Amino acid dipepetide frequency for Leucoagaricus sp. SymC.cos

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.93AlaAla: 6.93 ± 0.055	0.998AlaCys: 0.998 ± 0.015	3.576AlaAsp: 3.576 ± 0.03	4.36AlaGlu: 4.36 ± 0.035	3.157AlaPhe: 3.157 ± 0.027	4.859AlaGly: 4.859 ± 0.037	1.877AlaHis: 1.877 ± 0.02	4.151AlaIle: 4.151 ± 0.028	3.715AlaLys: 3.715 ± 0.031	7.494AlaLeu: 7.494 ± 0.044	1.715AlaMet: 1.715 ± 0.019	2.825AlaAsn: 2.825 ± 0.027	4.381AlaPro: 4.381 ± 0.041	3.152AlaGln: 3.152 ± 0.026	4.319AlaArg: 4.319 ± 0.031	6.854AlaSer: 6.854 ± 0.047	4.822AlaThr: 4.822 ± 0.035	4.801AlaVal: 4.801 ± 0.029	1.041AlaTrp: 1.041 ± 0.013	2.056AlaTyr: 2.056 ± 0.02	0.003AlaXaa: 0.003 ± 0.001
Cys	0.87CysAla: 0.87 ± 0.014	0.271CysCys: 0.271 ± 0.008	0.624CysAsp: 0.624 ± 0.012	0.576CysGlu: 0.576 ± 0.011	0.551CysPhe: 0.551 ± 0.011	0.871CysGly: 0.871 ± 0.015	0.414CysHis: 0.414 ± 0.009	0.767CysIle: 0.767 ± 0.013	0.568CysLys: 0.568 ± 0.011	1.365CysLeu: 1.365 ± 0.017	0.275CysMet: 0.275 ± 0.007	0.462CysAsn: 0.462 ± 0.009	0.764CysPro: 0.764 ± 0.015	0.474CysGln: 0.474 ± 0.011	0.704CysArg: 0.704 ± 0.014	0.993CysSer: 0.993 ± 0.014	0.701CysThr: 0.701 ± 0.013	0.807CysVal: 0.807 ± 0.013	0.257CysTrp: 0.257 ± 0.008	0.366CysTyr: 0.366 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.111AspAla: 4.111 ± 0.031	0.588AspCys: 0.588 ± 0.012	3.938AspAsp: 3.938 ± 0.042	4.156AspGlu: 4.156 ± 0.041	2.242AspPhe: 2.242 ± 0.022	3.642AspGly: 3.642 ± 0.029	1.269AspHis: 1.269 ± 0.016	3.194AspIle: 3.194 ± 0.027	2.32AspLys: 2.32 ± 0.02	5.058AspLeu: 5.058 ± 0.036	1.116AspMet: 1.116 ± 0.013	1.948AspAsn: 1.948 ± 0.02	3.394AspPro: 3.394 ± 0.026	1.733AspGln: 1.733 ± 0.021	2.708AspArg: 2.708 ± 0.027	4.034AspSer: 4.034 ± 0.036	2.83AspThr: 2.83 ± 0.022	3.836AspVal: 3.836 ± 0.032	0.879AspTrp: 0.879 ± 0.014	1.548AspTyr: 1.548 ± 0.019	0.001AspXaa: 0.001 ± 0.001
Glu	4.648GluAla: 4.648 ± 0.037	0.649GluCys: 0.649 ± 0.011	3.855GluAsp: 3.855 ± 0.036	5.351GluGlu: 5.351 ± 0.055	1.994GluPhe: 1.994 ± 0.022	3.647GluGly: 3.647 ± 0.029	1.359GluHis: 1.359 ± 0.016	3.173GluIle: 3.173 ± 0.028	3.524GluLys: 3.524 ± 0.035	5.361GluLeu: 5.361 ± 0.04	1.363GluMet: 1.363 ± 0.016	2.211GluAsn: 2.211 ± 0.021	2.627GluPro: 2.627 ± 0.027	2.132GluGln: 2.132 ± 0.023	3.893GluArg: 3.893 ± 0.034	3.886GluSer: 3.886 ± 0.026	3.049GluThr: 3.049 ± 0.025	3.722GluVal: 3.722 ± 0.033	0.946GluTrp: 0.946 ± 0.014	1.653GluTyr: 1.653 ± 0.019	0.001GluXaa: 0.001 ± 0.001
Phe	2.905PheAla: 2.905 ± 0.022	0.567PheCys: 0.567 ± 0.011	2.34PheAsp: 2.34 ± 0.022	2.116PheGlu: 2.116 ± 0.023	1.785PhePhe: 1.785 ± 0.023	2.86PheGly: 2.86 ± 0.027	1.029PheHis: 1.029 ± 0.013	2.131PheIle: 2.131 ± 0.022	1.681PheLys: 1.681 ± 0.019	3.765PheLeu: 3.765 ± 0.033	0.801PheMet: 0.801 ± 0.012	1.578PheAsn: 1.578 ± 0.019	2.128PhePro: 2.128 ± 0.022	1.359PheGln: 1.359 ± 0.017	1.981PheArg: 1.981 ± 0.021	3.381PheSer: 3.381 ± 0.03	2.29PheThr: 2.29 ± 0.022	2.607PheVal: 2.607 ± 0.025	0.63PheTrp: 0.63 ± 0.013	1.161PheTyr: 1.161 ± 0.015	0.001PheXaa: 0.001 ± 0.001
Gly	4.569GlyAla: 4.569 ± 0.031	0.867GlyCys: 0.867 ± 0.013	3.272GlyAsp: 3.272 ± 0.027	3.369GlyGlu: 3.369 ± 0.033	2.657GlyPhe: 2.657 ± 0.027	5.409GlyGly: 5.409 ± 0.062	1.675GlyHis: 1.675 ± 0.02	3.432GlyIle: 3.432 ± 0.031	3.42GlyLys: 3.42 ± 0.026	5.744GlyLeu: 5.744 ± 0.039	1.422GlyMet: 1.422 ± 0.019	2.42GlyAsn: 2.42 ± 0.027	3.111GlyPro: 3.111 ± 0.027	2.275GlyGln: 2.275 ± 0.019	3.726GlyArg: 3.726 ± 0.031	5.439GlySer: 5.439 ± 0.04	3.895GlyThr: 3.895 ± 0.03	4.276GlyVal: 4.276 ± 0.032	1.043GlyTrp: 1.043 ± 0.017	1.934GlyTyr: 1.934 ± 0.021	0.003GlyXaa: 0.003 ± 0.001
His	1.845HisAla: 1.845 ± 0.018	0.379HisCys: 0.379 ± 0.009	1.351HisAsp: 1.351 ± 0.014	1.299HisGlu: 1.299 ± 0.014	1.027HisPhe: 1.027 ± 0.014	1.624HisGly: 1.624 ± 0.02	0.924HisHis: 0.924 ± 0.016	1.52HisIle: 1.52 ± 0.016	1.008HisLys: 1.008 ± 0.013	2.599HisLeu: 2.599 ± 0.023	0.474HisMet: 0.474 ± 0.011	0.943HisAsn: 0.943 ± 0.015	1.959HisPro: 1.959 ± 0.019	1.036HisGln: 1.036 ± 0.015	1.487HisArg: 1.487 ± 0.018	2.197HisSer: 2.197 ± 0.022	1.484HisThr: 1.484 ± 0.018	1.594HisVal: 1.594 ± 0.018	0.367HisTrp: 0.367 ± 0.008	0.741HisTyr: 0.741 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.077IleAla: 4.077 ± 0.031	0.844IleCys: 0.844 ± 0.012	3.008IleAsp: 3.008 ± 0.022	2.766IleGlu: 2.766 ± 0.025	2.169IlePhe: 2.169 ± 0.023	3.162IleGly: 3.162 ± 0.027	1.459IleHis: 1.459 ± 0.015	2.887IleIle: 2.887 ± 0.026	2.316IleLys: 2.316 ± 0.024	5.16IleLeu: 5.16 ± 0.038	1.043IleMet: 1.043 ± 0.013	1.996IleAsn: 1.996 ± 0.019	3.533IlePro: 3.533 ± 0.028	2.055IleGln: 2.055 ± 0.02	2.934IleArg: 2.934 ± 0.028	4.269IleSer: 4.269 ± 0.034	3.132IleThr: 3.132 ± 0.026	3.493IleVal: 3.493 ± 0.027	0.824IleTrp: 0.824 ± 0.015	1.496IleTyr: 1.496 ± 0.018	0.001IleXaa: 0.001 ± 0.0
Lys	4.064LysAla: 4.064 ± 0.031	0.574LysCys: 0.574 ± 0.01	2.696LysAsp: 2.696 ± 0.023	3.464LysGlu: 3.464 ± 0.036	1.56LysPhe: 1.56 ± 0.017	2.961LysGly: 2.961 ± 0.027	1.204LysHis: 1.204 ± 0.016	2.459LysIle: 2.459 ± 0.024	3.254LysLys: 3.254 ± 0.038	4.314LysLeu: 4.314 ± 0.029	0.956LysMet: 0.956 ± 0.013	1.798LysAsn: 1.798 ± 0.017	2.739LysPro: 2.739 ± 0.027	1.748LysGln: 1.748 ± 0.017	3.365LysArg: 3.365 ± 0.031	3.572LysSer: 3.572 ± 0.031	2.739LysThr: 2.739 ± 0.025	2.893LysVal: 2.893 ± 0.025	0.743LysTrp: 0.743 ± 0.013	1.405LysTyr: 1.405 ± 0.016	0.001LysXaa: 0.001 ± 0.0
Leu	7.493LeuAla: 7.493 ± 0.044	1.268LeuCys: 1.268 ± 0.016	5.245LeuAsp: 5.245 ± 0.033	5.582LeuGlu: 5.582 ± 0.042	3.588LeuPhe: 3.588 ± 0.029	5.508LeuGly: 5.508 ± 0.036	2.55LeuHis: 2.55 ± 0.025	4.517LeuIle: 4.517 ± 0.032	4.647LeuLys: 4.647 ± 0.034	8.905LeuLeu: 8.905 ± 0.053	1.767LeuMet: 1.767 ± 0.017	3.566LeuAsn: 3.566 ± 0.026	6.165LeuPro: 6.165 ± 0.035	3.776LeuGln: 3.776 ± 0.029	5.779LeuArg: 5.779 ± 0.035	8.057LeuSer: 8.057 ± 0.044	5.396LeuThr: 5.396 ± 0.032	5.974LeuVal: 5.974 ± 0.042	1.25LeuTrp: 1.25 ± 0.017	2.428LeuTyr: 2.428 ± 0.023	0.002LeuXaa: 0.002 ± 0.001
Met	1.711MetAla: 1.711 ± 0.018	0.256MetCys: 0.256 ± 0.007	1.175MetAsp: 1.175 ± 0.016	1.221MetGlu: 1.221 ± 0.016	0.761MetPhe: 0.761 ± 0.014	1.255MetGly: 1.255 ± 0.018	0.506MetHis: 0.506 ± 0.008	1.064MetIle: 1.064 ± 0.014	1.082MetLys: 1.082 ± 0.013	1.829MetLeu: 1.829 ± 0.018	0.525MetMet: 0.525 ± 0.01	0.809MetAsn: 0.809 ± 0.013	1.191MetPro: 1.191 ± 0.016	0.764MetGln: 0.764 ± 0.012	1.194MetArg: 1.194 ± 0.016	1.758MetSer: 1.758 ± 0.017	1.311MetThr: 1.311 ± 0.017	1.213MetVal: 1.213 ± 0.016	0.286MetTrp: 0.286 ± 0.008	0.511MetTyr: 0.511 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.079AsnAla: 3.079 ± 0.025	0.461AsnCys: 0.461 ± 0.01	2.002AsnAsp: 2.002 ± 0.021	1.941AsnGlu: 1.941 ± 0.018	1.469AsnPhe: 1.469 ± 0.018	2.802AsnGly: 2.802 ± 0.032	0.939AsnHis: 0.939 ± 0.014	2.191AsnIle: 2.191 ± 0.023	1.639AsnLys: 1.639 ± 0.018	3.55AsnLeu: 3.55 ± 0.028	0.817AsnMet: 0.817 ± 0.012	1.55AsnAsn: 1.55 ± 0.022	2.672AsnPro: 2.672 ± 0.024	1.362AsnGln: 1.362 ± 0.018	1.886AsnArg: 1.886 ± 0.02	2.976AsnSer: 2.976 ± 0.03	2.341AsnThr: 2.341 ± 0.021	2.645AsnVal: 2.645 ± 0.026	0.558AsnTrp: 0.558 ± 0.01	1.026AsnTyr: 1.026 ± 0.015	0.001AsnXaa: 0.001 ± 0.001
Pro	4.488ProAla: 4.488 ± 0.043	0.553ProCys: 0.553 ± 0.011	3.168ProAsp: 3.168 ± 0.028	3.69ProGlu: 3.69 ± 0.028	2.398ProPhe: 2.398 ± 0.022	3.719ProGly: 3.719 ± 0.033	1.63ProHis: 1.63 ± 0.017	2.894ProIle: 2.894 ± 0.026	2.679ProLys: 2.679 ± 0.025	5.339ProLeu: 5.339 ± 0.041	1.029ProMet: 1.029 ± 0.015	2.49ProAsn: 2.49 ± 0.023	6.247ProPro: 6.247 ± 0.081	2.587ProGln: 2.587 ± 0.032	3.346ProArg: 3.346 ± 0.034	6.97ProSer: 6.97 ± 0.056	4.481ProThr: 4.481 ± 0.034	3.672ProVal: 3.672 ± 0.032	0.737ProTrp: 0.737 ± 0.011	1.636ProTyr: 1.636 ± 0.02	0.002ProXaa: 0.002 ± 0.0
Gln	3.161GlnAla: 3.161 ± 0.03	0.5GlnCys: 0.5 ± 0.011	1.94GlnAsp: 1.94 ± 0.02	2.292GlnGlu: 2.292 ± 0.023	1.387GlnPhe: 1.387 ± 0.018	2.163GlnGly: 2.163 ± 0.02	1.054GlnHis: 1.054 ± 0.017	1.899GlnIle: 1.899 ± 0.02	1.855GlnLys: 1.855 ± 0.02	3.573GlnLeu: 3.573 ± 0.028	0.801GlnMet: 0.801 ± 0.013	1.548GlnAsn: 1.548 ± 0.019	2.429GlnPro: 2.429 ± 0.031	2.115GlnGln: 2.115 ± 0.037	2.401GlnArg: 2.401 ± 0.026	2.955GlnSer: 2.955 ± 0.027	2.327GlnThr: 2.327 ± 0.023	2.318GlnVal: 2.318 ± 0.023	0.55GlnTrp: 0.55 ± 0.011	1.115GlnTyr: 1.115 ± 0.016	0.001GlnXaa: 0.001 ± 0.0
Arg	4.272ArgAla: 4.272 ± 0.031	0.733ArgCys: 0.733 ± 0.013	3.055ArgAsp: 3.055 ± 0.026	3.673ArgGlu: 3.673 ± 0.033	2.159ArgPhe: 2.159 ± 0.017	3.371ArgGly: 3.371 ± 0.028	1.473ArgHis: 1.473 ± 0.021	3.088ArgIle: 3.088 ± 0.024	3.371ArgLys: 3.371 ± 0.026	5.45ArgLeu: 5.45 ± 0.036	1.222ArgMet: 1.222 ± 0.014	2.231ArgAsn: 2.231 ± 0.025	3.441ArgPro: 3.441 ± 0.03	2.252ArgGln: 2.252 ± 0.022	4.593ArgArg: 4.593 ± 0.037	4.751ArgSer: 4.751 ± 0.037	3.246ArgThr: 3.246 ± 0.026	3.543ArgVal: 3.543 ± 0.027	0.93ArgTrp: 0.93 ± 0.014	1.638ArgTyr: 1.638 ± 0.019	0.003ArgXaa: 0.003 ± 0.001
Ser	6.341SerAla: 6.341 ± 0.036	0.934SerCys: 0.934 ± 0.016	4.266SerAsp: 4.266 ± 0.031	4.043SerGlu: 4.043 ± 0.033	3.279SerPhe: 3.279 ± 0.024	5.533SerGly: 5.533 ± 0.037	2.219SerHis: 2.219 ± 0.022	4.239SerIle: 4.239 ± 0.03	3.605SerLys: 3.605 ± 0.028	7.932SerLeu: 7.932 ± 0.043	1.664SerMet: 1.664 ± 0.017	3.171SerAsn: 3.171 ± 0.028	6.161SerPro: 6.161 ± 0.053	3.392SerGln: 3.392 ± 0.03	5.043SerArg: 5.043 ± 0.039	9.857SerSer: 9.857 ± 0.086	6.216SerThr: 6.216 ± 0.043	4.913SerVal: 4.913 ± 0.032	1.089SerTrp: 1.089 ± 0.016	2.063SerTyr: 2.063 ± 0.023	0.003SerXaa: 0.003 ± 0.001
Thr	4.624ThrAla: 4.624 ± 0.032	0.777ThrCys: 0.777 ± 0.012	2.661ThrAsp: 2.661 ± 0.023	2.87ThrGlu: 2.87 ± 0.025	2.483ThrPhe: 2.483 ± 0.025	3.949ThrGly: 3.949 ± 0.026	1.477ThrHis: 1.477 ± 0.016	3.331ThrIle: 3.331 ± 0.029	2.662ThrLys: 2.662 ± 0.024	5.785ThrLeu: 5.785 ± 0.039	1.155ThrMet: 1.155 ± 0.016	2.22ThrAsn: 2.22 ± 0.02	4.689ThrPro: 4.689 ± 0.04	2.172ThrGln: 2.172 ± 0.021	3.301ThrArg: 3.301 ± 0.029	6.0ThrSer: 6.0 ± 0.046	4.504ThrThr: 4.504 ± 0.041	3.767ThrVal: 3.767 ± 0.027	0.849ThrTrp: 0.849 ± 0.012	1.607ThrTyr: 1.607 ± 0.017	0.002ThrXaa: 0.002 ± 0.001
Val	4.85ValAla: 4.85 ± 0.034	0.867ValCys: 0.867 ± 0.013	3.782ValAsp: 3.782 ± 0.031	3.863ValGlu: 3.863 ± 0.031	2.605ValPhe: 2.605 ± 0.023	3.888ValGly: 3.888 ± 0.029	1.629ValHis: 1.629 ± 0.019	3.387ValIle: 3.387 ± 0.026	3.14ValLys: 3.14 ± 0.029	6.089ValLeu: 6.089 ± 0.035	1.332ValMet: 1.332 ± 0.017	2.403ValAsn: 2.403 ± 0.024	3.897ValPro: 3.897 ± 0.032	2.423ValGln: 2.423 ± 0.019	3.342ValArg: 3.342 ± 0.025	4.823ValSer: 4.823 ± 0.037	3.577ValThr: 3.577 ± 0.029	4.544ValVal: 4.544 ± 0.035	0.941ValTrp: 0.941 ± 0.016	1.778ValTyr: 1.778 ± 0.02	0.001ValXaa: 0.001 ± 0.001
Trp	1.036TrpAla: 1.036 ± 0.015	0.211TrpCys: 0.211 ± 0.007	0.932TrpAsp: 0.932 ± 0.018	0.898TrpGlu: 0.898 ± 0.015	0.617TrpPhe: 0.617 ± 0.014	0.865TrpGly: 0.865 ± 0.014	0.358TrpHis: 0.358 ± 0.008	0.801TrpIle: 0.801 ± 0.013	0.848TrpLys: 0.848 ± 0.013	1.353TrpLeu: 1.353 ± 0.017	0.395TrpMet: 0.395 ± 0.01	0.656TrpAsn: 0.656 ± 0.012	0.603TrpPro: 0.603 ± 0.011	0.503TrpGln: 0.503 ± 0.009	0.936TrpArg: 0.936 ± 0.014	1.153TrpSer: 1.153 ± 0.017	0.9TrpThr: 0.9 ± 0.013	0.885TrpVal: 0.885 ± 0.014	0.255TrpTrp: 0.255 ± 0.008	0.412TrpTyr: 0.412 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.009TyrAla: 2.009 ± 0.021	0.385TyrCys: 0.385 ± 0.009	1.657TyrAsp: 1.657 ± 0.018	1.511TyrGlu: 1.511 ± 0.019	1.209TyrPhe: 1.209 ± 0.017	1.868TyrGly: 1.868 ± 0.021	0.81TyrHis: 0.81 ± 0.013	1.492TyrIle: 1.492 ± 0.017	1.177TyrLys: 1.177 ± 0.015	2.795TyrLeu: 2.795 ± 0.026	0.552TyrMet: 0.552 ± 0.01	1.08TyrAsn: 1.08 ± 0.016	1.623TyrPro: 1.623 ± 0.021	1.074TyrGln: 1.074 ± 0.014	1.553TyrArg: 1.553 ± 0.019	2.036TyrSer: 2.036 ± 0.021	1.644TyrThr: 1.644 ± 0.018	1.658TyrVal: 1.658 ± 0.019	0.441TyrTrp: 0.441 ± 0.009	0.879TyrTyr: 0.879 ± 0.015	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.0	0.002XaaGly: 0.002 ± 0.001	0.001XaaHis: 0.001 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.001XaaLys: 0.001 ± 0.0	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.003XaaPro: 0.003 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.003XaaArg: 0.003 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.001XaaThr: 0.001 ± 0.0	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	2.064XaaXaa: 2.064 ± 0.299

Statistics based on 12747 proteins (5393887 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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