Amino acid dipepetide frequency for Denitrobaculum tricleocarpae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.981AlaAla: 14.981 ± 0.125	1.174AlaCys: 1.174 ± 0.025	6.16AlaAsp: 6.16 ± 0.072	7.808AlaGlu: 7.808 ± 0.089	4.423AlaPhe: 4.423 ± 0.063	9.823AlaGly: 9.823 ± 0.091	1.931AlaHis: 1.931 ± 0.032	5.796AlaIle: 5.796 ± 0.063	4.05AlaLys: 4.05 ± 0.057	12.264AlaLeu: 12.264 ± 0.107	3.134AlaMet: 3.134 ± 0.039	2.904AlaAsn: 2.904 ± 0.043	4.758AlaPro: 4.758 ± 0.061	4.084AlaGln: 4.084 ± 0.053	7.309AlaArg: 7.309 ± 0.09	6.258AlaSer: 6.258 ± 0.065	5.141AlaThr: 5.141 ± 0.063	8.553AlaVal: 8.553 ± 0.073	1.352AlaTrp: 1.352 ± 0.028	2.421AlaTyr: 2.421 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.034CysAla: 1.034 ± 0.024	0.139CysCys: 0.139 ± 0.008	0.591CysAsp: 0.591 ± 0.021	0.515CysGlu: 0.515 ± 0.017	0.382CysPhe: 0.382 ± 0.013	1.035CysGly: 1.035 ± 0.03	0.293CysHis: 0.293 ± 0.012	0.437CysIle: 0.437 ± 0.016	0.262CysLys: 0.262 ± 0.013	0.962CysLeu: 0.962 ± 0.027	0.175CysMet: 0.175 ± 0.011	0.274CysAsn: 0.274 ± 0.015	0.494CysPro: 0.494 ± 0.019	0.258CysGln: 0.258 ± 0.011	0.669CysArg: 0.669 ± 0.02	0.592CysSer: 0.592 ± 0.021	0.389CysThr: 0.389 ± 0.016	0.637CysVal: 0.637 ± 0.02	0.126CysTrp: 0.126 ± 0.009	0.249CysTyr: 0.249 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.313AspAla: 6.313 ± 0.073	0.584AspCys: 0.584 ± 0.018	3.341AspAsp: 3.341 ± 0.068	3.706AspGlu: 3.706 ± 0.044	2.489AspPhe: 2.489 ± 0.042	5.101AspGly: 5.101 ± 0.086	1.257AspHis: 1.257 ± 0.027	3.109AspIle: 3.109 ± 0.05	1.734AspLys: 1.734 ± 0.029	6.435AspLeu: 6.435 ± 0.075	1.333AspMet: 1.333 ± 0.028	1.416AspAsn: 1.416 ± 0.03	3.467AspPro: 3.467 ± 0.046	1.919AspGln: 1.919 ± 0.036	3.872AspArg: 3.872 ± 0.049	2.977AspSer: 2.977 ± 0.046	2.41AspThr: 2.41 ± 0.048	4.19AspVal: 4.19 ± 0.052	1.015AspTrp: 1.015 ± 0.024	1.685AspTyr: 1.685 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	7.888GluAla: 7.888 ± 0.07	0.393GluCys: 0.393 ± 0.015	3.541GluAsp: 3.541 ± 0.053	4.035GluGlu: 4.035 ± 0.063	1.945GluPhe: 1.945 ± 0.035	4.647GluGly: 4.647 ± 0.06	1.241GluHis: 1.241 ± 0.027	4.075GluIle: 4.075 ± 0.046	2.605GluLys: 2.605 ± 0.042	6.147GluLeu: 6.147 ± 0.059	1.674GluMet: 1.674 ± 0.027	2.073GluAsn: 2.073 ± 0.03	2.699GluPro: 2.699 ± 0.047	2.484GluGln: 2.484 ± 0.038	4.898GluArg: 4.898 ± 0.061	3.455GluSer: 3.455 ± 0.047	4.13GluThr: 4.13 ± 0.048	4.64GluVal: 4.64 ± 0.052	0.695GluTrp: 0.695 ± 0.021	1.046GluTyr: 1.046 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.342PheAla: 4.342 ± 0.061	0.498PheCys: 0.498 ± 0.019	2.739PheAsp: 2.739 ± 0.045	2.586PheGlu: 2.586 ± 0.037	1.654PhePhe: 1.654 ± 0.039	3.666PheGly: 3.666 ± 0.056	0.762PheHis: 0.762 ± 0.021	1.812PheIle: 1.812 ± 0.035	1.251PheLys: 1.251 ± 0.028	3.774PheLeu: 3.774 ± 0.061	0.818PheMet: 0.818 ± 0.022	1.136PheAsn: 1.136 ± 0.025	1.62PhePro: 1.62 ± 0.029	1.116PheGln: 1.116 ± 0.026	2.122PheArg: 2.122 ± 0.033	2.499PheSer: 2.499 ± 0.038	2.103PheThr: 2.103 ± 0.041	2.933PheVal: 2.933 ± 0.041	0.587PheTrp: 0.587 ± 0.019	1.037PheTyr: 1.037 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	8.41GlyAla: 8.41 ± 0.088	0.91GlyCys: 0.91 ± 0.024	4.656GlyAsp: 4.656 ± 0.104	5.106GlyGlu: 5.106 ± 0.061	3.794GlyPhe: 3.794 ± 0.057	7.05GlyGly: 7.05 ± 0.114	1.796GlyHis: 1.796 ± 0.03	4.498GlyIle: 4.498 ± 0.06	3.33GlyLys: 3.33 ± 0.044	8.868GlyLeu: 8.868 ± 0.081	2.118GlyMet: 2.118 ± 0.033	2.347GlyAsn: 2.347 ± 0.051	3.245GlyPro: 3.245 ± 0.042	2.999GlyGln: 2.999 ± 0.043	5.383GlyArg: 5.383 ± 0.061	4.925GlySer: 4.925 ± 0.072	4.259GlyThr: 4.259 ± 0.059	6.05GlyVal: 6.05 ± 0.065	1.218GlyTrp: 1.218 ± 0.025	2.384GlyTyr: 2.384 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.96HisAla: 1.96 ± 0.036	0.287HisCys: 0.287 ± 0.013	1.181HisAsp: 1.181 ± 0.028	1.115HisGlu: 1.115 ± 0.026	0.865HisPhe: 0.865 ± 0.023	1.696HisGly: 1.696 ± 0.032	0.54HisHis: 0.54 ± 0.018	0.951HisIle: 0.951 ± 0.022	0.583HisLys: 0.583 ± 0.019	2.137HisLeu: 2.137 ± 0.038	0.443HisMet: 0.443 ± 0.017	0.516HisAsn: 0.516 ± 0.016	1.269HisPro: 1.269 ± 0.033	0.612HisGln: 0.612 ± 0.018	1.338HisArg: 1.338 ± 0.027	1.123HisSer: 1.123 ± 0.028	0.782HisThr: 0.782 ± 0.023	1.23HisVal: 1.23 ± 0.028	0.315HisTrp: 0.315 ± 0.012	0.571HisTyr: 0.571 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.678IleAla: 6.678 ± 0.068	0.628IleCys: 0.628 ± 0.022	3.563IleAsp: 3.563 ± 0.044	4.055IleGlu: 4.055 ± 0.046	1.861IlePhe: 1.861 ± 0.037	4.796IleGly: 4.796 ± 0.058	0.924IleHis: 0.924 ± 0.025	2.401IleIle: 2.401 ± 0.046	1.7IleLys: 1.7 ± 0.032	5.001IleLeu: 5.001 ± 0.06	1.085IleMet: 1.085 ± 0.026	1.571IleAsn: 1.571 ± 0.029	2.43IlePro: 2.43 ± 0.04	1.383IleGln: 1.383 ± 0.028	2.965IleArg: 2.965 ± 0.039	3.338IleSer: 3.338 ± 0.048	2.88IleThr: 2.88 ± 0.039	3.904IleVal: 3.904 ± 0.053	0.674IleTrp: 0.674 ± 0.02	1.198IleTyr: 1.198 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.179LysAla: 4.179 ± 0.055	0.193LysCys: 0.193 ± 0.01	1.973LysAsp: 1.973 ± 0.037	1.891LysGlu: 1.891 ± 0.039	1.046LysPhe: 1.046 ± 0.026	2.699LysGly: 2.699 ± 0.036	0.712LysHis: 0.712 ± 0.02	2.075LysIle: 2.075 ± 0.035	1.482LysLys: 1.482 ± 0.04	3.569LysLeu: 3.569 ± 0.048	0.858LysMet: 0.858 ± 0.022	1.041LysAsn: 1.041 ± 0.024	2.021LysPro: 2.021 ± 0.045	1.187LysGln: 1.187 ± 0.025	2.482LysArg: 2.482 ± 0.036	2.329LysSer: 2.329 ± 0.038	2.246LysThr: 2.246 ± 0.044	2.57LysVal: 2.57 ± 0.042	0.386LysTrp: 0.386 ± 0.015	0.682LysTyr: 0.682 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.243LeuAla: 12.243 ± 0.104	0.975LeuCys: 0.975 ± 0.022	5.893LeuAsp: 5.893 ± 0.062	6.575LeuGlu: 6.575 ± 0.063	3.943LeuPhe: 3.943 ± 0.061	8.091LeuGly: 8.091 ± 0.072	1.826LeuHis: 1.826 ± 0.034	5.343LeuIle: 5.343 ± 0.072	4.056LeuLys: 4.056 ± 0.048	10.169LeuLeu: 10.169 ± 0.102	2.365LeuMet: 2.365 ± 0.04	2.928LeuAsn: 2.928 ± 0.045	5.463LeuPro: 5.463 ± 0.064	3.178LeuGln: 3.178 ± 0.049	6.705LeuArg: 6.705 ± 0.066	7.31LeuSer: 7.31 ± 0.073	5.755LeuThr: 5.755 ± 0.057	6.905LeuVal: 6.905 ± 0.067	1.187LeuTrp: 1.187 ± 0.027	2.16LeuTyr: 2.16 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.848MetAla: 2.848 ± 0.043	0.148MetCys: 0.148 ± 0.009	1.19MetAsp: 1.19 ± 0.027	1.308MetGlu: 1.308 ± 0.028	0.682MetPhe: 0.682 ± 0.019	1.746MetGly: 1.746 ± 0.035	0.389MetHis: 0.389 ± 0.015	1.453MetIle: 1.453 ± 0.03	1.054MetLys: 1.054 ± 0.024	2.345MetLeu: 2.345 ± 0.041	0.626MetMet: 0.626 ± 0.019	0.814MetAsn: 0.814 ± 0.02	1.33MetPro: 1.33 ± 0.026	0.8MetGln: 0.8 ± 0.02	1.509MetArg: 1.509 ± 0.028	1.727MetSer: 1.727 ± 0.029	1.972MetThr: 1.972 ± 0.03	1.661MetVal: 1.661 ± 0.032	0.191MetTrp: 0.191 ± 0.01	0.333MetTyr: 0.333 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	3.204AsnAla: 3.204 ± 0.046	0.331AsnCys: 0.331 ± 0.014	1.655AsnAsp: 1.655 ± 0.038	1.517AsnGlu: 1.517 ± 0.031	1.085AsnPhe: 1.085 ± 0.025	2.461AsnGly: 2.461 ± 0.047	0.538AsnHis: 0.538 ± 0.017	1.47AsnIle: 1.47 ± 0.032	0.814AsnLys: 0.814 ± 0.02	3.062AsnLeu: 3.062 ± 0.045	0.643AsnMet: 0.643 ± 0.019	0.813AsnAsn: 0.813 ± 0.024	1.891AsnPro: 1.891 ± 0.037	0.911AsnGln: 0.911 ± 0.022	1.877AsnArg: 1.877 ± 0.031	1.589AsnSer: 1.589 ± 0.031	1.303AsnThr: 1.303 ± 0.024	1.878AsnVal: 1.878 ± 0.041	0.46AsnTrp: 0.46 ± 0.017	0.741AsnTyr: 0.741 ± 0.021	0.0AsnXaa: 0.0 ± 0.0
Pro	5.353ProAla: 5.353 ± 0.068	0.362ProCys: 0.362 ± 0.02	3.554ProAsp: 3.554 ± 0.044	4.19ProGlu: 4.19 ± 0.051	1.851ProPhe: 1.851 ± 0.034	4.436ProGly: 4.436 ± 0.055	0.937ProHis: 0.937 ± 0.025	2.235ProIle: 2.235 ± 0.04	1.783ProLys: 1.783 ± 0.034	4.63ProLeu: 4.63 ± 0.062	1.079ProMet: 1.079 ± 0.024	1.348ProAsn: 1.348 ± 0.028	2.252ProPro: 2.252 ± 0.043	1.647ProGln: 1.647 ± 0.029	2.502ProArg: 2.502 ± 0.037	2.783ProSer: 2.783 ± 0.042	2.187ProThr: 2.187 ± 0.033	3.812ProVal: 3.812 ± 0.053	0.602ProTrp: 0.602 ± 0.018	1.109ProTyr: 1.109 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	4.08GlnAla: 4.08 ± 0.055	0.201GlnCys: 0.201 ± 0.012	1.85GlnAsp: 1.85 ± 0.039	2.04GlnGlu: 2.04 ± 0.035	1.007GlnPhe: 1.007 ± 0.023	2.522GlnGly: 2.522 ± 0.038	0.606GlnHis: 0.606 ± 0.02	1.986GlnIle: 1.986 ± 0.036	1.237GlnLys: 1.237 ± 0.024	3.052GlnLeu: 3.052 ± 0.044	0.888GlnMet: 0.888 ± 0.021	0.984GlnAsn: 0.984 ± 0.024	1.603GlnPro: 1.603 ± 0.032	1.274GlnGln: 1.274 ± 0.027	2.464GlnArg: 2.464 ± 0.039	2.156GlnSer: 2.156 ± 0.036	1.807GlnThr: 1.807 ± 0.036	2.499GlnVal: 2.499 ± 0.039	0.383GlnTrp: 0.383 ± 0.014	0.579GlnTyr: 0.579 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	6.6ArgAla: 6.6 ± 0.065	0.584ArgCys: 0.584 ± 0.02	3.926ArgAsp: 3.926 ± 0.049	4.294ArgGlu: 4.294 ± 0.056	2.764ArgPhe: 2.764 ± 0.039	4.317ArgGly: 4.317 ± 0.057	1.475ArgHis: 1.475 ± 0.029	3.671ArgIle: 3.671 ± 0.045	2.432ArgLys: 2.432 ± 0.044	7.226ArgLeu: 7.226 ± 0.078	1.609ArgMet: 1.609 ± 0.035	1.944ArgAsn: 1.944 ± 0.03	3.013ArgPro: 3.013 ± 0.045	2.435ArgGln: 2.435 ± 0.039	4.92ArgArg: 4.92 ± 0.065	3.882ArgSer: 3.882 ± 0.051	2.784ArgThr: 2.784 ± 0.04	4.467ArgVal: 4.467 ± 0.051	0.845ArgTrp: 0.845 ± 0.021	1.628ArgTyr: 1.628 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	6.433SerAla: 6.433 ± 0.07	0.548SerCys: 0.548 ± 0.019	3.662SerAsp: 3.662 ± 0.052	3.787SerGlu: 3.787 ± 0.05	2.731SerPhe: 2.731 ± 0.037	6.135SerGly: 6.135 ± 0.068	1.222SerHis: 1.222 ± 0.024	3.089SerIle: 3.089 ± 0.045	2.061SerLys: 2.061 ± 0.041	6.449SerLeu: 6.449 ± 0.068	1.475SerMet: 1.475 ± 0.026	1.717SerAsn: 1.717 ± 0.034	2.757SerPro: 2.757 ± 0.039	1.892SerGln: 1.892 ± 0.039	3.54SerArg: 3.54 ± 0.041	3.669SerSer: 3.669 ± 0.049	2.654SerThr: 2.654 ± 0.039	4.396SerVal: 4.396 ± 0.057	0.813SerTrp: 0.813 ± 0.021	1.533SerTyr: 1.533 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.326ThrAla: 6.326 ± 0.075	0.439ThrCys: 0.439 ± 0.016	2.752ThrAsp: 2.752 ± 0.039	2.979ThrGlu: 2.979 ± 0.041	1.894ThrPhe: 1.894 ± 0.036	4.811ThrGly: 4.811 ± 0.056	0.954ThrHis: 0.954 ± 0.023	2.604ThrIle: 2.604 ± 0.04	1.583ThrLys: 1.583 ± 0.03	5.688ThrLeu: 5.688 ± 0.06	1.103ThrMet: 1.103 ± 0.026	1.34ThrAsn: 1.34 ± 0.029	3.127ThrPro: 3.127 ± 0.04	1.594ThrGln: 1.594 ± 0.03	3.148ThrArg: 3.148 ± 0.04	3.009ThrSer: 3.009 ± 0.044	2.734ThrThr: 2.734 ± 0.035	3.85ThrVal: 3.85 ± 0.05	0.696ThrTrp: 0.696 ± 0.02	1.168ThrTyr: 1.168 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	8.093ValAla: 8.093 ± 0.076	0.705ValCys: 0.705 ± 0.018	3.869ValAsp: 3.869 ± 0.051	4.786ValGlu: 4.786 ± 0.054	3.078ValPhe: 3.078 ± 0.051	5.366ValGly: 5.366 ± 0.056	1.225ValHis: 1.225 ± 0.027	4.322ValIle: 4.322 ± 0.053	2.446ValLys: 2.446 ± 0.043	7.204ValLeu: 7.204 ± 0.077	1.914ValMet: 1.914 ± 0.034	2.0ValAsn: 2.0 ± 0.04	3.44ValPro: 3.44 ± 0.048	2.091ValGln: 2.091 ± 0.034	4.261ValArg: 4.261 ± 0.055	4.727ValSer: 4.727 ± 0.046	4.602ValThr: 4.602 ± 0.057	5.774ValVal: 5.774 ± 0.068	0.879ValTrp: 0.879 ± 0.022	1.574ValTyr: 1.574 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.065TrpAla: 1.065 ± 0.028	0.144TrpCys: 0.144 ± 0.009	0.691TrpAsp: 0.691 ± 0.019	0.637TrpGlu: 0.637 ± 0.018	0.573TrpPhe: 0.573 ± 0.017	0.883TrpGly: 0.883 ± 0.023	0.337TrpHis: 0.337 ± 0.013	0.699TrpIle: 0.699 ± 0.022	0.451TrpLys: 0.451 ± 0.016	1.576TrpLeu: 1.576 ± 0.027	0.324TrpMet: 0.324 ± 0.014	0.447TrpAsn: 0.447 ± 0.014	0.675TrpPro: 0.675 ± 0.018	0.576TrpGln: 0.576 ± 0.018	1.051TrpArg: 1.051 ± 0.026	0.858TrpSer: 0.858 ± 0.023	0.675TrpThr: 0.675 ± 0.022	0.83TrpVal: 0.83 ± 0.018	0.215TrpTrp: 0.215 ± 0.012	0.306TrpTyr: 0.306 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.296TyrAla: 2.296 ± 0.038	0.272TyrCys: 0.272 ± 0.011	1.568TyrAsp: 1.568 ± 0.028	1.383TyrGlu: 1.383 ± 0.029	0.99TyrPhe: 0.99 ± 0.022	2.066TyrGly: 2.066 ± 0.039	0.545TyrHis: 0.545 ± 0.017	1.009TyrIle: 1.009 ± 0.025	0.706TyrLys: 0.706 ± 0.022	2.512TyrLeu: 2.512 ± 0.042	0.461TyrMet: 0.461 ± 0.015	0.63TyrAsn: 0.63 ± 0.021	1.097TyrPro: 1.097 ± 0.024	0.778TyrGln: 0.778 ± 0.024	1.797TyrArg: 1.797 ± 0.035	1.359TyrSer: 1.359 ± 0.031	0.987TyrThr: 0.987 ± 0.024	1.578TyrVal: 1.578 ± 0.033	0.372TyrTrp: 0.372 ± 0.014	0.657TyrTyr: 0.657 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5784 proteins (1843579 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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