Amino acid dipepetide frequency for Leptospira weilii str. Ecochallenge

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.726AlaAla: 3.726 ± 0.082
0.569AlaCys: 0.569 ± 0.023
2.814AlaAsp: 2.814 ± 0.056
3.985AlaGlu: 3.985 ± 0.062
2.842AlaPhe: 2.842 ± 0.054
4.408AlaGly: 4.408 ± 0.073
0.88AlaHis: 0.88 ± 0.027
4.458AlaIle: 4.458 ± 0.069
4.02AlaLys: 4.02 ± 0.065
5.797AlaLeu: 5.797 ± 0.078
1.204AlaMet: 1.204 ± 0.035
2.522AlaAsn: 2.522 ± 0.054
1.75AlaPro: 1.75 ± 0.043
1.594AlaGln: 1.594 ± 0.043
2.579AlaArg: 2.579 ± 0.05
4.084AlaSer: 4.084 ± 0.078
2.549AlaThr: 2.549 ± 0.053
3.663AlaVal: 3.663 ± 0.072
0.596AlaTrp: 0.596 ± 0.023
1.876AlaTyr: 1.876 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.457CysAla: 0.457 ± 0.022
0.091CysCys: 0.091 ± 0.01
0.402CysAsp: 0.402 ± 0.019
0.509CysGlu: 0.509 ± 0.02
0.577CysPhe: 0.577 ± 0.024
0.754CysGly: 0.754 ± 0.027
0.188CysHis: 0.188 ± 0.015
0.669CysIle: 0.669 ± 0.025
0.654CysLys: 0.654 ± 0.023
0.854CysLeu: 0.854 ± 0.027
0.185CysMet: 0.185 ± 0.014
0.404CysAsn: 0.404 ± 0.019
0.365CysPro: 0.365 ± 0.019
0.219CysGln: 0.219 ± 0.014
0.397CysArg: 0.397 ± 0.022
0.7CysSer: 0.7 ± 0.027
0.383CysThr: 0.383 ± 0.018
0.531CysVal: 0.531 ± 0.02
0.093CysTrp: 0.093 ± 0.01
0.351CysTyr: 0.351 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
2.489AspAla: 2.489 ± 0.048
0.449AspCys: 0.449 ± 0.019
1.79AspAsp: 1.79 ± 0.048
2.896AspGlu: 2.896 ± 0.061
3.287AspPhe: 3.287 ± 0.051
2.969AspGly: 2.969 ± 0.056
0.903AspHis: 0.903 ± 0.027
3.194AspIle: 3.194 ± 0.055
3.061AspLys: 3.061 ± 0.047
5.982AspLeu: 5.982 ± 0.077
0.893AspMet: 0.893 ± 0.028
1.591AspAsn: 1.591 ± 0.048
2.567AspPro: 2.567 ± 0.049
1.606AspGln: 1.606 ± 0.039
2.799AspArg: 2.799 ± 0.046
4.1AspSer: 4.1 ± 0.067
2.111AspThr: 2.111 ± 0.047
2.451AspVal: 2.451 ± 0.047
0.643AspTrp: 0.643 ± 0.023
1.835AspTyr: 1.835 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
3.876GluAla: 3.876 ± 0.07
0.47GluCys: 0.47 ± 0.023
3.259GluAsp: 3.259 ± 0.073
6.24GluGlu: 6.24 ± 0.105
3.753GluPhe: 3.753 ± 0.064
3.805GluGly: 3.805 ± 0.063
0.913GluHis: 0.913 ± 0.027
6.682GluIle: 6.682 ± 0.077
7.122GluLys: 7.122 ± 0.094
6.636GluLeu: 6.636 ± 0.081
1.569GluMet: 1.569 ± 0.038
4.139GluAsn: 4.139 ± 0.068
1.815GluPro: 1.815 ± 0.051
1.839GluGln: 1.839 ± 0.039
3.54GluArg: 3.54 ± 0.061
4.929GluSer: 4.929 ± 0.071
3.854GluThr: 3.854 ± 0.062
3.907GluVal: 3.907 ± 0.063
0.826GluTrp: 0.826 ± 0.029
2.406GluTyr: 2.406 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.086PheAla: 3.086 ± 0.065
0.754PheCys: 0.754 ± 0.027
2.471PheAsp: 2.471 ± 0.046
3.405PheGlu: 3.405 ± 0.067
3.786PhePhe: 3.786 ± 0.079
3.755PheGly: 3.755 ± 0.058
1.258PheHis: 1.258 ± 0.038
3.351PheIle: 3.351 ± 0.063
3.042PheLys: 3.042 ± 0.057
7.289PheLeu: 7.289 ± 0.113
1.106PheMet: 1.106 ± 0.032
1.966PheAsn: 1.966 ± 0.045
2.771PhePro: 2.771 ± 0.058
2.574PheGln: 2.574 ± 0.047
3.273PheArg: 3.273 ± 0.059
4.954PheSer: 4.954 ± 0.081
2.707PheThr: 2.707 ± 0.05
3.134PheVal: 3.134 ± 0.052
0.807PheTrp: 0.807 ± 0.033
2.412PheTyr: 2.412 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
3.824GlyAla: 3.824 ± 0.081
0.596GlyCys: 0.596 ± 0.025
2.983GlyAsp: 2.983 ± 0.065
4.123GlyGlu: 4.123 ± 0.065
3.952GlyPhe: 3.952 ± 0.069
4.353GlyGly: 4.353 ± 0.085
1.088GlyHis: 1.088 ± 0.026
6.274GlyIle: 6.274 ± 0.085
5.919GlyLys: 5.919 ± 0.072
5.92GlyLeu: 5.92 ± 0.086
1.594GlyMet: 1.594 ± 0.037
3.456GlyAsn: 3.456 ± 0.07
1.695GlyPro: 1.695 ± 0.042
1.693GlyGln: 1.693 ± 0.04
2.798GlyArg: 2.798 ± 0.054
4.554GlySer: 4.554 ± 0.078
3.549GlyThr: 3.549 ± 0.065
4.008GlyVal: 4.008 ± 0.061
0.701GlyTrp: 0.701 ± 0.03
2.494GlyTyr: 2.494 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
0.798HisAla: 0.798 ± 0.028
0.212HisCys: 0.212 ± 0.015
0.661HisAsp: 0.661 ± 0.025
0.897HisGlu: 0.897 ± 0.031
1.154HisPhe: 1.154 ± 0.034
1.088HisGly: 1.088 ± 0.037
0.39HisHis: 0.39 ± 0.019
1.143HisIle: 1.143 ± 0.031
1.108HisLys: 1.108 ± 0.032
1.815HisLeu: 1.815 ± 0.047
0.283HisMet: 0.283 ± 0.016
0.668HisAsn: 0.668 ± 0.025
1.097HisPro: 1.097 ± 0.035
0.457HisGln: 0.457 ± 0.021
0.889HisArg: 0.889 ± 0.024
1.56HisSer: 1.56 ± 0.038
0.874HisThr: 0.874 ± 0.029
0.81HisVal: 0.81 ± 0.028
0.265HisTrp: 0.265 ± 0.017
0.666HisTyr: 0.666 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
4.69IleAla: 4.69 ± 0.077
0.78IleCys: 0.78 ± 0.027
3.426IleAsp: 3.426 ± 0.048
4.878IleGlu: 4.878 ± 0.073
4.313IlePhe: 4.313 ± 0.078
5.083IleGly: 5.083 ± 0.073
1.632IleHis: 1.632 ± 0.048
3.877IleIle: 3.877 ± 0.065
3.838IleLys: 3.838 ± 0.053
10.309IleLeu: 10.309 ± 0.109
1.078IleMet: 1.078 ± 0.03
2.515IleAsn: 2.515 ± 0.047
4.071IlePro: 4.071 ± 0.066
3.398IleGln: 3.398 ± 0.055
4.905IleArg: 4.905 ± 0.074
6.411IleSer: 6.411 ± 0.084
3.477IleThr: 3.477 ± 0.061
4.555IleVal: 4.555 ± 0.066
0.76IleTrp: 0.76 ± 0.028
2.671IleTyr: 2.671 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.029LysAla: 4.029 ± 0.072
0.343LysCys: 0.343 ± 0.018
4.09LysAsp: 4.09 ± 0.063
7.161LysGlu: 7.161 ± 0.09
3.301LysPhe: 3.301 ± 0.061
4.144LysGly: 4.144 ± 0.065
1.083LysHis: 1.083 ± 0.034
7.01LysIle: 7.01 ± 0.09
7.371LysLys: 7.371 ± 0.114
6.44LysLeu: 6.44 ± 0.085
1.666LysMet: 1.666 ± 0.037
5.023LysAsn: 5.023 ± 0.085
2.494LysPro: 2.494 ± 0.044
2.17LysGln: 2.17 ± 0.045
3.786LysArg: 3.786 ± 0.067
5.15LysSer: 5.15 ± 0.066
4.402LysThr: 4.402 ± 0.06
4.124LysVal: 4.124 ± 0.06
0.585LysTrp: 0.585 ± 0.025
2.355LysTyr: 2.355 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
5.786LeuAla: 5.786 ± 0.096
0.982LeuCys: 0.982 ± 0.033
5.043LeuAsp: 5.043 ± 0.074
7.713LeuGlu: 7.713 ± 0.096
6.106LeuPhe: 6.106 ± 0.101
6.676LeuGly: 6.676 ± 0.094
1.611LeuHis: 1.611 ± 0.034
7.385LeuIle: 7.385 ± 0.093
8.971LeuLys: 8.971 ± 0.103
9.736LeuLeu: 9.736 ± 0.129
1.88LeuMet: 1.88 ± 0.042
5.133LeuAsn: 5.133 ± 0.079
4.3LeuPro: 4.3 ± 0.069
3.354LeuGln: 3.354 ± 0.078
4.861LeuArg: 4.861 ± 0.078
8.746LeuSer: 8.746 ± 0.101
4.914LeuThr: 4.914 ± 0.078
5.485LeuVal: 5.485 ± 0.082
0.967LeuTrp: 0.967 ± 0.029
3.453LeuTyr: 3.453 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
1.246MetAla: 1.246 ± 0.034
0.125MetCys: 0.125 ± 0.012
1.2MetAsp: 1.2 ± 0.034
1.662MetGlu: 1.662 ± 0.038
0.857MetPhe: 0.857 ± 0.027
1.422MetGly: 1.422 ± 0.038
0.245MetHis: 0.245 ± 0.017
1.794MetIle: 1.794 ± 0.04
1.917MetLys: 1.917 ± 0.039
1.541MetLeu: 1.541 ± 0.039
0.412MetMet: 0.412 ± 0.019
1.254MetAsn: 1.254 ± 0.033
0.664MetPro: 0.664 ± 0.022
0.589MetGln: 0.589 ± 0.027
1.01MetArg: 1.01 ± 0.029
1.361MetSer: 1.361 ± 0.036
0.997MetThr: 0.997 ± 0.032
1.095MetVal: 1.095 ± 0.032
0.12MetTrp: 0.12 ± 0.012
0.443MetTyr: 0.443 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
2.653AsnAla: 2.653 ± 0.061
0.496AsnCys: 0.496 ± 0.023
1.874AsnAsp: 1.874 ± 0.046
2.749AsnGlu: 2.749 ± 0.055
2.794AsnPhe: 2.794 ± 0.056
3.219AsnGly: 3.219 ± 0.058
0.969AsnHis: 0.969 ± 0.029
3.031AsnIle: 3.031 ± 0.062
2.511AsnLys: 2.511 ± 0.046
5.822AsnLeu: 5.822 ± 0.092
0.819AsnMet: 0.819 ± 0.026
1.642AsnAsn: 1.642 ± 0.045
2.818AsnPro: 2.818 ± 0.049
2.073AsnGln: 2.073 ± 0.055
2.91AsnArg: 2.91 ± 0.053
4.109AsnSer: 4.109 ± 0.069
2.264AsnThr: 2.264 ± 0.053
2.712AsnVal: 2.712 ± 0.055
0.615AsnTrp: 0.615 ± 0.022
1.721AsnTyr: 1.721 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
2.112ProAla: 2.112 ± 0.041
0.231ProCys: 0.231 ± 0.013
2.428ProAsp: 2.428 ± 0.055
3.762ProGlu: 3.762 ± 0.062
2.3ProPhe: 2.3 ± 0.043
2.96ProGly: 2.96 ± 0.058
0.63ProHis: 0.63 ± 0.025
3.119ProIle: 3.119 ± 0.058
2.911ProLys: 2.911 ± 0.056
3.358ProLeu: 3.358 ± 0.062
0.825ProMet: 0.825 ± 0.027
2.071ProAsn: 2.071 ± 0.043
1.366ProPro: 1.366 ± 0.045
1.035ProGln: 1.035 ± 0.035
1.329ProArg: 1.329 ± 0.037
2.866ProSer: 2.866 ± 0.042
1.89ProThr: 1.89 ± 0.046
2.669ProVal: 2.669 ± 0.049
0.435ProTrp: 0.435 ± 0.02
1.329ProTyr: 1.329 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
1.85GlnAla: 1.85 ± 0.049
0.217GlnCys: 0.217 ± 0.014
1.582GlnAsp: 1.582 ± 0.038
2.516GlnGlu: 2.516 ± 0.052
1.581GlnPhe: 1.581 ± 0.045
1.884GlnGly: 1.884 ± 0.04
0.345GlnHis: 0.345 ± 0.02
2.954GlnIle: 2.954 ± 0.057
3.298GlnLys: 3.298 ± 0.062
2.555GlnLeu: 2.555 ± 0.056
0.673GlnMet: 0.673 ± 0.026
2.138GlnAsn: 2.138 ± 0.047
0.861GlnPro: 0.861 ± 0.032
0.676GlnGln: 0.676 ± 0.024
1.393GlnArg: 1.393 ± 0.035
2.232GlnSer: 2.232 ± 0.052
1.904GlnThr: 1.904 ± 0.046
1.794GlnVal: 1.794 ± 0.04
0.302GlnTrp: 0.302 ± 0.019
1.004GlnTyr: 1.004 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.417ArgAla: 2.417 ± 0.048
0.364ArgCys: 0.364 ± 0.02
2.287ArgAsp: 2.287 ± 0.05
3.782ArgGlu: 3.782 ± 0.06
3.155ArgPhe: 3.155 ± 0.06
2.548ArgGly: 2.548 ± 0.049
0.731ArgHis: 0.731 ± 0.027
4.961ArgIle: 4.961 ± 0.074
4.915ArgLys: 4.915 ± 0.074
4.486ArgLeu: 4.486 ± 0.073
1.302ArgMet: 1.302 ± 0.033
2.929ArgAsn: 2.929 ± 0.053
1.535ArgPro: 1.535 ± 0.038
1.286ArgGln: 1.286 ± 0.038
2.211ArgArg: 2.211 ± 0.055
3.401ArgSer: 3.401 ± 0.057
2.509ArgThr: 2.509 ± 0.047
2.646ArgVal: 2.646 ± 0.047
0.56ArgTrp: 0.56 ± 0.025
1.859ArgTyr: 1.859 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
4.379SerAla: 4.379 ± 0.062
0.685SerCys: 0.685 ± 0.025
3.702SerAsp: 3.702 ± 0.074
5.526SerGlu: 5.526 ± 0.08
4.87SerPhe: 4.87 ± 0.077
6.018SerGly: 6.018 ± 0.087
1.209SerHis: 1.209 ± 0.034
5.784SerIle: 5.784 ± 0.079
5.668SerLys: 5.668 ± 0.072
8.215SerLeu: 8.215 ± 0.098
1.596SerMet: 1.596 ± 0.043
3.343SerAsn: 3.343 ± 0.072
3.092SerPro: 3.092 ± 0.059
2.349SerGln: 2.349 ± 0.047
3.574SerArg: 3.574 ± 0.062
6.279SerSer: 6.279 ± 0.101
3.192SerThr: 3.192 ± 0.057
4.713SerVal: 4.713 ± 0.075
0.87SerTrp: 0.87 ± 0.031
2.764SerTyr: 2.764 ± 0.054
0.0SerXaa: 0.0 ± 0.0
Thr
2.84ThrAla: 2.84 ± 0.061
0.39ThrCys: 0.39 ± 0.02
2.56ThrAsp: 2.56 ± 0.048
3.174ThrGlu: 3.174 ± 0.054
2.707ThrPhe: 2.707 ± 0.054
3.93ThrGly: 3.93 ± 0.067
0.885ThrHis: 0.885 ± 0.029
3.872ThrIle: 3.872 ± 0.064
3.176ThrLys: 3.176 ± 0.059
5.118ThrLeu: 5.118 ± 0.073
0.878ThrMet: 0.878 ± 0.03
2.272ThrAsn: 2.272 ± 0.058
2.179ThrPro: 2.179 ± 0.049
1.457ThrGln: 1.457 ± 0.038
2.18ThrArg: 2.18 ± 0.045
3.593ThrSer: 3.593 ± 0.064
2.485ThrThr: 2.485 ± 0.067
3.169ThrVal: 3.169 ± 0.06
0.582ThrTrp: 0.582 ± 0.029
1.587ThrTyr: 1.587 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
3.319ValAla: 3.319 ± 0.063
0.567ValCys: 0.567 ± 0.026
2.687ValAsp: 2.687 ± 0.056
3.637ValGlu: 3.637 ± 0.055
3.647ValPhe: 3.647 ± 0.064
3.64ValGly: 3.64 ± 0.069
0.976ValHis: 0.976 ± 0.029
3.961ValIle: 3.961 ± 0.073
3.638ValLys: 3.638 ± 0.069
6.454ValLeu: 6.454 ± 0.085
1.148ValMet: 1.148 ± 0.034
2.37ValAsn: 2.37 ± 0.052
2.36ValPro: 2.36 ± 0.042
1.839ValGln: 1.839 ± 0.04
3.041ValArg: 3.041 ± 0.05
5.044ValSer: 5.044 ± 0.068
2.814ValThr: 2.814 ± 0.065
3.614ValVal: 3.614 ± 0.065
0.651ValTrp: 0.651 ± 0.023
1.995ValTyr: 1.995 ± 0.047
0.0ValXaa: 0.0 ± 0.0
Trp
0.509TrpAla: 0.509 ± 0.022
0.094TrpCys: 0.094 ± 0.009
0.567TrpAsp: 0.567 ± 0.024
0.767TrpGlu: 0.767 ± 0.028
0.565TrpPhe: 0.565 ± 0.028
0.685TrpGly: 0.685 ± 0.025
0.166TrpHis: 0.166 ± 0.012
1.132TrpIle: 1.132 ± 0.039
1.247TrpLys: 1.247 ± 0.039
0.905TrpLeu: 0.905 ± 0.032
0.263TrpMet: 0.263 ± 0.015
0.81TrpAsn: 0.81 ± 0.025
0.282TrpPro: 0.282 ± 0.018
0.256TrpGln: 0.256 ± 0.015
0.451TrpArg: 0.451 ± 0.023
0.697TrpSer: 0.697 ± 0.029
0.521TrpThr: 0.521 ± 0.025
0.597TrpVal: 0.597 ± 0.026
0.14TrpTrp: 0.14 ± 0.013
0.293TrpTyr: 0.293 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.829TyrAla: 1.829 ± 0.046
0.368TyrCys: 0.368 ± 0.02
1.791TyrAsp: 1.791 ± 0.045
2.198TyrGlu: 2.198 ± 0.051
2.354TyrPhe: 2.354 ± 0.052
2.233TyrGly: 2.233 ± 0.041
0.732TyrHis: 0.732 ± 0.028
2.016TyrIle: 2.016 ± 0.046
2.338TyrLys: 2.338 ± 0.05
3.87TyrLeu: 3.87 ± 0.066
0.581TyrMet: 0.581 ± 0.021
1.554TyrAsn: 1.554 ± 0.047
1.547TyrPro: 1.547 ± 0.038
1.296TyrGln: 1.296 ± 0.037
1.957TyrArg: 1.957 ± 0.044
3.058TyrSer: 3.058 ± 0.056
1.639TyrThr: 1.639 ± 0.041
1.725TyrVal: 1.725 ± 0.043
0.43TyrTrp: 0.43 ± 0.021
1.554TyrTyr: 1.554 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4702 proteins (1108066 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski