Amino acid dipepetide frequency for Bacteroidales bacterium KA00344

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.475AlaAla: 5.475 ± 0.105	0.901AlaCys: 0.901 ± 0.034	4.532AlaAsp: 4.532 ± 0.066	4.418AlaGlu: 4.418 ± 0.082	3.124AlaPhe: 3.124 ± 0.066	4.77AlaGly: 4.77 ± 0.077	1.352AlaHis: 1.352 ± 0.039	4.729AlaIle: 4.729 ± 0.084	4.526AlaLys: 4.526 ± 0.078	6.543AlaLeu: 6.543 ± 0.109	2.277AlaMet: 2.277 ± 0.049	3.39AlaAsn: 3.39 ± 0.072	2.255AlaPro: 2.255 ± 0.052	2.832AlaGln: 2.832 ± 0.048	3.247AlaArg: 3.247 ± 0.066	4.15AlaSer: 4.15 ± 0.082	4.03AlaThr: 4.03 ± 0.068	4.738AlaVal: 4.738 ± 0.082	0.868AlaTrp: 0.868 ± 0.033	2.868AlaTyr: 2.868 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.806CysAla: 0.806 ± 0.031	0.201CysCys: 0.201 ± 0.014	0.726CysAsp: 0.726 ± 0.03	0.697CysGlu: 0.697 ± 0.028	0.623CysPhe: 0.623 ± 0.024	1.048CysGly: 1.048 ± 0.034	0.344CysHis: 0.344 ± 0.018	0.83CysIle: 0.83 ± 0.034	0.754CysLys: 0.754 ± 0.027	1.091CysLeu: 1.091 ± 0.035	0.316CysMet: 0.316 ± 0.02	0.68CysAsn: 0.68 ± 0.027	0.532CysPro: 0.532 ± 0.03	0.384CysGln: 0.384 ± 0.021	0.656CysArg: 0.656 ± 0.028	0.8CysSer: 0.8 ± 0.031	0.659CysThr: 0.659 ± 0.025	0.838CysVal: 0.838 ± 0.034	0.176CysTrp: 0.176 ± 0.014	0.578CysTyr: 0.578 ± 0.026	0.0CysXaa: 0.0 ± 0.0
Asp	4.232AspAla: 4.232 ± 0.078	0.669AspCys: 0.669 ± 0.027	3.135AspAsp: 3.135 ± 0.065	3.981AspGlu: 3.981 ± 0.083	3.09AspPhe: 3.09 ± 0.07	4.398AspGly: 4.398 ± 0.076	1.093AspHis: 1.093 ± 0.037	4.086AspIle: 4.086 ± 0.07	3.973AspLys: 3.973 ± 0.069	4.376AspLeu: 4.376 ± 0.069	1.682AspMet: 1.682 ± 0.05	3.194AspAsn: 3.194 ± 0.064	1.859AspPro: 1.859 ± 0.055	1.376AspGln: 1.376 ± 0.042	2.755AspArg: 2.755 ± 0.056	3.09AspSer: 3.09 ± 0.079	2.907AspThr: 2.907 ± 0.054	3.85AspVal: 3.85 ± 0.066	0.852AspTrp: 0.852 ± 0.033	2.866AspTyr: 2.866 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	4.573GluAla: 4.573 ± 0.087	0.569GluCys: 0.569 ± 0.024	3.258GluAsp: 3.258 ± 0.061	4.26GluGlu: 4.26 ± 0.09	2.219GluPhe: 2.219 ± 0.052	3.792GluGly: 3.792 ± 0.062	1.359GluHis: 1.359 ± 0.041	3.986GluIle: 3.986 ± 0.083	4.436GluLys: 4.436 ± 0.089	5.304GluLeu: 5.304 ± 0.089	1.953GluMet: 1.953 ± 0.049	3.232GluAsn: 3.232 ± 0.057	1.691GluPro: 1.691 ± 0.045	2.684GluGln: 2.684 ± 0.057	3.293GluArg: 3.293 ± 0.058	2.824GluSer: 2.824 ± 0.049	3.236GluThr: 3.236 ± 0.055	3.796GluVal: 3.796 ± 0.069	0.739GluTrp: 0.739 ± 0.03	2.384GluTyr: 2.384 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.095PheAla: 3.095 ± 0.064	0.771PheCys: 0.771 ± 0.031	2.908PheAsp: 2.908 ± 0.063	2.355PheGlu: 2.355 ± 0.052	2.17PhePhe: 2.17 ± 0.063	3.253PheGly: 3.253 ± 0.067	0.938PheHis: 0.938 ± 0.033	2.96PheIle: 2.96 ± 0.068	2.543PheLys: 2.543 ± 0.059	3.804PheLeu: 3.804 ± 0.075	1.297PheMet: 1.297 ± 0.042	2.347PheAsn: 2.347 ± 0.062	1.646PhePro: 1.646 ± 0.042	1.263PheGln: 1.263 ± 0.037	2.153PheArg: 2.153 ± 0.053	3.258PheSer: 3.258 ± 0.068	2.674PheThr: 2.674 ± 0.063	3.181PheVal: 3.181 ± 0.061	0.546PheTrp: 0.546 ± 0.028	1.949PheTyr: 1.949 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.394GlyAla: 4.394 ± 0.089	0.972GlyCys: 0.972 ± 0.032	3.581GlyAsp: 3.581 ± 0.066	3.841GlyGlu: 3.841 ± 0.063	3.114GlyPhe: 3.114 ± 0.056	4.529GlyGly: 4.529 ± 0.096	1.429GlyHis: 1.429 ± 0.043	4.93GlyIle: 4.93 ± 0.083	5.352GlyLys: 5.352 ± 0.079	5.649GlyLeu: 5.649 ± 0.085	2.171GlyMet: 2.171 ± 0.053	3.564GlyAsn: 3.564 ± 0.07	1.267GlyPro: 1.267 ± 0.038	2.346GlyGln: 2.346 ± 0.051	3.47GlyArg: 3.47 ± 0.071	3.918GlySer: 3.918 ± 0.078	4.086GlyThr: 4.086 ± 0.071	4.809GlyVal: 4.809 ± 0.084	0.978GlyTrp: 0.978 ± 0.04	3.24GlyTyr: 3.24 ± 0.074	0.0GlyXaa: 0.0 ± 0.0
His	1.266HisAla: 1.266 ± 0.038	0.321HisCys: 0.321 ± 0.018	1.17HisAsp: 1.17 ± 0.039	1.149HisGlu: 1.149 ± 0.036	1.072HisPhe: 1.072 ± 0.034	1.418HisGly: 1.418 ± 0.041	0.628HisHis: 0.628 ± 0.026	1.615HisIle: 1.615 ± 0.047	1.173HisLys: 1.173 ± 0.038	1.902HisLeu: 1.902 ± 0.05	0.384HisMet: 0.384 ± 0.022	1.137HisAsn: 1.137 ± 0.035	1.04HisPro: 1.04 ± 0.035	0.793HisGln: 0.793 ± 0.028	1.153HisArg: 1.153 ± 0.032	1.196HisSer: 1.196 ± 0.043	1.192HisThr: 1.192 ± 0.037	1.269HisVal: 1.269 ± 0.038	0.26HisTrp: 0.26 ± 0.021	0.986HisTyr: 0.986 ± 0.037	0.0HisXaa: 0.0 ± 0.0
Ile	4.991IleAla: 4.991 ± 0.087	0.974IleCys: 0.974 ± 0.033	4.648IleAsp: 4.648 ± 0.077	3.932IleGlu: 3.932 ± 0.075	2.795IlePhe: 2.795 ± 0.06	4.58IleGly: 4.58 ± 0.081	1.282IleHis: 1.282 ± 0.035	4.72IleIle: 4.72 ± 0.094	4.055IleLys: 4.055 ± 0.071	5.368IleLeu: 5.368 ± 0.11	1.712IleMet: 1.712 ± 0.048	3.565IleAsn: 3.565 ± 0.064	2.93IlePro: 2.93 ± 0.055	2.1IleGln: 2.1 ± 0.047	3.303IleArg: 3.303 ± 0.059	4.425IleSer: 4.425 ± 0.078	3.855IleThr: 3.855 ± 0.08	4.57IleVal: 4.57 ± 0.088	0.72IleTrp: 0.72 ± 0.028	2.618IleTyr: 2.618 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.068LysAla: 5.068 ± 0.086	0.589LysCys: 0.589 ± 0.027	3.829LysAsp: 3.829 ± 0.075	4.558LysGlu: 4.558 ± 0.088	2.383LysPhe: 2.383 ± 0.05	4.375LysGly: 4.375 ± 0.076	1.502LysHis: 1.502 ± 0.042	4.266LysIle: 4.266 ± 0.072	5.009LysLys: 5.009 ± 0.09	5.448LysLeu: 5.448 ± 0.08	2.241LysMet: 2.241 ± 0.056	3.539LysAsn: 3.539 ± 0.065	2.397LysPro: 2.397 ± 0.052	2.867LysGln: 2.867 ± 0.065	3.317LysArg: 3.317 ± 0.06	3.511LysSer: 3.511 ± 0.069	3.936LysThr: 3.936 ± 0.058	4.201LysVal: 4.201 ± 0.072	0.792LysTrp: 0.792 ± 0.032	2.994LysTyr: 2.994 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	6.208LeuAla: 6.208 ± 0.087	1.428LeuCys: 1.428 ± 0.041	4.669LeuAsp: 4.669 ± 0.078	4.247LeuGlu: 4.247 ± 0.079	4.168LeuPhe: 4.168 ± 0.088	5.538LeuGly: 5.538 ± 0.088	1.902LeuHis: 1.902 ± 0.045	5.106LeuIle: 5.106 ± 0.079	5.902LeuLys: 5.902 ± 0.085	8.168LeuLeu: 8.168 ± 0.144	2.65LeuMet: 2.65 ± 0.066	4.585LeuAsn: 4.585 ± 0.077	3.822LeuPro: 3.822 ± 0.069	3.43LeuGln: 3.43 ± 0.075	4.494LeuArg: 4.494 ± 0.065	6.548LeuSer: 6.548 ± 0.101	5.106LeuThr: 5.106 ± 0.073	5.076LeuVal: 5.076 ± 0.093	1.033LeuTrp: 1.033 ± 0.039	3.469LeuTyr: 3.469 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.381MetAla: 2.381 ± 0.047	0.283MetCys: 0.283 ± 0.018	1.506MetAsp: 1.506 ± 0.044	1.774MetGlu: 1.774 ± 0.051	1.145MetPhe: 1.145 ± 0.036	2.047MetGly: 2.047 ± 0.054	0.546MetHis: 0.546 ± 0.025	1.638MetIle: 1.638 ± 0.047	2.558MetLys: 2.558 ± 0.056	2.824MetLeu: 2.824 ± 0.071	1.128MetMet: 1.128 ± 0.043	1.591MetAsn: 1.591 ± 0.04	1.296MetPro: 1.296 ± 0.038	1.299MetGln: 1.299 ± 0.035	1.583MetArg: 1.583 ± 0.049	1.738MetSer: 1.738 ± 0.043	1.761MetThr: 1.761 ± 0.04	1.783MetVal: 1.783 ± 0.042	0.285MetTrp: 0.285 ± 0.019	0.86MetTyr: 0.86 ± 0.031	0.0MetXaa: 0.0 ± 0.0
Asn	3.667AsnAla: 3.667 ± 0.07	0.575AsnCys: 0.575 ± 0.028	2.863AsnAsp: 2.863 ± 0.059	2.89AsnGlu: 2.89 ± 0.052	2.31AsnPhe: 2.31 ± 0.049	4.07AsnGly: 4.07 ± 0.081	1.098AsnHis: 1.098 ± 0.034	4.091AsnIle: 4.091 ± 0.084	3.39AsnLys: 3.39 ± 0.061	4.337AsnLeu: 4.337 ± 0.082	1.472AsnMet: 1.472 ± 0.036	2.891AsnAsn: 2.891 ± 0.066	2.337AsnPro: 2.337 ± 0.051	1.588AsnGln: 1.588 ± 0.04	2.649AsnArg: 2.649 ± 0.062	2.86AsnSer: 2.86 ± 0.068	2.901AsnThr: 2.901 ± 0.066	3.437AsnVal: 3.437 ± 0.078	0.662AsnTrp: 0.662 ± 0.029	2.37AsnTyr: 2.37 ± 0.063	0.0AsnXaa: 0.0 ± 0.0
Pro	2.454ProAla: 2.454 ± 0.048	0.388ProCys: 0.388 ± 0.02	2.376ProAsp: 2.376 ± 0.059	2.833ProGlu: 2.833 ± 0.055	1.787ProPhe: 1.787 ± 0.046	2.151ProGly: 2.151 ± 0.055	0.773ProHis: 0.773 ± 0.034	2.431ProIle: 2.431 ± 0.058	2.246ProLys: 2.246 ± 0.047	3.132ProLeu: 3.132 ± 0.056	1.103ProMet: 1.103 ± 0.035	1.905ProAsn: 1.905 ± 0.042	0.717ProPro: 0.717 ± 0.029	1.452ProGln: 1.452 ± 0.041	1.419ProArg: 1.419 ± 0.042	2.259ProSer: 2.259 ± 0.05	2.274ProThr: 2.274 ± 0.053	2.566ProVal: 2.566 ± 0.058	0.423ProTrp: 0.423 ± 0.025	1.709ProTyr: 1.709 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	2.478GlnAla: 2.478 ± 0.053	0.339GlnCys: 0.339 ± 0.018	1.745GlnAsp: 1.745 ± 0.048	2.241GlnGlu: 2.241 ± 0.067	1.444GlnPhe: 1.444 ± 0.037	2.257GlnGly: 2.257 ± 0.049	0.816GlnHis: 0.816 ± 0.031	2.422GlnIle: 2.422 ± 0.057	2.602GlnLys: 2.602 ± 0.062	3.423GlnLeu: 3.423 ± 0.079	1.168GlnMet: 1.168 ± 0.037	1.921GlnAsn: 1.921 ± 0.054	1.32GlnPro: 1.32 ± 0.035	1.911GlnGln: 1.911 ± 0.059	2.026GlnArg: 2.026 ± 0.05	2.056GlnSer: 2.056 ± 0.051	2.173GlnThr: 2.173 ± 0.042	2.157GlnVal: 2.157 ± 0.054	0.54GlnTrp: 0.54 ± 0.026	1.555GlnTyr: 1.555 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	3.044ArgAla: 3.044 ± 0.054	0.547ArgCys: 0.547 ± 0.023	2.479ArgAsp: 2.479 ± 0.056	3.135ArgGlu: 3.135 ± 0.063	2.295ArgPhe: 2.295 ± 0.05	2.817ArgGly: 2.817 ± 0.057	1.266ArgHis: 1.266 ± 0.04	3.447ArgIle: 3.447 ± 0.065	3.558ArgLys: 3.558 ± 0.071	4.804ArgLeu: 4.804 ± 0.087	1.724ArgMet: 1.724 ± 0.049	2.765ArgAsn: 2.765 ± 0.056	1.721ArgPro: 1.721 ± 0.044	2.175ArgGln: 2.175 ± 0.055	2.815ArgArg: 2.815 ± 0.068	2.62ArgSer: 2.62 ± 0.054	2.52ArgThr: 2.52 ± 0.055	2.82ArgVal: 2.82 ± 0.062	0.692ArgTrp: 0.692 ± 0.029	2.426ArgTyr: 2.426 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.202SerAla: 4.202 ± 0.079	0.846SerCys: 0.846 ± 0.03	3.252SerAsp: 3.252 ± 0.056	3.331SerGlu: 3.331 ± 0.063	3.043SerPhe: 3.043 ± 0.062	4.245SerGly: 4.245 ± 0.091	1.244SerHis: 1.244 ± 0.039	4.097SerIle: 4.097 ± 0.058	3.689SerLys: 3.689 ± 0.068	5.548SerLeu: 5.548 ± 0.092	1.743SerMet: 1.743 ± 0.041	2.938SerAsn: 2.938 ± 0.056	2.297SerPro: 2.297 ± 0.058	2.044SerGln: 2.044 ± 0.047	2.882SerArg: 2.882 ± 0.063	3.883SerSer: 3.883 ± 0.087	3.385SerThr: 3.385 ± 0.063	4.148SerVal: 4.148 ± 0.071	0.768SerTrp: 0.768 ± 0.029	2.734SerTyr: 2.734 ± 0.071	0.0SerXaa: 0.0 ± 0.0
Thr	4.165ThrAla: 4.165 ± 0.062	0.61ThrCys: 0.61 ± 0.024	3.554ThrAsp: 3.554 ± 0.064	3.129ThrGlu: 3.129 ± 0.052	2.746ThrPhe: 2.746 ± 0.066	4.089ThrGly: 4.089 ± 0.084	1.115ThrHis: 1.115 ± 0.034	4.051ThrIle: 4.051 ± 0.071	3.119ThrLys: 3.119 ± 0.052	5.456ThrLeu: 5.456 ± 0.081	1.502ThrMet: 1.502 ± 0.043	2.632ThrAsn: 2.632 ± 0.058	2.756ThrPro: 2.756 ± 0.055	1.865ThrGln: 1.865 ± 0.044	2.292ThrArg: 2.292 ± 0.053	3.42ThrSer: 3.42 ± 0.078	3.43ThrThr: 3.43 ± 0.074	4.03ThrVal: 4.03 ± 0.075	0.746ThrTrp: 0.746 ± 0.03	2.435ThrTyr: 2.435 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	4.787ValAla: 4.787 ± 0.089	1.015ValCys: 1.015 ± 0.035	3.781ValAsp: 3.781 ± 0.079	3.9ValGlu: 3.9 ± 0.081	2.946ValPhe: 2.946 ± 0.066	4.316ValGly: 4.316 ± 0.086	1.091ValHis: 1.091 ± 0.037	4.126ValIle: 4.126 ± 0.074	4.405ValLys: 4.405 ± 0.075	5.505ValLeu: 5.505 ± 0.083	1.923ValMet: 1.923 ± 0.051	3.24ValAsn: 3.24 ± 0.064	2.52ValPro: 2.52 ± 0.058	2.059ValGln: 2.059 ± 0.048	3.186ValArg: 3.186 ± 0.07	4.521ValSer: 4.521 ± 0.076	3.734ValThr: 3.734 ± 0.071	4.782ValVal: 4.782 ± 0.09	0.761ValTrp: 0.761 ± 0.031	2.678ValTyr: 2.678 ± 0.057	0.0ValXaa: 0.0 ± 0.0
Trp	0.751TrpAla: 0.751 ± 0.032	0.168TrpCys: 0.168 ± 0.015	0.732TrpAsp: 0.732 ± 0.03	0.644TrpGlu: 0.644 ± 0.029	0.53TrpPhe: 0.53 ± 0.023	0.96TrpGly: 0.96 ± 0.03	0.276TrpHis: 0.276 ± 0.018	0.753TrpIle: 0.753 ± 0.03	0.874TrpLys: 0.874 ± 0.031	1.229TrpLeu: 1.229 ± 0.038	0.437TrpMet: 0.437 ± 0.02	0.807TrpAsn: 0.807 ± 0.034	0.318TrpPro: 0.318 ± 0.02	0.583TrpGln: 0.583 ± 0.025	0.622TrpArg: 0.622 ± 0.029	0.759TrpSer: 0.759 ± 0.03	0.713TrpThr: 0.713 ± 0.032	0.697TrpVal: 0.697 ± 0.028	0.21TrpTrp: 0.21 ± 0.017	0.515TrpTyr: 0.515 ± 0.031	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.988TyrAla: 2.988 ± 0.061	0.573TyrCys: 0.573 ± 0.029	2.72TyrAsp: 2.72 ± 0.064	2.272TyrGlu: 2.272 ± 0.049	2.111TyrPhe: 2.111 ± 0.054	2.989TyrGly: 2.989 ± 0.072	1.073TyrHis: 1.073 ± 0.039	2.856TyrIle: 2.856 ± 0.058	2.658TyrLys: 2.658 ± 0.06	3.637TyrLeu: 3.637 ± 0.068	1.142TyrMet: 1.142 ± 0.038	2.537TyrAsn: 2.537 ± 0.063	1.677TyrPro: 1.677 ± 0.041	1.54TyrGln: 1.54 ± 0.04	2.354TyrArg: 2.354 ± 0.053	2.485TyrSer: 2.485 ± 0.065	2.569TyrThr: 2.569 ± 0.065	2.528TyrVal: 2.528 ± 0.059	0.527TyrTrp: 0.527 ± 0.025	2.101TyrTyr: 2.101 ± 0.059	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2869 proteins (880993 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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