Amino acid dipepetide frequency for Lactococcus phage ul36.t1k1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.619AlaAla: 4.619 ± 0.838
0.283AlaCys: 0.283 ± 0.182
4.242AlaAsp: 4.242 ± 0.627
3.771AlaGlu: 3.771 ± 0.785
2.168AlaPhe: 2.168 ± 0.425
4.996AlaGly: 4.996 ± 0.821
1.225AlaHis: 1.225 ± 0.32
4.713AlaIle: 4.713 ± 0.907
4.431AlaLys: 4.431 ± 0.527
7.164AlaLeu: 7.164 ± 1.146
1.414AlaMet: 1.414 ± 0.305
4.148AlaAsn: 4.148 ± 0.572
2.262AlaPro: 2.262 ± 0.501
2.828AlaGln: 2.828 ± 0.512
1.98AlaArg: 1.98 ± 0.393
3.582AlaSer: 3.582 ± 0.541
4.336AlaThr: 4.336 ± 0.876
4.336AlaVal: 4.336 ± 0.569
0.754AlaTrp: 0.754 ± 0.235
2.074AlaTyr: 2.074 ± 0.56
0.0AlaXaa: 0.0 ± 0.0
Cys
0.094CysAla: 0.094 ± 0.107
0.0CysCys: 0.0 ± 0.0
0.471CysAsp: 0.471 ± 0.269
0.566CysGlu: 0.566 ± 0.277
0.377CysPhe: 0.377 ± 0.174
0.566CysGly: 0.566 ± 0.303
0.377CysHis: 0.377 ± 0.341
0.377CysIle: 0.377 ± 0.177
0.377CysLys: 0.377 ± 0.221
0.189CysLeu: 0.189 ± 0.122
0.094CysMet: 0.094 ± 0.105
0.0CysAsn: 0.0 ± 0.0
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.189CysArg: 0.189 ± 0.125
0.471CysSer: 0.471 ± 0.217
0.283CysThr: 0.283 ± 0.195
0.0CysVal: 0.0 ± 0.0
0.094CysTrp: 0.094 ± 0.105
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.488AspAla: 3.488 ± 0.65
0.471AspCys: 0.471 ± 0.268
3.582AspAsp: 3.582 ± 0.668
4.996AspGlu: 4.996 ± 0.659
4.054AspPhe: 4.054 ± 0.682
6.316AspGly: 6.316 ± 1.237
0.471AspHis: 0.471 ± 0.214
4.148AspIle: 4.148 ± 0.602
5.75AspLys: 5.75 ± 0.726
4.242AspLeu: 4.242 ± 0.656
1.697AspMet: 1.697 ± 0.54
3.676AspAsn: 3.676 ± 0.496
1.32AspPro: 1.32 ± 0.409
0.754AspGln: 0.754 ± 0.34
2.168AspArg: 2.168 ± 0.353
4.713AspSer: 4.713 ± 0.68
3.299AspThr: 3.299 ± 0.607
3.865AspVal: 3.865 ± 0.708
0.754AspTrp: 0.754 ± 0.264
3.017AspTyr: 3.017 ± 0.484
0.0AspXaa: 0.0 ± 0.0
Glu
4.242GluAla: 4.242 ± 0.842
0.471GluCys: 0.471 ± 0.232
2.922GluAsp: 2.922 ± 0.509
6.316GluGlu: 6.316 ± 1.213
3.488GluPhe: 3.488 ± 0.672
2.357GluGly: 2.357 ± 0.528
1.32GluHis: 1.32 ± 0.334
5.656GluIle: 5.656 ± 0.764
6.976GluLys: 6.976 ± 1.368
7.919GluLeu: 7.919 ± 0.941
2.545GluMet: 2.545 ± 0.541
4.619GluAsn: 4.619 ± 0.966
1.885GluPro: 1.885 ± 0.593
3.771GluGln: 3.771 ± 0.661
2.828GluArg: 2.828 ± 0.717
4.054GluSer: 4.054 ± 0.635
4.525GluThr: 4.525 ± 0.676
4.996GluVal: 4.996 ± 0.841
1.508GluTrp: 1.508 ± 0.354
3.205GluTyr: 3.205 ± 0.58
0.0GluXaa: 0.0 ± 0.0
Phe
2.262PheAla: 2.262 ± 0.472
0.189PheCys: 0.189 ± 0.14
2.828PheAsp: 2.828 ± 0.556
4.336PheGlu: 4.336 ± 0.735
1.603PhePhe: 1.603 ± 0.438
2.357PheGly: 2.357 ± 0.404
0.283PheHis: 0.283 ± 0.168
3.488PheIle: 3.488 ± 0.495
3.771PheLys: 3.771 ± 0.495
2.074PheLeu: 2.074 ± 0.549
1.414PheMet: 1.414 ± 0.423
3.111PheAsn: 3.111 ± 0.429
1.037PhePro: 1.037 ± 0.349
1.32PheGln: 1.32 ± 0.413
1.414PheArg: 1.414 ± 0.462
2.545PheSer: 2.545 ± 0.476
2.828PheThr: 2.828 ± 0.57
3.111PheVal: 3.111 ± 0.557
0.471PheTrp: 0.471 ± 0.222
2.357PheTyr: 2.357 ± 0.614
0.0PheXaa: 0.0 ± 0.0
Gly
2.545GlyAla: 2.545 ± 0.585
0.189GlyCys: 0.189 ± 0.153
3.959GlyAsp: 3.959 ± 0.518
3.488GlyGlu: 3.488 ± 0.777
3.394GlyPhe: 3.394 ± 0.587
4.525GlyGly: 4.525 ± 0.698
1.037GlyHis: 1.037 ± 0.284
6.41GlyIle: 6.41 ± 0.841
5.279GlyLys: 5.279 ± 0.62
5.562GlyLeu: 5.562 ± 0.945
1.32GlyMet: 1.32 ± 0.386
3.582GlyAsn: 3.582 ± 0.515
1.131GlyPro: 1.131 ± 0.393
2.828GlyGln: 2.828 ± 0.513
2.262GlyArg: 2.262 ± 0.399
5.562GlySer: 5.562 ± 0.908
6.222GlyThr: 6.222 ± 0.935
4.054GlyVal: 4.054 ± 0.52
0.943GlyTrp: 0.943 ± 0.342
2.074GlyTyr: 2.074 ± 0.324
0.0GlyXaa: 0.0 ± 0.0
His
0.943HisAla: 0.943 ± 0.464
0.189HisCys: 0.189 ± 0.133
1.037HisAsp: 1.037 ± 0.34
1.508HisGlu: 1.508 ± 0.512
0.471HisPhe: 0.471 ± 0.202
1.131HisGly: 1.131 ± 0.353
0.377HisHis: 0.377 ± 0.185
0.848HisIle: 0.848 ± 0.29
0.566HisLys: 0.566 ± 0.184
1.037HisLeu: 1.037 ± 0.268
0.283HisMet: 0.283 ± 0.182
0.566HisAsn: 0.566 ± 0.23
0.566HisPro: 0.566 ± 0.249
0.471HisGln: 0.471 ± 0.22
0.471HisArg: 0.471 ± 0.213
0.943HisSer: 0.943 ± 0.334
0.66HisThr: 0.66 ± 0.206
0.943HisVal: 0.943 ± 0.405
0.094HisTrp: 0.094 ± 0.088
0.754HisTyr: 0.754 ± 0.314
0.0HisXaa: 0.0 ± 0.0
Ile
5.279IleAla: 5.279 ± 0.757
0.283IleCys: 0.283 ± 0.171
5.279IleAsp: 5.279 ± 0.667
5.185IleGlu: 5.185 ± 1.011
1.885IlePhe: 1.885 ± 0.437
4.808IleGly: 4.808 ± 0.762
1.131IleHis: 1.131 ± 0.416
5.562IleIle: 5.562 ± 1.365
7.07IleLys: 7.07 ± 0.878
5.279IleLeu: 5.279 ± 0.709
1.697IleMet: 1.697 ± 0.444
4.808IleAsn: 4.808 ± 0.639
3.111IlePro: 3.111 ± 0.703
3.017IleGln: 3.017 ± 0.553
2.545IleArg: 2.545 ± 0.532
6.127IleSer: 6.127 ± 0.825
4.525IleThr: 4.525 ± 0.912
3.676IleVal: 3.676 ± 0.583
0.283IleTrp: 0.283 ± 0.155
1.414IleTyr: 1.414 ± 0.331
0.0IleXaa: 0.0 ± 0.0
Lys
6.599LysAla: 6.599 ± 0.947
0.471LysCys: 0.471 ± 0.255
4.713LysAsp: 4.713 ± 0.793
8.013LysGlu: 8.013 ± 1.148
3.771LysPhe: 3.771 ± 0.713
4.808LysGly: 4.808 ± 0.557
0.754LysHis: 0.754 ± 0.264
5.939LysIle: 5.939 ± 0.718
7.07LysLys: 7.07 ± 1.193
7.07LysLeu: 7.07 ± 0.752
2.357LysMet: 2.357 ± 0.396
3.771LysAsn: 3.771 ± 0.667
2.262LysPro: 2.262 ± 0.495
4.054LysGln: 4.054 ± 0.705
2.828LysArg: 2.828 ± 0.541
5.373LysSer: 5.373 ± 0.91
4.431LysThr: 4.431 ± 0.758
4.996LysVal: 4.996 ± 0.636
1.508LysTrp: 1.508 ± 0.405
2.64LysTyr: 2.64 ± 0.48
0.0LysXaa: 0.0 ± 0.0
Leu
5.09LeuAla: 5.09 ± 0.774
0.283LeuCys: 0.283 ± 0.189
4.242LeuAsp: 4.242 ± 0.517
6.41LeuGlu: 6.41 ± 1.061
3.299LeuPhe: 3.299 ± 0.458
5.279LeuGly: 5.279 ± 0.832
0.471LeuHis: 0.471 ± 0.242
5.373LeuIle: 5.373 ± 0.99
6.222LeuLys: 6.222 ± 0.859
5.75LeuLeu: 5.75 ± 0.969
2.262LeuMet: 2.262 ± 0.506
3.394LeuAsn: 3.394 ± 0.627
4.242LeuPro: 4.242 ± 0.924
2.451LeuGln: 2.451 ± 0.659
3.205LeuArg: 3.205 ± 0.619
6.41LeuSer: 6.41 ± 0.878
5.939LeuThr: 5.939 ± 0.668
4.054LeuVal: 4.054 ± 0.697
1.225LeuTrp: 1.225 ± 0.359
1.791LeuTyr: 1.791 ± 0.434
0.0LeuXaa: 0.0 ± 0.0
Met
1.697MetAla: 1.697 ± 0.368
0.0MetCys: 0.0 ± 0.0
1.603MetAsp: 1.603 ± 0.528
1.885MetGlu: 1.885 ± 0.395
0.943MetPhe: 0.943 ± 0.334
1.603MetGly: 1.603 ± 0.385
0.283MetHis: 0.283 ± 0.172
1.791MetIle: 1.791 ± 0.464
1.791MetLys: 1.791 ± 0.387
1.32MetLeu: 1.32 ± 0.326
0.471MetMet: 0.471 ± 0.226
1.697MetAsn: 1.697 ± 0.415
0.283MetPro: 0.283 ± 0.144
1.131MetGln: 1.131 ± 0.372
1.037MetArg: 1.037 ± 0.275
2.168MetSer: 2.168 ± 0.587
2.734MetThr: 2.734 ± 0.417
0.848MetVal: 0.848 ± 0.273
0.283MetTrp: 0.283 ± 0.181
0.471MetTyr: 0.471 ± 0.279
0.0MetXaa: 0.0 ± 0.0
Asn
3.582AsnAla: 3.582 ± 0.776
0.094AsnCys: 0.094 ± 0.09
4.054AsnAsp: 4.054 ± 0.521
3.205AsnGlu: 3.205 ± 0.591
3.111AsnPhe: 3.111 ± 0.454
6.316AsnGly: 6.316 ± 0.838
0.66AsnHis: 0.66 ± 0.269
4.619AsnIle: 4.619 ± 0.501
4.431AsnLys: 4.431 ± 0.683
3.676AsnLeu: 3.676 ± 0.492
1.037AsnMet: 1.037 ± 0.375
3.771AsnAsn: 3.771 ± 0.602
2.357AsnPro: 2.357 ± 0.477
1.603AsnGln: 1.603 ± 0.332
2.168AsnArg: 2.168 ± 0.42
3.394AsnSer: 3.394 ± 0.621
2.922AsnThr: 2.922 ± 0.485
3.394AsnVal: 3.394 ± 0.527
0.471AsnTrp: 0.471 ± 0.17
2.451AsnTyr: 2.451 ± 0.455
0.0AsnXaa: 0.0 ± 0.0
Pro
1.508ProAla: 1.508 ± 0.483
0.094ProCys: 0.094 ± 0.106
2.168ProAsp: 2.168 ± 0.525
2.074ProGlu: 2.074 ± 0.481
1.037ProPhe: 1.037 ± 0.338
0.66ProGly: 0.66 ± 0.19
0.566ProHis: 0.566 ± 0.214
1.885ProIle: 1.885 ± 0.325
1.98ProLys: 1.98 ± 0.564
1.885ProLeu: 1.885 ± 0.667
0.848ProMet: 0.848 ± 0.252
1.131ProAsn: 1.131 ± 0.322
1.131ProPro: 1.131 ± 0.419
3.205ProGln: 3.205 ± 0.67
1.225ProArg: 1.225 ± 0.473
2.734ProSer: 2.734 ± 0.401
3.111ProThr: 3.111 ± 0.839
2.168ProVal: 2.168 ± 0.495
0.566ProTrp: 0.566 ± 0.244
1.131ProTyr: 1.131 ± 0.429
0.0ProXaa: 0.0 ± 0.0
Gln
3.676GlnAla: 3.676 ± 0.779
0.094GlnCys: 0.094 ± 0.107
1.791GlnAsp: 1.791 ± 0.406
3.299GlnGlu: 3.299 ± 0.666
1.791GlnPhe: 1.791 ± 0.375
2.828GlnGly: 2.828 ± 0.543
0.566GlnHis: 0.566 ± 0.198
2.64GlnIle: 2.64 ± 0.573
3.394GlnLys: 3.394 ± 0.557
3.394GlnLeu: 3.394 ± 0.646
1.508GlnMet: 1.508 ± 0.359
2.545GlnAsn: 2.545 ± 0.567
1.225GlnPro: 1.225 ± 0.359
1.98GlnGln: 1.98 ± 0.407
1.697GlnArg: 1.697 ± 0.458
2.262GlnSer: 2.262 ± 0.421
2.545GlnThr: 2.545 ± 0.435
2.451GlnVal: 2.451 ± 0.486
0.189GlnTrp: 0.189 ± 0.176
1.037GlnTyr: 1.037 ± 0.287
0.0GlnXaa: 0.0 ± 0.0
Arg
2.357ArgAla: 2.357 ± 0.528
0.377ArgCys: 0.377 ± 0.258
2.451ArgAsp: 2.451 ± 0.508
2.922ArgGlu: 2.922 ± 0.602
1.037ArgPhe: 1.037 ± 0.331
1.791ArgGly: 1.791 ± 0.43
0.754ArgHis: 0.754 ± 0.271
2.922ArgIle: 2.922 ± 0.566
3.959ArgLys: 3.959 ± 0.765
3.017ArgLeu: 3.017 ± 0.627
0.943ArgMet: 0.943 ± 0.248
1.603ArgAsn: 1.603 ± 0.394
0.754ArgPro: 0.754 ± 0.261
1.603ArgGln: 1.603 ± 0.373
1.697ArgArg: 1.697 ± 0.407
1.414ArgSer: 1.414 ± 0.392
1.508ArgThr: 1.508 ± 0.338
2.451ArgVal: 2.451 ± 0.535
0.566ArgTrp: 0.566 ± 0.244
1.32ArgTyr: 1.32 ± 0.442
0.0ArgXaa: 0.0 ± 0.0
Ser
4.242SerAla: 4.242 ± 0.704
0.189SerCys: 0.189 ± 0.118
5.468SerAsp: 5.468 ± 0.865
4.431SerGlu: 4.431 ± 0.75
3.771SerPhe: 3.771 ± 0.462
5.185SerGly: 5.185 ± 0.565
0.943SerHis: 0.943 ± 0.319
4.336SerIle: 4.336 ± 0.847
6.222SerLys: 6.222 ± 0.786
4.902SerLeu: 4.902 ± 0.719
0.943SerMet: 0.943 ± 0.325
5.468SerAsn: 5.468 ± 0.56
1.603SerPro: 1.603 ± 0.52
2.262SerGln: 2.262 ± 0.542
2.357SerArg: 2.357 ± 0.461
5.468SerSer: 5.468 ± 0.909
3.676SerThr: 3.676 ± 0.653
4.054SerVal: 4.054 ± 0.74
0.943SerTrp: 0.943 ± 0.312
3.299SerTyr: 3.299 ± 0.515
0.0SerXaa: 0.0 ± 0.0
Thr
5.468ThrAla: 5.468 ± 1.215
0.471ThrCys: 0.471 ± 0.241
3.676ThrAsp: 3.676 ± 0.706
4.713ThrGlu: 4.713 ± 0.68
1.791ThrPhe: 1.791 ± 0.556
5.09ThrGly: 5.09 ± 0.624
1.32ThrHis: 1.32 ± 0.367
4.525ThrIle: 4.525 ± 0.757
4.713ThrLys: 4.713 ± 0.81
4.996ThrLeu: 4.996 ± 0.773
0.754ThrMet: 0.754 ± 0.228
4.713ThrAsn: 4.713 ± 0.805
3.488ThrPro: 3.488 ± 0.611
2.64ThrGln: 2.64 ± 0.49
2.357ThrArg: 2.357 ± 0.525
4.148ThrSer: 4.148 ± 0.648
5.845ThrThr: 5.845 ± 1.199
4.619ThrVal: 4.619 ± 1.092
0.66ThrTrp: 0.66 ± 0.262
1.885ThrTyr: 1.885 ± 0.477
0.0ThrXaa: 0.0 ± 0.0
Val
4.148ValAla: 4.148 ± 0.511
0.283ValCys: 0.283 ± 0.173
4.619ValAsp: 4.619 ± 0.5
5.373ValGlu: 5.373 ± 0.736
2.262ValPhe: 2.262 ± 0.365
3.394ValGly: 3.394 ± 0.509
0.471ValHis: 0.471 ± 0.195
4.808ValIle: 4.808 ± 0.755
5.373ValLys: 5.373 ± 0.86
3.299ValLeu: 3.299 ± 0.653
1.131ValMet: 1.131 ± 0.293
2.64ValAsn: 2.64 ± 0.544
1.414ValPro: 1.414 ± 0.592
3.111ValGln: 3.111 ± 0.731
1.414ValArg: 1.414 ± 0.446
4.902ValSer: 4.902 ± 0.564
5.185ValThr: 5.185 ± 0.749
4.242ValVal: 4.242 ± 0.648
0.566ValTrp: 0.566 ± 0.246
1.98ValTyr: 1.98 ± 0.448
0.0ValXaa: 0.0 ± 0.0
Trp
1.037TrpAla: 1.037 ± 0.411
0.094TrpCys: 0.094 ± 0.085
0.754TrpAsp: 0.754 ± 0.336
0.754TrpGlu: 0.754 ± 0.253
0.66TrpPhe: 0.66 ± 0.256
0.283TrpGly: 0.283 ± 0.159
0.189TrpHis: 0.189 ± 0.125
0.566TrpIle: 0.566 ± 0.194
1.225TrpLys: 1.225 ± 0.284
1.414TrpLeu: 1.414 ± 0.377
0.566TrpMet: 0.566 ± 0.234
1.037TrpAsn: 1.037 ± 0.287
0.094TrpPro: 0.094 ± 0.088
0.566TrpGln: 0.566 ± 0.242
0.471TrpArg: 0.471 ± 0.21
0.848TrpSer: 0.848 ± 0.305
0.754TrpThr: 0.754 ± 0.371
0.66TrpVal: 0.66 ± 0.289
0.283TrpTrp: 0.283 ± 0.163
0.471TrpTyr: 0.471 ± 0.187
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.451TyrAla: 2.451 ± 0.527
0.0TyrCys: 0.0 ± 0.0
2.922TyrAsp: 2.922 ± 0.517
2.357TyrGlu: 2.357 ± 0.458
1.885TyrPhe: 1.885 ± 0.531
2.074TyrGly: 2.074 ± 0.553
0.66TyrHis: 0.66 ± 0.257
2.357TyrIle: 2.357 ± 0.576
2.922TyrLys: 2.922 ± 0.564
3.205TyrLeu: 3.205 ± 0.599
0.66TyrMet: 0.66 ± 0.248
1.037TyrAsn: 1.037 ± 0.301
0.943TyrPro: 0.943 ± 0.278
1.32TyrGln: 1.32 ± 0.339
1.131TyrArg: 1.131 ± 0.304
2.64TyrSer: 2.64 ± 0.591
2.545TyrThr: 2.545 ± 0.506
1.697TyrVal: 1.697 ± 0.435
0.566TyrTrp: 0.566 ± 0.231
1.791TyrTyr: 1.791 ± 0.395
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 51 proteins (10609 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski