Amino acid dipepetide frequency for Actibacterium mucosum KCTC 23349

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.926AlaAla: 16.926 ± 0.18	1.005AlaCys: 1.005 ± 0.032	7.614AlaAsp: 7.614 ± 0.094	8.45AlaGlu: 8.45 ± 0.113	4.553AlaPhe: 4.553 ± 0.067	10.577AlaGly: 10.577 ± 0.115	2.266AlaHis: 2.266 ± 0.047	6.105AlaIle: 6.105 ± 0.074	3.977AlaLys: 3.977 ± 0.079	13.729AlaLeu: 13.729 ± 0.136	3.928AlaMet: 3.928 ± 0.064	3.104AlaAsn: 3.104 ± 0.055	5.903AlaPro: 5.903 ± 0.105	4.834AlaGln: 4.834 ± 0.079	8.179AlaArg: 8.179 ± 0.103	5.164AlaSer: 5.164 ± 0.071	6.258AlaThr: 6.258 ± 0.085	8.47AlaVal: 8.47 ± 0.092	1.427AlaTrp: 1.427 ± 0.033	2.534AlaTyr: 2.534 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.064CysAla: 1.064 ± 0.029	0.092CysCys: 0.092 ± 0.009	0.643CysAsp: 0.643 ± 0.025	0.396CysGlu: 0.396 ± 0.019	0.357CysPhe: 0.357 ± 0.018	0.865CysGly: 0.865 ± 0.031	0.273CysHis: 0.273 ± 0.017	0.41CysIle: 0.41 ± 0.02	0.199CysLys: 0.199 ± 0.012	0.792CysLeu: 0.792 ± 0.027	0.163CysMet: 0.163 ± 0.013	0.237CysAsn: 0.237 ± 0.015	0.482CysPro: 0.482 ± 0.023	0.228CysGln: 0.228 ± 0.015	0.483CysArg: 0.483 ± 0.023	0.434CysSer: 0.434 ± 0.02	0.419CysThr: 0.419 ± 0.017	0.615CysVal: 0.615 ± 0.024	0.105CysTrp: 0.105 ± 0.009	0.185CysTyr: 0.185 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.674AspAla: 7.674 ± 0.105	0.476AspCys: 0.476 ± 0.021	3.664AspAsp: 3.664 ± 0.074	3.629AspGlu: 3.629 ± 0.067	2.348AspPhe: 2.348 ± 0.046	5.885AspGly: 5.885 ± 0.089	1.448AspHis: 1.448 ± 0.036	3.22AspIle: 3.22 ± 0.063	1.79AspLys: 1.79 ± 0.04	6.449AspLeu: 6.449 ± 0.092	1.811AspMet: 1.811 ± 0.042	1.527AspAsn: 1.527 ± 0.041	3.633AspPro: 3.633 ± 0.056	2.105AspGln: 2.105 ± 0.048	4.003AspArg: 4.003 ± 0.062	2.098AspSer: 2.098 ± 0.047	3.283AspThr: 3.283 ± 0.062	4.581AspVal: 4.581 ± 0.071	1.102AspTrp: 1.102 ± 0.03	1.491AspTyr: 1.491 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	7.536GluAla: 7.536 ± 0.117	0.373GluCys: 0.373 ± 0.018	3.156GluAsp: 3.156 ± 0.055	3.096GluGlu: 3.096 ± 0.082	2.007GluPhe: 2.007 ± 0.041	4.621GluGly: 4.621 ± 0.066	1.072GluHis: 1.072 ± 0.027	3.409GluIle: 3.409 ± 0.057	2.042GluLys: 2.042 ± 0.058	5.195GluLeu: 5.195 ± 0.078	1.828GluMet: 1.828 ± 0.038	1.9GluAsn: 1.9 ± 0.038	2.468GluPro: 2.468 ± 0.056	1.893GluGln: 1.893 ± 0.047	3.652GluArg: 3.652 ± 0.065	1.947GluSer: 1.947 ± 0.045	3.776GluThr: 3.776 ± 0.057	4.246GluVal: 4.246 ± 0.068	0.718GluTrp: 0.718 ± 