Amino acid dipepetide frequency for Estrella lausannensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.393AlaAla: 7.393 ± 0.139	0.922AlaCys: 0.922 ± 0.036	3.604AlaAsp: 3.604 ± 0.074	5.529AlaGlu: 5.529 ± 0.099	4.032AlaPhe: 4.032 ± 0.07	5.051AlaGly: 5.051 ± 0.102	1.53AlaHis: 1.53 ± 0.05	5.549AlaIle: 5.549 ± 0.086	5.844AlaLys: 5.844 ± 0.099	10.516AlaLeu: 10.516 ± 0.135	1.959AlaMet: 1.959 ± 0.049	2.363AlaAsn: 2.363 ± 0.07	2.941AlaPro: 2.941 ± 0.064	2.384AlaGln: 2.384 ± 0.069	3.629AlaArg: 3.629 ± 0.075	5.534AlaSer: 5.534 ± 0.094	3.567AlaThr: 3.567 ± 0.067	4.98AlaVal: 4.98 ± 0.091	0.755AlaTrp: 0.755 ± 0.034	2.328AlaTyr: 2.328 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.642CysAla: 0.642 ± 0.032	0.201CysCys: 0.201 ± 0.016	0.54CysAsp: 0.54 ± 0.028	0.549CysGlu: 0.549 ± 0.03	0.653CysPhe: 0.653 ± 0.03	0.805CysGly: 0.805 ± 0.036	0.334CysHis: 0.334 ± 0.024	0.634CysIle: 0.634 ± 0.026	0.58CysLys: 0.58 ± 0.032	1.394CysLeu: 1.394 ± 0.039	0.245CysMet: 0.245 ± 0.018	0.347CysAsn: 0.347 ± 0.023	0.697CysPro: 0.697 ± 0.041	0.426CysGln: 0.426 ± 0.023	0.606CysArg: 0.606 ± 0.026	0.728CysSer: 0.728 ± 0.032	0.465CysThr: 0.465 ± 0.026	0.586CysVal: 0.586 ± 0.027	0.124CysTrp: 0.124 ± 0.011	0.399CysTyr: 0.399 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	3.9AspAla: 3.9 ± 0.073	0.586AspCys: 0.586 ± 0.027	2.273AspAsp: 2.273 ± 0.056	3.796AspGlu: 3.796 ± 0.066	2.56AspPhe: 2.56 ± 0.054	2.902AspGly: 2.902 ± 0.064	1.057AspHis: 1.057 ± 0.032	3.358AspIle: 3.358 ± 0.063	3.183AspLys: 3.183 ± 0.074	5.893AspLeu: 5.893 ± 0.099	1.047AspMet: 1.047 ± 0.04	1.459AspAsn: 1.459 ± 0.045	2.781AspPro: 2.781 ± 0.066	1.766AspGln: 1.766 ± 0.044	2.475AspArg: 2.475 ± 0.065	3.119AspSer: 3.119 ± 0.061	2.108AspThr: 2.108 ± 0.051	2.862AspVal: 2.862 ± 0.069	0.682AspTrp: 0.682 ± 0.029	1.672AspTyr: 1.672 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.595GluAla: 6.595 ± 0.108	0.695GluCys: 0.695 ± 0.032	3.339GluAsp: 3.339 ± 0.075	7.289GluGlu: 7.289 ± 0.138	2.57GluPhe: 2.57 ± 0.054	5.439GluGly: 5.439 ± 0.103	1.278GluHis: 1.278 ± 0.042	5.307GluIle: 5.307 ± 0.094	6.345GluLys: 6.345 ± 0.119	6.684GluLeu: 6.684 ± 0.106	2.156GluMet: 2.156 ± 0.055	2.789GluAsn: 2.789 ± 0.066	2.248GluPro: 2.248 ± 0.055	2.341GluGln: 2.341 ± 0.059	4.493GluArg: 4.493 ± 0.085	4.674GluSer: 4.674 ± 0.067	3.639GluThr: 3.639 ± 0.078	4.407GluVal: 4.407 ± 0.093	0.863GluTrp: 0.863 ± 0.037	1.677GluTyr: 1.677 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	3.596PheAla: 3.596 ± 0.073	0.612PheCys: 0.612 ± 0.03	2.689PheAsp: 2.689 ± 0.055	3.075PheGlu: 3.075 ± 0.063	3.035PhePhe: 3.035 ± 0.076	3.37PheGly: 3.37 ± 0.074	1.068PheHis: 1.068 ± 0.039	2.975PheIle: 2.975 ± 0.061	2.876PheLys: 2.876 ± 0.064	5.355PheLeu: 5.355 ± 0.106	0.934PheMet: 0.934 ± 0.031	1.78PheAsn: 1.78 ± 0.05	1.915PhePro: 1.915 ± 0.043	1.684PheGln: 1.684 ± 0.047	2.073PheArg: 2.073 ± 0.048	4.061PheSer: 4.061 ± 0.081	2.305PheThr: 2.305 ± 0.061	2.902PheVal: 2.902 ± 0.06	0.499PheTrp: 0.499 ± 0.028	1.504PheTyr: 1.504 ± 0.047	0.001PheXaa: 0.001 ± 0.001
Gly	5.041GlyAla: 5.041 ± 0.092	0.857GlyCys: 0.857 ± 0.034	3.206GlyAsp: 3.206 ± 0.066	4.354GlyGlu: 4.354 ± 0.092	3.377GlyPhe: 3.377 ± 0.073	4.915GlyGly: 4.915 ± 0.14	1.439GlyHis: 1.439 ± 0.046	4.747GlyIle: 4.747 ± 0.082	5.161GlyLys: 5.161 ± 0.08	6.381GlyLeu: 6.381 ± 0.111	1.752GlyMet: 1.752 ± 0.049	2.194GlyAsn: 2.194 ± 0.06	1.957GlyPro: 1.957 ± 0.068	2.079GlyGln: 2.079 ± 0.05	3.236GlyArg: 3.236 ± 0.069	4.625GlySer: 4.625 ± 0.08	3.304GlyThr: 3.304 ± 0.067	4.498GlyVal: 4.498 ± 0.079	0.832GlyTrp: 0.832 ± 0.035	2.232GlyTyr: 2.232 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	1.471HisAla: 1.471 ± 0.038	0.271HisCys: 0.271 ± 0.024	1.066HisAsp: 1.066 ± 0.035	1.449HisGlu: 1.449 ± 0.045	1.309HisPhe: 1.309 ± 0.038	1.295HisGly: 1.295 ± 0.042	0.64HisHis: 0.64 ± 0.033	1.334HisIle: 1.334 ± 0.046	1.072HisLys: 1.072 ± 0.038	2.752HisLeu: 2.752 ± 0.067	0.45HisMet: 0.45 ± 0.022	0.59HisAsn: 0.59 ± 0.025	1.467HisPro: 1.467 ± 0.04	0.892HisGln: 0.892 ± 0.036	1.01HisArg: 1.01 ± 0.035	1.352HisSer: 1.352 ± 0.04	0.923HisThr: 0.923 ± 0.035	1.211HisVal: 1.211 ± 0.038	0.221HisTrp: 0.221 ± 0.016	0.763HisTyr: 0.763 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.13IleAla: 6.13 ± 0.093	0.666IleCys: 0.666 ± 0.03	3.905IleAsp: 3.905 ± 0.076	5.08IleGlu: 5.08 ± 0.084	2.665IlePhe: 2.665 ± 0.06	4.601IleGly: 4.601 ± 0.086	1.629IleHis: 1.629 ± 0.046	3.546IleIle: 3.546 ± 0.078	4.017IleLys: 4.017 ± 0.079	6.52IleLeu: 6.52 ± 0.106	1.146IleMet: 1.146 ± 0.045	2.42IleAsn: 2.42 ± 0.054	3.362IlePro: 3.362 ± 0.059	2.441IleGln: 2.441 ± 0.064	3.492IleArg: 3.492 ± 0.068	4.446IleSer: 4.446 ± 0.087	3.244IleThr: 3.244 ± 0.067	3.874IleVal: 3.874 ± 0.074	0.538IleTrp: 0.538 ± 0.029	1.733IleTyr: 1.733 ± 0.055	0.001IleXaa: 0.001 ± 0.001
Lys	6.001LysAla: 6.001 ± 0.109	0.507LysCys: 0.507 ± 0.022	3.649LysAsp: 3.649 ± 0.061	7.523LysGlu: 7.523 ± 0.136	1.86LysPhe: 1.86 ± 0.056	4.742LysGly: 4.742 ± 0.079	1.185LysHis: 1.185 ± 0.044	4.706LysIle: 4.706 ± 0.081	6.114LysLys: 6.114 ± 0.118	5.933LysLeu: 5.933 ± 0.097	1.873LysMet: 1.873 ± 0.046	2.879LysAsn: 2.879 ± 0.066	2.629LysPro: 2.629 ± 0.061	2.543LysGln: 2.543 ± 0.064	3.81LysArg: 3.81 ± 0.088	4.309LysSer: 4.309 ± 0.072	3.852LysThr: 3.852 ± 0.083	3.89LysVal: 3.89 ± 0.072	0.756LysTrp: 0.756 ± 0.029	1.381LysTyr: 1.381 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	8.748LeuAla: 8.748 ± 0.117	1.096LeuCys: 1.096 ± 0.035	5.261LeuAsp: 5.261 ± 0.082	7.339LeuGlu: 7.339 ± 0.124	6.147LeuPhe: 6.147 ± 0.119	6.361LeuGly: 6.361 ± 0.11	2.155LeuHis: 2.155 ± 0.058	7.21LeuIle: 7.21 ± 0.127	8.523LeuLys: 8.523 ± 0.126	11.559LeuLeu: 11.559 ± 0.169	2.663LeuMet: 2.663 ± 0.067	3.985LeuAsn: 3.985 ± 0.07	4.905LeuPro: 4.905 ± 0.088	4.09LeuGln: 4.09 ± 0.077	4.789LeuArg: 4.789 ± 0.08	9.003LeuSer: 9.003 ± 0.124	5.701LeuThr: 5.701 ± 0.1	5.613LeuVal: 5.613 ± 0.094	0.983LeuTrp: 0.983 ± 0.038	3.001LeuTyr: 3.001 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.078MetAla: 2.078 ± 0.054	0.169MetCys: 0.169 ± 0.016	1.145MetAsp: 1.145 ± 0.035	1.812MetGlu: 1.812 ± 0.055	0.719MetPhe: 0.719 ± 0.031	1.684MetGly: 1.684 ± 0.05	0.553MetHis: 0.553 ± 0.028	1.512MetIle: 1.512 ± 0.042	1.801MetLys: 1.801 ± 0.045	2.319MetLeu: 2.319 ± 0.054	0.643MetMet: 0.643 ± 0.028	1.006MetAsn: 1.006 ± 0.035	1.182MetPro: 1.182 ± 0.039	1.091MetGln: 1.091 ± 0.037	1.392MetArg: 1.392 ± 0.043	1.357MetSer: 1.357 ± 0.042	1.433MetThr: 1.433 ± 0.043	1.262MetVal: 1.262 ± 0.04	0.168MetTrp: 0.168 ± 0.015	0.377MetTyr: 0.377 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.634AsnAla: 2.634 ± 0.063	0.397AsnCys: 0.397 ± 0.023	1.607AsnAsp: 1.607 ± 0.05	2.269AsnGlu: 2.269 ± 0.057	1.637AsnPhe: 1.637 ± 0.043	2.031AsnGly: 2.031 ± 0.051	0.853AsnHis: 0.853 ± 0.032	2.378AsnIle: 2.378 ± 0.058	1.91AsnLys: 1.91 ± 0.052	4.072AsnLeu: 4.072 ± 0.086	0.763AsnMet: 0.763 ± 0.029	1.142AsnAsn: 1.142 ± 0.037	2.534AsnPro: 2.534 ± 0.054	1.381AsnGln: 1.381 ± 0.047	1.771AsnArg: 1.771 ± 0.051	2.077AsnSer: 2.077 ± 0.055	1.714AsnThr: 1.714 ± 0.042	1.891AsnVal: 1.891 ± 0.048	0.481AsnTrp: 0.481 ± 0.022	1.131AsnTyr: 1.131 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	3.091ProAla: 3.091 ± 0.068	0.499ProCys: 0.499 ± 0.027	2.261ProAsp: 2.261 ± 0.05	3.607ProGlu: 3.607 ± 0.069	2.436ProPhe: 2.436 ± 0.052	2.805ProGly: 2.805 ± 0.064	1.11ProHis: 1.11 ± 0.039	2.362ProIle: 2.362 ± 0.056	2.869ProLys: 2.869 ± 0.062	5.527ProLeu: 5.527 ± 0.095	0.892ProMet: 0.892 ± 0.032	1.261ProAsn: 1.261 ± 0.041	2.116ProPro: 2.116 ± 0.063	1.586ProGln: 1.586 ± 0.048	1.643ProArg: 1.643 ± 0.049	3.231ProSer: 3.231 ± 0.064	1.986ProThr: 1.986 ± 0.056	2.989ProVal: 2.989 ± 0.068	0.483ProTrp: 0.483 ± 0.027	1.429ProTyr: 1.429 ± 0.042	0.001ProXaa: 0.001 ± 0.001
Gln	3.075GlnAla: 3.075 ± 0.069	0.298GlnCys: 0.298 ± 0.02	1.943GlnAsp: 1.943 ± 0.052	3.376GlnGlu: 3.376 ± 0.074	1.567GlnPhe: 1.567 ± 0.046	2.661GlnGly: 2.661 ± 0.063	0.716GlnHis: 0.716 ± 0.031	2.367GlnIle: 2.367 ± 0.069	2.843GlnLys: 2.843 ± 0.068	3.3GlnLeu: 3.3 ± 0.068	0.892GlnMet: 0.892 ± 0.036	1.519GlnAsn: 1.519 ± 0.043	1.244GlnPro: 1.244 ± 0.039	1.534GlnGln: 1.534 ± 0.053	1.817GlnArg: 1.817 ± 0.047	2.198GlnSer: 2.198 ± 0.061	1.633GlnThr: 1.633 ± 0.05	2.095GlnVal: 2.095 ± 0.051	0.365GlnTrp: 0.365 ± 0.022	0.87GlnTyr: 0.87 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.492ArgAla: 3.492 ± 0.07	0.601ArgCys: 0.601 ± 0.031	2.31ArgAsp: 2.31 ± 0.058	4.266ArgGlu: 4.266 ± 0.08	2.671ArgPhe: 2.671 ± 0.06	3.161ArgGly: 3.161 ± 0.068	1.127ArgHis: 1.127 ± 0.039	3.302ArgIle: 3.302 ± 0.069	3.131ArgLys: 3.131 ± 0.07	5.273ArgLeu: 5.273 ± 0.09	1.289ArgMet: 1.289 ± 0.04	1.591ArgAsn: 1.591 ± 0.044	1.727ArgPro: 1.727 ± 0.054	2.157ArgGln: 2.157 ± 0.053	2.586ArgArg: 2.586 ± 0.062	3.104ArgSer: 3.104 ± 0.061	1.939ArgThr: 1.939 ± 0.049	3.043ArgVal: 3.043 ± 0.067	0.612ArgTrp: 0.612 ± 0.023	1.724ArgTyr: 1.724 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.195SerAla: 5.195 ± 0.096	0.943SerCys: 0.943 ± 0.041	3.185SerAsp: 3.185 ± 0.072	4.02SerGlu: 4.02 ± 0.074	3.853SerPhe: 3.853 ± 0.073	4.713SerGly: 4.713 ± 0.077	1.585SerHis: 1.585 ± 0.045	4.356SerIle: 4.356 ± 0.067	4.408SerLys: 4.408 ± 0.069	8.765SerLeu: 8.765 ± 0.123	1.646SerMet: 1.646 ± 0.041	2.143SerAsn: 2.143 ± 0.049	3.291SerPro: 3.291 ± 0.065	2.425SerGln: 2.425 ± 0.064	3.148SerArg: 3.148 ± 0.063	5.209SerSer: 5.209 ± 0.087	3.063SerThr: 3.063 ± 0.066	3.917SerVal: 3.917 ± 0.07	0.779SerTrp: 0.779 ± 0.031	2.235SerTyr: 2.235 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	3.911ThrAla: 3.911 ± 0.089	0.501ThrCys: 0.501 ± 0.026	2.321ThrAsp: 2.321 ± 0.053	2.978ThrGlu: 2.978 ± 0.064	2.185ThrPhe: 2.185 ± 0.052	3.55ThrGly: 3.55 ± 0.076	1.106ThrHis: 1.106 ± 0.042	3.146ThrIle: 3.146 ± 0.061	2.935ThrLys: 2.935 ± 0.076	6.155ThrLeu: 6.155 ± 0.093	1.052ThrMet: 1.052 ± 0.039	1.486ThrAsn: 1.486 ± 0.048	2.795ThrPro: 2.795 ± 0.066	1.591ThrGln: 1.591 ± 0.05	1.967ThrArg: 1.967 ± 0.053	3.033ThrSer: 3.033 ± 0.058	2.455ThrThr: 2.455 ± 0.063	3.028ThrVal: 3.028 ± 0.066	0.468ThrTrp: 0.468 ± 0.027	1.431ThrTyr: 1.431 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	4.855ValAla: 4.855 ± 0.073	0.642ValCys: 0.642 ± 0.029	3.194ValAsp: 3.194 ± 0.063	4.151ValGlu: 4.151 ± 0.076	2.947ValPhe: 2.947 ± 0.062	3.696ValGly: 3.696 ± 0.083	1.143ValHis: 1.143 ± 0.042	4.127ValIle: 4.127 ± 0.077	4.256ValLys: 4.256 ± 0.072	5.974ValLeu: 5.974 ± 0.1	1.436ValMet: 1.436 ± 0.045	2.178ValAsn: 2.178 ± 0.055	2.525ValPro: 2.525 ± 0.063	1.985ValGln: 1.985 ± 0.05	2.868ValArg: 2.868 ± 0.07	4.286ValSer: 4.286 ± 0.076	2.831ValThr: 2.831 ± 0.067	3.988ValVal: 3.988 ± 0.074	0.507ValTrp: 0.507 ± 0.023	1.581ValTyr: 1.581 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.607TrpAla: 0.607 ± 0.029	0.124TrpCys: 0.124 ± 0.012	0.534TrpAsp: 0.534 ± 0.025	0.675TrpGlu: 0.675 ± 0.031	0.399TrpPhe: 0.399 ± 0.027	0.68TrpGly: 0.68 ± 0.032	0.261TrpHis: 0.261 ± 0.017	0.862TrpIle: 0.862 ± 0.029	0.838TrpLys: 0.838 ± 0.036	1.208TrpLeu: 1.208 ± 0.045	0.307TrpMet: 0.307 ± 0.02	0.497TrpAsn: 0.497 ± 0.026	0.344TrpPro: 0.344 ± 0.019	0.465TrpGln: 0.465 ± 0.024	0.604TrpArg: 0.604 ± 0.033	0.617TrpSer: 0.617 ± 0.027	0.482TrpThr: 0.482 ± 0.025	0.639TrpVal: 0.639 ± 0.032	0.147TrpTrp: 0.147 ± 0.015	0.286TrpTyr: 0.286 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.957TyrAla: 1.957 ± 0.059	0.368TyrCys: 0.368 ± 0.022	1.446TyrAsp: 1.446 ± 0.055	1.69TyrGlu: 1.69 ± 0.051	1.686TyrPhe: 1.686 ± 0.048	1.726TyrGly: 1.726 ± 0.047	0.769TyrHis: 0.769 ± 0.034	1.68TyrIle: 1.68 ± 0.057	1.436TyrLys: 1.436 ± 0.043	3.553TyrLeu: 3.553 ± 0.074	0.556TyrMet: 0.556 ± 0.027	1.043TyrAsn: 1.043 ± 0.035	1.525TyrPro: 1.525 ± 0.044	1.451TyrGln: 1.451 ± 0.042	1.698TyrArg: 1.698 ± 0.047	1.917TyrSer: 1.917 ± 0.049	1.45TyrThr: 1.45 ± 0.046	1.493TyrVal: 1.493 ± 0.048	0.31TyrTrp: 0.31 ± 0.021	1.094TyrTyr: 1.094 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.012XaaXaa: 0.012 ± 0.012

Statistics based on 2216 proteins (808995 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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