Amino acid dipepetide frequency for Alistipes sp. CAG:514

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.985AlaAla: 7.985 ± 0.145	0.991AlaCys: 0.991 ± 0.045	5.012AlaAsp: 5.012 ± 0.093	5.258AlaGlu: 5.258 ± 0.106	3.433AlaPhe: 3.433 ± 0.073	6.582AlaGly: 6.582 ± 0.121	1.177AlaHis: 1.177 ± 0.042	4.618AlaIle: 4.618 ± 0.086	4.565AlaLys: 4.565 ± 0.096	7.452AlaLeu: 7.452 ± 0.124	2.15AlaMet: 2.15 ± 0.057	2.713AlaAsn: 2.713 ± 0.063	2.707AlaPro: 2.707 ± 0.076	2.358AlaGln: 2.358 ± 0.074	4.078AlaArg: 4.078 ± 0.086	5.408AlaSer: 5.408 ± 0.099	3.988AlaThr: 3.988 ± 0.067	6.177AlaVal: 6.177 ± 0.1	0.857AlaTrp: 0.857 ± 0.035	2.751AlaTyr: 2.751 ± 0.066	0.003AlaXaa: 0.003 ± 0.002
Cys	0.986CysAla: 0.986 ± 0.045	0.223CysCys: 0.223 ± 0.021	0.874CysAsp: 0.874 ± 0.034	0.757CysGlu: 0.757 ± 0.03	0.56CysPhe: 0.56 ± 0.031	1.287CysGly: 1.287 ± 0.049	0.279CysHis: 0.279 ± 0.024	0.654CysIle: 0.654 ± 0.032	0.569CysLys: 0.569 ± 0.029	1.151CysLeu: 1.151 ± 0.044	0.26CysMet: 0.26 ± 0.021	0.467CysAsn: 0.467 ± 0.027	0.649CysPro: 0.649 ± 0.037	0.344CysGln: 0.344 ± 0.024	0.703CysArg: 0.703 ± 0.035	0.877CysSer: 0.877 ± 0.038	0.57CysThr: 0.57 ± 0.031	0.906CysVal: 0.906 ± 0.039	0.186CysTrp: 0.186 ± 0.016	0.487CysTyr: 0.487 ± 0.024	0.001CysXaa: 0.001 ± 0.001
Asp	4.557AspAla: 4.557 ± 0.098	0.736AspCys: 0.736 ± 0.028	3.033AspAsp: 3.033 ± 0.077	3.958AspGlu: 3.958 ± 0.084	3.357AspPhe: 3.357 ± 0.072	5.434AspGly: 5.434 ± 0.12	0.944AspHis: 0.944 ± 0.036	4.148AspIle: 4.148 ± 0.076	3.811AspLys: 3.811 ± 0.083	5.261AspLeu: 5.261 ± 0.102	1.426AspMet: 1.426 ± 0.039	2.654AspAsn: 2.654 ± 0.071	2.598AspPro: 2.598 ± 0.061	1.36AspGln: 1.36 ± 0.047	3.211AspArg: 3.211 ± 0.067	3.873AspSer: 3.873 ± 0.085	2.811AspThr: 2.811 ± 0.077	4.218AspVal: 4.218 ± 0.079	0.963AspTrp: 0.963 ± 0.04	2.873AspTyr: 2.873 ± 0.066	0.001AspXaa: 0.001 ± 0.002
Glu	5.237GluAla: 5.237 ± 0.111	0.733GluCys: 0.733 ± 0.032	3.675GluAsp: 3.675 ± 0.078	4.403GluGlu: 4.403 ± 0.104	2.493GluPhe: 2.493 ± 0.064	4.507GluGly: 4.507 ± 0.082	0.991GluHis: 0.991 ± 0.041	4.348GluIle: 4.348 ± 0.085	4.353GluLys: 4.353 ± 0.091	5.104GluLeu: 5.104 ± 0.094	1.893GluMet: 1.893 ± 0.049	2.921GluAsn: 2.921 ± 0.068	2.043GluPro: 2.043 ± 0.054	1.753GluGln: 1.753 ± 0.061	3.461GluArg: 3.461 ± 0.067	3.634GluSer: 3.634 ± 0.077	3.137GluThr: 3.137 ± 0.065	4.25GluVal: 4.25 ± 0.084	0.753GluTrp: 0.753 ± 0.035	3.237GluTyr: 3.237 ± 0.068	0.0GluXaa: 0.0 ± 0.0
Phe	3.357PheAla: 3.357 ± 0.078	0.696PheCys: 0.696 ± 0.033	2.971PheAsp: 2.971 ± 0.064	2.413PheGlu: 2.413 ± 0.066	1.997PhePhe: 1.997 ± 0.059	3.781PheGly: 3.781 ± 0.088	0.79PheHis: 0.79 ± 0.034	2.763PheIle: 2.763 ± 0.078	2.498PheLys: 2.498 ± 0.061	3.683PheLeu: 3.683 ± 0.084	1.16PheMet: 1.16 ± 0.041	2.083PheAsn: 2.083 ± 0.055	1.776PhePro: 1.776 ± 0.045	1.046PheGln: 1.046 ± 0.04	2.68PheArg: 2.68 ± 0.062	3.447PheSer: 3.447 ± 0.083	2.624PheThr: 2.624 ± 0.078	3.045PheVal: 3.045 ± 0.069	0.646PheTrp: 0.646 ± 0.033	1.668PheTyr: 1.668 ± 0.05	0.0PheXaa: 0.0 ± 0.0
Gly	5.467GlyAla: 5.467 ± 0.104	1.093GlyCys: 1.093 ± 0.046	4.205GlyAsp: 4.205 ± 0.098	4.473GlyGlu: 4.473 ± 0.1	3.581GlyPhe: 3.581 ± 0.077	5.92GlyGly: 5.92 ± 0.14	1.518GlyHis: 1.518 ± 0.046	5.082GlyIle: 5.082 ± 0.087	5.664GlyLys: 5.664 ± 0.101	6.631GlyLeu: 6.631 ± 0.109	2.191GlyMet: 2.191 ± 0.058	3.475GlyAsn: 3.475 ± 0.08	1.813GlyPro: 1.813 ± 0.053	2.26GlyGln: 2.26 ± 0.061	4.068GlyArg: 4.068 ± 0.086	5.157GlySer: 5.157 ± 0.1	4.473GlyThr: 4.473 ± 0.085	5.657GlyVal: 5.657 ± 0.105	1.138GlyTrp: 1.138 ± 0.04	3.257GlyTyr: 3.257 ± 0.076	0.0GlyXaa: 0.0 ± 0.0
His	0.958HisAla: 0.958 ± 0.038	0.259HisCys: 0.259 ± 0.018	0.897HisAsp: 0.897 ± 0.04	0.931HisGlu: 0.931 ± 0.045	0.89HisPhe: 0.89 ± 0.034	1.17HisGly: 1.17 ± 0.044	0.434HisHis: 0.434 ± 0.03	1.264HisIle: 1.264 ± 0.044	0.98HisLys: 0.98 ± 0.042	1.578HisLeu: 1.578 ± 0.05	0.266HisMet: 0.266 ± 0.02	0.776HisAsn: 0.776 ± 0.033	0.928HisPro: 0.928 ± 0.039	0.404HisGln: 0.404 ± 0.025	0.916HisArg: 0.916 ± 0.035	1.08HisSer: 1.08 ± 0.039	0.881HisThr: 0.881 ± 0.034	0.92HisVal: 0.92 ± 0.037	0.239HisTrp: 0.239 ± 0.017	0.85HisTyr: 0.85 ± 0.036	0.0HisXaa: 0.0 ± 0.0
Ile	5.112IleAla: 5.112 ± 0.09	0.918IleCys: 0.918 ± 0.042	4.295IleAsp: 4.295 ± 0.083	3.724IleGlu: 3.724 ± 0.074	2.823IlePhe: 2.823 ± 0.077	4.62IleGly: 4.62 ± 0.098	1.097IleHis: 1.097 ± 0.04	3.805IleIle: 3.805 ± 0.092	3.335IleLys: 3.335 ± 0.07	5.425IleLeu: 5.425 ± 0.108	1.33IleMet: 1.33 ± 0.043	2.634IleAsn: 2.634 ± 0.072	3.027IlePro: 3.027 ± 0.065	1.64IleGln: 1.64 ± 0.051	3.424IleArg: 3.424 ± 0.074	4.337IleSer: 4.337 ± 0.098	3.325IleThr: 3.325 ± 0.074	4.53IleVal: 4.53 ± 0.087	0.664IleTrp: 0.664 ± 0.032	2.008IleTyr: 2.008 ± 0.053	0.001IleXaa: 0.001 ± 0.002
Lys	5.665LysAla: 5.665 ± 0.105	0.566LysCys: 0.566 ± 0.03	4.493LysAsp: 4.493 ± 0.098	4.748LysGlu: 4.748 ± 0.088	2.083LysPhe: 2.083 ± 0.053	4.581LysGly: 4.581 ± 0.081	0.73LysHis: 0.73 ± 0.036	3.535LysIle: 3.535 ± 0.078	3.695LysLys: 3.695 ± 0.088	4.134LysLeu: 4.134 ± 0.093	1.868LysMet: 1.868 ± 0.044	2.557LysAsn: 2.557 ± 0.063	2.246LysPro: 2.246 ± 0.051	1.376LysGln: 1.376 ± 0.049	2.807LysArg: 2.807 ± 0.062	3.577LysSer: 3.577 ± 0.074	3.617LysThr: 3.617 ± 0.075	4.975LysVal: 4.975 ± 0.094	0.789LysTrp: 0.789 ± 0.032	2.501LysTyr: 2.501 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	7.158LeuAla: 7.158 ± 0.105	1.24LeuCys: 1.24 ± 0.044	5.297LeuAsp: 5.297 ± 0.101	5.114LeuGlu: 5.114 ± 0.101	3.785LeuPhe: 3.785 ± 0.086	6.477LeuGly: 6.477 ± 0.111	1.348LeuHis: 1.348 ± 0.047	4.594LeuIle: 4.594 ± 0.092	5.547LeuLys: 5.547 ± 0.1	7.361LeuLeu: 7.361 ± 0.123	2.423LeuMet: 2.423 ± 0.053	3.883LeuAsn: 3.883 ± 0.074	3.9LeuPro: 3.9 ± 0.071	2.426LeuGln: 2.426 ± 0.055	4.928LeuArg: 4.928 ± 0.099	6.794LeuSer: 6.794 ± 0.118	5.104LeuThr: 5.104 ± 0.095	5.558LeuVal: 5.558 ± 0.114	0.993LeuTrp: 0.993 ± 0.036	3.081LeuTyr: 3.081 ± 0.069	0.001LeuXaa: 0.001 ± 0.001
Met	2.424MetAla: 2.424 ± 0.064	0.251MetCys: 0.251 ± 0.021	1.631MetAsp: 1.631 ± 0.044	1.648MetGlu: 1.648 ± 0.054	1.186MetPhe: 1.186 ± 0.044	1.714MetGly: 1.714 ± 0.047	0.381MetHis: 0.381 ± 0.024	1.664MetIle: 1.664 ± 0.05	1.89MetLys: 1.89 ± 0.053	2.37MetLeu: 2.37 ± 0.059	0.839MetMet: 0.839 ± 0.035	1.316MetAsn: 1.316 ± 0.048	1.134MetPro: 1.134 ± 0.043	0.667MetGln: 0.667 ± 0.032	1.503MetArg: 1.503 ± 0.051	1.763MetSer: 1.763 ± 0.053	1.694MetThr: 1.694 ± 0.054	1.693MetVal: 1.693 ± 0.049	0.25MetTrp: 0.25 ± 0.021	0.76MetTyr: 0.76 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.368AsnAla: 3.368 ± 0.07	0.527AsnCys: 0.527 ± 0.031	2.471AsnAsp: 2.471 ± 0.061	2.497AsnGlu: 2.497 ± 0.06	1.797AsnPhe: 1.797 ± 0.059	3.667AsnGly: 3.667 ± 0.074	0.786AsnHis: 0.786 ± 0.036	3.074AsnIle: 3.074 ± 0.078	2.131AsnLys: 2.131 ± 0.065	3.775AsnLeu: 3.775 ± 0.083	1.25AsnMet: 1.25 ± 0.039	1.89AsnAsn: 1.89 ± 0.062	2.398AsnPro: 2.398 ± 0.058	1.076AsnGln: 1.076 ± 0.044	2.018AsnArg: 2.018 ± 0.057	2.518AsnSer: 2.518 ± 0.064	2.138AsnThr: 2.138 ± 0.054	3.001AsnVal: 3.001 ± 0.068	0.55AsnTrp: 0.55 ± 0.03	1.844AsnTyr: 1.844 ± 0.057	0.0AsnXaa: 0.0 ± 0.0
Pro	3.42ProAla: 3.42 ± 0.078	0.419ProCys: 0.419 ± 0.027	3.094ProAsp: 3.094 ± 0.066	3.715ProGlu: 3.715 ± 0.079	1.811ProPhe: 1.811 ± 0.052	2.97ProGly: 2.97 ± 0.072	0.594ProHis: 0.594 ± 0.031	1.938ProIle: 1.938 ± 0.055	2.107ProLys: 2.107 ± 0.057	3.163ProLeu: 3.163 ± 0.075	0.963ProMet: 0.963 ± 0.037	1.341ProAsn: 1.341 ± 0.052	0.873ProPro: 0.873 ± 0.039	1.303ProGln: 1.303 ± 0.048	1.586ProArg: 1.586 ± 0.048	2.68ProSer: 2.68 ± 0.069	1.881ProThr: 1.881 ± 0.052	3.445ProVal: 3.445 ± 0.069	0.48ProTrp: 0.48 ± 0.029	1.621ProTyr: 1.621 ± 0.052	0.0ProXaa: 0.0 ± 0.0
Gln	2.291GlnAla: 2.291 ± 0.059	0.27GlnCys: 0.27 ± 0.019	1.463GlnAsp: 1.463 ± 0.043	1.768GlnGlu: 1.768 ± 0.051	1.156GlnPhe: 1.156 ± 0.042	1.89GlnGly: 1.89 ± 0.062	0.367GlnHis: 0.367 ± 0.021	1.858GlnIle: 1.858 ± 0.052	1.926GlnLys: 1.926 ± 0.05	2.197GlnLeu: 2.197 ± 0.06	0.918GlnMet: 0.918 ± 0.036	1.316GlnAsn: 1.316 ± 0.045	0.984GlnPro: 0.984 ± 0.039	0.864GlnGln: 0.864 ± 0.043	1.47GlnArg: 1.47 ± 0.046	1.596GlnSer: 1.596 ± 0.043	1.638GlnThr: 1.638 ± 0.055	1.804GlnVal: 1.804 ± 0.05	0.354GlnTrp: 0.354 ± 0.022	1.033GlnTyr: 1.033 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	3.048ArgAla: 3.048 ± 0.066	0.57ArgCys: 0.57 ± 0.032	2.77ArgAsp: 2.77 ± 0.067	3.271ArgGlu: 3.271 ± 0.078	2.726ArgPhe: 2.726 ± 0.069	3.025ArgGly: 3.025 ± 0.069	1.133ArgHis: 1.133 ± 0.04	4.068ArgIle: 4.068 ± 0.078	3.81ArgLys: 3.81 ± 0.086	5.177ArgLeu: 5.177 ± 0.089	1.893ArgMet: 1.893 ± 0.052	2.57ArgAsn: 2.57 ± 0.066	1.941ArgPro: 1.941 ± 0.057	1.861ArgGln: 1.861 ± 0.059	3.153ArgArg: 3.153 ± 0.072	3.111ArgSer: 3.111 ± 0.082	2.755ArgThr: 2.755 ± 0.069	3.02ArgVal: 3.02 ± 0.054	0.7ArgTrp: 0.7 ± 0.034	2.256ArgTyr: 2.256 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	5.348SerAla: 5.348 ± 0.094	0.957SerCys: 0.957 ± 0.04	4.027SerAsp: 4.027 ± 0.072	4.0SerGlu: 4.0 ± 0.082	3.47SerPhe: 3.47 ± 0.078	6.038SerGly: 6.038 ± 0.107	1.154SerHis: 1.154 ± 0.043	3.931SerIle: 3.931 ± 0.08	3.503SerLys: 3.503 ± 0.079	6.479SerLeu: 6.479 ± 0.113	1.633SerMet: 1.633 ± 0.051	2.326SerAsn: 2.326 ± 0.069	2.571SerPro: 2.571 ± 0.063	1.86SerGln: 1.86 ± 0.058	3.468SerArg: 3.468 ± 0.08	4.57SerSer: 4.57 ± 0.137	3.227SerThr: 3.227 ± 0.075	5.214SerVal: 5.214 ± 0.11	0.841SerTrp: 0.841 ± 0.038	2.757SerTyr: 2.757 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	4.411ThrAla: 4.411 ± 0.086	0.556ThrCys: 0.556 ± 0.034	3.344ThrAsp: 3.344 ± 0.078	3.074ThrGlu: 3.074 ± 0.072	2.527ThrPhe: 2.527 ± 0.062	4.64ThrGly: 4.64 ± 0.098	0.886ThrHis: 0.886 ± 0.036	3.408ThrIle: 3.408 ± 0.079	2.708ThrLys: 2.708 ± 0.062	5.41ThrLeu: 5.41 ± 0.106	1.18ThrMet: 1.18 ± 0.043	2.041ThrAsn: 2.041 ± 0.064	2.663ThrPro: 2.663 ± 0.063	1.327ThrGln: 1.327 ± 0.048	2.4ThrArg: 2.4 ± 0.059	3.38ThrSer: 3.38 ± 0.086	2.957ThrThr: 2.957 ± 0.08	4.531ThrVal: 4.531 ± 0.083	0.647ThrTrp: 0.647 ± 0.03	2.141ThrTyr: 2.141 ± 0.061	0.0ThrXaa: 0.0 ± 0.0
Val	5.821ValAla: 5.821 ± 0.097	0.99ValCys: 0.99 ± 0.038	4.158ValAsp: 4.158 ± 0.078	4.374ValGlu: 4.374 ± 0.089	3.001ValPhe: 3.001 ± 0.066	4.808ValGly: 4.808 ± 0.1	1.061ValHis: 1.061 ± 0.043	4.42ValIle: 4.42 ± 0.092	4.45ValLys: 4.45 ± 0.085	5.97ValLeu: 5.97 ± 0.094	1.811ValMet: 1.811 ± 0.053	3.191ValAsn: 3.191 ± 0.073	3.13ValPro: 3.13 ± 0.078	1.763ValGln: 1.763 ± 0.05	4.131ValArg: 4.131 ± 0.082	5.351ValSer: 5.351 ± 0.108	4.572ValThr: 4.572 ± 0.089	5.01ValVal: 5.01 ± 0.092	0.776ValTrp: 0.776 ± 0.038	2.46ValTyr: 2.46 ± 0.068	0.001ValXaa: 0.001 ± 0.001
Trp	0.811TrpAla: 0.811 ± 0.036	0.229TrpCys: 0.229 ± 0.02	0.697TrpAsp: 0.697 ± 0.033	0.663TrpGlu: 0.663 ± 0.033	0.653TrpPhe: 0.653 ± 0.03	0.881TrpGly: 0.881 ± 0.035	0.266TrpHis: 0.266 ± 0.021	0.733TrpIle: 0.733 ± 0.035	0.85TrpLys: 0.85 ± 0.04	1.204TrpLeu: 1.204 ± 0.059	0.431TrpMet: 0.431 ± 0.029	0.699TrpAsn: 0.699 ± 0.035	0.336TrpPro: 0.336 ± 0.021	0.447TrpGln: 0.447 ± 0.026	0.684TrpArg: 0.684 ± 0.036	0.83TrpSer: 0.83 ± 0.036	0.77TrpThr: 0.77 ± 0.037	0.639TrpVal: 0.639 ± 0.031	0.223TrpTrp: 0.223 ± 0.019	0.496TrpTyr: 0.496 ± 0.031	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.84TyrAla: 2.84 ± 0.072	0.567TyrCys: 0.567 ± 0.028	2.818TyrAsp: 2.818 ± 0.075	2.134TyrGlu: 2.134 ± 0.06	1.796TyrPhe: 1.796 ± 0.049	3.128TyrGly: 3.128 ± 0.075	0.683TyrHis: 0.683 ± 0.034	2.168TyrIle: 2.168 ± 0.053	2.15TyrLys: 2.15 ± 0.063	3.485TyrLeu: 3.485 ± 0.079	0.891TyrMet: 0.891 ± 0.039	1.927TyrAsn: 1.927 ± 0.066	1.687TyrPro: 1.687 ± 0.053	1.03TyrGln: 1.03 ± 0.045	2.168TyrArg: 2.168 ± 0.065	3.393TyrSer: 3.393 ± 0.082	2.066TyrThr: 2.066 ± 0.056	2.657TyrVal: 2.657 ± 0.066	0.493TyrTrp: 0.493 ± 0.027	1.831TyrTyr: 1.831 ± 0.056	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.003XaaGly: 0.003 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.002	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.004XaaXaa: 0.004 ± 0.002

Statistics based on 1898 proteins (700056 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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