0.028	1.031GluTyr: 1.031 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.95PheAla: 4.95 ± 0.08	0.449PheCys: 0.449 ± 0.018	3.111PheAsp: 3.111 ± 0.053	2.254PheGlu: 2.254 ± 0.044	1.584PhePhe: 1.584 ± 0.044	3.948PheGly: 3.948 ± 0.064	0.757PheHis: 0.757 ± 0.026	1.626PheIle: 1.626 ± 0.041	0.942PheLys: 0.942 ± 0.027	3.749PheLeu: 3.749 ± 0.076	0.884PheMet: 0.884 ± 0.026	1.158PheAsn: 1.158 ± 0.035	1.557PhePro: 1.557 ± 0.037	1.114PheGln: 1.114 ± 0.031	2.13PheArg: 2.13 ± 0.049	2.113PheSer: 2.113 ± 0.052	2.16PheThr: 2.16 ± 0.039	2.968PheVal: 2.968 ± 0.051	0.622PheTrp: 0.622 ± 0.025	1.03PheTyr: 1.03 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	10.182GlyAla: 10.182 ± 0.109	0.808GlyCys: 0.808 ± 0.028	5.085GlyAsp: 5.085 ± 0.083	4.422GlyGlu: 4.422 ± 0.073	3.908GlyPhe: 3.908 ± 0.062	7.362GlyGly: 7.362 ± 0.129	1.953GlyHis: 1.953 ± 0.048	4.452GlyIle: 4.452 ± 0.065	3.186GlyLys: 3.186 ± 0.062	9.157GlyLeu: 9.157 ± 0.103	2.577GlyMet: 2.577 ± 0.05	2.338GlyAsn: 2.338 ± 0.054	3.711GlyPro: 3.711 ± 0.06	3.443GlyGln: 3.443 ± 0.07	5.34GlyArg: 5.34 ± 0.081	3.99GlySer: 3.99 ± 0.063	4.771GlyThr: 4.771 ± 0.072	6.664GlyVal: 6.664 ± 0.086	1.467GlyTrp: 1.467 ± 0.043	2.267GlyTyr: 2.267 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.38HisAla: 2.38 ± 0.048	0.239HisCys: 0.239 ± 0.015	1.289HisAsp: 1.289 ± 0.039	1.003HisGlu: 1.003 ± 0.026	0.836HisPhe: 0.836 ± 0.029	1.926HisGly: 1.926 ± 0.049	0.561HisHis: 0.561 ± 0.025	0.985HisIle: 0.985 ± 0.032	0.56HisLys: 0.56 ± 0.023	2.104HisLeu: 2.104 ± 0.041	0.573HisMet: 0.573 ± 0.023	0.536HisAsn: 0.536 ± 0.021	1.404HisPro: 1.404 ± 0.037	0.614HisGln: 0.614 ± 0.023	1.246HisArg: 1.246 ± 0.035	0.967HisSer: 0.967 ± 0.032	0.853HisThr: 0.853 ± 0.029	1.569HisVal: 1.569 ± 0.035	0.35HisTrp: 0.35 ± 0.016	0.553HisTyr: 0.553 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.834IleAla: 6.834 ± 0.083	0.611IleCys: 0.611 ± 0.022	3.493IleAsp: 3.493 ± 0.06	3.354IleGlu: 3.354 ± 0.057	1.85IlePhe: 1.85 ± 0.044	4.823IleGly: 4.823 ± 0.075	0.936IleHis: 0.936 ± 0.027	2.194IleIle: 2.194 ± 0.046	1.365IleLys: 1.365 ± 0.034	4.785IleLeu: 4.785 ± 0.071	1.064IleMet: 1.064 ± 0.031	1.495IleAsn: 1.495 ± 0.038	2.331IlePro: 2.331 ± 0.052	1.256IleGln: 1.256 ± 0.032	3.042IleArg: 3.042 ± 0.048	2.917IleSer: 2.917 ± 0.057	2.983IleThr: 2.983 ± 0.064	3.731IleVal: 3.731 ± 0.062	0.706IleTrp: 0.706 ± 0.026	1.166IleTyr: 1.166 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	3.913LysAla: 3.913 ± 0.075	0.176LysCys: 0.176 ± 0.012	1.756LysAsp: 1.756 ± 0.045	1.462LysGlu: 1.462 ± 0.04	0.989LysPhe: 0.989 ± 0.032	2.698LysGly: 2.698 ± 0.053	0.624LysHis: 0.624 ± 0.026	1.638LysIle: 1.638 ± 0.041	1.103LysLys: 1.103 ± 0.039	3.154LysLeu: 3.154 ± 0.061	0.864LysMet: 0.864 ± 0.026	0.819LysAsn: 0.819 ± 0.031	1.891LysPro: 1.891 ± 0.043	0.915LysGln: 0.915 ± 0.029	2.072LysArg: 2.072 ± 0.045	1.892LysSer: 1.892 ± 0.044	1.975LysThr: 1.975 ± 0.041	2.405LysVal: 2.405 ± 0.044	0.44LysTrp: 0.44 ± 0.019	0.642LysTyr: 0.642 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.709LeuAla: 12.709 ± 0.135	0.941LeuCys: 0.941 ± 0.029	6.001LeuAsp: 6.001 ± 0.078	4.871LeuGlu: 4.871 ± 0.076	3.724LeuPhe: 3.724 ± 0.071	8.405LeuGly: 8.405 ± 0.084	1.942LeuHis: 1.942 ± 0.046	5.273LeuIle: 5.273 ± 0.086	3.238LeuLys: 3.238 ± 0.062	8.898LeuLeu: 8.898 ± 0.128	2.645LeuMet: 2.645 ± 0.049	3.123LeuAsn: 3.123 ± 0.053	5.529LeuPro: 5.529 ± 0.072	3.301LeuGln: 3.301 ± 0.068	6.817LeuArg: 6.817 ± 0.083	6.799LeuSer: 6.799 ± 0.082	6.013LeuThr: 6.013 ± 0.085	6.818LeuVal: 6.818 ± 0.087	1.269LeuTrp: 1.269 ± 0.033	1.839LeuTyr: 1.839 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	3.72MetAla: 3.72 ± 0.065	0.194MetCys: 0.194 ± 0.012	1.507MetAsp: 1.507 ± 0.036	1.246MetGlu: 1.246 ± 0.031	0.966MetPhe: 0.966 ± 0.03	2.25MetGly: 2.25 ± 0.048	0.471MetHis: 0.471 ± 0.02	1.464MetIle: 1.464 ± 0.04	0.993MetLys: 0.993 ± 0.032	2.629MetLeu: 2.629 ± 0.053	0.763MetMet: 0.763 ± 0.026	0.897MetAsn: 0.897 ± 0.025	1.529MetPro: 1.529 ± 0.039	1.083MetGln: 1.083 ± 0.031	1.839MetArg: 1.839 ± 0.048	1.715MetSer: 1.715 ± 0.039	1.983MetThr: 1.983 ± 0.04	1.999MetVal: 1.999 ± 0.039	0.277MetTrp: 0.277 ± 0.018	0.336MetTyr: 0.336 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.619AsnAla: 3.619 ± 0.063	0.271AsnCys: 0.271 ± 0.014	1.677AsnAsp: 1.677 ± 0.042	1.256AsnGlu: 1.256 ± 0.036	1.078AsnPhe: 1.078 ± 0.032	2.733AsnGly: 2.733 ± 0.061	0.582AsnHis: 0.582 ± 0.023	1.414AsnIle: 1.414 ± 0.035	0.771AsnLys: 0.771 ± 0.025	2.801AsnLeu: 2.801 ± 0.049	0.774AsnMet: 0.774 ± 0.024	0.799AsnAsn: 0.799 ± 0.032	1.969AsnPro: 1.969 ± 0.042	0.856AsnGln: 0.856 ± 0.028	1.867AsnArg: 1.867 ± 0.043	1.295AsnSer: 1.295 ± 0.036	1.497AsnThr: 1.497 ± 0.04	2.016AsnVal: 2.016 ± 0.05	0.522AsnTrp: 0.522 ± 0.021	0.726AsnTyr: 0.726 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.762ProAla: 5.762 ± 0.101	0.335ProCys: 0.335 ± 0.018	4.019ProAsp: 4.019 ± 0.072	3.858ProGlu: 3.858 ± 0.065	2.045ProPhe: 2.045 ± 0.035	4.413ProGly: 4.413 ± 0.064	1.082ProHis: 1.082 ± 0.028	2.174ProIle: 2.174 ± 0.04	1.666ProLys: 1.666 ± 0.037	4.616ProLeu: 4.616 ± 0.066	1.307ProMet: 1.307 ± 0.033	1.524ProAsn: 1.524 ± 0.04	2.154ProPro: 2.154 ± 0.056	1.789ProGln: 1.789 ± 0.042	2.663ProArg: 2.663 ± 0.052	2.468ProSer: 2.468 ± 0.041	2.567ProThr: 2.567 ± 0.052	4.378ProVal: 4.378 ± 0.065	0.644ProTrp: 0.644 ± 0.025	1.106ProTyr: 1.106 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.412GlnAla: 4.412 ± 0.073	0.205GlnCys: 0.205 ± 0.013	1.763GlnAsp: 1.763 ± 0.043	1.456GlnGlu: 1.456 ± 0.04	1.237GlnPhe: 1.237 ± 0.038	2.724GlnGly: 2.724 ± 0.056	0.616GlnHis: 0.616 ± 0.026	2.174GlnIle: 2.174 ± 0.049	1.152GlnLys: 1.152 ± 0.029	3.132GlnLeu: 3.132 ± 0.058	1.176GlnMet: 1.176 ± 0.033	1.096GlnAsn: 1.096 ± 0.032	1.763GlnPro: 1.763 ± 0.047	1.204GlnGln: 1.204 ± 0.039	2.213GlnArg: 2.213 ± 0.049	1.918GlnSer: 1.918 ± 0.045	2.031GlnThr: 2.031 ± 0.044	2.818GlnVal: 2.818 ± 0.056	0.409GlnTrp: 0.409 ± 0.02	0.619GlnTyr: 0.619 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.926ArgAla: 7.926 ± 0.094	0.418ArgCys: 0.418 ± 0.018	4.147ArgAsp: 4.147 ± 0.065	3.394ArgGlu: 3.394 ± 0.064	2.652ArgPhe: 2.652 ± 0.045	4.47ArgGly: 4.47 ± 0.07	1.447ArgHis: 1.447 ± 0.037	3.434ArgIle: 3.434 ± 0.055	2.193ArgLys: 2.193 ± 0.044	6.636ArgLeu: 6.636 ± 0.074	1.813ArgMet: 1.813 ± 0.036	1.901ArgAsn: 1.901 ± 0.047	3.028ArgPro: 3.028 ± 0.059	2.196ArgGln: 2.196 ± 0.043	4.439ArgArg: 4.439 ± 0.08	2.98ArgSer: 2.98 ± 0.056	2.745ArgThr: 2.745 ± 0.048	4.864ArgVal: 4.864 ± 0.08	0.84ArgTrp: 0.84 ± 0.03	1.363ArgTyr: 1.363 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	5.65SerAla: 5.65 ± 0.081	0.394SerCys: 0.394 ± 0.018	3.228SerAsp: 3.228 ± 0.051	2.565SerGlu: 2.565 ± 0.048	2.289SerPhe: 2.289 ± 0.052	5.197SerGly: 5.197 ± 0.074	1.101SerHis: 1.101 ± 0.034	2.446SerIle: 2.446 ± 0.045	1.516SerLys: 1.516 ± 0.042	4.699SerLeu: 4.699 ± 0.07	1.309SerMet: 1.309 ± 0.036	1.46SerAsn: 1.46 ± 0.037	2.449SerPro: 2.449 ± 0.044	1.601SerGln: 1.601 ± 0.04	3.017SerArg: 3.017 ± 0.052	2.353SerSer: 2.353 ± 0.049	2.631SerThr: 2.631 ± 0.051	3.781SerVal: 3.781 ± 0.067	0.669SerTrp: 0.669 ± 0.024	1.238SerTyr: 1.238 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	6.474ThrAla: 6.474 ± 0.089	0.477ThrCys: 0.477 ± 0.022	3.28ThrAsp: 3.28 ± 0.058	2.953ThrGlu: 2.953 ± 0.049	2.065ThrPhe: 2.065 ± 0.043	5.444ThrGly: 5.444 ± 0.083	1.185ThrHis: 1.185 ± 0.035	2.769ThrIle: 2.769 ± 0.051	1.637ThrLys: 1.637 ± 0.039	6.098ThrLeu: 6.098 ± 0.073	1.385ThrMet: 1.385 ± 0.038	1.384ThrAsn: 1.384 ± 0.041	3.452ThrPro: 3.452 ± 0.059	1.797ThrGln: 1.797 ± 0.046	3.536ThrArg: 3.536 ± 0.059	2.501ThrSer: 2.501 ± 0.048	2.851ThrThr: 2.851 ± 0.057	4.144ThrVal: 4.144 ± 0.06	0.69ThrTrp: 0.69 ± 0.022	1.286ThrTyr: 1.286 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	9.282ValAla: 9.282 ± 0.099	0.604ValCys: 0.604 ± 0.023	4.415ValAsp: 4.415 ± 0.072	4.539ValGlu: 4.539 ± 0.079	3.1ValPhe: 3.1 ± 0.051	5.648ValGly: 5.648 ± 0.076	1.361ValHis: 1.361 ± 0.037	4.212ValIle: 4.212 ± 0.069	2.109ValLys: 2.109 ± 0.048	7.796ValLeu: 7.796 ± 0.093	2.133ValMet: 2.133 ± 0.045	2.136ValAsn: 2.136 ± 0.045	3.529ValPro: 3.529 ± 0.061	2.488ValGln: 2.488 ± 0.05	3.883ValArg: 3.883 ± 0.063	4.218ValSer: 4.218 ± 0.06	4.755ValThr: 4.755 ± 0.067	5.99ValVal: 5.99 ± 0.088	0.959ValTrp: 0.959 ± 0.03	1.488ValTyr: 1.488 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.469TrpAla: 1.469 ± 0.036	0.13TrpCys: 0.13 ± 0.011	0.801TrpAsp: 0.801 ± 0.028	0.588TrpGlu: 0.588 ± 0.025	0.571TrpPhe: 0.571 ± 0.026	1.001TrpGly: 1.001 ± 0.032	0.349TrpHis: 0.349 ± 0.021	0.661TrpIle: 0.661 ± 0.024	0.383TrpLys: 0.383 ± 0.019	1.536TrpLeu: 1.536 ± 0.038	0.409TrpMet: 0.409 ± 0.023	0.471TrpAsn: 0.471 ± 0.023	0.716TrpPro: 0.716 ± 0.028	0.645TrpGln: 0.645 ± 0.023	1.062TrpArg: 1.062 ± 0.031	0.74TrpSer: 0.74 ± 0.028	0.752TrpThr: 0.752 ± 0.028	0.992TrpVal: 0.992 ± 0.033	0.214TrpTrp: 0.214 ± 0.015	0.28TrpTyr: 0.28 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.519TyrAla: 2.519 ± 0.05	0.244TyrCys: 0.244 ± 0.014	1.568TyrAsp: 1.568 ± 0.044	1.172TyrGlu: 1.172 ± 0.034	0.948TyrPhe: 0.948 ± 0.031	2.093TyrGly: 2.093 ± 0.046	0.52TyrHis: 0.52 ± 0.024	0.876TyrIle: 0.876 ± 0.028	0.608TyrLys: 0.608 ± 0.025	2.203TyrLeu: 2.203 ± 0.052	0.455TyrMet: 0.455 ± 0.021	0.619TyrAsn: 0.619 ± 0.025	1.073TyrPro: 1.073 ± 0.032	0.753TyrGln: 0.753 ± 0.023	1.403TyrArg: 1.403 ± 0.039	1.087TyrSer: 1.087 ± 0.03	1.103TyrThr: 1.103 ± 0.034	1.597TyrVal: 1.597 ± 0.044	0.338TyrTrp: 0.338 ± 0.017	0.557TyrTyr: 0.557 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3616 proteins (1123337 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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