Amino acid dipepetide frequency for Streptococcus satellite phage Javan739

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.588AlaAla: 0.588 ± 0.54
0.294AlaCys: 0.294 ± 0.258
3.236AlaAsp: 3.236 ± 0.983
5.884AlaGlu: 5.884 ± 1.719
2.354AlaPhe: 2.354 ± 0.986
2.942AlaGly: 2.942 ± 0.981
0.883AlaHis: 0.883 ± 0.541
5.59AlaIle: 5.59 ± 0.937
5.884AlaLys: 5.884 ± 0.962
3.236AlaLeu: 3.236 ± 1.447
2.354AlaMet: 2.354 ± 0.9
3.236AlaAsn: 3.236 ± 1.25
1.471AlaPro: 1.471 ± 0.636
2.354AlaGln: 2.354 ± 0.667
4.413AlaArg: 4.413 ± 1.138
2.648AlaSer: 2.648 ± 0.795
2.942AlaThr: 2.942 ± 0.934
3.236AlaVal: 3.236 ± 1.2
0.883AlaTrp: 0.883 ± 0.48
3.825AlaTyr: 3.825 ± 1.162
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.294CysCys: 0.294 ± 0.27
0.0CysAsp: 0.0 ± 0.0
0.588CysGlu: 0.588 ± 0.316
0.294CysPhe: 0.294 ± 0.27
0.294CysGly: 0.294 ± 0.258
0.294CysHis: 0.294 ± 0.223
0.0CysIle: 0.0 ± 0.0
0.294CysLys: 0.294 ± 0.258
1.177CysLeu: 1.177 ± 0.498
0.0CysMet: 0.0 ± 0.0
0.294CysAsn: 0.294 ± 0.295
0.294CysPro: 0.294 ± 0.223
0.0CysGln: 0.0 ± 0.0
0.294CysArg: 0.294 ± 0.359
0.588CysSer: 0.588 ± 0.517
0.294CysThr: 0.294 ± 0.36
0.588CysVal: 0.588 ± 0.395
0.0CysTrp: 0.0 ± 0.0
0.294CysTyr: 0.294 ± 0.348
0.0CysXaa: 0.0 ± 0.0
Asp
3.825AspAla: 3.825 ± 1.315
0.294AspCys: 0.294 ± 0.223
5.296AspAsp: 5.296 ± 1.459
6.472AspGlu: 6.472 ± 1.222
2.942AspPhe: 2.942 ± 1.204
4.119AspGly: 4.119 ± 1.026
0.588AspHis: 0.588 ± 0.31
4.119AspIle: 4.119 ± 0.885
5.296AspLys: 5.296 ± 1.255
7.355AspLeu: 7.355 ± 1.7
0.883AspMet: 0.883 ± 0.533
3.825AspAsn: 3.825 ± 1.055
0.883AspPro: 0.883 ± 0.372
0.294AspGln: 0.294 ± 0.348
3.53AspArg: 3.53 ± 1.422
2.942AspSer: 2.942 ± 0.991
3.53AspThr: 3.53 ± 1.086
2.648AspVal: 2.648 ± 1.248
0.0AspTrp: 0.0 ± 0.0
2.648AspTyr: 2.648 ± 1.034
0.0AspXaa: 0.0 ± 0.0
Glu
4.707GluAla: 4.707 ± 1.518
0.883GluCys: 0.883 ± 0.467
1.765GluAsp: 1.765 ± 0.59
5.884GluGlu: 5.884 ± 1.55
2.354GluPhe: 2.354 ± 1.038
3.825GluGly: 3.825 ± 0.952
2.059GluHis: 2.059 ± 0.846
8.532GluIle: 8.532 ± 1.374
9.415GluLys: 9.415 ± 2.048
9.12GluLeu: 9.12 ± 2.155
3.53GluMet: 3.53 ± 1.165
5.59GluAsn: 5.59 ± 1.639
1.471GluPro: 1.471 ± 0.527
2.059GluGln: 2.059 ± 0.625
5.59GluArg: 5.59 ± 1.614
3.53GluSer: 3.53 ± 1.148
5.296GluThr: 5.296 ± 1.066
5.59GluVal: 5.59 ± 1.578
0.0GluTrp: 0.0 ± 0.0
2.942GluTyr: 2.942 ± 1.145
0.0GluXaa: 0.0 ± 0.0
Phe
1.765PheAla: 1.765 ± 1.078
0.294PheCys: 0.294 ± 0.258
3.825PheAsp: 3.825 ± 1.236
2.648PheGlu: 2.648 ± 1.257
1.471PhePhe: 1.471 ± 0.748
2.354PheGly: 2.354 ± 0.67
1.177PheHis: 1.177 ± 0.478
3.825PheIle: 3.825 ± 1.044
1.471PheLys: 1.471 ± 0.694
4.707PheLeu: 4.707 ± 1.235
0.588PheMet: 0.588 ± 0.484
1.765PheAsn: 1.765 ± 0.605
1.177PhePro: 1.177 ± 0.55
1.471PheGln: 1.471 ± 0.669
1.765PheArg: 1.765 ± 0.494
2.354PheSer: 2.354 ± 0.733
3.53PheThr: 3.53 ± 1.178
2.354PheVal: 2.354 ± 0.715
0.294PheTrp: 0.294 ± 0.248
3.53PheTyr: 3.53 ± 0.929
0.0PheXaa: 0.0 ± 0.0
Gly
2.942GlyAla: 2.942 ± 0.972
0.0GlyCys: 0.0 ± 0.0
2.059GlyAsp: 2.059 ± 0.803
4.707GlyGlu: 4.707 ± 1.189
2.648GlyPhe: 2.648 ± 0.654
1.471GlyGly: 1.471 ± 0.406
0.883GlyHis: 0.883 ± 0.509
2.648GlyIle: 2.648 ± 0.938
4.119GlyLys: 4.119 ± 0.992
6.472GlyLeu: 6.472 ± 1.289
1.471GlyMet: 1.471 ± 0.713
0.883GlyAsn: 0.883 ± 0.561
0.0GlyPro: 0.0 ± 0.0
1.765GlyGln: 1.765 ± 0.793
3.236GlyArg: 3.236 ± 0.843
3.236GlySer: 3.236 ± 0.989
1.177GlyThr: 1.177 ± 0.467
4.707GlyVal: 4.707 ± 1.334
1.471GlyTrp: 1.471 ± 0.567
4.707GlyTyr: 4.707 ± 1.003
0.0GlyXaa: 0.0 ± 0.0
His
1.177HisAla: 1.177 ± 0.545
0.0HisCys: 0.0 ± 0.0
0.883HisAsp: 0.883 ± 0.474
1.177HisGlu: 1.177 ± 0.615
1.177HisPhe: 1.177 ± 0.724
0.588HisGly: 0.588 ± 0.428
0.883HisHis: 0.883 ± 0.571
0.588HisIle: 0.588 ± 0.474
0.883HisLys: 0.883 ± 0.498
0.883HisLeu: 0.883 ± 0.52
0.0HisMet: 0.0 ± 0.0
1.471HisAsn: 1.471 ± 0.489
0.0HisPro: 0.0 ± 0.0
1.471HisGln: 1.471 ± 0.837
1.765HisArg: 1.765 ± 0.59
0.883HisSer: 0.883 ± 0.48
1.177HisThr: 1.177 ± 0.596
0.0HisVal: 0.0 ± 0.0
0.0HisTrp: 0.0 ± 0.0
1.765HisTyr: 1.765 ± 0.712
0.0HisXaa: 0.0 ± 0.0
Ile
2.648IleAla: 2.648 ± 1.224
0.294IleCys: 0.294 ± 0.295
4.119IleAsp: 4.119 ± 0.923
7.061IleGlu: 7.061 ± 1.552
1.765IlePhe: 1.765 ± 0.764
4.119IleGly: 4.119 ± 1.271
1.177IleHis: 1.177 ± 0.831
5.59IleIle: 5.59 ± 1.367
5.884IleLys: 5.884 ± 1.246
8.238IleLeu: 8.238 ± 1.471
0.294IleMet: 0.294 ± 0.248
2.354IleAsn: 2.354 ± 0.881
3.236IlePro: 3.236 ± 0.967
1.765IleGln: 1.765 ± 0.637
2.648IleArg: 2.648 ± 0.709
4.119IleSer: 4.119 ± 1.149
3.236IleThr: 3.236 ± 0.826
3.53IleVal: 3.53 ± 0.75
0.588IleTrp: 0.588 ± 0.525
2.059IleTyr: 2.059 ± 0.815
0.0IleXaa: 0.0 ± 0.0
Lys
7.355LysAla: 7.355 ± 0.974
0.0LysCys: 0.0 ± 0.0
7.061LysAsp: 7.061 ± 1.383
8.532LysGlu: 8.532 ± 2.013
4.413LysPhe: 4.413 ± 1.163
4.413LysGly: 4.413 ± 0.776
1.765LysHis: 1.765 ± 1.136
4.413LysIle: 4.413 ± 1.506
7.944LysLys: 7.944 ± 1.696
10.003LysLeu: 10.003 ± 1.675
1.765LysMet: 1.765 ± 0.829
5.59LysAsn: 5.59 ± 1.739
2.059LysPro: 2.059 ± 0.808
3.236LysGln: 3.236 ± 1.102
5.59LysArg: 5.59 ± 1.17
4.413LysSer: 4.413 ± 1.361
6.178LysThr: 6.178 ± 1.466
3.825LysVal: 3.825 ± 1.052
1.765LysTrp: 1.765 ± 0.506
4.119LysTyr: 4.119 ± 0.953
0.0LysXaa: 0.0 ± 0.0
Leu
7.355LeuAla: 7.355 ± 1.492
0.294LeuCys: 0.294 ± 0.258
8.238LeuAsp: 8.238 ± 1.855
8.238LeuGlu: 8.238 ± 1.734
4.119LeuPhe: 4.119 ± 1.263
6.472LeuGly: 6.472 ± 1.429
0.883LeuHis: 0.883 ± 0.533
4.413LeuIle: 4.413 ± 1.039
10.297LeuLys: 10.297 ± 1.834
7.061LeuLeu: 7.061 ± 1.93
2.059LeuMet: 2.059 ± 0.748
8.532LeuAsn: 8.532 ± 2.156
2.942LeuPro: 2.942 ± 0.96
3.53LeuGln: 3.53 ± 0.9
5.001LeuArg: 5.001 ± 1.153
6.767LeuSer: 6.767 ± 1.721
7.355LeuThr: 7.355 ± 1.556
4.707LeuVal: 4.707 ± 0.862
0.294LeuTrp: 0.294 ± 0.277
2.354LeuTyr: 2.354 ± 0.967
0.0LeuXaa: 0.0 ± 0.0
Met
1.471MetAla: 1.471 ± 0.986
0.294MetCys: 0.294 ± 0.36
1.177MetAsp: 1.177 ± 0.457
2.942MetGlu: 2.942 ± 1.304
0.588MetPhe: 0.588 ± 0.534
1.471MetGly: 1.471 ± 0.875
0.0MetHis: 0.0 ± 0.0
0.588MetIle: 0.588 ± 0.472
1.765MetLys: 1.765 ± 0.559
2.059MetLeu: 2.059 ± 0.718
1.177MetMet: 1.177 ± 0.62
2.059MetAsn: 2.059 ± 0.701
0.883MetPro: 0.883 ± 0.745
0.588MetGln: 0.588 ± 0.331
1.765MetArg: 1.765 ± 0.581
2.059MetSer: 2.059 ± 0.965
2.648MetThr: 2.648 ± 1.035
1.471MetVal: 1.471 ± 0.836
0.0MetTrp: 0.0 ± 0.0
0.588MetTyr: 0.588 ± 0.331
0.0MetXaa: 0.0 ± 0.0
Asn
2.354AsnAla: 2.354 ± 0.8
0.294AsnCys: 0.294 ± 0.223
2.648AsnAsp: 2.648 ± 0.734
3.825AsnGlu: 3.825 ± 1.007
1.765AsnPhe: 1.765 ± 0.641
3.825AsnGly: 3.825 ± 0.981
0.588AsnHis: 0.588 ± 0.377
3.825AsnIle: 3.825 ± 1.257
6.767AsnLys: 6.767 ± 1.241
6.178AsnLeu: 6.178 ± 2.04
0.883AsnMet: 0.883 ± 0.628
2.648AsnAsn: 2.648 ± 0.841
3.236AsnPro: 3.236 ± 0.86
4.413AsnGln: 4.413 ± 0.793
2.354AsnArg: 2.354 ± 0.805
2.942AsnSer: 2.942 ± 0.803
2.059AsnThr: 2.059 ± 1.069
1.177AsnVal: 1.177 ± 0.736
0.883AsnTrp: 0.883 ± 0.418
1.471AsnTyr: 1.471 ± 0.751
0.0AsnXaa: 0.0 ± 0.0
Pro
1.471ProAla: 1.471 ± 0.438
0.294ProCys: 0.294 ± 0.339
2.942ProAsp: 2.942 ± 0.858
2.648ProGlu: 2.648 ± 0.979
2.354ProPhe: 2.354 ± 0.807
0.294ProGly: 0.294 ± 0.27
0.0ProHis: 0.0 ± 0.0
1.177ProIle: 1.177 ± 0.473
1.765ProLys: 1.765 ± 0.759
1.765ProLeu: 1.765 ± 0.633
0.883ProMet: 0.883 ± 0.498
2.059ProAsn: 2.059 ± 0.602
2.059ProPro: 2.059 ± 0.962
1.471ProGln: 1.471 ± 0.581
2.648ProArg: 2.648 ± 0.656
0.883ProSer: 0.883 ± 0.479
1.177ProThr: 1.177 ± 0.37
1.177ProVal: 1.177 ± 0.503
0.0ProTrp: 0.0 ± 0.0
1.177ProTyr: 1.177 ± 0.518
0.0ProXaa: 0.0 ± 0.0
Gln
3.53GlnAla: 3.53 ± 1.095
0.0GlnCys: 0.0 ± 0.0
2.059GlnAsp: 2.059 ± 0.883
3.825GlnGlu: 3.825 ± 1.386
1.471GlnPhe: 1.471 ± 0.725
1.765GlnGly: 1.765 ± 0.657
0.294GlnHis: 0.294 ± 0.27
2.942GlnIle: 2.942 ± 0.923
4.707GlnLys: 4.707 ± 1.424
2.648GlnLeu: 2.648 ± 1.002
0.883GlnMet: 0.883 ± 0.547
2.354GlnAsn: 2.354 ± 0.548
0.294GlnPro: 0.294 ± 0.37
2.059GlnGln: 2.059 ± 0.916
2.354GlnArg: 2.354 ± 0.732
0.588GlnSer: 0.588 ± 0.48
1.471GlnThr: 1.471 ± 0.666
3.53GlnVal: 3.53 ± 0.89
0.588GlnTrp: 0.588 ± 0.382
1.471GlnTyr: 1.471 ± 0.612
0.0GlnXaa: 0.0 ± 0.0
Arg
3.825ArgAla: 3.825 ± 0.83
0.0ArgCys: 0.0 ± 0.0
4.119ArgAsp: 4.119 ± 0.798
5.001ArgGlu: 5.001 ± 1.252
1.471ArgPhe: 1.471 ± 0.639
2.648ArgGly: 2.648 ± 0.999
0.883ArgHis: 0.883 ± 0.449
2.648ArgIle: 2.648 ± 0.849
5.884ArgLys: 5.884 ± 1.41
7.061ArgLeu: 7.061 ± 1.354
2.648ArgMet: 2.648 ± 1.058
2.059ArgAsn: 2.059 ± 0.716
2.059ArgPro: 2.059 ± 0.999
3.236ArgGln: 3.236 ± 0.948
2.942ArgArg: 2.942 ± 1.353
2.942ArgSer: 2.942 ± 1.046
2.059ArgThr: 2.059 ± 0.57
2.059ArgVal: 2.059 ± 0.825
0.294ArgTrp: 0.294 ± 0.339
3.53ArgTyr: 3.53 ± 1.104
0.0ArgXaa: 0.0 ± 0.0
Ser
2.942SerAla: 2.942 ± 0.95
0.883SerCys: 0.883 ± 0.435
4.413SerAsp: 4.413 ± 0.953
3.825SerGlu: 3.825 ± 0.918
2.942SerPhe: 2.942 ± 1.055
3.53SerGly: 3.53 ± 0.858
0.588SerHis: 0.588 ± 0.309
3.53SerIle: 3.53 ± 1.051
2.942SerLys: 2.942 ± 0.751
5.296SerLeu: 5.296 ± 0.941
2.354SerMet: 2.354 ± 0.904
2.354SerAsn: 2.354 ± 0.739
0.588SerPro: 0.588 ± 0.347
3.236SerGln: 3.236 ± 1.131
2.354SerArg: 2.354 ± 0.839
3.236SerSer: 3.236 ± 0.957
2.354SerThr: 2.354 ± 0.601
2.059SerVal: 2.059 ± 0.882
0.0SerTrp: 0.0 ± 0.0
2.942SerTyr: 2.942 ± 0.847
0.0SerXaa: 0.0 ± 0.0
Thr
2.354ThrAla: 2.354 ± 0.703
0.294ThrCys: 0.294 ± 0.27
2.354ThrAsp: 2.354 ± 1.189
2.354ThrGlu: 2.354 ± 0.589
2.354ThrPhe: 2.354 ± 0.617
2.942ThrGly: 2.942 ± 1.071
1.471ThrHis: 1.471 ± 0.61
3.53ThrIle: 3.53 ± 0.804
5.884ThrLys: 5.884 ± 1.071
5.59ThrLeu: 5.59 ± 1.185
1.177ThrMet: 1.177 ± 0.777
0.588ThrAsn: 0.588 ± 0.495
2.942ThrPro: 2.942 ± 0.679
2.059ThrGln: 2.059 ± 0.836
2.648ThrArg: 2.648 ± 0.884
2.942ThrSer: 2.942 ± 0.96
1.765ThrThr: 1.765 ± 0.605
5.59ThrVal: 5.59 ± 1.567
0.588ThrTrp: 0.588 ± 0.54
4.119ThrTyr: 4.119 ± 1.368
0.0ThrXaa: 0.0 ± 0.0
Val
4.413ValAla: 4.413 ± 1.011
0.294ValCys: 0.294 ± 0.258
3.53ValAsp: 3.53 ± 0.879
4.119ValGlu: 4.119 ± 0.79
2.354ValPhe: 2.354 ± 0.667
2.059ValGly: 2.059 ± 0.923
0.588ValHis: 0.588 ± 0.395
4.119ValIle: 4.119 ± 1.082
5.296ValLys: 5.296 ± 1.159
5.001ValLeu: 5.001 ± 1.371
1.471ValMet: 1.471 ± 0.737
3.825ValAsn: 3.825 ± 1.026
1.471ValPro: 1.471 ± 0.82
1.765ValGln: 1.765 ± 0.79
2.942ValArg: 2.942 ± 0.957
2.942ValSer: 2.942 ± 0.959
2.354ValThr: 2.354 ± 0.834
2.354ValVal: 2.354 ± 0.894
0.588ValTrp: 0.588 ± 0.458
2.354ValTyr: 2.354 ± 0.702
0.0ValXaa: 0.0 ± 0.0
Trp
0.294TrpAla: 0.294 ± 0.223
0.294TrpCys: 0.294 ± 0.248
0.0TrpAsp: 0.0 ± 0.0
1.471TrpGlu: 1.471 ± 0.546
0.294TrpPhe: 0.294 ± 0.27
0.294TrpGly: 0.294 ± 0.248
0.588TrpHis: 0.588 ± 0.473
0.588TrpIle: 0.588 ± 0.517
1.471TrpLys: 1.471 ± 0.584
0.588TrpLeu: 0.588 ± 0.304
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.294TrpGln: 0.294 ± 0.351
0.294TrpArg: 0.294 ± 0.248
0.588TrpSer: 0.588 ± 0.401
0.883TrpThr: 0.883 ± 0.372
0.588TrpVal: 0.588 ± 0.458
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.236TyrAla: 3.236 ± 1.074
0.588TyrCys: 0.588 ± 0.382
1.765TyrAsp: 1.765 ± 0.642
2.942TyrGlu: 2.942 ± 0.93
3.236TyrPhe: 3.236 ± 0.954
1.177TyrGly: 1.177 ± 0.613
1.177TyrHis: 1.177 ± 0.711
2.059TyrIle: 2.059 ± 0.627
6.767TyrLys: 6.767 ± 1.565
6.472TyrLeu: 6.472 ± 1.339
0.883TyrMet: 0.883 ± 0.46
2.648TyrAsn: 2.648 ± 0.65
1.177TyrPro: 1.177 ± 0.376
1.765TyrGln: 1.765 ± 0.493
3.236TyrArg: 3.236 ± 0.877
1.765TyrSer: 1.765 ± 0.55
2.059TyrThr: 2.059 ± 0.764
2.648TyrVal: 2.648 ± 0.777
0.294TyrTrp: 0.294 ± 0.277
2.059TyrTyr: 2.059 ± 0.75
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 21 proteins (3400 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski