± 0.197
0.604TrpIle: 0.604 ± 0.165
0.777TrpLys: 0.777 ± 0.236
1.295TrpLeu: 1.295 ± 0.294
0.173TrpMet: 0.173 ± 0.113
0.518TrpAsn: 0.518 ± 0.256
0.0TrpPro: 0.0 ± 0.0
0.691TrpGln: 0.691 ± 0.21
0.604TrpArg: 0.604 ± 0.184
1.468TrpSer: 1.468 ± 0.247
1.727TrpThr: 1.727 ± 0.53
0.864TrpVal: 0.864 ± 0.269
0.345TrpTrp: 0.345 ± 0.173
0.345TrpTyr: 0.345 ± 0.213
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.591TyrAla: 2.591 ± 0.589
0.518TyrCys: 0.518 ± 0.272
2.073TyrAsp: 2.073 ± 0.345
2.418TyrGlu: 2.418 ± 0.497
2.159TyrPhe: 2.159 ± 0.324
2.332TyrGly: 2.332 ± 0.416
0.691TyrHis: 0.691 ± 0.238
2.245TyrIle: 2.245 ± 0.472
2.591TyrLys: 2.591 ± 0.375
2.936TyrLeu: 2.936 ± 0.444
0.691TyrMet: 0.691 ± 0.233
1.813TyrAsn: 1.813 ± 0.34
0.95TyrPro: 0.95 ± 0.331
2.332TyrGln: 2.332 ± 0.493
1.813TyrArg: 1.813 ± 0.357
2.677TyrSer: 2.677 ± 0.57
2.418TyrThr: 2.418 ± 0.513
2.591TyrVal: 2.591 ± 0.577
0.259TyrTrp: 0.259 ± 0.136
1.209TyrTyr: 1.209 ± 0.398
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 43 proteins (11581 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski