Human papillomavirus type 16

Taxonomy: Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Alphapapillomavirus; Alphapapillomavirus 9

Average proteome isoelectric point is 7.03

Get precalculated fractions of proteins

Acidic
pI < 6.8
6.8-7.4
pI > 7.4
Basic
    
All



Virtual 2D-PAGE plot for 9 proteins (isoelectric point calculated using IPC2_protein)

Get csv file with sequences according to given criteria:
        -     Method 

     -  kDa    
                                                                                      

* You can choose from 21 different methods for calculating isoelectric point

Summary statistics related to proteome-wise predictions


    
Protein with the lowest isoelectric point:
>sp|P06922|VE4_HPV16 Protein E4 OS=Human papillomavirus type 16 OX=333760 GN=E4 PE=1 SV=2
MM1 pKa = 7.49HH2 pKa = 7.91GDD4 pKa = 3.35TPTLHH9 pKa = 7.48EE10 pKa = 4.77YY11 pKa = 10.18MLDD14 pKa = 3.81LQPEE18 pKa = 4.48TTDD21 pKa = 3.68LYY23 pKa = 11.12CYY25 pKa = 9.49EE26 pKa = 4.06QLNDD30 pKa = 3.39SSEE33 pKa = 4.36EE34 pKa = 3.83EE35 pKa = 4.45DD36 pKa = 5.2EE37 pKa = 4.26IDD39 pKa = 4.2GPAGQAEE46 pKa = 4.92PDD48 pKa = 3.3RR49 pKa = 11.84AHH51 pKa = 6.14YY52 pKa = 10.59NIVTFCCKK60 pKa = 9.95CDD62 pKa = 3.19STLRR66 pKa = 11.84LCVQSTHH73 pKa = 5.81VDD75 pKa = 2.76IRR77 pKa = 11.84TLEE80 pKa = 4.31DD81 pKa = 3.69LLMGTLGIVCPICSQKK97 pKa = 10.58PP98 pKa = 3.28

Molecular weight: 11.02 kDa
Isoelectric point according different methods:





Protein with the highest isoelectric point:
>sp|P0DKA0|VE8E2_HPV16 Protein E8^E2C OS=Human papillomavirus type 16 OX=333760 PE=1 SV=1
MM1 pKa = 8.0AILKK5 pKa = 8.76WKK7 pKa = 10.57LSRR10 pKa = 11.84CYY12 pKa = 10.56SSNEE16 pKa = 3.6VSSPEE21 pKa = 4.68IIRR24 pKa = 11.84QHH26 pKa = 6.26LANHH30 pKa = 6.95PAATHH35 pKa = 5.7TKK37 pKa = 9.48AVALGTEE44 pKa = 4.59EE45 pKa = 4.15TQTTIQRR52 pKa = 11.84PRR54 pKa = 11.84SEE56 pKa = 4.69PDD58 pKa = 2.73TGNPCHH64 pKa = 5.4TTKK67 pKa = 10.85LLHH70 pKa = 6.66RR71 pKa = 11.84DD72 pKa = 3.82SVDD75 pKa = 3.17SAPILTAFNSSHH87 pKa = 7.23KK88 pKa = 10.78GRR90 pKa = 11.84INCNSNTTPIVHH102 pKa = 7.01LKK104 pKa = 10.65GDD106 pKa = 4.07ANTLKK111 pKa = 10.58CLRR114 pKa = 11.84YY115 pKa = 9.52RR116 pKa = 11.84FKK118 pKa = 10.8KK119 pKa = 10.09HH120 pKa = 4.92CTLYY124 pKa = 10.13TAVSSTWHH132 pKa = 4.35WTGHH136 pKa = 4.49NVKK139 pKa = 9.62HH140 pKa = 6.44KK141 pKa = 10.44SAIVTLTYY149 pKa = 10.62DD150 pKa = 4.08SEE152 pKa = 4.19WQRR155 pKa = 11.84DD156 pKa = 3.64QFLSQVKK163 pKa = 9.39IPKK166 pKa = 9.08TITVSTGFMSII177 pKa = 3.8

Molecular weight: 19.92 kDa
Isoelectric point according different methods:





Peptides (in silico digests for buttom-up proteomics)

Below you can find in silico digests of the whole proteome with Trypsin, Chymotrypsin, Trypsin+LysC, LysN, ArgC proteases suitable for different mass spec machines.

Try
ESI
ChTry
ESI
ArgC
ESI
LysN
ESI
TryLysC
ESI

Try
MALDI
ChTry
MALDI
ArgC
MALDI
LysN
MALDI
TryLysC
MALDI

Try
LTQ
ChTry
LTQ
ArgC
LTQ
LysN
LTQ
TryLysC
LTQ

Try
MSlow
ChTry
MSlow
ArgC
MSlow
LysN
MSlow
TryLysC
MSlow

Try
MShigh
ChTry
MShigh
ArgC
MShigh
LysN
MShigh
TryLysC
MShigh

General Statistics

Number of major isoforms

Number of additional isoforms

Number of all proteins

Number of amino acids

Min. Seq. Length

Max. Seq. Length

Avg. Seq. Length

Avg. Mol. Weight

9

0

9

2600

83

649

288.9

32.37

Amino acid frequency

Ala

Cys

Asp

Glu

Phe

Gly

His

Ile

Lys

Leu

5.731 ± 0.333

3.154 ± 0.631

5.538 ± 0.466

4.423 ± 0.577

3.5 ± 0.477

5.385 ± 0.659

2.923 ± 0.694

5.731 ± 0.72

5.654 ± 0.716

8.769 ± 0.844

Met

Asn

Gln

Pro

Arg

Ser

Thr

Val

Trp

Tyr

1.769 ± 0.291

4.538 ± 0.596

6.038 ± 1.266

4.077 ± 0.453

4.385 ± 0.527

7.731 ± 0.617

9.385 ± 1.363

5.731 ± 0.408

1.385 ± 0.311

4.154 ± 0.335
Note: For amino acid frequency statistics the error has been estimated with the bootstraping (x100) at the protein level

Most of the basic statistics you can see at this page can be downloaded from this CSV file

For dipeptide frequency statistics click here
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski