Amino acid dipepetide frequency for Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.606AlaAla: 7.606 ± 1.15
0.951AlaCys: 0.951 ± 0.365
5.348AlaAsp: 5.348 ± 1.005
3.684AlaGlu: 3.684 ± 0.764
3.328AlaPhe: 3.328 ± 0.559
3.922AlaGly: 3.922 ± 0.839
1.07AlaHis: 1.07 ± 0.429
4.16AlaIle: 4.16 ± 0.969
3.684AlaLys: 3.684 ± 1.01
6.774AlaLeu: 6.774 ± 0.946
1.664AlaMet: 1.664 ± 0.341
3.684AlaAsn: 3.684 ± 0.758
5.229AlaPro: 5.229 ± 0.75
4.635AlaGln: 4.635 ± 0.503
5.824AlaArg: 5.824 ± 0.888
5.586AlaSer: 5.586 ± 0.8
4.279AlaThr: 4.279 ± 0.555
4.16AlaVal: 4.16 ± 0.796
0.951AlaTrp: 0.951 ± 0.314
2.377AlaTyr: 2.377 ± 0.276
0.0AlaXaa: 0.0 ± 0.0
Cys
0.832CysAla: 0.832 ± 0.241
0.119CysCys: 0.119 ± 0.114
0.357CysAsp: 0.357 ± 0.256
0.951CysGlu: 0.951 ± 0.276
0.713CysPhe: 0.713 ± 0.285
0.357CysGly: 0.357 ± 0.302
0.357CysHis: 0.357 ± 0.163
0.832CysIle: 0.832 ± 0.4
0.119CysLys: 0.119 ± 0.148
1.426CysLeu: 1.426 ± 0.408
0.951CysMet: 0.951 ± 0.483
0.475CysAsn: 0.475 ± 0.223
1.07CysPro: 1.07 ± 0.277
0.594CysGln: 0.594 ± 0.217
0.713CysArg: 0.713 ± 0.221
1.307CysSer: 1.307 ± 0.351
0.594CysThr: 0.594 ± 0.217
0.832CysVal: 0.832 ± 0.272
0.119CysTrp: 0.119 ± 0.101
0.594CysTyr: 0.594 ± 0.243
0.0CysXaa: 0.0 ± 0.0
Asp
6.061AspAla: 6.061 ± 0.684
0.951AspCys: 0.951 ± 0.312
4.397AspAsp: 4.397 ± 0.672
3.922AspGlu: 3.922 ± 0.731
1.902AspPhe: 1.902 ± 0.471
4.754AspGly: 4.754 ± 0.722
1.188AspHis: 1.188 ± 0.346
3.447AspIle: 3.447 ± 0.46
2.139AspLys: 2.139 ± 0.436
5.467AspLeu: 5.467 ± 0.729
1.664AspMet: 1.664 ± 0.384
1.307AspAsn: 1.307 ± 0.453
3.684AspPro: 3.684 ± 0.74
2.139AspGln: 2.139 ± 0.432
3.684AspArg: 3.684 ± 0.705
4.279AspSer: 4.279 ± 0.602
3.09AspThr: 3.09 ± 0.811
5.705AspVal: 5.705 ± 0.955
0.951AspTrp: 0.951 ± 0.296
2.258AspTyr: 2.258 ± 0.569
0.0AspXaa: 0.0 ± 0.0
Glu
3.803GluAla: 3.803 ± 0.515
0.357GluCys: 0.357 ± 0.163
1.902GluAsp: 1.902 ± 0.388
1.426GluGlu: 1.426 ± 0.35
1.07GluPhe: 1.07 ± 0.261
2.02GluGly: 2.02 ± 0.602
1.188GluHis: 1.188 ± 0.255
3.684GluIle: 3.684 ± 0.706
2.377GluLys: 2.377 ± 0.578
6.537GluLeu: 6.537 ± 1.276
1.188GluMet: 1.188 ± 0.3
0.832GluAsn: 0.832 ± 0.268
2.139GluPro: 2.139 ± 0.47
2.139GluGln: 2.139 ± 0.512
2.02GluArg: 2.02 ± 0.55
3.09GluSer: 3.09 ± 0.536
2.971GluThr: 2.971 ± 0.649
3.447GluVal: 3.447 ± 0.575
1.188GluTrp: 1.188 ± 0.362
1.07GluTyr: 1.07 ± 0.254
0.0GluXaa: 0.0 ± 0.0
Phe
1.783PheAla: 1.783 ± 0.25
0.475PheCys: 0.475 ± 0.197
1.902PheAsp: 1.902 ± 0.459
1.07PheGlu: 1.07 ± 0.275
1.188PhePhe: 1.188 ± 0.5
3.209PheGly: 3.209 ± 0.565
0.0PheHis: 0.0 ± 0.0
2.139PheIle: 2.139 ± 0.367
2.02PheLys: 2.02 ± 0.504
2.615PheLeu: 2.615 ± 0.609
1.426PheMet: 1.426 ± 0.501
1.545PheAsn: 1.545 ± 0.304
1.426PhePro: 1.426 ± 0.383
2.02PheGln: 2.02 ± 0.405
1.426PheArg: 1.426 ± 0.338
3.803PheSer: 3.803 ± 0.786
2.496PheThr: 2.496 ± 0.341
2.971PheVal: 2.971 ± 0.695
0.357PheTrp: 0.357 ± 0.178
0.951PheTyr: 0.951 ± 0.542
0.0PheXaa: 0.0 ± 0.0
Gly
4.16GlyAla: 4.16 ± 0.682
0.594GlyCys: 0.594 ± 0.212
3.447GlyAsp: 3.447 ± 0.747
2.734GlyGlu: 2.734 ± 0.6
2.377GlyPhe: 2.377 ± 0.483
2.258GlyGly: 2.258 ± 0.624
1.545GlyHis: 1.545 ± 0.446
2.971GlyIle: 2.971 ± 0.434
2.258GlyLys: 2.258 ± 0.317
4.279GlyLeu: 4.279 ± 0.782
2.139GlyMet: 2.139 ± 0.652
2.971GlyAsn: 2.971 ± 0.503
1.664GlyPro: 1.664 ± 0.472
2.02GlyGln: 2.02 ± 0.585
3.684GlyArg: 3.684 ± 0.569
3.328GlySer: 3.328 ± 0.409
2.734GlyThr: 2.734 ± 0.567
5.705GlyVal: 5.705 ± 0.584
1.545GlyTrp: 1.545 ± 0.333
2.02GlyTyr: 2.02 ± 0.407
0.0GlyXaa: 0.0 ± 0.0
His
1.902HisAla: 1.902 ± 0.626
0.238HisCys: 0.238 ± 0.202
1.664HisAsp: 1.664 ± 0.33
0.951HisGlu: 0.951 ± 0.255
0.357HisPhe: 0.357 ± 0.195
1.307HisGly: 1.307 ± 0.368
0.832HisHis: 0.832 ± 0.369
0.832HisIle: 0.832 ± 0.293
0.475HisLys: 0.475 ± 0.197
1.902HisLeu: 1.902 ± 0.354
0.475HisMet: 0.475 ± 0.222
0.594HisAsn: 0.594 ± 0.265
0.951HisPro: 0.951 ± 0.241
0.713HisGln: 0.713 ± 0.307
1.07HisArg: 1.07 ± 0.346
1.188HisSer: 1.188 ± 0.38
2.139HisThr: 2.139 ± 0.48
1.307HisVal: 1.307 ± 0.387
0.238HisTrp: 0.238 ± 0.182
0.832HisTyr: 0.832 ± 0.475
0.0HisXaa: 0.0 ± 0.0
Ile
3.922IleAla: 3.922 ± 0.837
0.951IleCys: 0.951 ± 0.285
4.397IleAsp: 4.397 ± 0.542
2.496IleGlu: 2.496 ± 0.441
1.426IlePhe: 1.426 ± 0.599
2.02IleGly: 2.02 ± 0.744
1.188IleHis: 1.188 ± 0.384
2.258IleIle: 2.258 ± 0.562
2.615IleLys: 2.615 ± 0.365
3.684IleLeu: 3.684 ± 0.626
2.496IleMet: 2.496 ± 0.582
3.09IleAsn: 3.09 ± 0.524
4.041IlePro: 4.041 ± 0.77
2.734IleGln: 2.734 ± 0.565
3.209IleArg: 3.209 ± 0.436
6.418IleSer: 6.418 ± 0.777
4.041IleThr: 4.041 ± 0.64
2.971IleVal: 2.971 ± 0.342
0.119IleTrp: 0.119 ± 0.101
1.545IleTyr: 1.545 ± 0.286
0.0IleXaa: 0.0 ± 0.0
Lys
2.258LysAla: 2.258 ± 0.535
0.475LysCys: 0.475 ± 0.291
1.902LysAsp: 1.902 ± 0.339
1.902LysGlu: 1.902 ± 0.516
0.832LysPhe: 0.832 ± 0.259
2.258LysGly: 2.258 ± 0.396
1.07LysHis: 1.07 ± 0.23
2.971LysIle: 2.971 ± 0.659
0.951LysLys: 0.951 ± 0.26
4.279LysLeu: 4.279 ± 0.637
0.832LysMet: 0.832 ± 0.378
1.664LysAsn: 1.664 ± 0.468
1.664LysPro: 1.664 ± 0.356
1.783LysGln: 1.783 ± 0.577
2.377LysArg: 2.377 ± 0.578
2.971LysSer: 2.971 ± 0.517
2.377LysThr: 2.377 ± 0.58
2.734LysVal: 2.734 ± 0.945
0.951LysTrp: 0.951 ± 0.257
1.783LysTyr: 1.783 ± 0.667
0.0LysXaa: 0.0 ± 0.0
Leu
7.25LeuAla: 7.25 ± 0.76
1.307LeuCys: 1.307 ± 0.346
8.319LeuAsp: 8.319 ± 1.183
6.18LeuGlu: 6.18 ± 0.588
2.971LeuPhe: 2.971 ± 0.581
3.447LeuGly: 3.447 ± 0.855
1.307LeuHis: 1.307 ± 0.469
3.447LeuIle: 3.447 ± 0.676
2.615LeuLys: 2.615 ± 0.562
7.844LeuLeu: 7.844 ± 1.196
3.803LeuMet: 3.803 ± 0.754
3.684LeuAsn: 3.684 ± 0.691
5.467LeuPro: 5.467 ± 0.813
4.992LeuGln: 4.992 ± 0.877
6.774LeuArg: 6.774 ± 0.6
10.102LeuSer: 10.102 ± 1.209
5.942LeuThr: 5.942 ± 0.724
6.18LeuVal: 6.18 ± 0.537
1.07LeuTrp: 1.07 ± 0.363
2.258LeuTyr: 2.258 ± 0.618
0.0LeuXaa: 0.0 ± 0.0
Met
2.971MetAla: 2.971 ± 0.532
0.357MetCys: 0.357 ± 0.185
1.664MetAsp: 1.664 ± 0.484
1.426MetGlu: 1.426 ± 0.653
1.07MetPhe: 1.07 ± 0.346
1.426MetGly: 1.426 ± 0.538
0.713MetHis: 0.713 ± 0.401
2.377MetIle: 2.377 ± 0.485
1.545MetLys: 1.545 ± 0.365
2.971MetLeu: 2.971 ± 0.464
1.188MetMet: 1.188 ± 0.497
1.902MetAsn: 1.902 ± 0.505
1.307MetPro: 1.307 ± 0.34
1.426MetGln: 1.426 ± 0.377
1.783MetArg: 1.783 ± 0.384
2.139MetSer: 2.139 ± 0.378
3.09MetThr: 3.09 ± 0.319
2.139MetVal: 2.139 ± 0.451
0.357MetTrp: 0.357 ± 0.173
1.664MetTyr: 1.664 ± 0.213
0.0MetXaa: 0.0 ± 0.0
Asn
2.852AsnAla: 2.852 ± 0.296
0.951AsnCys: 0.951 ± 0.398
2.139AsnAsp: 2.139 ± 0.449
1.545AsnGlu: 1.545 ± 0.286
1.426AsnPhe: 1.426 ± 0.405
2.971AsnGly: 2.971 ± 0.713
1.188AsnHis: 1.188 ± 0.373
1.545AsnIle: 1.545 ± 0.436
0.713AsnLys: 0.713 ± 0.285
2.971AsnLeu: 2.971 ± 0.794
0.832AsnMet: 0.832 ± 0.25
1.545AsnAsn: 1.545 ± 0.498
2.02AsnPro: 2.02 ± 0.494
2.496AsnGln: 2.496 ± 0.454
2.377AsnArg: 2.377 ± 0.418
3.328AsnSer: 3.328 ± 0.886
2.496AsnThr: 2.496 ± 0.459
4.754AsnVal: 4.754 ± 0.836
0.951AsnTrp: 0.951 ± 0.473
1.783AsnTyr: 1.783 ± 0.405
0.0AsnXaa: 0.0 ± 0.0
Pro
3.09ProAla: 3.09 ± 0.628
0.238ProCys: 0.238 ± 0.153
3.684ProAsp: 3.684 ± 0.39
2.139ProGlu: 2.139 ± 0.594
2.852ProPhe: 2.852 ± 0.51
2.852ProGly: 2.852 ± 0.574
1.188ProHis: 1.188 ± 0.306
3.09ProIle: 3.09 ± 0.522
1.902ProLys: 1.902 ± 0.784
5.942ProLeu: 5.942 ± 0.928
2.377ProMet: 2.377 ± 0.665
2.377ProAsn: 2.377 ± 0.492
3.209ProPro: 3.209 ± 0.874
2.02ProGln: 2.02 ± 0.404
2.377ProArg: 2.377 ± 0.811
4.754ProSer: 4.754 ± 0.462
4.516ProThr: 4.516 ± 0.692
2.971ProVal: 2.971 ± 0.396
1.07ProTrp: 1.07 ± 0.314
1.664ProTyr: 1.664 ± 0.383
0.0ProXaa: 0.0 ± 0.0
Gln
4.754GlnAla: 4.754 ± 1.119
0.713GlnCys: 0.713 ± 0.196
1.426GlnAsp: 1.426 ± 0.291
1.07GlnGlu: 1.07 ± 0.412
2.02GlnPhe: 2.02 ± 0.741
1.902GlnGly: 1.902 ± 0.414
0.832GlnHis: 0.832 ± 0.323
3.565GlnIle: 3.565 ± 0.527
1.783GlnLys: 1.783 ± 0.452
6.774GlnLeu: 6.774 ± 0.925
1.902GlnMet: 1.902 ± 0.463
2.139GlnAsn: 2.139 ± 0.392
1.902GlnPro: 1.902 ± 0.301
2.496GlnGln: 2.496 ± 0.54
2.734GlnArg: 2.734 ± 0.641
3.684GlnSer: 3.684 ± 0.643
2.02GlnThr: 2.02 ± 0.355
3.09GlnVal: 3.09 ± 0.602
0.713GlnTrp: 0.713 ± 0.23
2.139GlnTyr: 2.139 ± 0.57
0.0GlnXaa: 0.0 ± 0.0
Arg
4.279ArgAla: 4.279 ± 0.681
0.713ArgCys: 0.713 ± 0.253
3.209ArgAsp: 3.209 ± 0.702
2.971ArgGlu: 2.971 ± 0.768
2.139ArgPhe: 2.139 ± 0.398
2.971ArgGly: 2.971 ± 0.414
1.307ArgHis: 1.307 ± 0.372
3.328ArgIle: 3.328 ± 0.701
3.328ArgLys: 3.328 ± 0.93
5.111ArgLeu: 5.111 ± 1.151
2.139ArgMet: 2.139 ± 0.459
1.545ArgAsn: 1.545 ± 0.372
2.258ArgPro: 2.258 ± 0.737
2.496ArgGln: 2.496 ± 0.363
2.377ArgArg: 2.377 ± 0.56
4.397ArgSer: 4.397 ± 0.691
3.684ArgThr: 3.684 ± 0.64
5.229ArgVal: 5.229 ± 0.661
1.188ArgTrp: 1.188 ± 0.368
2.377ArgTyr: 2.377 ± 0.666
0.0ArgXaa: 0.0 ± 0.0
Ser
7.963SerAla: 7.963 ± 0.891
0.951SerCys: 0.951 ± 0.342
4.992SerAsp: 4.992 ± 0.63
3.09SerGlu: 3.09 ± 0.551
2.496SerPhe: 2.496 ± 0.258
5.111SerGly: 5.111 ± 0.877
1.307SerHis: 1.307 ± 0.37
4.992SerIle: 4.992 ± 0.695
2.258SerLys: 2.258 ± 0.739
9.389SerLeu: 9.389 ± 1.275
1.902SerMet: 1.902 ± 0.453
3.328SerAsn: 3.328 ± 0.989
4.279SerPro: 4.279 ± 0.634
3.447SerGln: 3.447 ± 0.722
4.873SerArg: 4.873 ± 0.979
7.963SerSer: 7.963 ± 0.937
5.111SerThr: 5.111 ± 0.672
6.061SerVal: 6.061 ± 0.667
0.951SerTrp: 0.951 ± 0.303
2.615SerTyr: 2.615 ± 0.482
0.0SerXaa: 0.0 ± 0.0
Thr
4.516ThrAla: 4.516 ± 0.805
0.713ThrCys: 0.713 ± 0.219
2.971ThrAsp: 2.971 ± 0.397
3.565ThrGlu: 3.565 ± 0.969
1.902ThrPhe: 1.902 ± 0.39
3.922ThrGly: 3.922 ± 0.712
1.188ThrHis: 1.188 ± 0.256
3.803ThrIle: 3.803 ± 0.824
2.852ThrLys: 2.852 ± 0.678
5.824ThrLeu: 5.824 ± 0.858
2.615ThrMet: 2.615 ± 0.556
2.377ThrAsn: 2.377 ± 0.883
3.922ThrPro: 3.922 ± 0.957
4.279ThrGln: 4.279 ± 0.643
3.209ThrArg: 3.209 ± 0.583
5.586ThrSer: 5.586 ± 0.814
3.209ThrThr: 3.209 ± 0.798
3.565ThrVal: 3.565 ± 0.502
1.307ThrTrp: 1.307 ± 0.504
1.902ThrTyr: 1.902 ± 0.371
0.0ThrXaa: 0.0 ± 0.0
Val
5.111ValAla: 5.111 ± 0.941
1.307ValCys: 1.307 ± 0.436
6.061ValAsp: 6.061 ± 1.308
1.783ValGlu: 1.783 ± 0.427
2.377ValPhe: 2.377 ± 0.458
4.754ValGly: 4.754 ± 0.474
1.426ValHis: 1.426 ± 0.37
3.328ValIle: 3.328 ± 0.616
2.971ValLys: 2.971 ± 0.713
6.537ValLeu: 6.537 ± 0.88
2.258ValMet: 2.258 ± 0.619
3.328ValAsn: 3.328 ± 0.466
5.348ValPro: 5.348 ± 1.034
2.377ValGln: 2.377 ± 0.571
4.516ValArg: 4.516 ± 0.716
6.656ValSer: 6.656 ± 0.838
4.873ValThr: 4.873 ± 1.128
5.705ValVal: 5.705 ± 1.05
0.951ValTrp: 0.951 ± 0.325
1.783ValTyr: 1.783 ± 0.566
0.0ValXaa: 0.0 ± 0.0
Trp
0.832TrpAla: 0.832 ± 0.303
0.475TrpCys: 0.475 ± 0.197
0.951TrpAsp: 0.951 ± 0.287
0.475TrpGlu: 0.475 ± 0.192
0.475TrpPhe: 0.475 ± 0.256
1.07TrpGly: 1.07 ± 0.375
0.357TrpHis: 0.357 ± 0.181
1.545TrpIle: 1.545 ± 0.473
0.357TrpLys: 0.357 ± 0.2
1.545TrpLeu: 1.545 ± 0.264
0.594TrpMet: 0.594 ± 0.323
0.357TrpAsn: 0.357 ± 0.172
0.713TrpPro: 0.713 ± 0.325
0.713TrpGln: 0.713 ± 0.227
0.594TrpArg: 0.594 ± 0.205
0.713TrpSer: 0.713 ± 0.308
1.783TrpThr: 1.783 ± 0.526
1.307TrpVal: 1.307 ± 0.416
0.0TrpTrp: 0.0 ± 0.0
0.713TrpTyr: 0.713 ± 0.368
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.971TyrAla: 2.971 ± 0.523
0.475TyrCys: 0.475 ± 0.262
2.258TyrAsp: 2.258 ± 0.497
1.07TyrGlu: 1.07 ± 0.211
1.902TyrPhe: 1.902 ± 0.374
1.902TyrGly: 1.902 ± 0.5
0.713TyrHis: 0.713 ± 0.249
1.307TyrIle: 1.307 ± 0.419
1.07TyrLys: 1.07 ± 0.388
3.209TyrLeu: 3.209 ± 0.906
0.951TyrMet: 0.951 ± 0.312
2.139TyrAsn: 2.139 ± 0.573
2.02TyrPro: 2.02 ± 0.585
2.139TyrGln: 2.139 ± 0.3
1.426TyrArg: 1.426 ± 0.416
1.783TyrSer: 1.783 ± 0.475
1.783TyrThr: 1.783 ± 0.278
2.615TyrVal: 2.615 ± 0.597
0.594TyrTrp: 0.594 ± 0.229
1.426TyrTyr: 1.426 ± 0.283
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (8415 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski