Amino acid dipepetide frequency for Rhizopus microsporus ATCC 52813

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.296AlaAla: 5.296 ± 0.05	1.039AlaCys: 1.039 ± 0.017	3.047AlaAsp: 3.047 ± 0.03	3.79AlaGlu: 3.79 ± 0.034	2.735AlaPhe: 2.735 ± 0.026	3.177AlaGly: 3.177 ± 0.035	1.402AlaHis: 1.402 ± 0.017	4.409AlaIle: 4.409 ± 0.034	4.187AlaLys: 4.187 ± 0.036	6.305AlaLeu: 6.305 ± 0.044	1.619AlaMet: 1.619 ± 0.021	2.829AlaAsn: 2.829 ± 0.025	2.671AlaPro: 2.671 ± 0.036	2.54AlaGln: 2.54 ± 0.027	3.049AlaArg: 3.049 ± 0.028	5.155AlaSer: 5.155 ± 0.04	3.954AlaThr: 3.954 ± 0.03	4.067AlaVal: 4.067 ± 0.04	0.724AlaTrp: 0.724 ± 0.016	2.214AlaTyr: 2.214 ± 0.024	0.0AlaXaa: 0.0 ± 0.0
Cys	0.779CysAla: 0.779 ± 0.015	0.339CysCys: 0.339 ± 0.011	0.728CysAsp: 0.728 ± 0.015	0.701CysGlu: 0.701 ± 0.013	0.714CysPhe: 0.714 ± 0.013	0.896CysGly: 0.896 ± 0.018	0.45CysHis: 0.45 ± 0.011	1.08CysIle: 1.08 ± 0.015	0.858CysLys: 0.858 ± 0.016	1.569CysLeu: 1.569 ± 0.022	0.367CysMet: 0.367 ± 0.01	0.667CysAsn: 0.667 ± 0.015	0.711CysPro: 0.711 ± 0.015	0.636CysGln: 0.636 ± 0.012	0.753CysArg: 0.753 ± 0.014	1.117CysSer: 1.117 ± 0.018	0.815CysThr: 0.815 ± 0.014	0.875CysVal: 0.875 ± 0.014	0.183CysTrp: 0.183 ± 0.008	0.543CysTyr: 0.543 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.386AspAla: 3.386 ± 0.03	0.718AspCys: 0.718 ± 0.015	4.208AspAsp: 4.208 ± 0.044	4.502AspGlu: 4.502 ± 0.039	2.246AspPhe: 2.246 ± 0.022	2.652AspGly: 2.652 ± 0.027	1.4AspHis: 1.4 ± 0.019	4.211AspIle: 4.211 ± 0.034	3.367AspLys: 3.367 ± 0.032	5.063AspLeu: 5.063 ± 0.035	1.501AspMet: 1.501 ± 0.019	2.744AspAsn: 2.744 ± 0.029	2.582AspPro: 2.582 ± 0.03	2.281AspGln: 2.281 ± 0.024	2.469AspArg: 2.469 ± 0.027	3.624AspSer: 3.624 ± 0.033	3.252AspThr: 3.252 ± 0.03	3.335AspVal: 3.335 ± 0.037	0.722AspTrp: 0.722 ± 0.016	2.145AspTyr: 2.145 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	4.319GluAla: 4.319 ± 0.04	0.814GluCys: 0.814 ± 0.012	4.186GluAsp: 4.186 ± 0.041	6.816GluGlu: 6.816 ± 0.076	2.29GluPhe: 2.29 ± 0.026	2.83GluGly: 2.83 ± 0.029	1.586GluHis: 1.586 ± 0.02	3.887GluIle: 3.887 ± 0.034	5.118GluLys: 5.118 ± 0.046	5.951GluLeu: 5.951 ± 0.042	1.537GluMet: 1.537 ± 0.02	3.146GluAsn: 3.146 ± 0.028	2.323GluPro: 2.323 ± 0.025	3.436GluGln: 3.436 ± 0.037	3.615GluArg: 3.615 ± 0.037	4.293GluSer: 4.293 ± 0.035	3.456GluThr: 3.456 ± 0.032	3.21GluVal: 3.21 ± 0.034	0.762GluTrp: 0.762 ± 0.014	2.377GluTyr: 2.377 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	2.553PheAla: 2.553 ± 0.026	0.687PheCys: 0.687 ± 0.013	2.576PheAsp: 2.576 ± 0.025	2.522PheGlu: 2.522 ± 0.026	1.846PhePhe: 1.846 ± 0.025	2.544PheGly: 2.544 ± 0.035	0.956PheHis: 0.956 ± 0.016	2.854PheIle: 2.854 ± 0.035	2.414PheLys: 2.414 ± 0.022	3.727PheLeu: 3.727 ± 0.035	1.089PheMet: 1.089 ± 0.017	1.948PheAsn: 1.948 ± 0.025	1.619PhePro: 1.619 ± 0.021	1.524PheGln: 1.524 ± 0.021	1.761PheArg: 1.761 ± 0.023	3.094PheSer: 3.094 ± 0.029	2.344PheThr: 2.344 ± 0.023	2.635PheVal: 2.635 ± 0.024	0.573PheTrp: 0.573 ± 0.014	1.59PheTyr: 1.59 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	3.014GlyAla: 3.014 ± 0.039	0.79GlyCys: 0.79 ± 0.015	2.478GlyAsp: 2.478 ± 0.027	2.546GlyGlu: 2.546 ± 0.027	2.301GlyPhe: 2.301 ± 0.03	3.05GlyGly: 3.05 ± 0.046	1.407GlyHis: 1.407 ± 0.021	3.396GlyIle: 3.396 ± 0.035	3.205GlyLys: 3.205 ± 0.03	4.608GlyLeu: 4.608 ± 0.037	1.142GlyMet: 1.142 ± 0.02	2.231GlyAsn: 2.231 ± 0.026	1.782GlyPro: 1.782 ± 0.023	2.011GlyGln: 2.011 ± 0.023	2.464GlyArg: 2.464 ± 0.029	3.83GlySer: 3.83 ± 0.04	2.867GlyThr: 2.867 ± 0.034	3.105GlyVal: 3.105 ± 0.032	0.721GlyTrp: 0.721 ± 0.013	2.154GlyTyr: 2.154 ± 0.025	0.0GlyXaa: 0.0 ± 0.0
His	1.44HisAla: 1.44 ± 0.02	0.44HisCys: 0.44 ± 0.01	1.334HisAsp: 1.334 ± 0.019	1.421HisGlu: 1.421 ± 0.02	1.106HisPhe: 1.106 ± 0.017	1.309HisGly: 1.309 ± 0.022	1.004HisHis: 1.004 ± 0.019	1.7HisIle: 1.7 ± 0.02	1.372HisLys: 1.372 ± 0.02	2.443HisLeu: 2.443 ± 0.026	0.606HisMet: 0.606 ± 0.013	1.08HisAsn: 1.08 ± 0.018	1.436HisPro: 1.436 ± 0.022	1.256HisGln: 1.256 ± 0.021	1.381HisArg: 1.381 ± 0.017	1.906HisSer: 1.906 ± 0.021	1.4HisThr: 1.4 ± 0.018	1.54HisVal: 1.54 ± 0.022	0.326HisTrp: 0.326 ± 0.009	0.952HisTyr: 0.952 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.169IleAla: 4.169 ± 0.037	1.037IleCys: 1.037 ± 0.016	3.839IleAsp: 3.839 ± 0.031	4.289IleGlu: 4.289 ± 0.033	2.461IlePhe: 2.461 ± 0.024	3.12IleGly: 3.12 ± 0.031	1.798IleHis: 1.798 ± 0.023	3.919IleIle: 3.919 ± 0.039	4.284IleLys: 4.284 ± 0.038	5.816IleLeu: 5.816 ± 0.043	1.492IleMet: 1.492 ± 0.021	2.859IleAsn: 2.859 ± 0.027	3.257IlePro: 3.257 ± 0.032	3.011IleGln: 3.011 ± 0.03	3.237IleArg: 3.237 ± 0.025	4.729IleSer: 4.729 ± 0.036	3.628IleThr: 3.628 ± 0.027	3.921IleVal: 3.921 ± 0.036	0.73IleTrp: 0.73 ± 0.014	2.274IleTyr: 2.274 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	4.346LysAla: 4.346 ± 0.034	0.778LysCys: 0.778 ± 0.016	3.806LysAsp: 3.806 ± 0.034	5.396LysGlu: 5.396 ± 0.051	2.014LysPhe: 2.014 ± 0.026	2.91LysGly: 2.91 ± 0.03	1.696LysHis: 1.696 ± 0.019	3.607LysIle: 3.607 ± 0.032	6.015LysLys: 6.015 ± 0.058	5.782LysLeu: 5.782 ± 0.039	1.586LysMet: 1.586 ± 0.019	3.114LysAsn: 3.114 ± 0.027	2.925LysPro: 2.925 ± 0.031	3.291LysGln: 3.291 ± 0.034	4.323LysArg: 4.323 ± 0.038	4.569LysSer: 4.569 ± 0.035	3.727LysThr: 3.727 ± 0.031	3.69LysVal: 3.69 ± 0.034	0.711LysTrp: 0.711 ± 0.013	2.383LysTyr: 2.383 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	6.125LeuAla: 6.125 ± 0.038	1.536LeuCys: 1.536 ± 0.02	5.355LeuAsp: 5.355 ± 0.04	5.934LeuGlu: 5.934 ± 0.051	4.119LeuPhe: 4.119 ± 0.041	4.636LeuGly: 4.636 ± 0.041	2.209LeuHis: 2.209 ± 0.025	5.332LeuIle: 5.332 ± 0.045	6.25LeuLys: 6.25 ± 0.044	9.228LeuLeu: 9.228 ± 0.069	2.206LeuMet: 2.206 ± 0.024	4.378LeuAsn: 4.378 ± 0.036	4.653LeuPro: 4.653 ± 0.031	4.16LeuGln: 4.16 ± 0.033	4.61LeuArg: 4.61 ± 0.03	7.612LeuSer: 7.612 ± 0.051	5.117LeuThr: 5.117 ± 0.038	5.429LeuVal: 5.429 ± 0.039	1.019LeuTrp: 1.019 ± 0.016	3.251LeuTyr: 3.251 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	1.756MetAla: 1.756 ± 0.023	0.307MetCys: 0.307 ± 0.009	1.534MetAsp: 1.534 ± 0.019	1.489MetGlu: 1.489 ± 0.022	0.925MetPhe: 0.925 ± 0.015	1.133MetGly: 1.133 ± 0.018	0.535MetHis: 0.535 ± 0.013	1.518MetIle: 1.518 ± 0.021	1.581MetLys: 1.581 ± 0.018	2.156MetLeu: 2.156 ± 0.025	0.744MetMet: 0.744 ± 0.015	1.36MetAsn: 1.36 ± 0.018	1.106MetPro: 1.106 ± 0.016	0.969MetGln: 0.969 ± 0.015	1.045MetArg: 1.045 ± 0.015	2.086MetSer: 2.086 ± 0.027	1.693MetThr: 1.693 ± 0.021	1.405MetVal: 1.405 ± 0.021	0.225MetTrp: 0.225 ± 0.008	0.763MetTyr: 0.763 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.988AsnAla: 2.988 ± 0.027	0.622AsnCys: 0.622 ± 0.015	2.808AsnAsp: 2.808 ± 0.03	3.164AsnGlu: 3.164 ± 0.031	1.634AsnPhe: 1.634 ± 0.022	2.444AsnGly: 2.444 ± 0.028	1.22AsnHis: 1.22 ± 0.016	3.141AsnIle: 3.141 ± 0.032	3.179AsnLys: 3.179 ± 0.028	3.937AsnLeu: 3.937 ± 0.032	1.254AsnMet: 1.254 ± 0.018	3.413AsnAsn: 3.413 ± 0.048	2.24AsnPro: 2.24 ± 0.026	2.112AsnGln: 2.112 ± 0.022	2.269AsnArg: 2.269 ± 0.025	3.446AsnSer: 3.446 ± 0.031	3.046AsnThr: 3.046 ± 0.027	2.854AsnVal: 2.854 ± 0.031	0.565AsnTrp: 0.565 ± 0.011	1.704AsnTyr: 1.704 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	2.732ProAla: 2.732 ± 0.029	0.528ProCys: 0.528 ± 0.014	2.427ProAsp: 2.427 ± 0.028	3.135ProGlu: 3.135 ± 0.031	2.009ProPhe: 2.009 ± 0.025	2.032ProGly: 2.032 ± 0.025	1.047ProHis: 1.047 ± 0.019	2.902ProIle: 2.902 ± 0.033	2.854ProLys: 2.854 ± 0.031	4.118ProLeu: 4.118 ± 0.033	0.968ProMet: 0.968 ± 0.018	2.251ProAsn: 2.251 ± 0.023	3.012ProPro: 3.012 ± 0.049	1.905ProGln: 1.905 ± 0.028	2.002ProArg: 2.002 ± 0.023	4.484ProSer: 4.484 ± 0.043	3.205ProThr: 3.205 ± 0.035	2.945ProVal: 2.945 ± 0.03	0.478ProTrp: 0.478 ± 0.011	1.594ProTyr: 1.594 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	2.794GlnAla: 2.794 ± 0.029	0.593GlnCys: 0.593 ± 0.013	2.351GlnAsp: 2.351 ± 0.025	3.153GlnGlu: 3.153 ± 0.03	1.712GlnPhe: 1.712 ± 0.022	1.852GlnGly: 1.852 ± 0.02	1.28GlnHis: 1.28 ± 0.021	2.43GlnIle: 2.43 ± 0.023	2.988GlnLys: 2.988 ± 0.03	4.511GlnLeu: 4.511 ± 0.037	1.117GlnMet: 1.117 ± 0.018	1.833GlnAsn: 1.833 ± 0.02	2.198GlnPro: 2.198 ± 0.032	4.159GlnGln: 4.159 ± 0.088	2.431GlnArg: 2.431 ± 0.026	3.156GlnSer: 3.156 ± 0.03	2.385GlnThr: 2.385 ± 0.027	2.599GlnVal: 2.599 ± 0.024	0.52GlnTrp: 0.52 ± 0.012	1.549GlnTyr: 1.549 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	2.981ArgAla: 2.981 ± 0.025	0.705ArgCys: 0.705 ± 0.013	2.464ArgAsp: 2.464 ± 0.024	3.097ArgGlu: 3.097 ± 0.037	2.074ArgPhe: 2.074 ± 0.021	2.271ArgGly: 2.271 ± 0.03	1.467ArgHis: 1.467 ± 0.021	3.192ArgIle: 3.192 ± 0.028	3.78ArgLys: 3.78 ± 0.032	5.062ArgLeu: 5.062 ± 0.035	1.255ArgMet: 1.255 ± 0.019	2.233ArgAsn: 2.233 ± 0.023	2.292ArgPro: 2.292 ± 0.028	2.526ArgGln: 2.526 ± 0.025	3.553ArgArg: 3.553 ± 0.041	3.683ArgSer: 3.683 ± 0.038	2.647ArgThr: 2.647 ± 0.024	2.773ArgVal: 2.773 ± 0.03	0.625ArgTrp: 0.625 ± 0.014	1.871ArgTyr: 1.871 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	4.631SerAla: 4.631 ± 0.033	1.096SerCys: 1.096 ± 0.019	3.941SerAsp: 3.941 ± 0.037	4.041SerGlu: 4.041 ± 0.034	3.444SerPhe: 3.444 ± 0.033	3.685SerGly: 3.685 ± 0.037	1.828SerHis: 1.828 ± 0.023	5.245SerIle: 5.245 ± 0.039	4.84SerLys: 4.84 ± 0.036	7.286SerLeu: 7.286 ± 0.043	1.822SerMet: 1.822 ± 0.023	4.01SerAsn: 4.01 ± 0.036	3.8SerPro: 3.8 ± 0.037	3.08SerGln: 3.08 ± 0.03	3.751SerArg: 3.751 ± 0.034	8.497SerSer: 8.497 ± 0.071	5.372SerThr: 5.372 ± 0.047	4.533SerVal: 4.533 ± 0.039	0.846SerTrp: 0.846 ± 0.014	2.355SerTyr: 2.355 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	4.082ThrAla: 4.082 ± 0.038	0.91ThrCys: 0.91 ± 0.017	2.928ThrAsp: 2.928 ± 0.029	3.506ThrGlu: 3.506 ± 0.031	2.511ThrPhe: 2.511 ± 0.029	3.087ThrGly: 3.087 ± 0.036	1.367ThrHis: 1.367 ± 0.02	4.029ThrIle: 4.029 ± 0.029	3.545ThrLys: 3.545 ± 0.033	5.553ThrLeu: 5.553 ± 0.041	1.352ThrMet: 1.352 ± 0.018	2.732ThrAsn: 2.732 ± 0.024	3.147ThrPro: 3.147 ± 0.031	2.154ThrGln: 2.154 ± 0.024	2.672ThrArg: 2.672 ± 0.027	5.059ThrSer: 5.059 ± 0.042	4.572ThrThr: 4.572 ± 0.065	3.898ThrVal: 3.898 ± 0.033	0.656ThrTrp: 0.656 ± 0.012	1.826ThrTyr: 1.826 ± 0.023	0.0ThrXaa: 0.0 ± 0.0
Val	3.974ValAla: 3.974 ± 0.038	0.976ValCys: 0.976 ± 0.015	3.627ValAsp: 3.627 ± 0.032	3.704ValGlu: 3.704 ± 0.037	2.537ValPhe: 2.537 ± 0.03	2.958ValGly: 2.958 ± 0.03	1.505ValHis: 1.505 ± 0.02	3.91ValIle: 3.91 ± 0.035	3.798ValLys: 3.798 ± 0.04	5.492ValLeu: 5.492 ± 0.041	1.444ValMet: 1.444 ± 0.022	2.815ValAsn: 2.815 ± 0.028	2.858ValPro: 2.858 ± 0.029	2.498ValGln: 2.498 ± 0.024	2.704ValArg: 2.704 ± 0.027	4.315ValSer: 4.315 ± 0.037	3.398ValThr: 3.398 ± 0.033	3.796ValVal: 3.796 ± 0.04	0.704ValTrp: 0.704 ± 0.013	2.22ValTyr: 2.22 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	0.667TrpAla: 0.667 ± 0.013	0.185TrpCys: 0.185 ± 0.006	0.693TrpAsp: 0.693 ± 0.015	0.632TrpGlu: 0.632 ± 0.013	0.527TrpPhe: 0.527 ± 0.014	0.556TrpGly: 0.556 ± 0.012	0.282TrpHis: 0.282 ± 0.009	0.841TrpIle: 0.841 ± 0.016	0.89TrpLys: 0.89 ± 0.016	1.101TrpLeu: 1.101 ± 0.017	0.326TrpMet: 0.326 ± 0.008	0.65TrpAsn: 0.65 ± 0.013	0.417TrpPro: 0.417 ± 0.01	0.45TrpGln: 0.45 ± 0.009	0.631TrpArg: 0.631 ± 0.012	0.946TrpSer: 0.946 ± 0.017	0.725TrpThr: 0.725 ± 0.015	0.614TrpVal: 0.614 ± 0.012	0.19TrpTrp: 0.19 ± 0.007	0.408TrpTyr: 0.408 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.177TyrAla: 2.177 ± 0.021	0.68TyrCys: 0.68 ± 0.014	2.078TyrAsp: 2.078 ± 0.026	2.114TyrGlu: 2.114 ± 0.024	1.65TyrPhe: 1.65 ± 0.023	1.959TyrGly: 1.959 ± 0.025	1.012TyrHis: 1.012 ± 0.015	2.268TyrIle: 2.268 ± 0.023	2.142TyrLys: 2.142 ± 0.023	3.454TyrLeu: 3.454 ± 0.035	0.904TyrMet: 0.904 ± 0.015	1.749TyrAsn: 1.749 ± 0.02	1.597TyrPro: 1.597 ± 0.022	1.612TyrGln: 1.612 ± 0.022	1.832TyrArg: 1.832 ± 0.023	2.499TyrSer: 2.499 ± 0.028	1.984TyrThr: 1.984 ± 0.023	2.008TyrVal: 2.008 ± 0.022	0.454TyrTrp: 0.454 ± 0.011	1.556TyrTyr: 1.556 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10804 proteins (4076562 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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