Amino acid dipepetide frequency for Micromonospora echinospora (Micromonospora purpurea)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.779AlaAla: 21.779 ± 0.144	0.959AlaCys: 0.959 ± 0.022	9.211AlaAsp: 9.211 ± 0.086	8.223AlaGlu: 8.223 ± 0.076	3.248AlaPhe: 3.248 ± 0.043	14.483AlaGly: 14.483 ± 0.105	2.631AlaHis: 2.631 ± 0.04	3.441AlaIle: 3.441 ± 0.046	2.033AlaLys: 2.033 ± 0.043	14.33AlaLeu: 14.33 ± 0.132	2.295AlaMet: 2.295 ± 0.032	2.137AlaAsn: 2.137 ± 0.04	7.171AlaPro: 7.171 ± 0.075	3.344AlaGln: 3.344 ± 0.044	10.506AlaArg: 10.506 ± 0.09	5.442AlaSer: 5.442 ± 0.056	8.305AlaThr: 8.305 ± 0.07	13.145AlaVal: 13.145 ± 0.109	1.876AlaTrp: 1.876 ± 0.032	2.769AlaTyr: 2.769 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	0.992CysAla: 0.992 ± 0.021	0.099CysCys: 0.099 ± 0.008	0.493CysAsp: 0.493 ± 0.016	0.323CysGlu: 0.323 ± 0.013	0.204CysPhe: 0.204 ± 0.011	0.879CysGly: 0.879 ± 0.023	0.186CysHis: 0.186 ± 0.009	0.132CysIle: 0.132 ± 0.009	0.085CysLys: 0.085 ± 0.007	0.688CysLeu: 0.688 ± 0.02	0.099CysMet: 0.099 ± 0.007	0.134CysAsn: 0.134 ± 0.007	0.482CysPro: 0.482 ± 0.017	0.215CysGln: 0.215 ± 0.01	0.685CysArg: 0.685 ± 0.021	0.376CysSer: 0.376 ± 0.015	0.424CysThr: 0.424 ± 0.016	0.657CysVal: 0.657 ± 0.018	0.132CysTrp: 0.132 ± 0.01	0.161CysTyr: 0.161 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.827AspAla: 7.827 ± 0.078	0.403AspCys: 0.403 ± 0.016	3.975AspAsp: 3.975 ± 0.044	3.719AspGlu: 3.719 ± 0.045	1.462AspPhe: 1.462 ± 0.028	6.695AspGly: 6.695 ± 0.061	1.426AspHis: 1.426 ± 0.027	1.52AspIle: 1.52 ± 0.029	0.773AspLys: 0.773 ± 0.024	7.062AspLeu: 7.062 ± 0.063	0.724AspMet: 0.724 ± 0.018	0.898AspAsn: 0.898 ± 0.022	5.26AspPro: 5.26 ± 0.054	1.699AspGln: 1.699 ± 0.027	6.153AspArg: 6.153 ± 0.055	2.26AspSer: 2.26 ± 0.035	3.083AspThr: 3.083 ± 0.038	5.264AspVal: 5.264 ± 0.057	1.03AspTrp: 1.03 ± 0.023	1.11AspTyr: 1.11 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.406GluAla: 6.406 ± 0.064	0.332GluCys: 0.332 ± 0.013	2.055GluAsp: 2.055 ± 0.036	2.518GluGlu: 2.518 ± 0.038	1.44GluPhe: 1.44 ± 0.026	3.216GluGly: 3.216 ± 0.043	1.326GluHis: 1.326 ± 0.026	2.091GluIle: 2.091 ± 0.032	0.971GluLys: 0.971 ± 0.026	6.238GluLeu: 6.238 ± 0.066	0.807GluMet: 0.807 ± 0.02	0.874GluAsn: 0.874 ± 0.024	3.461GluPro: 3.461 ± 0.045	2.129GluGln: 2.129 ± 0.035	5.078GluArg: 5.078 ± 0.06	2.167GluSer: 2.167 ± 0.04	2.587GluThr: 2.587 ± 0.036	4.709GluVal: 4.709 ± 0.055	0.716GluTrp: 0.716 ± 0.017	1.071GluTyr: 1.071 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	3.689PheAla: 3.689 ± 0.045	0.255PheCys: 0.255 ± 0.01	2.058PheAsp: 2.058 ± 0.029	1.174PheGlu: 1.174 ± 0.023	0.843PhePhe: 0.843 ± 0.023	2.957PheGly: 2.957 ± 0.041	0.591PheHis: 0.591 ± 0.017	0.58PheIle: 0.58 ± 0.018	0.376PheLys: 0.376 ± 0.015	2.477PheLeu: 2.477 ± 0.039	0.312PheMet: 0.312 ± 0.012	0.53PheAsn: 0.53 ± 0.016	1.362PhePro: 1.362 ± 0.025	0.628PheGln: 0.628 ± 0.018	1.875PheArg: 1.875 ± 0.03	1.317PheSer: 1.317 ± 0.026	1.958PheThr: 1.958 ± 0.03	2.485PheVal: 2.485 ± 0.036	0.437PheTrp: 0.437 ± 0.016	0.582PheTyr: 0.582 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	10.713GlyAla: 10.713 ± 0.071	0.833GlyCys: 0.833 ± 0.022	5.455GlyAsp: 5.455 ± 0.046	4.627GlyGlu: 4.627 ± 0.043	2.766GlyPhe: 2.766 ± 0.034	8.938GlyGly: 8.938 ± 0.088	2.225GlyHis: 2.225 ± 0.032	3.08GlyIle: 3.08 ± 0.037	1.741GlyLys: 1.741 ± 0.035	9.356GlyLeu: 9.356 ± 0.077	1.879GlyMet: 1.879 ± 0.031	1.814GlyAsn: 1.814 ± 0.042	5.69GlyPro: 5.69 ± 0.054	2.867GlyGln: 2.867 ± 0.042	8.406GlyArg: 8.406 ± 0.064	4.867GlySer: 4.867 ± 0.049	6.365GlyThr: 6.365 ± 0.065	8.383GlyVal: 8.383 ± 0.069	1.945GlyTrp: 1.945 ± 0.029	2.436GlyTyr: 2.436 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.505HisAla: 2.505 ± 0.038	0.192HisCys: 0.192 ± 0.01	1.372HisAsp: 1.372 ± 0.024	1.063HisGlu: 1.063 ± 0.021	0.579HisPhe: 0.579 ± 0.015	2.154HisGly: 2.154 ± 0.033	0.7HisHis: 0.7 ± 0.02	0.507HisIle: 0.507 ± 0.016	0.237HisLys: 0.237 ± 0.011	2.624HisLeu: 2.624 ± 0.041	0.277HisMet: 0.277 ± 0.011	0.363HisAsn: 0.363 ± 0.015	1.831HisPro: 1.831 ± 0.031	0.613HisGln: 0.613 ± 0.016	2.361HisArg: 2.361 ± 0.036	0.879HisSer: 0.879 ± 0.021	1.148HisThr: 1.148 ± 0.023	1.844HisVal: 1.844 ± 0.03	0.34HisTrp: 0.34 ± 0.013	0.419HisTyr: 0.419 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.211IleAla: 4.211 ± 0.051	0.277IleCys: 0.277 ± 0.01	2.151IleAsp: 2.151 ± 0.033	1.753IleGlu: 1.753 ± 0.026	0.76IlePhe: 0.76 ± 0.02	3.233IleGly: 3.233 ± 0.043	0.542IleHis: 0.542 ± 0.015	0.8IleIle: 0.8 ± 0.023	0.54IleLys: 0.54 ± 0.016	2.307IleLeu: 2.307 ± 0.035	0.379IleMet: 0.379 ± 0.014	0.657IleAsn: 0.657 ± 0.019	1.52IlePro: 1.52 ± 0.032	0.641IleGln: 0.641 ± 0.018	2.357IleArg: 2.357 ± 0.032	1.524IleSer: 1.524 ± 0.028	1.922IleThr: 1.922 ± 0.03	2.667IleVal: 2.667 ± 0.04	0.397IleTrp: 0.397 ± 0.014	0.536IleTyr: 0.536 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	1.868LysAla: 1.868 ± 0.043	0.098LysCys: 0.098 ± 0.007	0.736LysAsp: 0.736 ± 0.022	0.699LysGlu: 0.699 ± 0.022	0.343LysPhe: 0.343 ± 0.013	1.117LysGly: 1.117 ± 0.027	0.304LysHis: 0.304 ± 0.012	0.69LysIle: 0.69 ± 0.02	0.431LysLys: 0.431 ± 0.019	1.623LysLeu: 1.623 ± 0.031	0.287LysMet: 0.287 ± 0.011	0.342LysAsn: 0.342 ± 0.014	1.021LysPro: 1.021 ± 0.025	0.515LysGln: 0.515 ± 0.016	1.137LysArg: 1.137 ± 0.027	0.816LysSer: 0.816 ± 0.024	0.95LysThr: 0.95 ± 0.027	1.45LysVal: 1.45 ± 0.031	0.218LysTrp: 0.218 ± 0.012	0.308LysTyr: 0.308 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	16.555LeuAla: 16.555 ± 0.132	0.734LeuCys: 0.734 ± 0.02	7.197LeuAsp: 7.197 ± 0.067	3.737LeuGlu: 3.737 ± 0.045	2.611LeuPhe: 2.611 ± 0.039	9.242LeuGly: 9.242 ± 0.071	2.336LeuHis: 2.336 ± 0.036	2.723LeuIle: 2.723 ± 0.042	1.305LeuLys: 1.305 ± 0.028	11.661LeuLeu: 11.661 ± 0.108	1.312LeuMet: 1.312 ± 0.027	1.574LeuAsn: 1.574 ± 0.028	6.84LeuPro: 6.84 ± 0.065	1.803LeuGln: 1.803 ± 0.031	9.47LeuArg: 9.47 ± 0.072	4.655LeuSer: 4.655 ± 0.049	7.346LeuThr: 7.346 ± 0.06	10.442LeuVal: 10.442 ± 0.104	1.278LeuTrp: 1.278 ± 0.028	1.709LeuTyr: 1.709 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	1.972MetAla: 1.972 ± 0.032	0.115MetCys: 0.115 ± 0.008	0.742MetAsp: 0.742 ± 0.019	0.55MetGlu: 0.55 ± 0.018	0.453MetPhe: 0.453 ± 0.015	1.071MetGly: 1.071 ± 0.027	0.274MetHis: 0.274 ± 0.01	0.634MetIle: 0.634 ± 0.016	0.292MetLys: 0.292 ± 0.012	1.648MetLeu: 1.648 ± 0.024	0.259MetMet: 0.259 ± 0.011	0.344MetAsn: 0.344 ± 0.012	1.046MetPro: 1.046 ± 0.025	0.396MetGln: 0.396 ± 0.014	1.368MetArg: 1.368 ± 0.024	1.187MetSer: 1.187 ± 0.022	1.497MetThr: 1.497 ± 0.025	1.32MetVal: 1.32 ± 0.026	0.194MetTrp: 0.194 ± 0.009	0.276MetTyr: 0.276 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.108AsnAla: 2.108 ± 0.033	0.162AsnCys: 0.162 ± 0.009	0.933AsnAsp: 0.933 ± 0.025	0.724AsnGlu: 0.724 ± 0.02	0.479AsnPhe: 0.479 ± 0.014	1.932AsnGly: 1.932 ± 0.038	0.394AsnHis: 0.394 ± 0.016	0.565AsnIle: 0.565 ± 0.018	0.312AsnLys: 0.312 ± 0.014	1.869AsnLeu: 1.869 ± 0.029	0.268AsnMet: 0.268 ± 0.01	0.462AsnAsn: 0.462 ± 0.02	1.449AsnPro: 1.449 ± 0.028	0.55AsnGln: 0.55 ± 0.016	1.429AsnArg: 1.429 ± 0.027	0.845AsnSer: 0.845 ± 0.019	1.048AsnThr: 1.048 ± 0.032	1.419AsnVal: 1.419 ± 0.031	0.322AsnTrp: 0.322 ± 0.013	0.448AsnTyr: 0.448 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	10.103ProAla: 10.103 ± 0.103	0.315ProCys: 0.315 ± 0.012	5.042ProAsp: 5.042 ± 0.062	3.987ProGlu: 3.987 ± 0.051	1.469ProPhe: 1.469 ± 0.024	6.828ProGly: 6.828 ± 0.07	1.276ProHis: 1.276 ± 0.023	1.489ProIle: 1.489 ± 0.028	0.89ProLys: 0.89 ± 0.023	5.42ProLeu: 5.42 ± 0.048	0.979ProMet: 0.979 ± 0.022	1.038ProAsn: 1.038 ± 0.023	4.534ProPro: 4.534 ± 0.081	1.577ProGln: 1.577 ± 0.028	4.111ProArg: 4.111 ± 0.057	3.003ProSer: 3.003 ± 0.041	4.336ProThr: 4.336 ± 0.052	6.539ProVal: 6.539 ± 0.071	0.94ProTrp: 0.94 ± 0.02	1.326ProTyr: 1.326 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.466GlnAla: 3.466 ± 0.053	0.155GlnCys: 0.155 ± 0.009	1.097GlnAsp: 1.097 ± 0.024	1.138GlnGlu: 1.138 ± 0.027	0.673GlnPhe: 0.673 ± 0.016	1.906GlnGly: 1.906 ± 0.03	0.603GlnHis: 0.603 ± 0.019	1.007GlnIle: 1.007 ± 0.025	0.415GlnLys: 0.415 ± 0.015	2.964GlnLeu: 2.964 ± 0.033	0.442GlnMet: 0.442 ± 0.014	0.458GlnAsn: 0.458 ± 0.017	1.886GlnPro: 1.886 ± 0.032	1.115GlnGln: 1.115 ± 0.028	2.722GlnArg: 2.722 ± 0.038	1.119GlnSer: 1.119 ± 0.025	1.311GlnThr: 1.311 ± 0.023	2.831GlnVal: 2.831 ± 0.04	0.506GlnTrp: 0.506 ± 0.015	0.543GlnTyr: 0.543 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	10.399ArgAla: 10.399 ± 0.078	0.678ArgCys: 0.678 ± 0.019	4.818ArgAsp: 4.818 ± 0.049	4.359ArgGlu: 4.359 ± 0.049	2.532ArgPhe: 2.532 ± 0.039	5.883ArgGly: 5.883 ± 0.054	2.39ArgHis: 2.39 ± 0.038	3.257ArgIle: 3.257 ± 0.046	1.215ArgLys: 1.215 ± 0.026	9.792ArgLeu: 9.792 ± 0.086	1.84ArgMet: 1.84 ± 0.031	1.501ArgAsn: 1.501 ± 0.027	5.876ArgPro: 5.876 ± 0.058	2.683ArgGln: 2.683 ± 0.033	8.956ArgArg: 8.956 ± 0.096	4.174ArgSer: 4.174 ± 0.052	5.166ArgThr: 5.166 ± 0.048	6.822ArgVal: 6.822 ± 0.061	1.716ArgTrp: 1.716 ± 0.027	2.106ArgTyr: 2.106 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.226SerAla: 6.226 ± 0.055	0.381SerCys: 0.381 ± 0.016	2.353SerAsp: 2.353 ± 0.035	1.855SerGlu: 1.855 ± 0.038	1.415SerPhe: 1.415 ± 0.026	5.507SerGly: 5.507 ± 0.059	0.882SerHis: 0.882 ± 0.022	1.395SerIle: 1.395 ± 0.028	0.673SerLys: 0.673 ± 0.02	4.268SerLeu: 4.268 ± 0.045	0.909SerMet: 0.909 ± 0.02	0.881SerAsn: 0.881 ± 0.022	3.092SerPro: 3.092 ± 0.041	1.058SerGln: 1.058 ± 0.023	3.711SerArg: 3.711 ± 0.04	2.408SerSer: 2.408 ± 0.034	3.152SerThr: 3.152 ± 0.047	4.123SerVal: 4.123 ± 0.046	0.91SerTrp: 0.91 ± 0.021	1.177SerTyr: 1.177 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.904ThrAla: 8.904 ± 0.077	0.42ThrCys: 0.42 ± 0.014	3.936ThrAsp: 3.936 ± 0.047	3.028ThrGlu: 3.028 ± 0.034	1.692ThrPhe: 1.692 ± 0.03	7.356ThrGly: 7.356 ± 0.065	1.124ThrHis: 1.124 ± 0.025	1.871ThrIle: 1.871 ± 0.032	0.847ThrLys: 0.847 ± 0.022	5.933ThrLeu: 5.933 ± 0.053	0.951ThrMet: 0.951 ± 0.022	1.112ThrAsn: 1.112 ± 0.027	4.53ThrPro: 4.53 ± 0.052	1.195ThrGln: 1.195 ± 0.026	4.388ThrArg: 4.388 ± 0.046	3.041ThrSer: 3.041 ± 0.05	4.152ThrThr: 4.152 ± 0.068	6.809ThrVal: 6.809 ± 0.068	1.014ThrTrp: 1.014 ± 0.024	1.362ThrTyr: 1.362 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	13.11ValAla: 13.11 ± 0.098	0.707ValCys: 0.707 ± 0.018	6.52ValAsp: 6.52 ± 0.061	5.05ValGlu: 5.05 ± 0.055	2.433ValPhe: 2.433 ± 0.032	7.844ValGly: 7.844 ± 0.062	1.89ValHis: 1.89 ± 0.029	2.533ValIle: 2.533 ± 0.039	1.308ValLys: 1.308 ± 0.031	10.05ValLeu: 10.05 ± 0.085	1.173ValMet: 1.173 ± 0.025	1.782ValAsn: 1.782 ± 0.035	5.969ValPro: 5.969 ± 0.061	1.98ValGln: 1.98 ± 0.031	7.727ValArg: 7.727 ± 0.063	4.37ValSer: 4.37 ± 0.048	6.632ValThr: 6.632 ± 0.056	9.664ValVal: 9.664 ± 0.091	1.154ValTrp: 1.154 ± 0.025	1.544ValTyr: 1.544 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	1.656TrpAla: 1.656 ± 0.026	0.161TrpCys: 0.161 ± 0.01	0.758TrpAsp: 0.758 ± 0.018	0.662TrpGlu: 0.662 ± 0.02	0.511TrpPhe: 0.511 ± 0.018	1.04TrpGly: 1.04 ± 0.024	0.417TrpHis: 0.417 ± 0.014	0.5TrpIle: 0.5 ± 0.015	0.259TrpLys: 0.259 ± 0.011	1.939TrpLeu: 1.939 ± 0.029	0.256TrpMet: 0.256 ± 0.011	0.418TrpAsn: 0.418 ± 0.014	0.939TrpPro: 0.939 ± 0.022	0.662TrpGln: 0.662 ± 0.017	1.674TrpArg: 1.674 ± 0.032	1.078TrpSer: 1.078 ± 0.023	1.119TrpThr: 1.119 ± 0.024	1.087TrpVal: 1.087 ± 0.025	0.367TrpTrp: 0.367 ± 0.013	0.389TrpTyr: 0.389 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.839TyrAla: 2.839 ± 0.035	0.169TyrCys: 0.169 ± 0.01	1.441TyrAsp: 1.441 ± 0.038	1.004TyrGlu: 1.004 ± 0.022	0.574TyrPhe: 0.574 ± 0.018	2.106TyrGly: 2.106 ± 0.037	0.492TyrHis: 0.492 ± 0.013	0.36TyrIle: 0.36 ± 0.013	0.249TyrLys: 0.249 ± 0.01	2.282TyrLeu: 2.282 ± 0.037	0.189TyrMet: 0.189 ± 0.009	0.398TyrAsn: 0.398 ± 0.016	1.245TyrPro: 1.245 ± 0.028	0.687TyrGln: 0.687 ± 0.019	2.05TyrArg: 2.05 ± 0.039	0.846TyrSer: 0.846 ± 0.021	1.165TyrThr: 1.165 ± 0.026	1.78TyrVal: 1.78 ± 0.032	0.4TyrTrp: 0.4 ± 0.014	0.433TyrTyr: 0.433 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6415 proteins (2282014 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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