Amino acid dipepetide frequency for Alkalibacter saccharofermentans DSM 14828

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.266AlaAla: 5.266 ± 0.106	0.727AlaCys: 0.727 ± 0.038	3.423AlaAsp: 3.423 ± 0.063	4.011AlaGlu: 4.011 ± 0.085	2.915AlaPhe: 2.915 ± 0.07	5.23AlaGly: 5.23 ± 0.097	1.081AlaHis: 1.081 ± 0.039	5.672AlaIle: 5.672 ± 0.097	4.83AlaLys: 4.83 ± 0.1	6.834AlaLeu: 6.834 ± 0.117	2.22AlaMet: 2.22 ± 0.058	2.423AlaAsn: 2.423 ± 0.053	1.668AlaPro: 1.668 ± 0.053	2.003AlaGln: 2.003 ± 0.061	2.601AlaArg: 2.601 ± 0.062	4.035AlaSer: 4.035 ± 0.08	3.117AlaThr: 3.117 ± 0.068	5.351AlaVal: 5.351 ± 0.09	0.465AlaTrp: 0.465 ± 0.026	2.397AlaTyr: 2.397 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.619CysAla: 0.619 ± 0.031	0.128CysCys: 0.128 ± 0.015	0.712CysAsp: 0.712 ± 0.029	0.699CysGlu: 0.699 ± 0.033	0.404CysPhe: 0.404 ± 0.024	1.074CysGly: 1.074 ± 0.042	0.237CysHis: 0.237 ± 0.021	0.774CysIle: 0.774 ± 0.033	0.707CysLys: 0.707 ± 0.037	0.802CysLeu: 0.802 ± 0.033	0.244CysMet: 0.244 ± 0.019	0.463CysAsn: 0.463 ± 0.028	0.541CysPro: 0.541 ± 0.031	0.261CysGln: 0.261 ± 0.019	0.45CysArg: 0.45 ± 0.026	0.678CysSer: 0.678 ± 0.033	0.469CysThr: 0.469 ± 0.026	0.605CysVal: 0.605 ± 0.031	0.064CysTrp: 0.064 ± 0.011	0.359CysTyr: 0.359 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.27AspAla: 3.27 ± 0.072	0.602AspCys: 0.602 ± 0.034	2.98AspAsp: 2.98 ± 0.079	5.123AspGlu: 5.123 ± 0.084	3.0AspPhe: 3.0 ± 0.072	3.767AspGly: 3.767 ± 0.087	0.921AspHis: 0.921 ± 0.037	5.797AspIle: 5.797 ± 0.089	4.942AspLys: 4.942 ± 0.096	5.512AspLeu: 5.512 ± 0.088	1.919AspMet: 1.919 ± 0.052	2.537AspAsn: 2.537 ± 0.062	2.041AspPro: 2.041 ± 0.062	1.406AspGln: 1.406 ± 0.048	2.451AspArg: 2.451 ± 0.06	3.345AspSer: 3.345 ± 0.069	2.563AspThr: 2.563 ± 0.06	4.053AspVal: 4.053 ± 0.078	0.504AspTrp: 0.504 ± 0.03	2.651AspTyr: 2.651 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	4.812GluAla: 4.812 ± 0.091	0.535GluCys: 0.535 ± 0.029	4.773GluAsp: 4.773 ± 0.091	6.643GluGlu: 6.643 ± 0.123	2.892GluPhe: 2.892 ± 0.063	5.076GluGly: 5.076 ± 0.097	1.059GluHis: 1.059 ± 0.032	7.145GluIle: 7.145 ± 0.11	7.46GluLys: 7.46 ± 0.116	6.647GluLeu: 6.647 ± 0.112	2.443GluMet: 2.443 ± 0.058	4.376GluAsn: 4.376 ± 0.079	1.654GluPro: 1.654 ± 0.048	1.72GluGln: 1.72 ± 0.05	3.026GluArg: 3.026 ± 0.069	4.084GluSer: 4.084 ± 0.077	3.392GluThr: 3.392 ± 0.077	4.698GluVal: 4.698 ± 0.084	0.462GluTrp: 0.462 ± 0.026	2.693GluTyr: 2.693 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	2.933PheAla: 2.933 ± 0.067	0.462PheCys: 0.462 ± 0.026	2.947PheAsp: 2.947 ± 0.064	3.103PheGlu: 3.103 ± 0.066	1.969PhePhe: 1.969 ± 0.066	3.266PheGly: 3.266 ± 0.075	0.658PheHis: 0.658 ± 0.033	3.633PheIle: 3.633 ± 0.086	2.886PheLys: 2.886 ± 0.068	3.845PheLeu: 3.845 ± 0.098	1.231PheMet: 1.231 ± 0.047	2.041PheAsn: 2.041 ± 0.055	1.339PhePro: 1.339 ± 0.043	0.89PheGln: 0.89 ± 0.034	1.445PheArg: 1.445 ± 0.048	2.973PheSer: 2.973 ± 0.074	2.188PheThr: 2.188 ± 0.062	3.003PheVal: 3.003 ± 0.072	0.305PheTrp: 0.305 ± 0.025	1.595PheTyr: 1.595 ± 0.055	0.0PheXaa: 0.0 ± 0.0
Gly	4.97GlyAla: 4.97 ± 0.092	0.977GlyCys: 0.977 ± 0.044	3.797GlyAsp: 3.797 ± 0.077	4.842GlyGlu: 4.842 ± 0.106	3.595GlyPhe: 3.595 ± 0.07	5.197GlyGly: 5.197 ± 0.124	1.266GlyHis: 1.266 ± 0.046	7.0GlyIle: 7.0 ± 0.116	5.676GlyLys: 5.676 ± 0.083	6.597GlyLeu: 6.597 ± 0.118	2.389GlyMet: 2.389 ± 0.069	3.109GlyAsn: 3.109 ± 0.082	1.59GlyPro: 1.59 ± 0.056	1.687GlyGln: 1.687 ± 0.041	2.921GlyArg: 2.921 ± 0.066	4.294GlySer: 4.294 ± 0.096	3.728GlyThr: 3.728 ± 0.081	5.353GlyVal: 5.353 ± 0.102	0.66GlyTrp: 0.66 ± 0.033	3.142GlyTyr: 3.142 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	0.935HisAla: 0.935 ± 0.034	0.227HisCys: 0.227 ± 0.019	0.909HisAsp: 0.909 ± 0.043	1.113HisGlu: 1.113 ± 0.04	0.707HisPhe: 0.707 ± 0.032	1.277HisGly: 1.277 ± 0.045	0.403HisHis: 0.403 ± 0.028	1.456HisIle: 1.456 ± 0.047	1.075HisLys: 1.075 ± 0.037	1.53HisLeu: 1.53 ± 0.042	0.509HisMet: 0.509 ± 0.025	0.68HisAsn: 0.68 ± 0.034	0.827HisPro: 0.827 ± 0.035	0.517HisGln: 0.517 ± 0.028	0.739HisArg: 0.739 ± 0.035	0.958HisSer: 0.958 ± 0.031	0.841HisThr: 0.841 ± 0.036	1.048HisVal: 1.048 ± 0.043	0.15HisTrp: 0.15 ± 0.016	0.667HisTyr: 0.667 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.29IleAla: 6.29 ± 0.112	0.929IleCys: 0.929 ± 0.038	5.539IleAsp: 5.539 ± 0.089	6.557IleGlu: 6.557 ± 0.11	3.532IlePhe: 3.532 ± 0.085	6.069IleGly: 6.069 ± 0.111	1.334IleHis: 1.334 ± 0.046	7.102IleIle: 7.102 ± 0.126	7.116IleLys: 7.116 ± 0.119	7.805IleLeu: 7.805 ± 0.134	2.36IleMet: 2.36 ± 0.064	4.281IleAsn: 4.281 ± 0.085	3.288IlePro: 3.288 ± 0.086	2.139IleGln: 2.139 ± 0.058	3.341IleArg: 3.341 ± 0.069	6.242IleSer: 6.242 ± 0.105	4.429IleThr: 4.429 ± 0.099	5.451IleVal: 5.451 ± 0.096	0.524IleTrp: 0.524 ± 0.032	3.029IleTyr: 3.029 ± 0.077	0.0IleXaa: 0.0 ± 0.0
Lys	5.144LysAla: 5.144 ± 0.076	0.647LysCys: 0.647 ± 0.036	5.119LysAsp: 5.119 ± 0.093	6.958LysGlu: 6.958 ± 0.097	2.286LysPhe: 2.286 ± 0.054	5.067LysGly: 5.067 ± 0.08	1.183LysHis: 1.183 ± 0.043	7.129LysIle: 7.129 ± 0.109	7.085LysLys: 7.085 ± 0.114	6.129LysLeu: 6.129 ± 0.102	2.536LysMet: 2.536 ± 0.064	4.558LysAsn: 4.558 ± 0.08	2.223LysPro: 2.223 ± 0.055	1.81LysGln: 1.81 ± 0.058	3.361LysArg: 3.361 ± 0.072	4.685LysSer: 4.685 ± 0.09	3.989LysThr: 3.989 ± 0.081	5.142LysVal: 5.142 ± 0.099	0.541LysTrp: 0.541 ± 0.026	3.028LysTyr: 3.028 ± 0.069	0.0LysXaa: 0.0 ± 0.0
Leu	6.274LeuAla: 6.274 ± 0.1	0.88LeuCys: 0.88 ± 0.035	5.491LeuAsp: 5.491 ± 0.087	7.078LeuGlu: 7.078 ± 0.119	3.722LeuPhe: 3.722 ± 0.09	6.658LeuGly: 6.658 ± 0.124	1.362LeuHis: 1.362 ± 0.046	7.535LeuIle: 7.535 ± 0.124	7.652LeuLys: 7.652 ± 0.115	8.05LeuLeu: 8.05 ± 0.117	2.785LeuMet: 2.785 ± 0.065	4.331LeuAsn: 4.331 ± 0.081	3.125LeuPro: 3.125 ± 0.052	1.964LeuGln: 1.964 ± 0.06	3.422LeuArg: 3.422 ± 0.065	6.61LeuSer: 6.61 ± 0.104	4.473LeuThr: 4.473 ± 0.086	6.087LeuVal: 6.087 ± 0.09	0.675LeuTrp: 0.675 ± 0.035	3.065LeuTyr: 3.065 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	2.23MetAla: 2.23 ± 0.06	0.242MetCys: 0.242 ± 0.019	1.992MetAsp: 1.992 ± 0.055	2.438MetGlu: 2.438 ± 0.056	1.071MetPhe: 1.071 ± 0.041	2.309MetGly: 2.309 ± 0.061	0.423MetHis: 0.423 ± 0.026	2.609MetIle: 2.609 ± 0.066	2.567MetLys: 2.567 ± 0.061	2.705MetLeu: 2.705 ± 0.06	0.945MetMet: 0.945 ± 0.043	1.528MetAsn: 1.528 ± 0.044	1.176MetPro: 1.176 ± 0.037	0.667MetGln: 0.667 ± 0.035	1.038MetArg: 1.038 ± 0.036	1.876MetSer: 1.876 ± 0.048	1.622MetThr: 1.622 ± 0.045	2.111MetVal: 2.111 ± 0.052	0.149MetTrp: 0.149 ± 0.014	0.818MetTyr: 0.818 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	2.869AsnAla: 2.869 ± 0.064	0.501AsnCys: 0.501 ± 0.029	2.479AsnAsp: 2.479 ± 0.067	3.276AsnGlu: 3.276 ± 0.073	1.833AsnPhe: 1.833 ± 0.055	3.109AsnGly: 3.109 ± 0.071	0.883AsnHis: 0.883 ± 0.036	4.516AsnIle: 4.516 ± 0.086	3.693AsnLys: 3.693 ± 0.077	4.377AsnLeu: 4.377 ± 0.076	1.459AsnMet: 1.459 ± 0.044	2.364AsnAsn: 2.364 ± 0.066	2.223AsnPro: 2.223 ± 0.06	1.406AsnGln: 1.406 ± 0.047	2.049AsnArg: 2.049 ± 0.056	2.712AsnSer: 2.712 ± 0.067	2.227AsnThr: 2.227 ± 0.051	3.006AsnVal: 3.006 ± 0.073	0.394AsnTrp: 0.394 ± 0.026	1.85AsnTyr: 1.85 ± 0.054	0.0AsnXaa: 0.0 ± 0.0
Pro	1.927ProAla: 1.927 ± 0.061	0.339ProCys: 0.339 ± 0.022	2.052ProAsp: 2.052 ± 0.063	2.947ProGlu: 2.947 ± 0.068	1.497ProPhe: 1.497 ± 0.05	2.637ProGly: 2.637 ± 0.06	0.66ProHis: 0.66 ± 0.029	2.451ProIle: 2.451 ± 0.058	2.048ProLys: 2.048 ± 0.059	2.801ProLeu: 2.801 ± 0.068	0.872ProMet: 0.872 ± 0.035	1.335ProAsn: 1.335 ± 0.045	0.784ProPro: 0.784 ± 0.035	0.889ProGln: 0.889 ± 0.04	1.054ProArg: 1.054 ± 0.042	1.836ProSer: 1.836 ± 0.051	1.541ProThr: 1.541 ± 0.043	2.917ProVal: 2.917 ± 0.064	0.299ProTrp: 0.299 ± 0.027	1.28ProTyr: 1.28 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	1.728GlnAla: 1.728 ± 0.047	0.248GlnCys: 0.248 ± 0.02	1.309GlnAsp: 1.309 ± 0.045	1.84GlnGlu: 1.84 ± 0.055	0.932GlnPhe: 0.932 ± 0.037	1.792GlnGly: 1.792 ± 0.048	0.356GlnHis: 0.356 ± 0.022	2.364GlnIle: 2.364 ± 0.058	2.181GlnLys: 2.181 ± 0.059	2.202GlnLeu: 2.202 ± 0.058	0.859GlnMet: 0.859 ± 0.035	1.296GlnAsn: 1.296 ± 0.043	0.655GlnPro: 0.655 ± 0.029	0.722GlnGln: 0.722 ± 0.037	1.234GlnArg: 1.234 ± 0.043	1.442GlnSer: 1.442 ± 0.049	1.198GlnThr: 1.198 ± 0.045	1.722GlnVal: 1.722 ± 0.052	0.241GlnTrp: 0.241 ± 0.02	0.815GlnTyr: 0.815 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.289ArgAla: 2.289 ± 0.065	0.433ArgCys: 0.433 ± 0.026	2.331ArgAsp: 2.331 ± 0.06	3.275ArgGlu: 3.275 ± 0.069	1.839ArgPhe: 1.839 ± 0.055	2.529ArgGly: 2.529 ± 0.063	0.735ArgHis: 0.735 ± 0.035	3.529ArgIle: 3.529 ± 0.07	3.125ArgLys: 3.125 ± 0.06	3.664ArgLeu: 3.664 ± 0.071	1.266ArgMet: 1.266 ± 0.045	1.974ArgAsn: 1.974 ± 0.051	1.088ArgPro: 1.088 ± 0.038	1.183ArgGln: 1.183 ± 0.045	1.716ArgArg: 1.716 ± 0.051	2.09ArgSer: 2.09 ± 0.065	1.853ArgThr: 1.853 ± 0.052	2.674ArgVal: 2.674 ± 0.061	0.31ArgTrp: 0.31 ± 0.022	1.632ArgTyr: 1.632 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	3.924SerAla: 3.924 ± 0.074	0.631SerCys: 0.631 ± 0.032	3.429SerAsp: 3.429 ± 0.065	3.99SerGlu: 3.99 ± 0.084	2.918SerPhe: 2.918 ± 0.072	5.129SerGly: 5.129 ± 0.097	1.1SerHis: 1.1 ± 0.036	5.444SerIle: 5.444 ± 0.087	4.36SerLys: 4.36 ± 0.075	5.848SerLeu: 5.848 ± 0.095	1.886SerMet: 1.886 ± 0.062	2.638SerAsn: 2.638 ± 0.07	2.02SerPro: 2.02 ± 0.062	1.824SerGln: 1.824 ± 0.055	2.621SerArg: 2.621 ± 0.075	3.852SerSer: 3.852 ± 0.089	2.947SerThr: 2.947 ± 0.076	4.436SerVal: 4.436 ± 0.078	0.482SerTrp: 0.482 ± 0.03	2.402SerTyr: 2.402 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	3.48ThrAla: 3.48 ± 0.083	0.462ThrCys: 0.462 ± 0.029	2.866ThrAsp: 2.866 ± 0.066	3.106ThrGlu: 3.106 ± 0.066	2.041ThrPhe: 2.041 ± 0.061	4.633ThrGly: 4.633 ± 0.096	0.86ThrHis: 0.86 ± 0.034	3.943ThrIle: 3.943 ± 0.071	2.999ThrLys: 2.999 ± 0.06	4.657ThrLeu: 4.657 ± 0.081	1.341ThrMet: 1.341 ± 0.047	2.01ThrAsn: 2.01 ± 0.056	1.953ThrPro: 1.953 ± 0.061	1.251ThrGln: 1.251 ± 0.041	1.712ThrArg: 1.712 ± 0.053	2.788ThrSer: 2.788 ± 0.059	2.495ThrThr: 2.495 ± 0.067	3.804ThrVal: 3.804 ± 0.093	0.354ThrTrp: 0.354 ± 0.024	1.699ThrTyr: 1.699 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	4.685ValAla: 4.685 ± 0.088	0.758ValCys: 0.758 ± 0.035	4.322ValAsp: 4.322 ± 0.076	5.398ValGlu: 5.398 ± 0.089	3.342ValPhe: 3.342 ± 0.077	4.649ValGly: 4.649 ± 0.097	1.137ValHis: 1.137 ± 0.041	5.766ValIle: 5.766 ± 0.102	5.048ValLys: 5.048 ± 0.092	6.842ValLeu: 6.842 ± 0.108	1.996ValMet: 1.996 ± 0.052	3.099ValAsn: 3.099 ± 0.073	2.292ValPro: 2.292 ± 0.062	1.553ValGln: 1.553 ± 0.041	2.448ValArg: 2.448 ± 0.061	4.501ValSer: 4.501 ± 0.079	3.34ValThr: 3.34 ± 0.081	5.334ValVal: 5.334 ± 0.087	0.414ValTrp: 0.414 ± 0.027	2.518ValTyr: 2.518 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.453TrpAla: 0.453 ± 0.029	0.084TrpCys: 0.084 ± 0.01	0.494TrpAsp: 0.494 ± 0.025	0.534TrpGlu: 0.534 ± 0.026	0.356TrpPhe: 0.356 ± 0.026	0.567TrpGly: 0.567 ± 0.027	0.147TrpHis: 0.147 ± 0.015	0.638TrpIle: 0.638 ± 0.031	0.489TrpLys: 0.489 ± 0.027	0.699TrpLeu: 0.699 ± 0.035	0.219TrpMet: 0.219 ± 0.015	0.391TrpAsn: 0.391 ± 0.027	0.215TrpPro: 0.215 ± 0.021	0.24TrpGln: 0.24 ± 0.019	0.307TrpArg: 0.307 ± 0.022	0.426TrpSer: 0.426 ± 0.025	0.329TrpThr: 0.329 ± 0.023	0.443TrpVal: 0.443 ± 0.025	0.082TrpTrp: 0.082 ± 0.012	0.245TrpTyr: 0.245 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.175TyrAla: 2.175 ± 0.054	0.478TyrCys: 0.478 ± 0.028	2.419TyrAsp: 2.419 ± 0.057	2.663TyrGlu: 2.663 ± 0.068	1.859TyrPhe: 1.859 ± 0.045	2.755TyrGly: 2.755 ± 0.053	0.763TyrHis: 0.763 ± 0.031	2.853TyrIle: 2.853 ± 0.075	2.679TyrLys: 2.679 ± 0.073	3.693TyrLeu: 3.693 ± 0.07	1.036TyrMet: 1.036 ± 0.038	1.792TyrAsn: 1.792 ± 0.059	1.462TyrPro: 1.462 ± 0.051	1.004TyrGln: 1.004 ± 0.037	1.599TyrArg: 1.599 ± 0.042	2.455TyrSer: 2.455 ± 0.062	1.712TyrThr: 1.712 ± 0.049	2.202TyrVal: 2.202 ± 0.058	0.286TyrTrp: 0.286 ± 0.022	1.585TyrTyr: 1.585 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2181 proteins (692899 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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