Amino acid dipepetide frequency for Burkholderiales bacterium PBB3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.59AlaAla: 15.59 ± 0.139
1.275AlaCys: 1.275 ± 0.036
6.187AlaAsp: 6.187 ± 0.063
5.818AlaGlu: 5.818 ± 0.067
3.911AlaPhe: 3.911 ± 0.056
9.18AlaGly: 9.18 ± 0.093
2.658AlaHis: 2.658 ± 0.05
5.19AlaIle: 5.19 ± 0.069
4.874AlaLys: 4.874 ± 0.071
14.504AlaLeu: 14.504 ± 0.117
3.389AlaMet: 3.389 ± 0.052
3.535AlaAsn: 3.535 ± 0.056
5.668AlaPro: 5.668 ± 0.081
6.339AlaGln: 6.339 ± 0.075
7.093AlaArg: 7.093 ± 0.087
7.057AlaSer: 7.057 ± 0.078
6.489AlaThr: 6.489 ± 0.087
8.755AlaVal: 8.755 ± 0.089
1.964AlaTrp: 1.964 ± 0.045
2.559AlaTyr: 2.559 ± 0.045
0.0AlaXaa: 0.0 ± 0.0
Cys
1.175CysAla: 1.175 ± 0.035
0.108CysCys: 0.108 ± 0.009
0.496CysAsp: 0.496 ± 0.021
0.477CysGlu: 0.477 ± 0.019
0.315CysPhe: 0.315 ± 0.014
0.899CysGly: 0.899 ± 0.026
0.274CysHis: 0.274 ± 0.016
0.456CysIle: 0.456 ± 0.017
0.335CysLys: 0.335 ± 0.015
0.906CysLeu: 0.906 ± 0.029
0.216CysMet: 0.216 ± 0.012
0.285CysAsn: 0.285 ± 0.015
0.459CysPro: 0.459 ± 0.02
0.324CysGln: 0.324 ± 0.015
0.476CysArg: 0.476 ± 0.018
0.574CysSer: 0.574 ± 0.022
0.54CysThr: 0.54 ± 0.022
0.731CysVal: 0.731 ± 0.024
0.191CysTrp: 0.191 ± 0.026
0.199CysTyr: 0.199 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.86AspAla: 6.86 ± 0.064
0.497AspCys: 0.497 ± 0.018
2.639AspAsp: 2.639 ± 0.048
2.745AspGlu: 2.745 ± 0.046
2.088AspPhe: 2.088 ± 0.039
4.332AspGly: 4.332 ± 0.07
1.074AspHis: 1.074 ± 0.03
2.569AspIle: 2.569 ± 0.046
2.019AspLys: 2.019 ± 0.047
5.298AspLeu: 5.298 ± 0.072
1.221AspMet: 1.221 ± 0.03
1.381AspAsn: 1.381 ± 0.029
2.641AspPro: 2.641 ± 0.042
1.861AspGln: 1.861 ± 0.038
2.933AspArg: 2.933 ± 0.053
2.676AspSer: 2.676 ± 0.046
2.835AspThr: 2.835 ± 0.049
3.861AspVal: 3.861 ± 0.05
0.964AspTrp: 0.964 ± 0.027
1.481AspTyr: 1.481 ± 0.034
0.0AspXaa: 0.0 ± 0.0
Glu
5.859GluAla: 5.859 ± 0.084
0.367GluCys: 0.367 ± 0.013
2.26GluAsp: 2.26 ± 0.043
2.269GluGlu: 2.269 ± 0.044
1.941GluPhe: 1.941 ± 0.039
3.401GluGly: 3.401 ± 0.052
1.16GluHis: 1.16 ± 0.03
2.586GluIle: 2.586 ± 0.044
2.143GluLys: 2.143 ± 0.05
5.663GluLeu: 5.663 ± 0.06
1.252GluMet: 1.252 ± 0.031
1.337GluAsn: 1.337 ± 0.035
2.252GluPro: 2.252 ± 0.042
2.294GluGln: 2.294 ± 0.044
3.742GluArg: 3.742 ± 0.057
2.804GluSer: 2.804 ± 0.044
2.502GluThr: 2.502 ± 0.04
3.847GluVal: 3.847 ± 0.058
0.67GluTrp: 0.67 ± 0.02
1.064GluTyr: 1.064 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.403PheAla: 4.403 ± 0.061
0.401PheCys: 0.401 ± 0.018
2.469PheAsp: 2.469 ± 0.047
2.101PheGlu: 2.101 ± 0.04
1.442PhePhe: 1.442 ± 0.039
3.18PheGly: 3.18 ± 0.045
0.694PheHis: 0.694 ± 0.024
1.514PheIle: 1.514 ± 0.037
1.584PheLys: 1.584 ± 0.032
3.05PheLeu: 3.05 ± 0.056
0.805PheMet: 0.805 ± 0.019
1.278PheAsn: 1.278 ± 0.029
1.448PhePro: 1.448 ± 0.037
1.183PheGln: 1.183 ± 0.029
1.688PheArg: 1.688 ± 0.035
2.438PheSer: 2.438 ± 0.043
1.996PheThr: 1.996 ± 0.041
2.862PheVal: 2.862 ± 0.048
0.54PheTrp: 0.54 ± 0.02
0.979PheTyr: 0.979 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
8.415GlyAla: 8.415 ± 0.101
0.831GlyCys: 0.831 ± 0.024
3.937GlyAsp: 3.937 ± 0.063
3.751GlyGlu: 3.751 ± 0.052
3.176GlyPhe: 3.176 ± 0.055
6.508GlyGly: 6.508 ± 0.102
1.788GlyHis: 1.788 ± 0.037
3.863GlyIle: 3.863 ± 0.052
3.718GlyLys: 3.718 ± 0.061
8.742GlyLeu: 8.742 ± 0.088
2.166GlyMet: 2.166 ± 0.039
2.501GlyAsn: 2.501 ± 0.064
2.797GlyPro: 2.797 ± 0.05
3.572GlyGln: 3.572 ± 0.054
4.422GlyArg: 4.422 ± 0.063
4.917GlySer: 4.917 ± 0.073
4.618GlyThr: 4.618 ± 0.077
6.385GlyVal: 6.385 ± 0.065
1.276GlyTrp: 1.276 ± 0.03
2.321GlyTyr: 2.321 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
2.629HisAla: 2.629 ± 0.05
0.309HisCys: 0.309 ± 0.014
1.046HisAsp: 1.046 ± 0.03
0.995HisGlu: 0.995 ± 0.028
0.943HisPhe: 0.943 ± 0.028
1.825HisGly: 1.825 ± 0.038
0.603HisHis: 0.603 ± 0.021
1.058HisIle: 1.058 ± 0.029
0.681HisLys: 0.681 ± 0.023
2.212HisLeu: 2.212 ± 0.042
0.524HisMet: 0.524 ± 0.019
0.552HisAsn: 0.552 ± 0.017
1.354HisPro: 1.354 ± 0.033
0.838HisGln: 0.838 ± 0.03
1.317HisArg: 1.317 ± 0.034
1.296HisSer: 1.296 ± 0.035
1.228HisThr: 1.228 ± 0.03
1.405HisVal: 1.405 ± 0.033
0.431HisTrp: 0.431 ± 0.019
0.667HisTyr: 0.667 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
6.08IleAla: 6.08 ± 0.075
0.427IleCys: 0.427 ± 0.019
2.884IleAsp: 2.884 ± 0.044
2.932IleGlu: 2.932 ± 0.046
1.406IlePhe: 1.406 ± 0.034
3.775IleGly: 3.775 ± 0.055
0.913IleHis: 0.913 ± 0.026
1.546IleIle: 1.546 ± 0.042
1.776IleLys: 1.776 ± 0.037
3.506IleLeu: 3.506 ± 0.062
0.75IleMet: 0.75 ± 0.024
1.591IleAsn: 1.591 ± 0.036
2.048IlePro: 2.048 ± 0.04
1.611IleGln: 1.611 ± 0.033
2.468IleArg: 2.468 ± 0.037
2.84IleSer: 2.84 ± 0.054
2.717IleThr: 2.717 ± 0.047
3.31IleVal: 3.31 ± 0.055
0.536IleTrp: 0.536 ± 0.019
1.032IleTyr: 1.032 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
4.616LysAla: 4.616 ± 0.071
0.238LysCys: 0.238 ± 0.013
2.057LysAsp: 2.057 ± 0.041
1.795LysGlu: 1.795 ± 0.042
1.227LysPhe: 1.227 ± 0.036
2.682LysGly: 2.682 ± 0.048
0.787LysHis: 0.787 ± 0.025
1.757LysIle: 1.757 ± 0.037
1.779LysLys: 1.779 ± 0.047
4.31LysLeu: 4.31 ± 0.06
0.973LysMet: 0.973 ± 0.027
1.291LysAsn: 1.291 ± 0.034
2.495LysPro: 2.495 ± 0.046
1.402LysGln: 1.402 ± 0.031
2.498LysArg: 2.498 ± 0.04
2.32LysSer: 2.32 ± 0.04
2.596LysThr: 2.596 ± 0.047
3.0LysVal: 3.0 ± 0.052
0.393LysTrp: 0.393 ± 0.016
0.826LysTyr: 0.826 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
13.604LeuAla: 13.604 ± 0.131
1.067LeuCys: 1.067 ± 0.029
5.731LeuAsp: 5.731 ± 0.07
5.208LeuGlu: 5.208 ± 0.067
3.365LeuPhe: 3.365 ± 0.055
8.702LeuGly: 8.702 ± 0.101
2.336LeuHis: 2.336 ± 0.046
4.422LeuIle: 4.422 ± 0.064
4.275LeuLys: 4.275 ± 0.064
10.938LeuLeu: 10.938 ± 0.143
2.638LeuMet: 2.638 ± 0.047
3.235LeuAsn: 3.235 ± 0.051
5.812LeuPro: 5.812 ± 0.073
5.073LeuGln: 5.073 ± 0.067
6.975LeuArg: 6.975 ± 0.084
6.619LeuSer: 6.619 ± 0.075
5.654LeuThr: 5.654 ± 0.068
7.892LeuVal: 7.892 ± 0.082
1.482LeuTrp: 1.482 ± 0.035
2.066LeuTyr: 2.066 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
3.15MetAla: 3.15 ± 0.052
0.183MetCys: 0.183 ± 0.011
1.232MetAsp: 1.232 ± 0.031
1.156MetGlu: 1.156 ± 0.031
0.696MetPhe: 0.696 ± 0.023
2.071MetGly: 2.071 ± 0.043
0.545MetHis: 0.545 ± 0.018
0.82MetIle: 0.82 ± 0.027
1.065MetLys: 1.065 ± 0.027
2.627MetLeu: 2.627 ± 0.041
0.54MetMet: 0.54 ± 0.021
0.877MetAsn: 0.877 ± 0.024
1.49MetPro: 1.49 ± 0.034
1.224MetGln: 1.224 ± 0.034
1.592MetArg: 1.592 ± 0.033
1.489MetSer: 1.489 ± 0.031
1.519MetThr: 1.519 ± 0.035
1.908MetVal: 1.908 ± 0.04
0.219MetTrp: 0.219 ± 0.012
0.387MetTyr: 0.387 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.751AsnAla: 3.751 ± 0.055
0.274AsnCys: 0.274 ± 0.014
1.567AsnAsp: 1.567 ± 0.047
1.287AsnGlu: 1.287 ± 0.029
1.129AsnPhe: 1.129 ± 0.03
2.543AsnGly: 2.543 ± 0.06
0.643AsnHis: 0.643 ± 0.022
1.384AsnIle: 1.384 ± 0.033
1.027AsnLys: 1.027 ± 0.033
3.046AsnLeu: 3.046 ± 0.055
0.638AsnMet: 0.638 ± 0.022
0.926AsnAsn: 0.926 ± 0.032
1.992AsnPro: 1.992 ± 0.041
1.168AsnGln: 1.168 ± 0.029
1.774AsnArg: 1.774 ± 0.033
1.658AsnSer: 1.658 ± 0.042
1.905AsnThr: 1.905 ± 0.04
2.124AsnVal: 2.124 ± 0.043
0.492AsnTrp: 0.492 ± 0.018
0.861AsnTyr: 0.861 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.177ProAla: 6.177 ± 0.089
0.358ProCys: 0.358 ± 0.016
2.835ProAsp: 2.835 ± 0.045
3.037ProGlu: 3.037 ± 0.045
1.786ProPhe: 1.786 ± 0.039
4.072ProGly: 4.072 ± 0.053
1.084ProHis: 1.084 ± 0.032
2.028ProIle: 2.028 ± 0.039
1.901ProLys: 1.901 ± 0.039
5.045ProLeu: 5.045 ± 0.07
1.357ProMet: 1.357 ± 0.031
1.508ProAsn: 1.508 ± 0.028
2.416ProPro: 2.416 ± 0.055
2.263ProGln: 2.263 ± 0.041
2.327ProArg: 2.327 ± 0.044
2.974ProSer: 2.974 ± 0.049
2.938ProThr: 2.938 ± 0.054
4.06ProVal: 4.06 ± 0.06
0.837ProTrp: 0.837 ± 0.027
1.109ProTyr: 1.109 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
5.988GlnAla: 5.988 ± 0.079
0.379GlnCys: 0.379 ± 0.02
1.935GlnAsp: 1.935 ± 0.03
1.839GlnGlu: 1.839 ± 0.04
1.479GlnPhe: 1.479 ± 0.031
3.418GlnGly: 3.418 ± 0.053
1.047GlnHis: 1.047 ± 0.03
1.884GlnIle: 1.884 ± 0.037
1.39GlnLys: 1.39 ± 0.032
4.574GlnLeu: 4.574 ± 0.067
1.098GlnMet: 1.098 ± 0.026
1.118GlnAsn: 1.118 ± 0.03
2.157GlnPro: 2.157 ± 0.04
1.996GlnGln: 1.996 ± 0.042
3.291GlnArg: 3.291 ± 0.054
2.647GlnSer: 2.647 ± 0.044
2.374GlnThr: 2.374 ± 0.045
3.275GlnVal: 3.275 ± 0.052
0.804GlnTrp: 0.804 ± 0.026
0.896GlnTyr: 0.896 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
6.525ArgAla: 6.525 ± 0.068
0.54ArgCys: 0.54 ± 0.019
3.073ArgAsp: 3.073 ± 0.047
3.229ArgGlu: 3.229 ± 0.054
2.471ArgPhe: 2.471 ± 0.044
3.841ArgGly: 3.841 ± 0.055
1.417ArgHis: 1.417 ± 0.033
3.148ArgIle: 3.148 ± 0.058
2.366ArgLys: 2.366 ± 0.045
6.809ArgLeu: 6.809 ± 0.071
1.733ArgMet: 1.733 ± 0.034
1.889ArgAsn: 1.889 ± 0.039
2.562ArgPro: 2.562 ± 0.043
2.653ArgGln: 2.653 ± 0.044
3.602ArgArg: 3.602 ± 0.059
3.496ArgSer: 3.496 ± 0.057
3.092ArgThr: 3.092 ± 0.051
4.433ArgVal: 4.433 ± 0.059
1.101ArgTrp: 1.101 ± 0.029
1.729ArgTyr: 1.729 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
7.213SerAla: 7.213 ± 0.082
0.496SerCys: 0.496 ± 0.021
2.943SerAsp: 2.943 ± 0.049
2.687SerGlu: 2.687 ± 0.051
2.292SerPhe: 2.292 ± 0.044
5.435SerGly: 5.435 ± 0.073
1.249SerHis: 1.249 ± 0.03
2.714SerIle: 2.714 ± 0.047
2.242SerLys: 2.242 ± 0.041
6.201SerLeu: 6.201 ± 0.074
1.462SerMet: 1.462 ± 0.037
1.894SerAsn: 1.894 ± 0.046
3.158SerPro: 3.158 ± 0.055
2.301SerGln: 2.301 ± 0.041
3.24SerArg: 3.24 ± 0.049
3.699SerSer: 3.699 ± 0.069
3.518SerThr: 3.518 ± 0.057
4.496SerVal: 4.496 ± 0.066
0.853SerTrp: 0.853 ± 0.028
1.436SerTyr: 1.436 ± 0.033
0.0SerXaa: 0.0 ± 0.0
Thr
6.523ThrAla: 6.523 ± 0.09
0.49ThrCys: 0.49 ± 0.022
2.763ThrAsp: 2.763 ± 0.048
2.626ThrGlu: 2.626 ± 0.047
1.846ThrPhe: 1.846 ± 0.042
4.869ThrGly: 4.869 ± 0.075
1.283ThrHis: 1.283 ± 0.03
2.306ThrIle: 2.306 ± 0.043
1.738ThrLys: 1.738 ± 0.04
6.669ThrLeu: 6.669 ± 0.073
1.145ThrMet: 1.145 ± 0.03
1.526ThrAsn: 1.526 ± 0.038
3.752ThrPro: 3.752 ± 0.053
2.454ThrGln: 2.454 ± 0.04
3.015ThrArg: 3.015 ± 0.051
3.22ThrSer: 3.22 ± 0.056
3.379ThrThr: 3.379 ± 0.057
4.519ThrVal: 4.519 ± 0.068
0.832ThrTrp: 0.832 ± 0.028
1.222ThrTyr: 1.222 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
9.251ValAla: 9.251 ± 0.094
0.738ValCys: 0.738 ± 0.026
3.997ValAsp: 3.997 ± 0.057
3.777ValGlu: 3.777 ± 0.058
2.839ValPhe: 2.839 ± 0.047
5.741ValGly: 5.741 ± 0.068
1.535ValHis: 1.535 ± 0.034
3.408ValIle: 3.408 ± 0.054
2.783ValLys: 2.783 ± 0.045
8.374ValLeu: 8.374 ± 0.094
1.958ValMet: 1.958 ± 0.043
2.327ValAsn: 2.327 ± 0.047
3.732ValPro: 3.732 ± 0.054
3.25ValGln: 3.25 ± 0.054
4.576ValArg: 4.576 ± 0.058
4.556ValSer: 4.556 ± 0.072
4.176ValThr: 4.176 ± 0.064
6.503ValVal: 6.503 ± 0.094
1.143ValTrp: 1.143 ± 0.03
1.63ValTyr: 1.63 ± 0.03
0.0ValXaa: 0.0 ± 0.0
Trp
1.57TrpAla: 1.57 ± 0.037
0.183TrpCys: 0.183 ± 0.012
0.723TrpAsp: 0.723 ± 0.027
0.588TrpGlu: 0.588 ± 0.021
0.626TrpPhe: 0.626 ± 0.024
1.216TrpGly: 1.216 ± 0.045
0.388TrpHis: 0.388 ± 0.018
0.649TrpIle: 0.649 ± 0.021
0.527TrpLys: 0.527 ± 0.019
2.044TrpLeu: 2.044 ± 0.049
0.466TrpMet: 0.466 ± 0.018
0.468TrpAsn: 0.468 ± 0.02
0.677TrpPro: 0.677 ± 0.023
0.802TrpGln: 0.802 ± 0.019
1.065TrpArg: 1.065 ± 0.028
0.883TrpSer: 0.883 ± 0.025
0.772TrpThr: 0.772 ± 0.022
1.206TrpVal: 1.206 ± 0.032
0.282TrpTrp: 0.282 ± 0.015
0.295TrpTyr: 0.295 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.656TyrAla: 2.656 ± 0.044
0.274TyrCys: 0.274 ± 0.013
1.202TyrAsp: 1.202 ± 0.028
1.097TyrGlu: 1.097 ± 0.03
1.074TyrPhe: 1.074 ± 0.033
2.016TyrGly: 2.016 ± 0.042
0.435TyrHis: 0.435 ± 0.019
0.848TyrIle: 0.848 ± 0.027
0.82TyrLys: 0.82 ± 0.027
2.577TyrLeu: 2.577 ± 0.044
0.459TyrMet: 0.459 ± 0.019
0.666TyrAsn: 0.666 ± 0.02
1.204TyrPro: 1.204 ± 0.03
0.98TyrGln: 0.98 ± 0.026
1.618TyrArg: 1.618 ± 0.036
1.364TyrSer: 1.364 ± 0.03
1.329TyrThr: 1.329 ± 0.034
1.723TyrVal: 1.723 ± 0.034
0.419TyrTrp: 0.419 ± 0.017
0.607TyrTyr: 0.607 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4253 proteins (1417406 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski