Amino acid dipepetide frequency for Anoxybacter fermentans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.579AlaAla: 4.579 ± 0.094	0.557AlaCys: 0.557 ± 0.03	2.928AlaAsp: 2.928 ± 0.063	4.571AlaGlu: 4.571 ± 0.081	2.404AlaPhe: 2.404 ± 0.054	5.016AlaGly: 5.016 ± 0.088	1.063AlaHis: 1.063 ± 0.034	5.562AlaIle: 5.562 ± 0.093	4.299AlaLys: 4.299 ± 0.077	6.618AlaLeu: 6.618 ± 0.114	1.57AlaMet: 1.57 ± 0.047	2.495AlaAsn: 2.495 ± 0.049	1.748AlaPro: 1.748 ± 0.041	2.039AlaGln: 2.039 ± 0.059	3.455AlaArg: 3.455 ± 0.064	2.943AlaSer: 2.943 ± 0.067	2.682AlaThr: 2.682 ± 0.051	4.595AlaVal: 4.595 ± 0.087	0.503AlaTrp: 0.503 ± 0.022	2.114AlaTyr: 2.114 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.446CysAla: 0.446 ± 0.023	0.134CysCys: 0.134 ± 0.012	0.48CysAsp: 0.48 ± 0.022	0.591CysGlu: 0.591 ± 0.028	0.365CysPhe: 0.365 ± 0.019	0.915CysGly: 0.915 ± 0.033	0.23CysHis: 0.23 ± 0.017	0.696CysIle: 0.696 ± 0.028	0.635CysLys: 0.635 ± 0.025	0.812CysLeu: 0.812 ± 0.03	0.191CysMet: 0.191 ± 0.014	0.422CysAsn: 0.422 ± 0.022	0.586CysPro: 0.586 ± 0.03	0.314CysGln: 0.314 ± 0.018	0.441CysArg: 0.441 ± 0.023	0.526CysSer: 0.526 ± 0.025	0.414CysThr: 0.414 ± 0.023	0.474CysVal: 0.474 ± 0.026	0.11CysTrp: 0.11 ± 0.011	0.368CysTyr: 0.368 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	2.766AspAla: 2.766 ± 0.062	0.469AspCys: 0.469 ± 0.024	2.344AspAsp: 2.344 ± 0.061	4.274AspGlu: 4.274 ± 0.072	2.491AspPhe: 2.491 ± 0.059	3.587AspGly: 3.587 ± 0.085	0.865AspHis: 0.865 ± 0.036	4.427AspIle: 4.427 ± 0.078	3.501AspLys: 3.501 ± 0.072	6.214AspLeu: 6.214 ± 0.087	1.035AspMet: 1.035 ± 0.038	1.961AspAsn: 1.961 ± 0.053	2.425AspPro: 2.425 ± 0.093	1.883AspGln: 1.883 ± 0.049	2.358AspArg: 2.358 ± 0.051	2.211AspSer: 2.211 ± 0.053	1.885AspThr: 1.885 ± 0.051	3.233AspVal: 3.233 ± 0.062	0.627AspTrp: 0.627 ± 0.033	2.418AspTyr: 2.418 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.588GluAla: 4.588 ± 0.076	0.498GluCys: 0.498 ± 0.025	3.845GluAsp: 3.845 ± 0.072	7.9GluGlu: 7.9 ± 0.117	2.873GluPhe: 2.873 ± 0.066	4.472GluGly: 4.472 ± 0.072	1.035GluHis: 1.035 ± 0.035	7.759GluIle: 7.759 ± 0.111	7.264GluLys: 7.264 ± 0.115	8.009GluLeu: 8.009 ± 0.113	2.309GluMet: 2.309 ± 0.048	3.717GluAsn: 3.717 ± 0.08	2.099GluPro: 2.099 ± 0.057	2.196GluGln: 2.196 ± 0.056	3.795GluArg: 3.795 ± 0.072	2.877GluSer: 2.877 ± 0.059	2.881GluThr: 2.881 ± 0.062	5.712GluVal: 5.712 ± 0.09	0.702GluTrp: 0.702 ± 0.029	2.881GluTyr: 2.881 ± 0.088	0.0GluXaa: 0.0 ± 0.0
Phe	2.591PheAla: 2.591 ± 0.052	0.48PheCys: 0.48 ± 0.026	2.341PheAsp: 2.341 ± 0.058	2.668PheGlu: 2.668 ± 0.057	2.336PhePhe: 2.336 ± 0.065	3.136PheGly: 3.136 ± 0.059	0.757PheHis: 0.757 ± 0.029	4.078PheIle: 4.078 ± 0.074	3.349PheLys: 3.349 ± 0.059	4.492PheLeu: 4.492 ± 0.09	0.996PheMet: 0.996 ± 0.033	2.121PheAsn: 2.121 ± 0.052	1.518PhePro: 1.518 ± 0.039	1.32PheGln: 1.32 ± 0.036	1.73PheArg: 1.73 ± 0.044	2.758PheSer: 2.758 ± 0.06	2.3PheThr: 2.3 ± 0.048	2.689PheVal: 2.689 ± 0.059	0.478PheTrp: 0.478 ± 0.026	1.893PheTyr: 1.893 ± 0.052	0.0PheXaa: 0.0 ± 0.0
Gly	4.303GlyAla: 4.303 ± 0.094	0.778GlyCys: 0.778 ± 0.032	3.221GlyAsp: 3.221 ± 0.057	4.874GlyGlu: 4.874 ± 0.086	3.432GlyPhe: 3.432 ± 0.069	4.873GlyGly: 4.873 ± 0.094	1.172GlyHis: 1.172 ± 0.039	6.861GlyIle: 6.861 ± 0.101	5.33GlyLys: 5.33 ± 0.068	7.122GlyLeu: 7.122 ± 0.102	1.986GlyMet: 1.986 ± 0.056	2.921GlyAsn: 2.921 ± 0.096	1.848GlyPro: 1.848 ± 0.053	2.438GlyGln: 2.438 ± 0.052	3.284GlyArg: 3.284 ± 0.073	3.369GlySer: 3.369 ± 0.06	3.495GlyThr: 3.495 ± 0.072	5.19GlyVal: 5.19 ± 0.087	0.784GlyTrp: 0.784 ± 0.03	2.988GlyTyr: 2.988 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.881HisAla: 0.881 ± 0.032	0.192HisCys: 0.192 ± 0.016	0.796HisAsp: 0.796 ± 0.03	0.924HisGlu: 0.924 ± 0.029	0.774HisPhe: 0.774 ± 0.029	1.13HisGly: 1.13 ± 0.038	0.445HisHis: 0.445 ± 0.024	1.271HisIle: 1.271 ± 0.04	1.038HisLys: 1.038 ± 0.036	1.911HisLeu: 1.911 ± 0.046	0.339HisMet: 0.339 ± 0.022	0.698HisAsn: 0.698 ± 0.031	1.011HisPro: 1.011 ± 0.034	0.632HisGln: 0.632 ± 0.026	0.784HisArg: 0.784 ± 0.03	0.87HisSer: 0.87 ± 0.032	0.736HisThr: 0.736 ± 0.033	0.868HisVal: 0.868 ± 0.034	0.201HisTrp: 0.201 ± 0.016	0.742HisTyr: 0.742 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.829IleAla: 5.829 ± 0.088	0.914IleCys: 0.914 ± 0.037	4.938IleAsp: 4.938 ± 0.076	6.642IleGlu: 6.642 ± 0.1	4.445IlePhe: 4.445 ± 0.101	6.182IleGly: 6.182 ± 0.095	1.431IleHis: 1.431 ± 0.039	8.045IleIle: 8.045 ± 0.117	6.971IleLys: 6.971 ± 0.089	9.099IleLeu: 9.099 ± 0.122	1.858IleMet: 1.858 ± 0.053	4.24IleAsn: 4.24 ± 0.071	3.976IlePro: 3.976 ± 0.066	2.846IleGln: 2.846 ± 0.053	4.2IleArg: 4.2 ± 0.072	5.316IleSer: 5.316 ± 0.087	4.643IleThr: 4.643 ± 0.084	5.313IleVal: 5.313 ± 0.074	0.797IleTrp: 0.797 ± 0.037	3.466IleTyr: 3.466 ± 0.074	0.0IleXaa: 0.0 ± 0.0
Lys	4.84LysAla: 4.84 ± 0.073	0.601LysCys: 0.601 ± 0.031	4.177LysAsp: 4.177 ± 0.074	7.929LysGlu: 7.929 ± 0.112	2.703LysPhe: 2.703 ± 0.058	4.846LysGly: 4.846 ± 0.075	0.975LysHis: 0.975 ± 0.035	7.16LysIle: 7.16 ± 0.093	7.188LysLys: 7.188 ± 0.117	6.925LysLeu: 6.925 ± 0.096	2.1LysMet: 2.1 ± 0.054	3.842LysAsn: 3.842 ± 0.078	2.296LysPro: 2.296 ± 0.049	1.966LysGln: 1.966 ± 0.049	3.663LysArg: 3.663 ± 0.071	3.282LysSer: 3.282 ± 0.062	3.601LysThr: 3.601 ± 0.062	5.63LysVal: 5.63 ± 0.087	0.691LysTrp: 0.691 ± 0.028	3.186LysTyr: 3.186 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	7.218LeuAla: 7.218 ± 0.108	0.86LeuCys: 0.86 ± 0.037	5.278LeuAsp: 5.278 ± 0.078	7.454LeuGlu: 7.454 ± 0.103	4.036LeuPhe: 4.036 ± 0.085	6.971LeuGly: 6.971 ± 0.124	1.444LeuHis: 1.444 ± 0.039	9.287LeuIle: 9.287 ± 0.126	9.704LeuLys: 9.704 ± 0.109	9.69LeuLeu: 9.69 ± 0.138	2.44LeuMet: 2.44 ± 0.046	4.903LeuAsn: 4.903 ± 0.085	3.84LeuPro: 3.84 ± 0.065	2.84LeuGln: 2.84 ± 0.056	4.258LeuArg: 4.258 ± 0.075	5.878LeuSer: 5.878 ± 0.083	5.681LeuThr: 5.681 ± 0.077	6.813LeuVal: 6.813 ± 0.092	0.778LeuTrp: 0.778 ± 0.034	3.18LeuTyr: 3.18 ± 0.071	0.0LeuXaa: 0.0 ± 0.0
Met	1.979MetAla: 1.979 ± 0.051	0.155MetCys: 0.155 ± 0.013	1.306MetAsp: 1.306 ± 0.038	1.956MetGlu: 1.956 ± 0.044	0.728MetPhe: 0.728 ± 0.032	1.892MetGly: 1.892 ± 0.051	0.287MetHis: 0.287 ± 0.016	2.193MetIle: 2.193 ± 0.051	2.098MetLys: 2.098 ± 0.053	2.08MetLeu: 2.08 ± 0.05	0.679MetMet: 0.679 ± 0.025	1.126MetAsn: 1.126 ± 0.035	0.851MetPro: 0.851 ± 0.027	0.667MetGln: 0.667 ± 0.024	1.041MetArg: 1.041 ± 0.035	1.221MetSer: 1.221 ± 0.033	1.271MetThr: 1.271 ± 0.04	1.936MetVal: 1.936 ± 0.047	0.168MetTrp: 0.168 ± 0.014	0.64MetTyr: 0.64 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	2.347AsnAla: 2.347 ± 0.056	0.497AsnCys: 0.497 ± 0.022	1.968AsnAsp: 1.968 ± 0.05	2.918AsnGlu: 2.918 ± 0.057	2.125AsnPhe: 2.125 ± 0.058	2.872AsnGly: 2.872 ± 0.06	0.846AsnHis: 0.846 ± 0.031	3.999AsnIle: 3.999 ± 0.074	2.999AsnLys: 2.999 ± 0.074	5.585AsnLeu: 5.585 ± 0.082	0.975AsnMet: 0.975 ± 0.027	2.221AsnAsn: 2.221 ± 0.054	2.362AsnPro: 2.362 ± 0.058	1.886AsnGln: 1.886 ± 0.051	2.232AsnArg: 2.232 ± 0.048	2.287AsnSer: 2.287 ± 0.054	1.927AsnThr: 1.927 ± 0.05	2.629AsnVal: 2.629 ± 0.056	0.541AsnTrp: 0.541 ± 0.026	2.059AsnTyr: 2.059 ± 0.044	0.0AsnXaa: 0.0 ± 0.0
Pro	2.156ProAla: 2.156 ± 0.055	0.307ProCys: 0.307 ± 0.019	2.399ProAsp: 2.399 ± 0.052	3.859ProGlu: 3.859 ± 0.071	1.768ProPhe: 1.768 ± 0.048	2.956ProGly: 2.956 ± 0.057	0.713ProHis: 0.713 ± 0.026	3.102ProIle: 3.102 ± 0.063	1.941ProLys: 1.941 ± 0.052	3.411ProLeu: 3.411 ± 0.077	0.728ProMet: 0.728 ± 0.032	1.391ProAsn: 1.391 ± 0.038	1.038ProPro: 1.038 ± 0.038	1.048ProGln: 1.048 ± 0.031	1.425ProArg: 1.425 ± 0.037	1.557ProSer: 1.557 ± 0.044	1.802ProThr: 1.802 ± 0.051	2.953ProVal: 2.953 ± 0.066	0.337ProTrp: 0.337 ± 0.021	1.535ProTyr: 1.535 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	1.987GlnAla: 1.987 ± 0.046	0.22GlnCys: 0.22 ± 0.015	1.278GlnAsp: 1.278 ± 0.038	2.192GlnGlu: 2.192 ± 0.047	1.297GlnPhe: 1.297 ± 0.037	1.914GlnGly: 1.914 ± 0.041	0.451GlnHis: 0.451 ± 0.022	3.426GlnIle: 3.426 ± 0.061	2.744GlnLys: 2.744 ± 0.063	3.376GlnLeu: 3.376 ± 0.066	0.888GlnMet: 0.888 ± 0.031	1.485GlnAsn: 1.485 ± 0.04	1.048GlnPro: 1.048 ± 0.035	1.135GlnGln: 1.135 ± 0.039	1.611GlnArg: 1.611 ± 0.047	1.398GlnSer: 1.398 ± 0.039	1.386GlnThr: 1.386 ± 0.04	2.61GlnVal: 2.61 ± 0.052	0.287GlnTrp: 0.287 ± 0.02	1.229GlnTyr: 1.229 ± 0.061	0.0GlnXaa: 0.0 ± 0.0
Arg	2.75ArgAla: 2.75 ± 0.058	0.463ArgCys: 0.463 ± 0.022	2.288ArgAsp: 2.288 ± 0.05	3.891ArgGlu: 3.891 ± 0.074	2.087ArgPhe: 2.087 ± 0.051	3.092ArgGly: 3.092 ± 0.065	0.737ArgHis: 0.737 ± 0.028	4.212ArgIle: 4.212 ± 0.063	3.828ArgLys: 3.828 ± 0.066	4.977ArgLeu: 4.977 ± 0.079	1.251ArgMet: 1.251 ± 0.038	2.002ArgAsn: 2.002 ± 0.042	1.558ArgPro: 1.558 ± 0.044	1.519ArgGln: 1.519 ± 0.039	2.427ArgArg: 2.427 ± 0.066	2.004ArgSer: 2.004 ± 0.053	1.937ArgThr: 1.937 ± 0.043	3.315ArgVal: 3.315 ± 0.07	0.485ArgTrp: 0.485 ± 0.022	1.993ArgTyr: 1.993 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	2.727SerAla: 2.727 ± 0.056	0.452SerCys: 0.452 ± 0.02	2.446SerAsp: 2.446 ± 0.059	3.207SerGlu: 3.207 ± 0.062	2.578SerPhe: 2.578 ± 0.055	3.992SerGly: 3.992 ± 0.074	0.858SerHis: 0.858 ± 0.032	4.558SerIle: 4.558 ± 0.079	3.581SerLys: 3.581 ± 0.071	5.352SerLeu: 5.352 ± 0.072	1.243SerMet: 1.243 ± 0.034	2.17SerAsn: 2.17 ± 0.054	1.853SerPro: 1.853 ± 0.045	1.674SerGln: 1.674 ± 0.043	2.448SerArg: 2.448 ± 0.058	2.777SerSer: 2.777 ± 0.058	2.368SerThr: 2.368 ± 0.051	2.951SerVal: 2.951 ± 0.061	0.53SerTrp: 0.53 ± 0.025	2.097SerTyr: 2.097 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	3.138ThrAla: 3.138 ± 0.066	0.406ThrCys: 0.406 ± 0.021	2.511ThrAsp: 2.511 ± 0.062	3.07ThrGlu: 3.07 ± 0.064	2.235ThrPhe: 2.235 ± 0.052	4.06ThrGly: 4.06 ± 0.068	0.881ThrHis: 0.881 ± 0.031	4.26ThrIle: 4.26 ± 0.071	2.569ThrLys: 2.569 ± 0.052	4.835ThrLeu: 4.835 ± 0.089	0.93ThrMet: 0.93 ± 0.034	2.07ThrAsn: 2.07 ± 0.051	2.111ThrPro: 2.111 ± 0.052	1.251ThrGln: 1.251 ± 0.039	2.23ThrArg: 2.23 ± 0.045	2.393ThrSer: 2.393 ± 0.058	2.447ThrThr: 2.447 ± 0.058	3.52ThrVal: 3.52 ± 0.074	0.391ThrTrp: 0.391 ± 0.023	1.769ThrTyr: 1.769 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	4.313ValAla: 4.313 ± 0.082	0.612ValCys: 0.612 ± 0.026	3.755ValAsp: 3.755 ± 0.068	5.297ValGlu: 5.297 ± 0.09	2.836ValPhe: 2.836 ± 0.06	4.916ValGly: 4.916 ± 0.083	1.017ValHis: 1.017 ± 0.036	6.363ValIle: 6.363 ± 0.103	5.382ValLys: 5.382 ± 0.092	6.618ValLeu: 6.618 ± 0.083	1.733ValMet: 1.733 ± 0.045	3.132ValAsn: 3.132 ± 0.055	2.376ValPro: 2.376 ± 0.052	2.044ValGln: 2.044 ± 0.052	2.891ValArg: 2.891 ± 0.057	3.5ValSer: 3.5 ± 0.064	3.44ValThr: 3.44 ± 0.078	5.323ValVal: 5.323 ± 0.088	0.575ValTrp: 0.575 ± 0.025	2.324ValTyr: 2.324 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.523TrpAla: 0.523 ± 0.025	0.084TrpCys: 0.084 ± 0.01	0.471TrpAsp: 0.471 ± 0.028	0.726TrpGlu: 0.726 ± 0.03	0.427TrpPhe: 0.427 ± 0.022	0.685TrpGly: 0.685 ± 0.028	0.177TrpHis: 0.177 ± 0.015	0.858TrpIle: 0.858 ± 0.036	0.662TrpLys: 0.662 ± 0.031	1.01TrpLeu: 1.01 ± 0.034	0.245TrpMet: 0.245 ± 0.018	0.511TrpAsn: 0.511 ± 0.024	0.312TrpPro: 0.312 ± 0.021	0.392TrpGln: 0.392 ± 0.023	0.487TrpArg: 0.487 ± 0.023	0.485TrpSer: 0.485 ± 0.031	0.378TrpThr: 0.378 ± 0.02	0.686TrpVal: 0.686 ± 0.028	0.148TrpTrp: 0.148 ± 0.012	0.36TrpTyr: 0.36 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.781TyrAla: 1.781 ± 0.044	0.47TyrCys: 0.47 ± 0.024	2.207TyrAsp: 2.207 ± 0.12	2.47TyrGlu: 2.47 ± 0.058	2.088TyrPhe: 2.088 ± 0.049	2.761TyrGly: 2.761 ± 0.062	0.86TyrHis: 0.86 ± 0.031	3.035TyrIle: 3.035 ± 0.057	2.516TyrLys: 2.516 ± 0.051	4.418TyrLeu: 4.418 ± 0.083	0.779TyrMet: 0.779 ± 0.031	1.848TyrAsn: 1.848 ± 0.059	1.569TyrPro: 1.569 ± 0.048	1.871TyrGln: 1.871 ± 0.058	2.055TyrArg: 2.055 ± 0.049	2.21TyrSer: 2.21 ± 0.047	1.805TyrThr: 1.805 ± 0.057	2.009TyrVal: 2.009 ± 0.047	0.493TyrTrp: 0.493 ± 0.023	1.867TyrTyr: 1.867 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3011 proteins (927558 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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